Claims
- 1. A compound of the formula ##STR105## wherein n is an integer from 1 to 4, inclusive;
- R.sub.1 is hydrogen or carboxylic acid acyl;
- R.sub.2 is hydrogen, --OR.sub.1, --NHSO.sub.2 R.sub.7, --NHCOR.sub.8 --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 R.sub.7, --CONHR.sub.8, halogen or --CN;
- R.sub.3 is hydrogen, halogen, --R.sub.7 or --OR.sub.7 ;
- R.sub.4 is hydrogen, methyl or ethyl;
- R.sub.5 and R.sub.6 are each hydrogen or methyl;
- R.sub.7 is alkyl of 1 to 4 carbon atoms;
- R.sub.8 is hydrogen or alkyl of 1 to 4 carbon atoms;
- R.sub.9 is hydrogen, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, optionally interrupted by oxygen;
- R.sub.10 is hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or pyridyl; and
- Z is --CH.sub.2 -- or --CO--;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 2. A compound of claim 1,
- where
- n is an integer from 1 to 4, inclusive;
- R.sub.1 is hydrogen;
- R.sub.2 is hydrogen, hydroxyl, --NHSO.sub.2 CH.sub.3, --NHCOR.sub.8, --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 CH.sub.3, --CONHR.sub.8, chlorine or fluorine;
- R.sub.3 is hydrogen, chlorine, methyl or methoxy;
- R.sub.5, R.sub.6, R.sub.8 and R.sub.10 are each hydrogen or methyl;
- R.sub.9 is hydrogen or 4-methoxy; and
- Z is --CO--;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 3. A compound of claim 1, wherein n is 2 or 3.
- 4. A compound of claim 2, wherein n is 2 or 3.
- 5. A broncholytic, uterus-relaxing or antiallergic pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective broncholytic, uterus-relaxing or antiallergic amount of a compound of claim 1 where R.sub.2 is other than --CONHR.sub.8.
- 6. The method of relieving bronchial spasms, relaxing the uterus or suppressing allergic reactions in a warmblooded animal in need thereof, which comprises perorally, parenterally or rectally administering to said animal an effective broncholytic, uterus-relaxing or antiallergic amount of a compound of claim 1 where R.sub.2 is other than --CONHR.sub.8.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2833140 |
Jul 1978 |
DEX |
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Parent Case Info
This is a continuation of copending application Ser. No. 156,928, filed June 6, 1980, now abandoned; which, in turn, is a continuation of copending application Ser. No. 060,389, filed July 25, 1979, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3274194 |
Hayao |
Sep 1966 |
|
3718648 |
Beyerle et al. |
Feb 1973 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
1934037 |
Jan 1971 |
DEX |
Continuations (2)
|
Number |
Date |
Country |
Parent |
156928 |
Jun 1980 |
|
Parent |
60389 |
Jul 1979 |
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