Claims
- 1. A compound of formula: ##STR187## in which: when Z.sub.1 is C.sub.1 -C.sub.4 alkylene, W is NR.sub.1 R.sub.2, in which R.sub.1 is selected from H and C.sub.1 -C.sub.4 alkyl, and R.sub.2 is selected from H, C.sub.1 -C.sub.4 alkyl, CONQ.sub.1 Q.sub.2 and CSNQ.sub.1 Q.sub.2 in which Q.sub.1 and Q.sub.2 are independently selected from H and C.sub.1 -C.sub.4 alkyl, SO.sub.2 Q.sub.3 in which Q.sub.3 is C.sub.1 -C.sub.4 alkyl, COOQ.sub.4 in which Q.sub.4 is selected from C.sub.1 -C.sub.4 alkyl and benzyl, or R.sub.1 and R.sub.2 taken together form with N a saturated heterocycle morpholine, pyrrolidine, piperidine, piperazine or 4-(C.sub.1 -C.sub.3)alkyl-piperazine; or W is N(O)R.sub.1 R.sub.2 in which R.sub.1, R.sub.2 are independently selected from H and C.sub.1 -C.sub.4 alkyl; or W is selected from the group consisting of C.sub.1 -C.sub.4 alkoxy, and C.sub.1 -C.sub.4 thioalkoxy;
- when Z.sub.1 is phenylene, W is NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2 are independently selected from H and C.sub.1 -C.sub.4 alkyl;
- Z.sub.2 is C.sub.1 -C.sub.4 alkylene;
- R.sub.3 is selected from H, C.sub.1 -C.sub.8 alkyl and halogen;
- Ar.sub.1 is selected from phenyl optionally substituted by one or more groups selected from halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 thioalkoxy, hydroxy, COOQ.sub.5 in which Q.sub.5 is C.sub.1 -C.sub.4 alkyl, carboxamido, cyano, amino, acetamido, nitro and trifluoromethyl; naphtyl, benzyl and cyclohexyl;
- Ar.sub.2 is pyridyl, optionally substituted by a radical selected from C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; or a pharmaceutically acceptable acid or base salt thereof.
- 2. A compound according to claim 1 of formula I in which Ar.sub.1 is an at least ortho-substituted phenyl.
- 3. A compound according to claim 1 of formula I in which Z.sub.1 is C.sub.1 -C.sub.4 alkylene, and W is NR.sub.1 R.sub.2.
- 4. A compound according to claim 1 of formula I in which Z.sub.1 is C.sub.2 -C.sub.4 alkylene, and W is NR.sub.1 R.sub.2 and Ar.sub.2 is selected from 2-pyridyl and 3-pyridyl.
- 5. A compound according to claim 1 selected from the group consisting of:
- 2(N-�2-N',N'-dimethylaminoethyl!N-�3-pyridylmethyl!amino)4-(2,4-dichlorophenyl)5-methyl oxazole,
- 2(N-�2-N',N'-dimethylaminoethyl!N-�3-pyridylmethyl!amino)4-(4-methylphenyl)5-methyloxazole, and
- 2-(N-�2-pyrrolidinoethyl!N-�3-pyridylmethyl!amino)4-(2,4-dichlorophenyl)5-methyl oxazole.
Priority Claims (1)
Number |
Date |
Country |
Kind |
89 17491 |
Dec 1989 |
FRX |
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Parent Case Info
This is a division of application Ser. No. 08/511,468 filed Aug. 4, 1995; now U.S. Pat. No. 5,780,468.
Foreign Referenced Citations (3)
Number |
Date |
Country |
0149884 |
Aug 1984 |
EPX |
0283390 |
Sep 1988 |
EPX |
880749 |
Jun 1953 |
DEX |
Divisions (1)
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Number |
Date |
Country |
Parent |
511468 |
Aug 1995 |
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