Claims
- 1. A compound of the formula ##STR64## wherein m is 0 or 1;
- p is 0, 1, 2, or 3;
- q is 0 or 1;
- R.sup.1 is hydrogen, hydroxy, or lower alkyl;
- R.sup.4 is hydrogen, lower alkyl, cycloalkyl, or optionally substituted phenyl;
- R.sup.5 is optionally substituted phenyl;
- R.sup.9 is lower alkyl or optionally substituted phenyl; and
- R.sup.10 is hydrogen or lower alkyl;
- with the proviso that R.sup.9, R.sup.10, and the sidechain cannot be attached to the oxygen atom;
- or a pharmaceutically acceptable acid addition salt or N-oxide thereof.
- 2. The compound of claim 1, wherein m is 0, p is 0, q is 0, and R.sup.1 is hydrogen, or a pharmaceutically acceptable acid addition salt or N-oxide thereof.
- 3. The compound of claim 2, wherein R.sup.9 is optionally substituted phenyl and R.sup.10 is lower alkyl, or a pharmaceutically acceptable acid addition salt or N-oxide thereof.
- 4. The compound of claim 3, wherein R.sup.4 and R.sup.5 are both phenyl, or a pharmaceutically acceptable acid addition salt or N-oxide thereof.
- 5. The compound of claim 4, wherein R.sup.9 is 5-phenyl, R.sup.10 is 3-methyl, and the sidechain is in the 2-position, namely 4-diphenylmethyl-1-[(5-phenyl-3-methylfuran-2-yl)methyl]piperidine, or a pharmaceutically acceptable acid addition salt or N-oxide thereof.
- 6. The compound of claim 4, wherein R.sup.9 is 5-(4-trifluoromethyl)phenyl, R.sup.10 is 3-methyl, and the sidechain is in the 2-position, namely 4-diphenylmethyl-1-[(5-(4-trifluoromethylphenyl)-3-methylfuran-2-yl)methyl]piperidine, or a pharmaceutically acceptable acid addition salt or N-oxide thereof.
- 7. The compound of claim 3, wherein R.sup.4 is 4-fluorophenyl and R.sup.5 is hydrogen, or a pharmaceutically acceptable acid addition salt or N-oxide thereof.
- 8. The compound of claim 7, wherein R.sup.9 is 5-(4-methylphenyl), R.sup.10 is 3-methyl, and the sidechain is in the 2-position, namely 4-(4-fluorophenyl)methyl-1-[(5-(4-methylphenyl)-3-methylfuran-2-yl)methyl]piperidine, or a pharmaceutically acceptable acid addition salt or N-oxide thereof.
- 9. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable acid addition salt or N-oxide thereof, in admixture with one or more pharmaceutically acceptable non-toxic carriers.
- 10. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 6, or a pharmaceutically acceptable acid addition salt or N-oxide thereof, in admixture with one or more pharmaceutically acceptable non-toxic carriers.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a division of U.S. patent application Ser. No. 08/045,568, filed Apr. 9, 1993, now U.S. Pat. No. 5,428,037.
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Divisions (1)
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Number |
Date |
Country |
Parent |
45568 |
Apr 1993 |
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