Claims
- 1. A compound of the formula: ##STR11## wherein X is ##STR12## R.sup.1 is methyl, ##STR13## R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen or methyl; R.sup.4 is hydrogen, lower alkyl or alkanoyl; R.sup.5 is hydrogen, lower alkyl, amino, lower alkylamino, di(lower alkyl)-amino or OR.sup.6 ; and R.sup.6 is hydrogen or lower alkyl;
- or pharmaceutically acceptable salts thereof.
- 2. The compound of claim 1 wherein R.sup.1 is carboxyl, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl or di(lower-alkyl)carbamoyl.
- 3. The compound of claim 2 wherein R.sup.1 is lower alkoxycarbonyl.
- 4. The compound of claim 3 wherein said compound is ethyl p-[(E)-2-(4,4-dimethyl-1,2,3,4-tetrahydro-6-quinolinyl)propenyl]benzoate.
- 5. The compound of claim 3 wherein said compound is ethyl p-[(E)-2-(1,4,4-trimethyl-1,2,3,4-tetrahydro-6-quinolinyl)propenyl]benzoate.
- 6. A method for combatting acne or psoriasis comprising administering to a patient an effective amount of a compound of the formula ##STR14## wherein X is ##STR15## R.sup.1 is methyl, ##STR16## R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen or methyl; R.sup.4 is hydrogen, lower alkyl or alkanoyl; R.sup.5 is hydrogen, lower alkyl, amino, lower alkylamino, di(lower-alkyl)amino or OR.sup.6 ; and R.sup.6 is hydrogen or lower alkyl;
- or pharmaceutically acceptable salts thereof.
- 7. The method of claim 6 wherein said compound is administered orally.
- 8. The method of claim 6 wherein said amount is from 1 to 100 mg per day.
- 9. The method of claim 6 wherein said compound is administered topically.
- 10. The method of claim 9 wherein said preparation contains said compound in an amount of from 0.1 to 5% based upon the weight of said composition.
- 11. A method for combatting neoplasms comprising administering to a patient in an effective amount of a compound of the formula: ##STR17## wherein X is ##STR18## R.sup.1 is methyl, ##STR19## R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen or methyl; R.sup.4 is hydrogen, lower alkyl or lower alkanoyl; R.sup.5 is hydrogen, lower alkyl, amino, alkylamino, di(lower-alkyl)amino or OR.sup.6 ; and R.sup.6 is hydrogen or lower alkyl;
- or pharmaceutically acceptable salts thereof.
- 12. The method of claim 11 wherein said amoutn is from 0.5 to 100 mg per day administered orally.
- 13. The method of claim 12 wherein said compound is administered orally.
- 14. A composition in oral unit dosage form comprising from about 0.5 to about 100 mg of a compound of the formula: ##STR20## wherein X is ##STR21## R.sup.1 is methyl, ##STR22## R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen or methyl; R.sup.4 is hydrogen, lower alkyl or alkanoyl; R.sup.5 is hydrogen, lower alkyl, amino, lower alkylamino, di(lower-alkyl)amino or OR.sup.6 ; and R.sup.6 is hydrogen or lower alkyl;
- and an inert pharmaceutically acceptable carrier.
- 15. The composition of claim 14 wherein said compound is present in an amount of from 5 to 30 mg.
- 16. A composition for topical administration comprising a therapeutically inert pharmaceutically acceptable carrier and from about 0.1 to 5% by weight based upon the weight of the composition of a compound of the formula: ##STR23## wherein X is ##STR24## R.sup.1 is methyl, ##STR25## R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen or methyl; R.sup.4 is hydrogen, lower alkyl or alkanoyl; R.sup.5 is hydrogen, lower alkyl, amino, lower alkylamino, di(lower-alkyl)amino or OR.sup.6 ; and R.sup.6 is hydrogen or lower alkyl;
- or pharmaceutically acceptable salts thereof.
- 17. The compound of claim 14 wherein said composition is in the form of a shampoo, cream, lotion or salve.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2956/82 |
May 1982 |
CHX |
|
Parent Case Info
This is a division of application Ser. No. 06/491,618 filed May 5, 1983.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4396553 |
Klaus |
Aug 1983 |
|
4456618 |
Dawson et al. |
Jun 1984 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
491618 |
May 1983 |
|