Heterocyclic dihydropyrimidine compounds

Description

FIELD OF THE INVENTION

[0002] The present invention provides for heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, more especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur) and to pharmaceutical compositions containing such compounds. The present invention further provides for methods of using such compounds in the treatment of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

BACKGROUND OF THE INVENTION

[0003] The importance of potassium channels was first recognized aproximately fifty years ago when Hodgkin and Huxley discovered that potassium ions contributed to the current that excited the squid giant axon. Research in the area, however, was hampered by the lack of selective, high affinity ligands for potassium channels. But the advent of recombinant DNA techniques and single cell and whole cell voltage clamp techniques has changed the slow pace of the field. Indeed, potassium channels that exhibit functional, pharmacological and tissue distribution characteristics have been cloned. These cloned potassim channels are useful targets in assays for identifying candidate compounds for the treatment of various disease states. Potassium channels have turned out to be the most diverse family of ion channels discovered to date. They modulate a number of cellular events such as muscle contraction, neuro-endocrine secretion, frequency and duration of action potentials, electrolyte homeostatis, and resting membrane potential.

[0004] Potassium channels are expressed in eukaryotic and procaryotic cells and are elements in the control of electrical and non-electrical cellular functions. Potassium channels have been classified according to their biophysical and pharmacological characteristics. Subclasses of these channels have been named based on amino acid sequence and functional properties. Salient among these are the voltage dependent potassium channels, for example voltage gated potassium channels (e.g., Kv1, Kv2, Kv3, Kv4). Subtypes within these subclasses have been characterized as to their putative function, pharmacology and distribution in cells and tissues (Chandy and Gutman, “Voltage-gated potassium channel genes” in Handbook of Receptors and Channels—Ligand and Voltage-gated Ion Channels, ed. R. A. North, 1995; Doupnik et al., Curr. Opin. Neurobiol. 5:268, 1995). For example, the Kv1 class of potassium channels is further subdivided depending on the molecular sequence of the channel, for example Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6, and Kv1.7. Functional voltage-gated K+ channels can exist as multimeric structures formed by the association of either identical or dissimilar subunits. This phenomena is thought to account for the wide diversity of K+ channels. However, subunit compositions of native K channels and the physiologic role that particular channels play are, in most cases, still unclear.

[0005] Membrane depolarization by Kv1.3 inhibition has been shown to be an effective method to prevent T-cell proliferation and therefore has applications in many autoimmune conditions. Inhibition of K+ channels in the plasma membrane of human T-lymphocytes has been postulated to play a role in eliciting immunosuppressive responses by regulating intracellular Ca++ homeostasis, which has been found to be important in T-cell activation.

[0006] The Kv1.3 voltage-gated potassium channel is found in neurons, blood cells, osteoclasts and T-lymphocytes. The Chandy and Cahalan laboratories proposed a hypothesis that blocking the Kv1.3 channel would elicit an immunosuppressant response. (Chandy et al., J. Exp. Med. 160, 369, 1984; Decoursey et al., Nature, 307, 465, 1984). However, the K+ channel blockers employed in their studies were non-selective. Until research with the peptide margatoxin, a peptide found in scorpion venom, no specific inhibitor of the Kv1.3 channel existed to test this hypothesis. Although a laboratory (Price et al., Proc. Natl, Acad, Sci. USA, 86, 10171, 1989) showed that charybdotoxin would block Kv1.3 in human T-cells, charybdotoxin was subsequently shown to inhibit four different K+ channels (Kv1.3 and three distinct small conductance Ca++ activated K+ channels) in human T-lymphocytes, limiting the use of this toxin as a probe for the physiological role of Kv1.3 (Leonard et al., Proc. Natl, Acad. Sci, USA, 89, 10094, 1992). Margatoxin, on the other hand, blocks only Kv1.3 in T-cells, and has immunosuppressant activity on both in in vitro and in vivo models. (Lin et al., J. exp. Med, 177, 637, 1993). The therapeutic utility of this compound, however, is limited by its potent toxicity. Recently, a class of compounds has been reported that may be an attractive alternative to the above mentioned drugs, see for example U.S. Pat. Nos. 5,670,504; 5,631,282; 5,696,156; 5,679,705; and 5,696,156. While addressing some of the activity/toxicity problems of previous drugs, these compounds tend to be of large molecular weight and are generally produced by synthetic manipulation of a natural product, isolation of which is cumbersome and labor intensive.

[0007] Immunoregulatory abnormalities have been shown to exist in a wide variety of autoimmune and chronic inflammatory diseases, including systemic lupus erythematosis, chronic rheumatoid arthritis, type I and II diabetes mellitus, inflammatory bowel disease, biliary cirrhosis, uveitis, multiple sclerosis and other disorders such as Crohn's disease, ulcerative colitis, bullous pemphigoid, sarcoidosis, psoriasis, ichthyosis, Graves ophthalmopathy and asthma.

[0008] Although the underlying pathogenesis of each of these conditions may be quite different, they have in common the appearance of a variety of auto-antibodies and self-reactive lymphocytes. Such self-reactivity may be due, in part, to a loss of the homeostatic controls under which the normal immune system operates. Similarly, following a bone-marrow or an organ transplantation, the host lymphocytes recognize the foreign tissue antigens and begin to produce antibodies which lead to graft rejection.

[0009] One end result of an autoimmune or a rejection process is tissue destruction caused by inflammatory cells and the mediators they release. Anti-inflammatory agents such as NSAID's act principally by blocking the effect or secretion of these mediators but do nothing to modify the immunologic basis of the disease. On the other hand, cytotoxic agents, such as cyclophosphamide, act in such a nonspecific fashion that both the normal and autoimmune responses are shut off. Indeed, patients treated with such nonspecific immunosuppressive agents are as likely to succumb from infection as they are from their autoimmune disease.

[0010] Cyclosporin A (CsA), which was approved by the US FDA in 1983 is currently the leading drug used to prevent rejection of transplanted organs. In 1993, FK-506 (Prograf) was approved by the US FDA for the prevention of rejection in liver transplantation. CsA and FK-506 act by inhibiting the body's immune system from mobilizing its vast arsenal of natural protecting agents to reject the transplant's foreign protein. In 1994, CsA was approved by the US FDA for the treatment of severe psoriasis and has been approved by European regulatory agencies for the treatment of atopic dermatitis. Though they are effective in fighting transplant rejection, CsA and FK-506 are known to cause several undesirable side effects including nephrotoxicity, neurotoxicity, and gastrointestinal discomfort. Therefore, a selective immunosuppressant without these side effects still remains to be developed. Potassium channel inhibitors promise to be the solution to this problem.

[0011] Atrial fibrillation (AF) and atrial flutter are the most common cardiac arrhythmias in clinical practice and are likely to increase in prevalence with the aging of the population. Currently, AF affects more than 1 million Americans annually, represents over 5% of all admissions for cardiovascular diseases and causes more than 80,000 strokes each year in the United States. While AF is rarely a lethal arrhythmia, it is responsible for substantial morbidity and can lead to complications such as the development of congestive heart failure or thromboembolism. Currently available Class I and Class III antiarrhythmic drugs reduce the rate of recurrence of AF, but are of limited use because of a variety of potentially adverse effects including ventricular proarrhythmia. Because current therapy is inadequate and fraught with side effects, there is a clear need to develop new therapeutic approaches.

[0012] Antiarrhythmic agents of Class III are drugs that cause a selective prolongation of the duration of the action potential without significant cardiac depression. Available drugs in this class are limited in number. Examples such as sotalol and amiodarone have been shown to possess interesting Class III properties (Singh B. N., Vaughan Williams E. M. “A Third Class of Anti-Arrhythmic Action: Effects On Atrial And Ventricular Intracellular Potentials And Other Pharmacological Actions On Cardiac Muscle, of MJ 1999 and AH 3747” Br. J. Pharmacol 1970; 39:675-689. and Singh B. N., Vaughan Williams E. M, “The Effect of Amiodarone, A New Anti-Anginal Drug, On Cardiac Muscle”, Br J. Pharmacol 1970; 39:657-667), but these are not selective Class III agents. Sotalol also possesses Class II effects which may cause cardiac depression and is contraindicated in certain susceptible patients. Amiodarone, also is not a selective Class III antiarrhythmic agent because it possesses multiple electrophysiological actions and is severely limited by side effects (Nademanee, K. “The Amiodarone Odessey”. J. Am. Coll. Cardiol. 1992;20:1063-1065.) Drugs of this class are expected to be effective in preventing ventricular fibrillation. Selective class III agents, by definition, are not considered to cause myocardial depression or an induction of arrhythmias due to inhibition of conduction of the action potential as seen with Class I antiarrhythmic agents.

[0013] Class III agents increase myocardial refractoriness via a prolongation of cardiac action potential duration. Theoretically, prolongation of the cardiac action potential can be achieved by enhancing inward currents (i.e. Na+ or Ca2+ currents; hereinafter INa and ICa, respectively) or by reducing outward repolarizing potassium (K+) currents. The delayed rectifier (IK) K+ current is the main outward current involved in the overall repolarization process during the action potential plateau, whereas the transient outward (Ito) and inward rectifier (IKI) K+ currents are responsible for the rapid initial and terminal phases of repolarization, respectively. Cellular electrophysiologic studies have demonstrated that IK consists of two pharmacologically and kinetically distinct K+ current subtypes, IKr (rapidly activating and deactivating) and IKs (slowly activating and deactivating) (Sanguinetti and Jurkiewicz, Two Components Of Cardiac Delayed Rectifier K+ Current: Differential Sensitivity To Block By Class III Antiarrhythmic Agents, J Gen Physiol 1990, 96:195-215). Class III antiarrhythmic agents currently in development, including d-sotalol, dofetilide (UK-68,798), almokalant (H234/09), E-403 1 and methanesulfonamide-N-[1′-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl)-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4′-piperidin)-6yl]monochloride, predominantly, if not exclusively, block IKr. Although, amiodarone is a blocker of IKs (Balser J. R. Bennett, P. B., Hondeghem, L. M. and Roden, D. M. “Suppression Of Time-Dependent Outward Current In Guinea Pig Ventricular Myocytes: Actions Of Quinidine And Amiodarone. Circ. Res. 1991, 69:519-529), it also blocks INa and ICa, effects thyroid function, is as a nonspecific adrenergic blocker, and acts as an inhibitor of the enzyme phospholipase (Nademanee, K. “The Amiodarone Odessey” .J.Am. Coll. Cardiol. 1992;20:1063-1065). Therefore its method of treating arrhythmia is uncertain. Most Class III agents that are known to be in development predominantly block IKr.

[0014] Reentrant excitation (reentry) has been shown to be a prominent mechanism underlying supraventricular arrhythmias in man. Reentrant excitation requires a critical balance between slow conduction velocity and sufficiently brief refractory periods to allow for the initiation and maintenance of multiple reentry circuits to coexist simultaneously and sustain AF. Increasing myocardial refractoriness by prolonging action potential duration (APD), prevents and/or terminates reentrant arrhythmias. Most selective Class III antiarrhythmic agents currently in development, such as d-sotalol and dofetilide predominantly, if not exclusively, block Ikr, the rapidly activating component of IK found both in the human atrium and ventricle.

[0015] Since these Ikr blockers increase APD and refractoriness both in atria and ventricle without affecting conduction per se, theoretically they represent potential useful agents for the treatment of arrhythmias like AF. These agents have a liability in that they have an enhanced risk of proarrhythmia at slow heart rates. For example, torsades de points has been observed when these compounds are utilized (Roden, D. M. “Current Status of Class Ell Antiarrhythmic Drug Therapy”, Am J. Cardiol, 1993; 72:44B-49B). This exaggerated effect at slow heart rates has been termed “reverse frequency-dependence”, and is in contrast to frequency-independent or frequency-dependent actions (Hondeghem, L. M. “Development of Class mf Antiarrhythmic Agents”. J.Cadiovasc.Cardiol. 20 (Suppl.2):S17-S22).

[0016] The slowly activating component of the delayed rectifier (Iks) potentially overcomes some of the limitations of Ikr blockers associated with ventricular arrhythmias. Because of its slow activation kinetics however, the role of Iks in atrial repolarization may be limited due to the relatively short APD of the atrium. Consequently, although Iks blockers may provide distinct advantage in the case of ventricular arrhythmias, their ability to affect SVT is considered to be minimal.

[0017] The ultra-rapidly activating delayed rectifier K+ current (Ikur) is believed to represent the native counterpart to a cloned potassium channel designated Kv1.5 and, while present in human atrium, it appears to be absent in human ventricle. Furthermore, because of its rapidity of activation and limited slow inactivation, Ikur is believed to contribute significantly to repolarization in human atrium. Consequently, a specific blocker of Ikur, that is a compound which blocks Kv1.5, would overcome the short coming of other compounds by prolonging refractoriness by retarding repolarization in the human atrium without causing the delays in ventricular reporlarization that underlie arrhythmogenic after depolarizations and acquired long QT syndrome observed during treatment with current Class III drugs.

[0018] In intact human atrial myocytes an ultra-rapidly activating delayed rectifier K+ current Ikur which is also known as the sustained outward current, Isus, or Iso, has been identified and this current has properties and kinetics identical to those expressed by the human K+ channel clone (hKv1.5, HK2) when isolated from human heart and stably expressed in human (HEK-293) cell lines. (Wang et al., 1993, Circ Res 73:1061-1076; Fedida et al., 1993, Circ Res 73:210-216; Snyders et al., 1993, J Gen Physiol 101:513-543) and originally cloned from rat brain (Swanson et al., 10, Neuron 4:929-939). Although various antiaryythmic agents are now available on the market, those having both satisfactory efficacy and a high margin of safety have not been obtained. For example, antiarrythmic agents of Class I according to the classification scheme of Vaughan-Williams (“Classification Of Antiarrhythmic Drugs: In: Cardiac Arrhythmias, edited by: E. Sandoe, E. Flensted-Jensen, K. Olesen; Sweden, Astra, Sodertalje, pp449-472, 1981) which cause a selective inhibition of the maximum velocity of the upstroke of the action potential (max) are inadequate for preventing ventricular fibrillation. In addition, they have problems regarding safety, namely, they cause a depression of myocardial contractility and have a tendency to induce arrhythmias due to an inhibition of impulse conduction. Beta-adrenoceptor blockers and calcium antagonists which belong to Class II and IV, respectively, have a defect in that their effects are either limited to a certain type of arrhythmia or are contraindicated because of their cardiac depressant properties in certain patients with cardiovascular disease. Their safety, however, is higher than that of the antiarrhythmic agents of Class I.

SUMMARY OF THE INVENTION

[0019] The present invention provides heterocyclic dihydropyrimidine compounds of the following formula I, including enantiomers, diastereomers, and salts thereof, useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+channels, more especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur) for the treatment of disorders such as arrhythmia and IKur-associated disorders:

[0020] where

[0021] X1, X2 and X3 are independently selected from N, NR, (CR7)q, (CHR7)q, or C═O, wherein the bonds connecting X1, X2 and X3 to adjacent atoms may be single or double bonds forming a 5 to 7-membered saturated, partially unsaturated or aromatic ring;

[0022] R1, R2, R3, R4, R5, R6 and R7 are the same or different and are independently selected from groups of the formula —(CH2)n—(Z1)m—(CH2)p—Z2; or

[0023] R1, R2, R3, R4 and R5 may, in one or more pairs of two (such as R1 and R2, R1 and R3, R2 and R3, R3 and R4 or R4 and R5), together with the atoms to which they are bonded, form a carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic group; or

[0024] R6 and R7 may, in one or more pairs of two (such as R6 and R7, R6 and R6, or R7 and R7), together with the atoms to which they are bonded, form a carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic group;

[0025] Z1 is —CZ3Z4—, —O—, —NZ3—, —S—, —SO—, —SO2—, —C(O)—, —C(O)Z3—, —C(O)NZ4—, —C(S)—, —C(═NOZ3)—, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo;

[0026] Z2 is hydrogen, —OZ5, —OC(O)Z5, —NZ5—C(O)—Z6, —NZ5—CO2—Z6, —NZ5(C═O)—NZ6Z7, —NZ5Z6, —NO2, halo, —CN, —C(O)Z5, —CO2Z5, —C(S)Z5, —(C═NOZ5)Z6, —C(O)NZ5Z6, —C(S)NZ5Z6, —SZ5, —SOZ5, —SO2Z5, —SO2NZ5Z6, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo (such as heteroaryl), or substituted heterocyclo;

[0027] Z3, Z4, Z5, Z6 and Z7 are independently hydrogen, halo, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo; or

[0028] Z3, Z4, Z5, Z6 and Z7 may, in one or more pairs of two (such as Z3 and Z4, Z5 and Z6 or Z6 and Z7), together with the atoms to which they are bonded, form a carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic group;

[0029] n and p are independently selected from integers from 0 to 10 wherein, when m is 0, p is also 0;

[0030] m is an integer selected from 0 or 1; and

[0031] q is an integer selected from 1 to 3.

[0032] The present invention provides novel methods for the prevention and treatment of arrhythmia and IKur-associated disorders employing one or more compounds of the formula I, enantiomers, diastereomers or pharmaceutically acceptable salts thereof. In particular the present invention provides a novel method for the selective prevention and treatment of supraventricular arrhythmias.

[0033] In addition, compounds within the formula I, as well as enantiomers, diastereomers and salts thereof are novel compounds, including compounds of formula I* and salts thereof:

[0034] where

[0035] X1, X2, X3, R1, R2, R4 and R5 are as defined above;

[0036] R3* is —OZ5, —OC(O)—Z5, —NZ5—C(O)2—Z6, —NZ(C═O)—NZ6Z7, —NZ5Z6, —(C═NOZ)Z, —C(O)NZ5*Z6*, —C(S)NZ5*Z6*, —SZ, —SOZ5, —SO2Z5, —SO2NZ5Z6, C(O)Z3*Z2*, halo, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo or substituted heterocylco;

[0037] Z2* is other than hydrogen when Z3* is heterocyclo;

[0038] Z3* is heterocyclo or substituted heterocyclo;

[0039] Z5* is substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo; and

[0040] Z6* is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo, provided that Z6* is not hydrogen when Z5* is unsubstituted cycloalkyl, unsubstituted aryl, or unsubstituted benzyl;

[0041] or Z5* and Z6* may together with the nitrogen atom to which they are bonded form a heterocyclic group or substituted heterocyclic group, provided that Z5* and Z6* do not together form unsubstituted piperidinyl, unsubstituted pyrrolidinyl, or unsubstituted morpholinyl, and further provided that when

[0042] (i) R1 and R5 are each hydrogen; and

[0043] (ii) R2 is aryl or substituted aryl; and

[0044] (iii) R4 is heterocyclo-substituted aryl; and

[0045] (iv) X1, X2 and X3 form the ring

[0046] where R7* is H or alkyl

[0047] Z5* and Z6* do not together form unsubstituted piperazinyl or N-alkyl-substituted piperazinyl;

Preferred Compounds

[0048] Compounds of the formula I and salts thereof wherein one or more, and especially all, of X1, X2, X3, R1, R2, R3, R4 and R5 are selected from the following definitions, are preferred compounds of the present invention:

[0049] R1 is hydrogen;

[0050] R2 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo or substituted carbocyclo;

[0051] R3 is —(CH2)n—Z2, —(CH2)n—C(O)Z3—(CH2)p—Z2, or —(CH2)n—C(O)NZ4—(CH2)p—Z2;

[0052] R4 is alkyl or substituted alkyl; and

[0053] R5 is hydrogen, or —(CH2)n—Z2; and

[0054] X1, X2 and X3, together with the atoms to which they are bonded, form a ring selected from:

[0055] where R6 and/or R7 are the same or different, as defined above.

[0056] Compounds of the formula I and salts thereof wherein one or more, and especially all, of X1, X2, X3, R1, R2, R3, R4 and R5 are selected from the following definitions, are more preferred compounds of the present invention:

[0057] R1 is hydrogen;

[0058] R2 is aryl (especially where aryl is phenyl), substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo or substituted carbocyclo;

[0059] R3 is —(CH2)n—Z2, —(CH2)n—C(O)Z3—(CH2)p—Z2, or —(CH2)n—C(O)NZ4—(CH2)p—Z2 wherein

[0060] Z2 is selected from —C(O)NZ5Z6, —CO2Z5, —SO2Z5, —NZ5Z6, —NZ5CO2Z6, —NZ5C(O)Z6, —OZ5, aryl, substituted aryl, heterocyclo, substituted heterocyclo, alkyl or substituted alkyl;

[0061] Z3 is heterocyclo or substituted heterocyclo; and

[0062] n and p are independently selected from integers 0 to 3;

[0063] R4is alkyl, or substituted alkyl;

[0064] R5 is hydrogen, or —(CH2)n—Z2 wherein Z2 is selected from —C(O)NZ5Z6, —CO2Z5, —NZ5Z6, aryl, substituted aryl, alkyl, or substituted alkyl; and

[0065] X1, X2 and X3, together with the atoms to which they are bonded, form a ring selected from:

[0066] Compounds of the formula I and salts thereof wherein one or more, and especially all, of X1, X2, X3, R1, R2, R3, R4 and R5 are selected from the following definitions, are most preferred compounds of the present invention:

[0067] R1 is hydrogen;

[0068] R2 is aryl (especially where aryl is phenyl), substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo or substituted carbocyclo;

[0069] R3 is heterocyclo or substituted heterocyclo, —C(O)NZ5Z6, —C(O)Z3—CONZ5Z6, —C(O)Z3—Z2, or —C(O)Z3—CO2Z5, wherein Z3 is heterocyclo or substituted heterocyclo, and Z2 is aryl or substituted aryl;

[0070] R4 is alkyl (especially lower alkyl) or substituted alkyl (especially halo-substituted alkyl or alkoxy-substituted alkyl);

[0071] R5 is hydrogen, alkyl or substituted alkyl; and

[0072] X1, X2 and X3, together with the atoms to which they are bonded, form a ring selected from:

[0073] wherein

[0074] R6 is H or C(O)Z5, where Z5 is alkyl or carbocyclo; and

[0075] R7 is independently selected from H, alkyl, substituted alkyl (especially halo-substituted), halo, or CN

DETAILED DESCRIPTION OF THE INVENTION

[0076] The following are definitions of terms used in this specification. The initial definition provided for a group or term herein applies to that group or term throughout the present specification, individually or as part of another group, unless otherwise indicated.

[0077] The terms “alk” or “alkyl” refer to straight or branched chain hydrocarbon groups having 1 to 12 carbon atoms, preferably 1 to 8 carbon atoms, such as methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, pentyl, hexyl, heptyl, octyl, etc. Lower alkyl groups, that is, alkyl groups of 1 to 6 carbon atoms, are generally most preferred. The term “substituted alkyl” refers to alkyl groups substituted with one or more groups (such as by groups described above in the definition of RI), preferably selected from aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo, substituted carbocyclo, halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally subsituted), alkylester (optionally substituted), arylester (optionally substituted), alkanoyl (optionally substituted), aryol (optionally substituted), cyano, nitro, amino, substituted amino, amido, lactam, urea, urethane, sulfonyl, etc.

[0078] The term “alkenyl” refers to straight or branched chain hydrocarbon groups having 2 to 12 carbon atoms, preferably 2 to 4 carbon atoms, and at least one double carbon to carbon bond (either cis or trans), such as ethenyl. The term “substituted alkenyl” refers to alkenyl groups substituted with one or more groups (such as by groups described above in the definition of R1), preferably selected from aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo, substituted carbocyclo, halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), alkanoyl (optionally substituted), aryol (optionally substituted), cyano, nitro, amino, substituted amino, amido, lactam, urea, urethane, sulfonyl, etc.

[0079] The term “alkynyl” refers to straight or branched chain hydrocarbon groups having 2 to 12 carbon atoms, preferably 2 to 4 carbon atoms, and at least one triple carbon to carbon bond, such as ethynyl. The term “substituted alkynyl” refers to alkynyl groups substituted with one or more groups (such as by groups described above in the definition of R1), preferably selected from aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo, substituted carbocyclo, halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), alkanoyl (optionally substituted), aryol (optionally substituted), cyano, nitro, amino, substituted amino, amido, lactam, urea, urethane, sulfonyl, etc.

[0080] The terms “ar” or “aryl” refer to aromatic homocyclic (i.e., hydrocarbon) mono-, bi- or tricyclic ring-containing groups preferably having 6 to 12 members such as phenyl, naphthyl and biphenyl. Phenyl is a preferred aryl group. The term “substituted aryl” refers to aryl groups substituted with one or more groups (such as by groups described above in the definition of R1), preferably selected from alkyl, substituted alkyl, alkenyl (optionally substituted), aryl (optionally substituted), heterocyclo (optionally substituted), halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally substituted), alkanoyl (optionally substituted), aroyl, (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), cyano, nitro, amino, substituted amino, amido, lactam, urea, urethane, sulfonyl, etc., where optionally one or more pair of substituents together with the atoms to which they are bonded form a 3 to 7 member ring.

[0081] The terms “cycloalkyl” and “cycloalkenyl” refer to mono-, bi- or tri homocylcic ring groups of 3 to 15 carbon atoms which are, respectively, fully saturated and partially unsaturated. The term “cycloalkenyl” includes bi- and tricyclic ring systems that are not aromatic as a whole, but contain aromatic portions (e.g. fluorene, tetrahydronapthalene, dihydroindene, and the like). The rings of multi-ring cycloalkyl groups may be either fused, bridged and/or joined through one or more spiro unions. The terms “substituted cycloalkyl” and “substituted cycloalkenyl” refer, respectively, to cycloalkyl and cycloalkenyl groups substituted with one or more groups (such as by groups described above in the definition of R1), preferably selected from aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo, substituted carbocyclo, halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), alkanoyl (optionally substituted), aryol (optionally substituted), cyano, nitro, amino, substituted amino, amido, lactam, urea, urethane, sulfonyl, etc.

[0082] The terms “carbocyclo”, “carbocyclic” or “carbocyclic group” refer to both cycloalkyl and cycloalkenyl groups. The terms “substituted carbocyclo”, “substituted carbocyclic” or “substituted carbocyclic group” refer to carbocyclo or carbocyclic groups substituted with one or more groups as described in the definition of cycloalkyl and cycloalkenyl.

[0083] The terms “halogen” and “halo” refer to fluorine, chlorine, bromine and iodine.

[0084] The terms “heterocycle”, “heterocyclic”, “heterocyclic group” or “heterocyclo” refer to fully saturated or partially or completely unsaturated, including aromatic (“heteroaryl”) or nonaromatic cyclic groups (for example, 3 to 13 member monocyclic, 7 to 17 member bicyclic, or 10 to 20 member tricyclic ring systems, preferably containing a total of 3 to 10 ring atoms) which have at least one heteroatom in at least one carbon atom-containing ring. Each ring of the heterocyclic group containing a heteroatom may have 1, 2, 3 or 4 heteroatoms selected from nitrogen atoms, oxygen atoms and/or sulfur atoms, where the nitrogen and sulfur heteroatoms may optionally be oxidized and the nitrogen heteroatoms may optionally be quatemized. The heterocyclic group may be attached at any heteroatom or carbon atom of the ring or ring system. The rings of multi-ring heterocycles may be either fused, bridged and/or joined through one or more spiro unions.

[0085] Exemplary monocyclic heterocyclic groups include azetidinyl, pyrrolidinyl, pyrrolyl, pyrazolyl, oxetanyl, pyrazolinyl, irnidazolyl, imidazolinyl, imidazolidinyl, oxazolyl, oxazolidinyl, isoxazolinyl, isoxazolyl, thiazolyl, thiadiazolyl, thiazolidinyl, isothiazolyl, isothiazolidinyl, furyl, tetrahydrofuryl, thienyl, oxadiazolyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolodinyl, 2-oxoazepinyl, azepinyl, 4-piperidonyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, tetrahydropyranyl, tetrazoyl, triazolyl, morpholinyl, thiamorpholinyl, thiamorpholinyl sulfoxide, thiamorpholinyl sulfone, 1,3-dioxolane and tetrahydro-l,l-dioxothienyl,

[0086] and the like.

[0087] Exemplary bicyclic heterocyclic groups include indolyl, benzothiazolyl, benzoxazolyl, benzothienyl, quinuclidinyl, quinolinyl, tetra-hydroisoquinolinyl, isoquinolinyl, benzimidazolyl, benzopyranyl, indolizinyl, benzofuryl, benzofuranly, dihydrobenzofuranyl, chromonyl, coumarinyl, benzodioxolyl, dihydrobenzodioxolyl, benzodioxinyl, cinnolinyl, quinoxalinyl, indazolyl, pyrrolopyridyl, furopyridinyl (such as furo[2,3-c]pyridinyl, furo[3,2-b]pyridinyl] or furo[2,3-b]pyridinyl), dihydroisoindolyl, dihydroquinazolinyl (such as 3,4-dihydro-4-oxo-quinazolinyl), tetrahydroquinolinyl, azabicycloalkyls (such as 6-azabicyclo[3.2.1 ]octane), azaspiroalkyls (such as 1,4 dioxa-8-azaspiro[4.5]decane), imidazopyridinyl (such as imidazo[1,5-a]pyridin-3-yl), triazolopyridinyl (such as 1,2,4-triazolo[4,3-a]pyridin-3-yl), and hexahydroimidazopyridinyl (such as 1,5,6,7,8,8a-hexahydroimidazo[1,5-a]pyridin-3-yl),

[0088] and the like.

[0089] Exemplary tricyclic heterocyclic groups include carbazolyl, benzidolyl, phenanthrolinyl, acridinyl, phenanthridinyl, xanthenyl and the like.

[0090] The terms “substituted heterocycle”, “substituted heterocyclic”, “substituted heterocyclic group” and “substituted heterocyclo” refer to heterocycle, heterocyclic and heterocyclo groups substituted with one or more groups (such as by groups described above in the definition of R1), preferably selected from alkyl, substituted alkyl, alkenyl, oxo, aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo (optionally substituted), halo, hydroxy, alkoxy (optionally substituted), aryloxy (optionally substituted), alkanoyl (optionally substituted), aroyl (optionally substituted), alkylester (optionally substituted), arylester (optionally substituted), cyano, nitro, amido, amino, substituted amino, lactam, urea, urethane, sulfonyl, etc., where optionally one or more pair of substituents together with the atoms to which they are bonded form a 3 to 7 member ring.

[0091] The term “alkanoyl” refers to alkyl group (which may be optionally substituted as described above) linked to a carbonyl group (i.e. —C(O)-alkyl). Similarly, the term “aroyl” refers to an aryl group (which may be optionally substituted as described above) linked to a carbonyl group (i.e., —C(O)-aryl).

[0092] Throughout the specification, groups and substituents thereof may be chosen to provide stable moieties and compounds.

[0093] The compounds of formula I form salts which are also within the scope of this invention. Reference to a compound of the formula I herein is understood to include reference to salts thereof, unless otherwise indicated. The term “salt(s)”, as employed herein, denotes acidic and/or basic salts formed with inorganic and/or organic acids and bases. In addition, when a compound of formula I contains both a basic moiety and an acidic moiety, zwitterions (“inner salts”) may be formed and are included within the term “salt(s)” as used herein. Pharmaceutically acceptable (i.e., non-toxic, physiologically acceptable) salts are preferred, although other salts are also useful, e.g., in isolation or purification steps which may be employed during preparation. Salts of the compounds of the formula I may be formed, for example, by reacting a compound I with an amount of acid or base, such as an equivalent amount, in a medium such as one in which the salt precipitates or in an aqueous medium followed by lyophilization.

[0094] The compounds of formula I which contain a basic moiety may form salts with a variety of organic and inorganic acids. Exemplary acid addition salts include acetates (such as those formed with acetic acid or trihaloacetic acid, for example, trifluoroacetic acid), adipates, alginates, ascorbates, aspartates, benzoates, benzenesulfonates, bisulfates, borates, butyrates, citrates, camphorates, camphorsulfonates, cyclopentanepropionates, digluconates, dodecylsulfates, ethanesulfonates, fumarates, glucoheptanoates, glycerophosphates, hemisulfates, heptanoates, hexanoates, hydrochlorides (formed with hydrochloric acid), hydrobromides (formed with hydrogen bromide), hydroiodides, 2-hydroxyethanesulfonates, lactates, maleates (formed with maleic acid), methanesulfonates (formed with methanesulfonic acid), 2-naphthalenesulfonates, nicotinates, nitrates, oxalates, pectinates, persulfates, 3-phenylpropionates, phosphates, picrates, pivalates, propionates, salicylates, succinates, sulfates (such as those formed with sulfuric acid), sulfonates (such as those mentioned herein), tartrates, thiocyanates, toluenesulfonates such as tosylates, undecanoates, and the like.

[0095] The compounds of formula I which contain an acidic moiety may form salts with a variety of organic and inorganic bases. Exemplary basic salts include ammonium salts, alkali metal salts such as sodium, lithium, and potassium salts, alkaline earth metal salts such as calcium and magnesium salts, salts with organic bases (for example, organic amines) such as benzathines, dicyclohexylamines, hydrabamines (formed with N,N-bis(dehydroabietyl)ethylenediamine), N-methyl-D-glucamines, N-methyl-D-glucamides, t-butyl amines, and salts with amino acids such as arginine, lysine and the like.

[0096] Basic nitrogen-containing groups may be quatemized with agents such as lower alkyl halides (e.g. methyl, ethyl, propyl, and butyl chlorides, bromides and iodides), dialkyl sulfates (e.g. dimethyl, diethyl, dibutyl, and diamyl sulfates), long chain halides (e.g. decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides), aralkyl halides (e.g. benzyl and phenethyl bromides), and others.

[0097] Prodrugs and solvates of the compounds of the invention are also contemplated herein. The term “prodrug”, as employed herein, denotes a compound which, upon administration to a subject, undergoes chemical conversion by metabolic or chemical processes to yield a compound of the formula I, or a salt and/or solvate thereof. Solvates of the compounds of formula I are preferably hydrates.

[0098] To the extent that compounds of the formula I, and salts thereof, may exist in their tautomeric form, all such tautomeric forms are contemplated herein as part of the present invention.

[0099] All stereoisomers of the present compounds, such as those which may exist due to asymmetric carbons on the various R and Z substituents, including enantiomeric forms (which may exist even in the absence of asymmetric carbons) and diastereomeric forms, are contemplated within the scope of this invention. Individual stereoisomers of the compounds of the invention may, for example, be substantially free of other isomers, or may be admixed, for example, as racemates or with all other, or other selected, stereoisomers. The chiral centers of the present invention can have the S or R configuration as defined by the IUPAC 1974 Recommendations.

[0100] The terms “including”, “such as”, “for example” and the like are intended to refer to exemplary embodiments and not to limit the scope of the present invention.

Schemes

[0101] Compounds of formula I may be prepared using the sequence of steps outlined below.

[0102] Compounds 1, 2 and 4 used in this preparation are commercially available or are readily prepared by methods well known to those skilled in the art. For example compounds of formula 1 where R3=CONZ5Z6 can be prepared by the method of Witzeman (JOC 1991, 56(5), 1713) which involves warming an amine and a t-butoxy-β-ketoester neat or in a suitable solvent (xylenes, toluene, etc.)

[0103] Alternately compounds of formula 1 where R4=methyl and R3=CONZ5Z6 may be prepared by reaction of an amine with diketene in a suitable solvent such as dichloromethane at temperatures between −100-22° C.

[0104] Compounds of formula 3 can be prepared by modification of the Knovenagel condensation. For example condensation of a compound of formula 1 and a compound of formula 2 at temperatures between 22-170° C. in solvents such as toluene or dimethylformamide in the presence of an acid such as acetic acid and an a base such as piperidine with removal of water generated during the reaction by the use of 4 Å dry molecular sieves or a Dean-Stark trap affords compounds of formula 3 as a mixture of cis and trans stereoisomers.

[0105] Compounds of formula I may also be prepared by condensation of compounds of formula 3 with compounds of formula 4 by warming at temperatures between 30-150° C in alcoholic solvents such as ethanol or propanol or by warming between 30-150° C. in a solvent such as dimethylformamide and in the presence of a base such as sodium acetate.

[0106] Compounds of formula I where R3=ester may be prepared by condensation of compounds of formula 1, formula 2 and heterocycles of formula 4 by warming between temperatures of 30-150° C. in the presence of a base such as sodium carbonate or sodium bicarbonate in a suitable solvent such as dimethylformamide.

[0107] Compounds of formula I where R3=amide maybe prepared by treating compounds of formula I where R3=ester with a suitable amine and trimethylaluminium in a solvent such as toluene at temperatures between 0-150° C.

[0108] Compounds of formula I where R3=amide may also be prepared by condensing compounds of formula I where R3=COOH with a suitable amine by amidation methods well known to those skilled in the art. For example treatment of a compound of formula I where R3=COOH with 1-[3-(dimethylamino)propyl]-3-ethylcarbodiirnide hydrochloride (EDCI) and dimethylaminopyridine (DMAP) in a solvent such as dichloromethane affords compounds of formula I where R3=amide.

[0109] Compounds of formula I where R5 is a substituent other than hydrogen may be formed by reacting a compound of formula 5 with a reactive species M-R5 such that a compound of formula Ia is obtained, where M is Cl, Br, OR etc., and R5 is as defined above (other than hydrogen).

[0110] Compounds of formula I where X1, X2 and X3 form a ring of the structure

[0111] where R6 is a substituent other than hydrogen may be formed by reacting a compound of formula 7 with a reactive species M-R6 such that a compound of formula Ib is obtained where M is Cl, Br, OR, etc. and R6 is as defined above.

[0112] Compounds of formula Ic where R3 is a amino containing heterocycle may be formed by condensing compounds of formula I where R3 is an acid or ester with an amine which is attached through a linker to M. M may be NH2, NHR, SH, or OH. The linker unit may be selected such that unsubstituted, substituted or fused heterocycles are formed.

[0113] Additional compounds within the scope of the present invention can be prepared from the compounds obtained by the above described methods through conversion of the substituent groups to other functionality by the usual methods of chemical synthesis, as illustrated in the following examples.

[0114] Compounds of formula I that contain chiral centers maybe obtained in non-racemic form by non-racemic synthesis or resolution by methods well known to those skilled in the art. Compounds that are non-racemic are designated as “chiral” in the examples.

[0115] In the examples described below it may be necessary to protect reactive functionality such as hydroxy, amino, thio or carboxy groups, where these are desired in the final product, to avoid their unwanted participation in reactions. The introduction and removal of protecting groups are well known to those skilled in the art, for example see (Green, T. W. in “Protective Groups in Organic Synthesis”, John Wiley and Sons, 1991).

Utility

[0116] Compounds within the scope of the present invention inhibit the Kv1 subfamily of voltage-gated K+ channels, and as such are useful in the treatment and/or prevention of various disorders: cardiac arrhythmias, including supraventricular arrhythmias, atrial arrhythmias, atrial flutter, atrial fibrillation, complications of cardiac ischemia, and use as heart rate control agents; angina pectoris including relief of Prinzmetal's symptoms, vasospastic symptoms and variant symptoms; gastrointestinal disorders including reflux esauphagitis, functional dispepsia, motility disorders (including constipation and diarrhea), and irritable bowel syndrome; disorders of vascular and visceral smooth muscle including asthma, chronic obstructive pulmonary disease, adult respiratory distress syndrome, peripheral vascular disease (including intermittent claudication), venous insufficiency, impotence, cerebral and coronary spasm and Raynaud's disease; inflammatory and immunological disease including inflammatory bowel disease, rheumatoid arthritis, graft rejection, asthma. chronic obstructive pulmonary disease, cystic fibrosis and atherosclerosis; cell poliferative disorders including restenosis and cancer (including leukemia); disorders of the auditory system; disorders of the visual system including macular degeneration and cataracts; diabetes including diabetic retinopathy, diabetic nephropathy and diabetic neuropathy; muscle disease including myotonia and wasting; peripheral neuropathy; cognitive disorders; migraine; memory loss including Alzheimer's and dementia; CNS mediated motor dysfunction including Parkinson's disease, and ataxia; epilepsy; and other ion channel mediated disorders.

[0117] As inhibitors of the Kv1 subfamily of voltage-gated K+ channels compounds of the present invention are useful to treat a variety of disorders including resistance by transplantation of organs or tissue, graft-versus-host diseases brought about by medulla ossium transplantation, rheumatoid arthritis, systemic lupus erythematosus, hashimoto's thyroiditis, multiple sclerosis, myasthenia gravis, type I diabetes uveitis, juvenile-onset or recent-onset diabetes mellitus, posterior uveitis, allergic encephalomyelitis, glomerulonephritis, infectious diseases caused by pathogenicmicroorganisms, inflammatory and hyperproliferative skin diseases, psoriasis, atopical dermatitis, contact dermatitis, eczematous dermatitises, seborrhoeis dermatitis, Lichen planus, Pemphigus, bullous pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythemas, cutaneous eosinophilias, Lupus erythematosus, acne, Alopecia areata, keratoconjunctivitis, vernal conjunctivitis, uveitis associated with Behcet's disease, keratitis, herpetic keratitis, conical cornea, dystrophia epithelialis corneae, corneal leukoma, ocular pemphigus, Mooren's ulcer Scleritis, Graves' opthalmopathy, Vogt-Koyanagi-Harada syndrome, sarcoidosis, pollen allergies, reversible obstructive airway disease, bronchial asthma, allergic asthma, intrinsic asthma, extrinsic asthma, dust asthma, chronic or inveterate asthma, late asthma and airway hyper-responsiveness, bronchitis, gastric ulcers, vascular damage caused by ischemic diseases and thrombosis, ischemic bowel diseases, inflammatory bowel diseases, necrotizing enterocolitis, intestinal lesions associated with thermal burns and leukotriene B4-mediated diseases, Coeliaz diseases, proctitis, eosinophilic gastroenteritis, mastocytosis, Crohn's disease, ulcerative colitis, ,migraine, rhinitis, eczema, interstitial nephritis, Good-pasture's syndrome, hemolytic-uremic syndrome, diabetic nephropathy, multiple myositis, Guillain-Barre syndrome, Meniere's disease, polyneuritis, multiple neuritis, mononeuritis, radiculopathy, hyperthroidism, Basedow's disease, pure red cell aplasia, aplastic anemia, hypoplastic anemia, idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, agranulocytosis, pernicious anemia, megaloblastic anemia, anerythroplasia, osteoporosis, sarcoidosis, fibroid lung, idopathic interstitial pneumonia, dermatomyositis, leukoderma vulgaris, ichthyosis vulgaris, photoallergic sensitivity, cutaneous T cell lymphoma, arteriosclerosis, atherosclerosis, aortitis syndrome, polyarteritis nodosa, myocardosis, scleroderma, Wegener's granuloma, Sjogren's syndrome, adiposis, eosinophilic fascitis, lesions of gingiva, periodontium, alveolar bone, substantia osses dentis, glomerulonephritis, male pattern alopecia or alopecia senilis by preventing epilation or providing hair germination and/or promoting hair generation and hair growth, muscular dystrophy; Pyoderma and Sezary's syndrome, Addison's disease, ischemia-reperfusion injury of organs which occurs upon preservation, transplantation or ischemic disease, endotoxin-shock, pseudomembranous colitis, colitis caused by drug or radiation, ischemic acute renal insufficiency, chronic renal insufficiency, toxinosis caused by lung-oxygen or drugs, lung cancer, pulmonary emphysema, cataracta, siderosis, retinitis, pigentosa, senile macular degeneration, vitreal scarring, comeal alkali bum, dermatitis erythema multiforme, linear IgA ballous dermatitis and cement dermatitis, gingivitis, periodontitis, sepsis, pancreatitis, diseases caused by environmental pollution, aging, carcinogenis, metastatis of carcinoma and hypobaropathy, disease caused by histamine or leukotriene-C4 release, Behcet's disease, autoimmune hepatitis, primary biliary cirrhosis sclerosing cholangitis, partial liver resection, acute liver necrosis, necrosis caused by toxin, viral hepatitis, shock, or anoxia, B-virus hepatitis, non-A/non-B hepatitis, cirrhosis, alcoholic cirrhosis, hepatic failure, fulminant hepatic failure, late-onset hepatic failure, “acute-on-chronic” liver failure, augention of chemotherapeutic effect, cytomegalovirus infection, HCMV infection, AIDS, cancer, senile dementia, trauma, and chronic bacterial infection.

[0118] The compounds of the present invention are antiarrhythmic agents which are useful in the prevention and treatment (including partial alleviation or cure) of arrhythmias. As inhibitors of Kv1.5 compounds within the scope of the present invention are particularly useful in the selective prevention and treatment of supraventricular arrhythmias such as atrial fibrillation, and atrial flutter. By “selective prevention and treatment of supraventricular arrhythmias” is meant the prevention or treatment of supraventricular arrhythmias wherein the ratio of the prolongation of the atrial effective refractory period to the prolongation of the ventricular effective refractory period is greater than 1:1. This ratio is preferably greater than 4:1, more preferably greater than 10:1, and most preferably such that prolongation of the atrial effective refractory response period is achieved without significantly detectable prolongation of the ventricular effective refractory period.

[0119] In addition, the compounds within the scope of the present invention block IKur, and thus may be useful in the prevention and treatment of all IKur-associated conditions. An “IKur-associated condition” is a disorder which may be prevented, partially alleviated or cured by the administration of an IKur blocker. The Kv1.5 gene is known to be expressed in stomach tissue, intestinal/colon tissue, the pulmonary artery, and pancreatic beta cells. Thus, administration of an IKur blocker could provide useful treatment for disorders such as: reflux esauphagitis, functional dispepsia, constipation, asthma, and diabetes. Additionally, Kv1.5 is known to be expressed in the anterior pituitary. Thus, administration of an IKur blocker could stimulate growth hormone secretion. IKur inhibitors can additionally be useful in cell poliferative disorders such as leukemia, and autoimmune diseases such as rheumatoid arthritis and transplant rejection.

[0120] The present invention thus provides methods for the prevention or treatment of one or more of the aforementioned disorders, comprising the step of administering to a subject in need thereof an effective amount of at least one compound of the formula I. Other therapeutic agents such as those described below may be employed with the inventive compounds in the present methods. In the methods of the present invention, such other therapeutic agent(s) may be administered prior to, simultaneously with or following the administration of the compound(s) of the present invention.

[0121] The present invention also provides pharmaceutical compositions comprising at least one of the compounds of the formula I or salts thereof capable of preventing or treating one or more of the aforementioned disorders in an amount effective therefor, and a pharmaceutically acceptable vehicle or diluent. The compositions of the present invention may contain other therapeutic agents as described below, and may be formulated, for example, by employing conventional solid or liquid vehicles or diluents, as well as pharmaceutical additives of a type appropriate to the mode of desired administration (for example, excipients, binders, preservatives, stabilizers, flavors, etc.) according to techniques such as those well known in the art of pharmaceutical formulation.

[0122] The compounds of the formula I may be administered by any suitable means, for example, orally, such as in the form of tablets, capsules, granules or powders; sublingually; bucally; parenterally, such as by subcutaneous, intravenous, intramuscular, or intrastemal injection or infusion techniques (e.g., as sterile injectable aqueous or non-aqueous solutions or suspensions); nasally such as by inhalation spray; topically, such as in the form of a cream or ointment; or rectally such as in the form of suppositories; in dosage unit formulations containing non-toxic, pharmaceutically acceptable vehicles or diluents. The present compounds may, for example, be administered in a form suitable for immediate release or extended release. Immediate release or extended release may be achieved by the use of suitable pharmaceutical compositions comprising the present compounds, or, particularly in the case of extended release, by the use of devices such as subcutaneous implants or osmotic pumps. In the case where the compounds of formula I are being administered to prevent or treat arrhythmias, the compounds may be administered to achieve chemical conversion to normal sinus rhythm, or may optionally be used in conjunction with electrical cardioconversion.

[0123] Exemplary compositions for oral administration include suspensions which may contain, for example, microcrystalline cellulose for imparting bulk, alginic acid or sodium alginate as a suspending agent, methylcellulose as a viscosity enhancer, and sweeteners or flavoring agents such as those known in the art; and immediate release tablets which may contain, for example, microcrystalline cellulose, dicalcium phosphate, starch, magnesium stearate and/or lactose and/or other excipients, binders, extenders, disintegrants, diluents and lubricants such as those known in the art. The compounds of formula I may also be delivered through the oral cavity by sublingual and/or buccal administration. Molded tablets, compressed tablets or freeze-dried tablets are exemplary forms which may be used. Exemplary compositions include those formulating the present compound(s) with fast dissolving diluents such as mannitol, lactose, sucrose and/or cyclodextrins. Also included in such formulations may be high molecular weight excipients such as celluloses (avicel) or polyethylene glycols (PEG). Such formulations may also include an excipient to aid mucosal adhesion such as hydroxy propyl cellulose (HPC), hydroxy propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (SCMC), maleic anhydride copolymer (e.g., Gantrez), and agents to control release such as polyacrylic copolymer (e.g., Carbopol 934). Lubricants, glidants, flavors, coloring agents and stabilizers may also be added for ease of fabrication and use.

[0124] Exemplary compositions for nasal aerosol or inhalation administration include solutions in saline which may contain, for example, benzyl alcohol or other suitable preservatives, absorption promoters to enhance bioavailability, and/or other solubilizing or dispersing agents such as those known in the art.

[0125] Exemplary compositions for parenteral administration include injectable solutions or suspensions which may contain, for example, suitable non-toxic, parenterally acceptable diluents or solvents, such as mannitol, 1,3-butanediol, water, Ringer's solution, an isotonic sodium chloride solution, or other suitable dispersing or wetting and suspending agents, including synthetic mono- or diglycerides, and fatty acids, including oleic acid.

[0126] Exemplary compositions for rectal administration include suppositories which may contain, for example, a suitable nonirritating excipient, such as cocoa butter, synthetic glyceride esters or polyethylene glycols, which are solid at ordinary temperatures, but liquify and/or dissolve in the rectal cavity to release the drug.

[0127] Exemplary compositions for topical administration include a topical carrier such as Plastibase (mineral oil gelled with polyethylene).

[0128] The effective amount of a compound of the present invention may be determined by one of ordinary skill in the art, and includes exemplary dosage amounts for an adult human of from about 0.001 to 100 mg/kg of body weight of active compound per day, which may be administered in a single dose or in the form of individual divided doses, such as from 1 to 4 times per day. It will be understood that the specific dose level and frequency of dosage for any particular subject may be varied and will depend upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of that compound, the species, age, body weight, general health, sex and diet of the subject, the mode and time of administration, rate of excretion, drug combination, and severity of the particular condition. Preferred subjects for treatment include animals, most preferably mammalian species such as humans, and domestic animals such as dogs, cats and the like, subject to the aforementioned disorders.

[0129] The compounds of the present invention may be employed alone or in combination with each other and/or other suitable therapeutic agents useful in the treatment of the aforementioned disorders or other disorders, including: other antiarrhythmic agents such as Class I agents (e.g., propafenone), Class II agents (e.g., carvadiol and propranolol), Class III agents (e.g., sotalol, dofetilide, amiodarone, azimilide and ibutilide), Class IV agents (e.g., diltiazem and verapamil), 5HT antagonists (e.g., sulamserod, serraline and tropsetron), and dronedarone; calcium channel blockers (both L-type and T-type) such as diltiazem, verapamil, nifedipine, amlodipine and mybefradil; Cyclooxygenase inibitors (i.e., COX-1 and/or COX-2 inhibitors) such as aspirin, indomethacin, ibuprofen, piroxicam, naproxen, celebrex, vioxx and NSAIDs; anti-platelet agents such as GPIIb/IIIa blockers (e.g., abciximab, eptifibatide and tirofiban), P2Y12 antagonists (e.g., clopidogrel, ticlopidine and CS-747), thromboxane receptor antagonists (e.g., ifetroban), aspirin, and PDE-III inhibitors (e.g., dipyridamole) with or without aspirin; diruetics such as chlorothiazide, hydrochlorothiazide, flumethiazide, hydroflumethiazide, bendroflumethiazide, methylchlorothiazide, trichloromethiazide, polythiazide, benzthiazide, ethacrynic acid tricrynafen, chlorthalidone, furosemide, musolimine, bumetanide, triamtrenene, amiloride, and spironolactone; anti-hypertensive agents such as alpha adrenergic blockers, beta adrenergic blockers, calcium channel blockers, diuretics, renin inhibitors, ACE inhibitors, (e.g., captropril, zofenopril, fosinopril, enalapril, ceranopril, cilazopril, delapril, pentopril, quinapril, ramipril, lisinopril), A II antagonists (e.g., losartan, irbesartan, valsartan), ET antagonists (e.g. sitaxsentan, atrsentan and compounds disclosed in U.S. Pat. Nos. 5,612,359 and 6,043,265), Dual ET/AII antagonist (e.g., compounds disclosed in WO 00/01389), neutral endopeptidase (NEP) inhibitors, vasopepsidase inhibitors (dual NEP-ACE inhibitors) (e.g., omapatrilat and gemopatrilat), nitrates, and combinations of such anti-hypertensive agents; antithrombotic/thrombolytic agents such as tissue plasminogen activator (tPA), recombinant tPA, tenecteplase (TNK), lanoteplase (nPA), factor VIIa inhibitors, factor Xa inhibitors, thromin inibitors (e.g., hirudin and argatroban), PAI-1 inhibitors (i.e., inactivators of tissue plasminogen activator inhibitors), α2-antiplasmin inhibitors, streptokinase, urokinase, prourokinase, anisoylated plasminogen streptokinase activator complex, and animal or salivary gland plasminogen activators; anticoagulants such as warfarin and heparins (including unfractionated and low molecular weight heparins such as enoxaparin and dalteparin); HMG-CoA reductase inhibitors such as pravastatin lovastatin, atorvastatin, simvastatin, NK-104 (a.k.a. itavastatin, or nisvastatin or nisbastatin) and ZD-4522 (a.k.a. rosuvastatin, or atavastatin or visastatin); other cholesterol/lipid lowering agents such as squalene synthetase inhibitors, fibrates, and bile acid sequestrants (e.g., questran); antipoliferative agents such as cyclosporin A, taxol, FK 506, and adriamycin; antitumor agents such as taxol, adriamycin, epothilones, cisplatin and carboplatin; anti-diabetic agents such as biguanides (e.g. metformin), glucosidase inhibitors (e.g. acarbose), insulins, meglitinides (e.g. repaglinide), sulfonylureas (e.g. glimepiride, glyburide and glipizide), biguanide/glyburide combinations (i.e,. glucovance), thiozolidinediones (e.g. troglitazone, rosiglitazone and pioglitazone), PPAR-gamma agonists, aP2 inhibitors, and DP4 inhibitors; thyroid mimetics (including thyroid receptor antagonists) (e.g., thyrotropin, polythyroid, KB-130015, and dronedarone); Mineralocorticoid receptor antagonists such as spironolactone and eplerinone; growth hormone secretagogues; anti-osteoporosis agents (e.g., alendronate and raloxifene); hormone replacement therapy agents such as estrogen (including conjugated estrogens in premarin), and estradiol; antidepressants such as nefazodone and sertraline; antianxiety agents such as diazepam, lorazepam, buspirone, and hydroxyzine pamoate; oral contraceptives; anti-ulcer and gastroesophageal reflux disease agents such as famotidine, ranitidine, and omeprazole; anti-obesity agents such as orlistat; cardiac glycosides including digitalis and ouabain; phosphodiesterase inibitors including PDE III inhibitors (e.g. cilostazol), and PDE V inhibitors (e.g., sildenafil); protein tyrosine kinase inhibitors; steroidal anti-inflammatory agents such as prednisone, and dexamethasone; and other anti-inflammatory agents such as enbrel.

[0130] The above other therapeutic agents, when employed in combination with the compounds of the present invention, may be used, for example, in those amounts indicated in the Physicians' Desk Reference (PDR) or as otherwise determined by one of ordinary skill in the art.

[0131] Assays to determine the degree of activity of a compound as an IKur inhibitor are well known in the art and are described in references such as J. Gen. Physiol. Apr;101(4):513-43, and Br. J. Pharmacol. 1995 May;115(2):267-74.

[0132] Assays to determine the degree of activity of a compound as an inhibitor of other members of the Kv1 subfamily are also well known in the art. For example, inhibition of Kv1.1, Kv1.2 and Kv1.3 can be measured using procedures described by Grissmer S, et al., Mol Pharmacol 1994 June;45(6): 1227-34. Inhibition of Kv1.4 can be measured using procedures described by Petersen K R, and Nerbonne J M, Pflugers Arch 1999 February;437(3):381-92. Inhibition of Kv1.6 can be measured using procedures described by Bowlby M R, and Levitan I B, J Neurophysiol 1995 June;73(6):2221-9. And inhibition of Kv1.7 can be measured using procedures described by Kalman K, et al., J Biol Chem 1998 March 6;273(10):5851-7.

[0133] Compounds within the scope of the present invention demonstrate activity in Kv1 assays such as the ones described above.

[0134] All documents cited in the present specification are incorporated herein by reference in their entirety.

[0135] The following examples and preparations describe the manner and process of making and using the invention and are illustrative rather than limiting. It is to be understood that there may be other embodiments which fall within the spirit and scope of the invention as defined by the claims appended hereto. Abbreviations employed herein are defined below.

[0136] CDI=carbonyl diimidazole

[0137] DCM=dichloromethane

[0138] DMAP=dimethylaminopyridine

[0139] DMF=dimethylformamide

[0140] DMPU=1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

[0141] EDCI (or EDC)=1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

[0142] M+H=monoisotopic mass plus one proton

[0143] Et=ethyl

[0144] h=hours

[0145] HPLC=high performance liquid chromatography

[0146] HOBT=hydroxybenzotriazole

[0147] LC/MS=liquid chromatography/mass spectrometry

[0148] Me=methyl

[0149] min=minutes

[0150] MS=mass spectrometry

[0151] NaOAc=sodium acetate

[0152] Ph=phenyl

[0153] PPA=poly phosphoric acid

[0154] Pr=propyl

[0155] Py=pyridine

[0156] PyBrOP=bromo-tris-pyrrolidino-phosphonium hexafluorophosphate

[0157] RT=room temperature

[0158] Rt=retention time

[0159] TEA=triethylamine

[0160] TFA=trifluoroacetic acid

[0161] TLC=thin layer chromatography

[0162] THF=tetrahydrofuran

[0163] TMSOTf=trimethylsilyl trifluoromethanesulfonate

EXAMPLE 1

7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid Methyl Ester

[0164]

[0165] Step A: A mixture of methyl acetoacetate 1 (5 mL, 46 mmol), 2,3-dichlorobenzaldehyde 2 (8.1 g, 46 mmol), piperidine (1.1 ml, 12 mmol), and acetic acid (0.6 mL, 11 mmol) in toluene (200 mL) was refluxed overnight with azeotropic removal of water via a Dean-Stark trap. The mixture was cooled to room temperature, quenched with water, transferred to a separatory funnel, diluted with ethyl acetate, washed with aqueous NaOH (1M), aqueous HCl (1M), water and brine and concentrated in vacuo. The residue was purified by flash chromatography (silica gel, 33% Ethyl acetate/hexanes) to afford 10.8 g (85% yield) of compound 3 as a mixture of diasteromers. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient (10% MeOH/H2O with 0.1% TFA-90% MeOH/H2O with 0.1% TFA), 4 mL/min. Diastereomer A, Rt=3.51 min,(53%) Diastereomer B, Rt=3.70 min (45%). MS (M+H: 273).

[0166] Step B: A mixture of compound 3 (5 g, 18.3 mmol), 3-arinopyrazole 4 (1.5 g, 18.3 mmol) in 1-propanol (60 mL) was refluxed for 6 h. The mixture was cooled to room temperature and concentrated and recrystallized from ethyl acetate/hexanes to give 1.25 g (20%) of the title compound as a yellow solid. The mother liquor was concentrated and purified by flash chromatography (silica gel, 5% methanol/dichloromethane) to give an additional 1.62 g (26%) of the title compound. Combined yield 2.87 g (46%). Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient (10% MeOH/H2O with 0.1% TFA-90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.38 min, (96% pure). MS (M+H: 338). HMR (CDCl3, 400 MHz) 7.98(1H, app. s), 7.15(3H, m), 6.91(1H,s), 5.52(1H, app. s), 3.61(3H, s), 2.39(3H,s).

EXAMPLES 2 AND 3

[0167] The compounds of Examples 2 and 3, shown in the table provided below, were prepared in a manner similar to that described in Example 1.

1ExampleStructureName(M + H)2

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid methyl ester3383

7-(4-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid methyl ester303

EXAMPLE 4

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl Ester

[0168]

[0169] Compound 1: Compound 1 was prepared by condensing t-butoxyacetoacetate and 2,4-dichlorobenzaldehyde as described in Example 1 step A.

[0170] Title Compound: A mixture of compound 1 (44.4 g, 141 mmol), 3-aminopyrazole 2 (17.6 g 212 mmol) and sodium acetate (46.3 g, 564 mmol) in dimethylformamide (300 mL) was stirred at 70° C. overnight (17 h). The mixture was cooled to room temperature, transferred to a separatory funnel, diluted with water and ethyl acetate, washed with water (a small amount of methanol was added to breakup emulsions that formed) and brine, dried over anhydrous sodium sulfate and concentrated. A precipitate formed. The precipitate was collected and washed with ethyl acetate, ethyl ether and hexanes and dried to give 8.93 g. The mother liquor was concentrated to give a second crop of precipitate 9.32 g. LC/MS analysis indicated the precipitates were not pure. The precipitates were combined, dissolved in dichloromethane and concentrated onto enough silica gel such that a free flowing powder was obtained. The resulting powder was loaded onto a chromatography column prepacked with silica gel and dichloromethane. Elution with 100% dichloromethane followed by 3% methanol/dichloromethane gave 15.1 g (29% yield) of the title compound. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient (10% MeOH/H2O with 0.1% TFA-90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=4.63min, (97% pure). MS (M+H: 380). HMR (CD3OD, 400 MHz) 7.41(2H, m), 7.33(1H, d, J=2 Hz), 7.08(1H, m), 6.21(1H,s), 5.68(1H, d, J=2 Hz), 2.43(3H, s), 1.37(9H,s).

[0171] A mixture of t-butoxyacetoacetate 1 (22.6 g, 143 mmol), 3,4-dichlorobenzaldehyde 2 (25.0 g, 143 mmol), 3-aminopyrazole 3 (15.4 g, 185 mmol) and sodium bicarbonate (36 g, 428 mmol) in dimethylformamide (250 mL) was stirred at 70° C. overnight (18 h). The mixture was cooled to room temperature, quenched with ethyl acetate and water, transferred to a separatory funnel, washed with water and brine, dried over sodium sulfate, filtered and concentrated. The residue was recrystallized from ethyl acetate/hexanes to give 16.8 g (31% yield) of the title compound as a white solid. Data for the title compound is given in method 1.

EXAMPLES 5 and 6

[0172] The compounds of Examples 5 and 6, shown in the table provided below, were prepared in a manner similar to that described in Example 4, Method 1.

2ExampleStructureName(M + H)5

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyra- zolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester4486

7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyra- zolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester448

EXAMPLES 7-11

[0173] The compounds of Examples 7-11, shown in the table provided below, were prepared in a manner similar to that described in Example 4, Method 2. The compound of Example 4, method 2 could be resolved into the corresponding enantiomers A (Example 8) and B (Example 9) by preparative chiral HPLC (Chiralcel OD column (50×500 mm), eluting with 7% isopropanol/hexanes containing 0.1% * triethylamine amine at 50 mL/min), UV detection at 254λ. Analytical HPLC (Chiralcel OD column (4.6×250 mm) eluting with 10% isopropanol/hexanes containing 0.1% triethylamine amine at 1 mL/min), UV detection at 254λ, enantiomer A (Rt=6.98 min, 98% ee) enantiomer B (Rt=9.22 min, 98% ee).

3ExampleStructureName(M + H)7

7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester3808

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethylester, enantiomer A3809

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethylester, enantiomer B38010

7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidine-6-car- boxylic acid 1,1-dimethylethyl ester39411

3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester380

EXAMPLE 12

7-(2,3-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid 1,1-dimethylethyl Ester

[0174]

[0175] Compound 1: Compound 1 was prepared as described in Example 4, method 1.

[0176] Title Compound: Sodium hydride (0.186 g, 7.76 mmol) was added to a 0° C. solution of 1 (2.27 g, 5.97 mmol) in dimethylformamide (30 mL). After 10 min., methyl iodide (0.41 mL, 6.57 mmol) was added. After an additional 85 min, the mixture was quenched with saturated ammonium chloride solution, diluted with ethyl acetate, transferred to a separatory funnel, washed with saturated ammonium chloride, water and brine, dried over anhydrous sodium sulfate and concentrated onto enough silica gel such that a free flowing powder was obtained. The resulting powder was loaded onto a chromatography column prepacked with 100% dichloromethane. Elution with 0-10% ethyl acetate/dichloromethane gave 1.16 g (49%) of the tile compound as a slightly yellow solid. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 ML/min. Rt=3.46 min, (96% pure). MS (M+H: 394). HMR (CD3Cl, 400 MHz) 7.39(1H, d, J=2 Hz), 7.35(1H, m), 7.23(1H, m), 7.1 1(1H, m), 6.91(1H,s), 5.58(1H, d, J=2 Hz), 2.38(3H, s), 2.62(3H, s), 1.27(9H,s).

EXAMPLE 13

7-(3,4-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid 1,1-dimethylethyl Ester

[0177]

[0178] The title compound was prepared in a similar manner to that provided in Example 12 yielding a compound with (M+H): 394.

EXAMPLE 14

4,7-Dihydro-5-methyl-7-(1-methylethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic Acid 1,1-dimethylethyl Ester

[0179]

[0180] A pressure tube was dried with a heat gun under nitrogen. The pressure tube was charged in the following order with isobutyraldehyde 2(0.262 g, 3.63 mmol), dimethylformamide (3 mL), t-butylacetoacetate 1 (0.574 g, 3.63 mmol), 3-aminopyrazole 3 (0.362 g, 4.36 mmol) and sodium acetate (1.22 g, 14.5 mmol). The mixture was flushed with nitrogen. The tube was sealed and warmed to 75° C. and stirred overnight. The mixture was cooled to room temperature, diluted with ethyl acetate to a volume of 20 mL, washed with lithium chloride (2.4M, 10 mL) and brine, dried over anhydrous sodium sulfate, filtered and concentrated to give 1.02 of a yellow oil. The oil was purified by flash chromatography (silica, 45% ethyl acetate/heptane) to give 0.42 g (41% yield) of the title compound. Reverse Phase HPLC: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.2% PPA, Solvent B: 90% MeOH/H2O with 0.2% PPA), 4 mL/min. Rt=3.83 min, (100% pure). Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.06min. MS (EM, M+1: 278). HMR (CDCl3, 400 MHz): 7.37(1H,d,J=2.2 Hz), 6.35(1H,s), 5.55(1H,d,J=1.8 Hz), 5.29(1H,d,J=2.2 Hz), 2.41(3H,s), 1.50(9H,s), 1.28-1.19(1H,m), 1.07(3H,d,J=7.0 Hz), 0.60(3H,d,J=7.0 Hz).

EXAMPLE 15

7-Cyclopropyl-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl Ester

[0181]

[0182] The title compound was prepared in a similar manner to that provided in Example 14 yielding a compound with (M+H): 275.

EXAMPLE 16

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid

[0183]

[0184] Compound 1: Compound 1 was prepared as described in Example 4.

[0185] Title Compound: HCl (4M in dioxane) was added to solid compound 1 (1.13 g, 2.97 mmol) at room temperature. The solid dissolves and a precipitate forms. The resulting thick reaction mixture was allowed to stir overnight and was concentrated in vacuo to give 1.14 g (120% contains dioxane) of the title compound as a white solid. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.54 miin, (93% pure). MS (M+H: 324). HMR (CD3OD, 400 MHz) 7.96(1H, d, J=3 Hz), 7.51(2H, m), 7.21(1H, m), 6.49(1H,s), 6.1 1(1H, d, J=3 Hz), 2.51(3H, s). The title compound was used in subsequent reactions without further purification.

EXAMPLE 17

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic Acid

[0186]

[0187] Compound 1: Compound 1 (the compound of Example 5) was prepared in a manner similar to that described in Example 4.

[0188] Title Compound: Trimethylsilyl trifluoromethanesulfonate (0.873 mL, 4.82 mmol) was added to a room temperature solution of compound 1 (1.08 g, 2.41 mmol) in dichloromethane (50 mL). After 2 h triethylamine (0.672 ml, 4.82 mmol) was added and the reaction mixture was poured into water. The organic layer was separated and dried over Na2SO4, concentrated, and purified by flash chromatography (50% ethylacetate/hexane→100% ethyl acetate) to give 0.71 g (75% yield) of the title compound as a white solid. MS (M+H: 392).

EXAMPLE 18

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine

[0189]

[0190] Compound 1: Compound 1 was prepared as described in Example 1.

[0191] Title Compound: Trimethylaluminium (1.1 mL, 2.2 mmol, 2 M in toluene) was dropwise added to a room temperature solution of 1-phenypiperazine 2 (0.4 mL, 2.2 mmol) in toluene (7 mL). After one hour compound 1 (0.50 g, 1.5 mmol) was added and the resulting mixture was stirred at 100° C. for 18 h. The mixture was cooled to room temperature, quenched with water, diluted with ethyl acetate, transferred to a separatory funnel, washed with aqueous HCl (1M), water and brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography (silica gel, 50% ethyl acetate/hexanes followed by 5% methanol/dichloromethane to provide 0.22 g (32%) of a solid which was further purified by recrystallization from methanol/ethyl ether to give 0.15 g (22%) of the title compound. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, SolventB: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.58 min, (92% pure). MS (M+H: 468). Additional Data for the title compound is reported in Method 2, step C variation 1.

[0192] Step A Variation 1: A mixture of N-phenylpiperazine 1 (6.7 mL, 41 mmol) and t-butoxyacetoacetate 2 (6.8 mL, 45 mmol) in toluene (50 mL) was refluxed overnight. The mixture was cooled to room temperature, transferred to a separatory funnel, diluted with ethyl ether and extracted (3×) with aqueous HCl (1M). The HCl extracts were combined and washed with ethyl ether (2×), made basic (pH 9) with aqueous NaOH (50% w/w) and extracted with ethyl acetate. The ethyl acetate extracts were combined, washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated to give 9.76 g (97.6%) of compound 4 as a thick amber oil. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, SolventB: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=1.65 min, (100% pure). MS (M+H: 247). HMR (CDCl3, 400 MHz) 7.28(2H, m), 6.91(3H, m), 3.80(2H, m), 3.78(2H, m), 3.59(4H, m), 3.19(4H, m), 2.30(3H, s).

[0193] Step A Variation 2: Diketene 3 (5.50 g, 65.5 mmol) was slowly added over 15 min. to a 0° C. solution of 4-phenylpiperazine 1 (5.31 g, 32.7 mmol) in dichloromethane (50 mL). TLC after 4 h indicated compound 1 was not completely consumed. Additional diketene (5.50 g, 65.5 mmol) was added. After an additional 1.5 h the reaction was quenched with 1N NaOH, transferred to a separatory funnel, washed with 1H NaOH and brine, dried over sodium sulfate, concentrated onto enough silica gel such that a free flowing powder was obtained. The resulting powder was loaded onto a chromatography column prepacked with silica and 50% ethyl acetate/hexanes. Elution with 50-100% ethylacetate/hexanes gave 8.2 g (100%) of compound 4 as a thick yellow oil. Data for compound 4 is given above in step A variation 1.

[0194] Step B: A mixture of compound 4 (9.76 g, 40 mmol), 2,3-dichlorobenzaldehyde 6 (7.89 g, 45 mmol), piperidine (1.0 ml, 10 mmol), acetic acid (0.59 mL, 10 mmol) in toluene (100 mL) was refluxed overnight with azeotropic removal of water via a Dean-Stark trap. The mixture was cooled to room temperature and concentrated in vacuo and was typically used in subsequent reactions without purification. Compound 6 may be Purified by silica gel chromatography (30-40% ethyl acetate/hexanes). Reverse Phase LC/MS: YMC S5 ODS 4.6×50 nmm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, SolventB: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.83 min, (96% pure). MS (M+H: 404). HMR (CDCl3, 400 MHz) 7.82(1H, s), 7.55(1H, dd, J=1, 8 Hz), 7.48(1H, dd, J=1, 8 Hz), 7.23(3H, m), 6.89(1H, app. t, 7 Hz), 6.81(2H, d, J=8 Hz), 3.78(2H, m), 3.34(1H, m), 3.23(2H, m), 2.96(1H, m), 2.85(1H, m), 2.50(3H, s), 2.42(1H, M).

[0195] Step C Variation 1: A mixture of compound 6 (16 g, 40 nmmol), 3-aminopyrazole 7 (5.1 g 62 mmol) and sodium acetate (10.1 g, 123 mmol) in dimethylformamide (100 mL) was stirred at 70° C. overnight (17 h). The mixture was cooled to room temperature, transferred to a separatory funnel, diluted with water and ethyl acetate, washed with water (a small amount of methanol was added to breakup emulsions that formed) and brine, dried over anhydrous sodium sulfate and concentrated. The resulting residue was purified by silica gel chromatography. Elution with 50% ethyl acetate/hexanes followed by 100% ethyl acetate afforded 6.2 g (33% yield from compound 1) of the title compound. The title compound could be resolved into the corresponding enantiomers A (Example 28) and B (Example 29) by preparative chiral HPLC (Chiracel OD column (50×500 mm), eluting with 30% isopropanol/hexanes containing 0.1% triethylamine amine at 50 mL/min), UV detection at 254λ, enantiomer A Rt=42 min, enantiomer B Rt=54 min. Analytical HPLC (Chiracel OD column (4.6×250 mm) eluting with 30% isopropanol/hexanes containing 0.1% triethylamine amine at 1 mL/min), UV detection at 254λ, enantiomer A Rt=11.7 min, enantiomer B Rt=17.6 min. Data given for enantiomer A: Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.54miin, (91% pure). MS (M+H: 468). HMR (HCl salt of 8a, CD3OD, 400 MHz) 7.94(1H, d, J=3 Hz), 7.56(8H, m), 7.38(1H, m), 6.05(1H, d, J=3 Hz), 4.23(1H,m), 3.57(7H, m), 2.01(3H, s).

[0196] Step C Variation 2: A mixture of compound 5 (6.0 g, 15 mmol), 3-aminopyrazole 7 (1.24 g, 15 mmol) in n-propanol (50 mL) was refluxed overnight (19 h). The mixture was cooled to room temperature, transferred to a separatory funnel, diluted with ethyl acetate. An attempt to wash the solution with saturated ammonium chloride resulted in the formation of a precipitate. The precipitate was dissolved with water and methanol. The resulting mixture was washed with water and brine, dried over anhydrous sodium sulfate and concentrated. The resulting residue was purified by silica gel chromatography. Elution with 70% ethyl acetate/hexanes followed by 100% ethyl acetate afforded 2.7 g (39% yield) of the title compound as a white solid. The title compound could be resolved into the corresponding enantiomers A and B as described in Step C variation 1.

EXAMPLES 19-27

[0197] The compounds of Examples 19-27, shown in the table provided below, were prepared in a manner similar to that described in Example 18, Method 1.

4ExampleStructureName(M + H)19

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-phenylpiperazine46820

7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-N-propylpyrazolo[1,5-a]pyri- midine-6-carboxamide36521

7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-N-phenylpyrazolo[1,5-a]pyri- midine-6-carboxamide39922

4-[[7-(2,3-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]morpholine39323

7-(2,3-Dichlorophenyl)-4,7-dihy- dro-5-methyl-N-propylpyrazolo[1,5-a]pyri- midine-6-carboxamide36524

7-(2,3-Dichlorophenyl)-4,7-dihy- dro-5-methyl-N-phenylpyrazolo[1,5-a]pyri- midine-6-carboxamide39925

7-(2,3-Dichlorophenyl)-4,7-dihy- dro-5-methyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyri- midine-6-carboxamide42726

7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyri- midine-6-carboxamide42727

7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-N-3-pyridinylpyrazolo[1,5-a]pyri- midine-6-carboxamide400

EXAMPLES 28-82

[0198] The compounds of Examples 28-82, shown in the table provided below, were prepared in a manner similar to that described in Example 18, Method 2.

[0199] HPLC resolution of Example 47, Chiralcel OD column (50×500 mm), eluting with 30% isopropanol/hexanes containing 0.1% triethylarnine at 50 mL/min), UV detection at 254λ, provided enantiomers A (Example 50) and B (Example 51). Chiralcel OD column (4.6×250 mm) eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254λ, enantiomer A Rt=9.8 min, >99% ee. Enantiomer B Rt=14.2 min, >99% ee.

[0200] HPLC resolution of Example 70, Chiralpak AD column (50×500 mm), eluting with 15% ethanol/hexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ, provided enantiomers A (Example 72) and B (Example 71). Chiralpak AD column (4.6×250 mm) eluting with 15% ethanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254 λ, enantiomer A Rt=6.9 min, >99% ee. Enantiomer B Rt=13.4 min, >99% ee.

[0201] HPLC resolution of Example 80, Chiralpak AD column (50×500 mm), eluting with 25% isopropanol/hexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ, provided enantiomers A (Example 81) and B (Example 82). Chiralpak AD column (4.6×250 mm) eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254 λ, enantiomer A Rt=5.3 min, >99% ee. Enantiomer B Rt=7.1 min, >99% ee.

5ExampleStructureName(M + H)28

1-[[7-(2,3-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-phenylpiperazine, enantiomer A46829

1-[[7-(2,3-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-phenylpiperazine, enantiomer B46830

1-[[7-(4-Chlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-phenylpiperazine43331

1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methyl-N-(phenyl- methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide41332

4-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]morpholine39333

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-methylpiperazine40634

7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(phenyl- methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide41335

7-(4-Chlorophenyl)-4,7-dihydro-5-methyl-N-(phenyl- methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide37836

4-[[7-(4-Chlorophenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]morpholine35837

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine39138

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine39139

7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methyl-N-(3-phenyl- propyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide44140

1-[[5-(3,4-Dichlorophenyl)-5,8-dihydro-7-meth- yl-imidazo[1,2-a]pyrimidin-6-yl]carbonyl]-4-phe- nyl-piperazine46841

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(phenylmethyl)piperidine48142

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[(1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(phenylmethyl)piperazine48243

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N,N-di- propylpyrazolo[1,5-a]pyrimidine-6-carboxamide40744

1-[[7-(3-Chlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine45145

1-[[7-(3,4-Difluorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine45346

1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methyl[1,2,4]triazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-phenylpiperazine46947

1-[[7-(2,3-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine48648

1-(4-Fluorophenyl)-4-[(4,7-di- hydro-5-methyl-7-phenylpyrazolo[1,5-a]pyri- midin-6-yl)carbonyl]piperazine41749

1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-tetra- hydro-5-methyl-2-oxopyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-phenylpiperazine48450

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine, enantiomer A48651

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine, enantiomer B48652

1-[[5-(2,3-Dichlorophenyl)-5,8-dihydro-7-meth- yl-imidazo[1,2-a]pyrimidin-6-yl]carbo- nyl]-4-phenyl-piperazine46853

1-(4-Fluorophenyl)-4-[[7-(3-fluorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-piperazine43554

1-[[7-(3,5-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine48655

1-[(7-Cyclohexyl-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-phenylpiperazine40556

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-meth- yl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)carbo- nyl]-4-phenylpiperazine46957

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-di- methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phe- nylpiperazine48258

7-(2,3-Dichlorophenyl)-4,7-dihydro-5-meth- yl-6-[(4-phenyl-1-piperazinyl)-carbonyl]pyra- zolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester54059

1-[[4-(2,3-Dichloro- phenyl)-4,6,7,8-tetrahydro-2-methyl-1H-pyri- mido[1,2-a]pyrimidin-3-yl]carbonyl]-4-phenyl-piperazine48460

4-[[7-(3,4-Dichloro- phenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-1-pi- perazinecarboxylic acid 1,1-dimethylethyl ester49261

1-[[7-(3,4-Dichloro- phenyl)-4,7-dihydro-2,5-dimethylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine48262

1-[[7-(3,4-Dichloro- phenyl)-4,7-dihydro-5-methyl-2-phenyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-phenylpiperazine54463

7-(3,4-Dichlorophen- yl)-4,7-dihydro-2,5-dimethyl-N-(3-phenyl- propyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide45564

1-[[7-(2,3-Dichloro- phenyl)-2-(1,1-dimethylethyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-phenylpiperazine52465

1-[[7-(3,4-Dichloro- phenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperidine46766

7-(3,4-Dichlorophneyl)-4,7-di- hydro-5-methyl-6-[[(3-phenyl- propyl)amino]carbonyl]pyra- zolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester51367

7-(2,3-Dichlorophenyl)-4,7-di- hydro-5-methyl-6-[(4-phen- yl-1-piperazinyl)-carbonyl]pyra- zolo[1,5-a]pyrimidine-2-carboxylic acid ethyl ester54068

1-[[3-Cyano-7-(2,3-dichloro- phenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine51169

1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methyl-2-(trifluoromethyl)pyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine55470

1-[[7-(2,3-Dichlorophenyl)-4,7-di- hydro-5-methyl-2-(trifluoromethyl)pyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine55471

1-[[7-(2,3-Dichlorophenyl)-4,7di- hydro-5-methyl-2-(trifluoromethyl)pyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer B55472

1-[[7-(2,3-Dichlorophenyl)-4,7-di- hydro-2,5-dimethylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer B55473

7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methyl-N-(3-phenylpropyl)-2-(tri- fluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide50974

7-(3,4-Dichlorophenyl)-6-[[4-(4-fluoro- phenyl)-1-piperazinyl]carbonyl]-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midine-2-carboxylic acid methyl ester54475

(2S)-1-[[7-(2,3-Dichlorophenyl)-4,7-di- hydro-5-methyl-2-(trifluoromethyl)pyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxy- methyl)pyrrolidine48976

1-[[7-(2,3-Dichloro- phenyl)-2-fluoro-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine50477

100

(2S)-1-[[2-Chloro-7-(2,3-dichloro- phenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxy- methyl)pyrrolidine45578

101

(2S)-1-[[2-Chloro-7-(3,4-dichloro- phenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxy- methyl)pyrrolidine45579

102

(2S)-1-[[7-(2,3-Dichlorophe- nyl)-2-fluoro-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine43980

103

1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-2,5-dimethylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine50081

104

1-[[7-(3,4-Dichlorophneyl)-4,7-di- hydro-2,5-dimethylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer A50082

105

1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-2,5-dimethylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer B500

EXAMPLE 83

7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N, N-dipropylpyrazolo[1,5-a]pyrimidine-6-carboxamide

[0202]

106

[0203] Compound 1: Compound 1 was prepared as described in Example 18, Method 2 Step A1 from t-butoxyacetoacetate and dipropylamine.

[0204] Title Compound: A mixture of compound 1 (0.2 g, 1.1 mmol), 2,3-dichlorobenzaldehyde 2 (0.23 g, 1.3 mmol), piperidine (0.015 ml, 0.27 mmol), acetic acid (0.027 mL, 0.27 mmol) and 4A Molecular Sieves (spatula tip) in dimethylformamide (1 mL) was stirred at 70° C. overnight. The mixture was cooled to room temperature. 3-aminopyrazole 3 (0.13 g, 1.6 mmol) and sodium acetate (0.28 g, 3.5 mmol) were added and the mixture was stirred overnight at 70° C. The mixture was cooled to room temperature, transferred to a separatory funnel, diluted with water and ethyl acetate, washed with water (a small amount of methanol was added to breakup emulsions that formed) and brine, dried over anhydrous sodium sulfate and concentrated. The resulting residue was purified by silica gel chromatography (50% ethyl acetate/hexanes followed by 100% ethyl acetate) to afford 0.10 g (23% yield from compound 1) of the title compound. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=2.94 min, (96% pure). MS (M+H: 407).

EXAMPLES 84-169

[0205] The compounds of Examples 84-169, shown in the table provided below, were prepared in a manner similar to that described in Example 83.

[0206] HPLC resolution of Example 84, Chiralpak AS column (50×500 mm), eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ, provided enantiomers A (Example 166) and B (Example 167). Chiralpak AS column (4.6×250 mm) eluting with 40% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254 λ, enantiomer A Rt=5.53 min, >99% ee. Enantiomer B Rt=12.0 min, 98% ee.

[0207] HPLC resolution of Example 165, Chiralpak AD column (50×500 mm), eluting with 20% isopropanol/hexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ provided enantiomers A (Example 169) and B (Example 168). Chiralpak AD column (4.6×250 mm) eluting with 20% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254 λ,enantiomer A Rt=8.3 min, >99% ee. Enantiomer B Rt=12.8 min, 98% ee.

EXAMPLES 401-406

[0208] The compounds of Examples 401-406, shown in the table provided below, were prepared in a manner similar to that described in Example 400.

[0209] HPLC resolution of Example 403, Chiralpak AD column (50×500 mm), eluting with 35% isopropanol/hexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ provided enantiomers A (Example 405) and B (Example 404). Chiralpak AD column (4.6×250 mm) eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254 λ, enantiomer A Rt=14.4 min, >99% ee. Enantiomer B Rt=28.7 mnin, >99% ee.

6ExampleStructureName(M + H)401

107

1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-4,5-dimethylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]piperidine405402

108

1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-4,5-dimethylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine500403

109

1-[[7-(2,3-Dichlorophenyl)-4,7-di- hydro-4,5-dimethylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine50090

110

1-[[4,7-Dihydro-7-(2-methoxy- phenyl)-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine44791

111

1-[[7-(2,3-Dimethoxyphenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine47792

112

1-[[7-(2,4-Dimethoxyphenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine47793

113

1-[[7-(2,5-Dimethoxyphenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine47794

114

1-[[4,7-Dihydro-5-methyl-7-[2-(tri- fluoromethyl)phenyl]pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine48595

115

1-[[4,7-Dihydro-5-methyl-7-(2-methyl- phenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine43196

116

1-[[4,7-Dihydro-5-methyl-7-(3-phenoxy- phenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine50997

117

1-[[7-(3,4-Dimethoxyphenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine47798

118

1-[[7-(3,5-Dimethoxyphenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine47799

119

1-[[4,7-Dihydro-5-methyl-7-[3-(phenyl- methoxy)phenyl]pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine523100

120

1-[[4,7-Dihydro-7-(3-hydroxy- phenyl)-5-methyl-pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine433101

121

1-[[4,7-Dihydro-5-methyl-7-[3-(tri- fluoromethyl)phenyl]pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine485102

122

1-[[4,7-Dihydro-5-methyl-7-(3-methyl- phenyl)pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine431103

123

1-[[7-(4-Cyanophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine442104

124

1-(4-Fluorophenyl)-4-[[7-(4-fluoro- phenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine435105

125

N-[4-[6-[[4-(4-Fluoro- phenyl)-1-piperazinyl]carbonyl]-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-7-yl]phenyl]acetamide474106

126

1-[[7-[4-(Dimethylamino)phe- nyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine460107

127

1-[[4,7-Dihydro-7-(4-methoxy- phenyl)-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine447108

128

1-[[4,7-Dihydro-5-methyl-7-[4-(phenyl- methoxy)phenyl]pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine523109

129

1-[[7-(4-Butoxyphenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine489110

130

1-[[4,7-Dihydro-5-methyl-7-(2-thie- nyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine423111

131

1-[[4,7-Dihydro-5-methyl-7-(3-thie- nyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine423112

132

1-[[4,7-Dihydro-5-methyl-7-[4-(tri- fluoromethyl)phenyl]pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine485113

133

1-[[4,7-Dihydro-5-methyl-7-(4-methyl- phenyl)pyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine431114

134

1-[[4,7-Dihydro-5-methyl-7-(2-nitro- phenyl)pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine462115

135

1-[[4,7-Dihydro-5-methyl-7-(4-nitro- phenyl)pyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine462116

136

1-[[7-(2,6-Difluorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine453117

137

1-[[7-(2,4-Difluorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine453118

138

1-[[7-(2,5-Difluorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine453119

139

1-[[7-(3,5-Difluorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine453120

140

1-[[4,7-Dihydro-5-methyl-7-[2-(phenyl- methoxy)phenyl]pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine523121

141

1-[[7-(3,4-Dimethylphenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine445122

142

1-[[4,7-Dihydro-5-methyl-7-[4-(tri- fluoromethoxy)phenyl]pyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine501123

143

1-[[4,7-Dihydro-5-methyl-7-[3-(tri- fluoromethoxy)phenyl]pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine501124

144

1-[[7-(3-Cyanophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine442125

145

1-[[4,7-Dihydro-7-(3-methoxy- phenyl)-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]arbonyl]-4-(4-fluorophenyl)piperazine447126

146

1-[[7-(4-Chlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine451127

147

1-[[4,7-Dihydro-5-methyl-7-(4-phenoxy- phenyl)pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine509128

148

1-[[4,7-Dihydro-5-methyl-7-(3-nitro- phenyl)pyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine462129

149

1-[[4,7-Dihydro-5-methyl-7-(5-meth- yl-2-furanyl)pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine421130

150

1-[[4,7-Dihydro-7-(1H-imida- zol-2-yl)-5-methylpyrazolo[1,5-a]py- rimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine407131

151

1-[[4,7-Dihydro-5-methyl-7-(1H-pyr- rol-2-yl)pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine406132

152

1-[[4,7-Dihydro-5-methyl-7-(2-pyri- dinyl)pyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine418133

153

1-[[7-(3-Chloro-4-methoxyphenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine481134

154

1-[[4,7-Dihydro-7-(4-methoxy-1,3-benzodiox- ol-6-yl)-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine491135

155

1-[[4,7-Dihydro-7-[5-(hydroxy- methyl)-2-furanyl]-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine437136

156

1-[[4,7-Dihydro-7-(1H-indol-3-yl)-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine456137

157

1-[[4,7-Dihydro-5-methyl-7-(3-py- ridinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine418138

158

1-[[4,7-Dihydro-5-methyl-7-(3-quino- linyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine468139

159

1-[[4,7-Dihydro-5-methyl-7-(4-quino- linyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine468140

160

1-[[7-(2,3-Dihydro-1,4-benzodi- oxin-6-yl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine475141

161

1-[[4,7-Dihydro-5-methyl-7-(2,3,5-tri- chlorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine520142

162

1-[[7-(2,5-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine486143

163

1-(4-Fluorophenyl)-4-[[7-(3-fura- nyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-piperazine407144

164

1-[[7-(2-Benzofuranyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine457145

165

1-[[4,7-Dihydro-5-methyl-7-(3-methyl- benzo[b]thiophen-2-yl)pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine487146

166

1-[[4,7-Dihydro-5-methyl-7-(2-quino- linyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine468147

167

1-[[4,7-Dihydro-5-methyl-7-(2-thia- zolyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine424148

168

1-(4-Fluorophenyl)-4-[[7-(2-fura- nyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine407149

169

1-[[4,7-Dihydro-7-[3-methoxy-4-(phenyl- methoxy)phenyl]-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine553150

170

1-[[4,7-Dihydro-7-[4-methoxy-3-(phenyl- methoxy)phenyl]-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine553151

171

1-[[4,7-Dihydro-5-methyl-7-(2-naphtha- lenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine467152

172

1-[[7-[3,4-Bis(phenylmethoxy)phen- yl]-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine629153

173

1-[[7-(1,3-Benzodioxol-5-yl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine461154

174

1-[[7-[3,5-Bis(trifluoromethyl)phe- nyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine553155

175

1-[[4,7-Dihydro-5-methyl-7-[5-[1-meth- yl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thie- nyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine571156

176

1-[[7-(5-Ethyl-2-furanyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine435157

177

1-[[7-(2,3-Dihydro-5-benzofuranyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine459158

178

1-[[7-(3-Bromophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine496159

179

1-[[4,7-Dihydro-5-methyl-7-[4-(1-pyrroli- dinyl)-phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine486160

180

1-[[4,7-Dihydro-5-methyl-7-(3-meth- yl-2-thienyl)pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine437161

181

1-[[4,7-Dihydro-5-methyl-7-(5-meth- yl-2-thienyl)pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine437162

182

1-[[7-(1,3-Benzodioxol-4-yl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine461163

183

1-[[7-(5-Chloro-2-thienyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine457164

184

1-[[7-(3,5-Dimethylphenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine445165

185

1-[[7-(2,3-Dichlorophenyl)-4,7-dihy- dro-2,5-dimethylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine500166

186

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine, enantiomer A486167

187

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine, enantiomer B486168

188

1-[[7-(2,3-Dichlorophenyl)-4,7-dihy- dro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]car- bonyl]-4-(4-fluorophenyl)piperazine, enantiomer B500169

189

1-[[7-(2,3-Dichlorophenyl)-4,7-dihy- dro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]car- bonyl]-4-(4-fluorophenyl)piperazine, enantiomer A500

EXAMPLE 170

8-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,4-dioxa-8-azaspiro[4.5]decane

[0210]

190

[0211] Compound 1: Compound 1 was prepared as described in Example 16.

[0212] Title Compound: Compound 2 (0.068 g, 0.47 mmol) was added to a suspension of compound 1 (0.10 g, 0.32 mmol), EDCI (0.09 g, 0.47 mmol), DMAP(0.004 g, 0.03 mmol) in dichloromethane (1 mL). When LC/MS indicated the reaction was complete the mixture was loaded directly onto a Worldwide Monitoring CLEAN-UP CARTRIDGE (silica gel, CUSIL12M6) which had been equilibrated with 100% hexanes. Elution with 100% hexanes (40 mL), followed by 50% Ethyl acetate/hexanes (40 mL) and 100% ethyl acetate (70 mL). The purest fractions (TLC analysis) were combined to give 0.043 g (30% yield) of the title compound as a white solid. Reverse Phase LCJMS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=2.12 min, (97% pure). MS (M+H: 449). HMR (DMSO-d6, 400 MHz, 100° C.) 9.02(1H, bs), 7.49(1H, d, J=8 Hz), 7.26(1H, d, J=2 Hz), 7.14(1H, d, J=2 Hz), 6.95(1H, d, J=8 Hz), 6.08(1H, s), 5.55(1H, d, J=2 Hz), 3.84(4H, m), 3.55(2H,m), 3.20(2H, m), 1.86(3H, s), 1.37(2H, m), 1.26(2H, m).

EXAMPLES 171-377

[0213] The compounds of Examples 171-377, shown in the table provided below, were prepared in a manner similar to that described in Example 170.

[0214] HPLC resolution of Example 194, Chiralpak AD column (50×500 mm), eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ,provided enantiomers A (Example 250)and B (Example 251). Chiralpak AD column (4.6×250 mm) eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254 λ,enantiomer A Rt=5.32 min, 99% ee. Enantiomer B Rt=8.59 min, 98% ee.

[0215] HPLC resolution of Example 221, Chiralpak AS column (50×500 mm), eluting with 50% isopropanol/hexanes containing 0.1% triethylamine at 42 mL/min), UV detection at 254 λ provided enantiomers A (Example 328) and B (Example 329). Chiralpak AS column (4.6×250 mm) eluting with 30% isopropanol/hexanes containing 0.1% triethylamine amine at 1 mL/min), UV detection at 254λ enantiomer A Rt=5.12 min, >99% ee. Enantiomer B Rt=8.70 min, >99% ee.

[0216] HPLC resolution of Example 288, Chiralpak AD column (50×500 mm), eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ provided enantiomers A (Example 376) and B (Example 377). Chiralpak AD column (4.6×250 mm) eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254 λ,enantiomer A Rt=3.8 min, >99% ee. Enantiomer B Rt=5.6 min, >99% ee.

[0217] HPLC resolution of Example 333, Chiralpak AD column (50×500 mm), eluting with 40% isopropanovhexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ, provided enantiomers A (Example 364) and B (Example 365). Chiralpak AD column (4.6×250 mm) eluting with 40% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254 λ,enantiomer A Rt=4.92 min, >99% ee. Enantiomer B Rt=8.0 min, >97% ee.

[0218] The compound of Example 360 was separated into pure diastereo-isomers by column chromatography (silica gel eluted with 75% ethyl acetate, hexane). The faster eluting isomer is diastereomer 1, the slower eluting isomer is diasteromer 2. When separated by TLC (20% acetone, dichloromethane), diasteriomer 1 has an Rf of 0.26 and diastereromer 2 has an Rf of 0.17. Diastereomer 2 was further separated into pure chiral form via preparative chiral HPLC (Chiralpak AD 5 cm×50 cm column eluted with 13% ethanol in hexane with 0.1% TEA at 50 mL/min with UV detection at 254 nM). The faster eluting isomer is enantiomer A (HPLC retention time 8.1 min, 4.6×250 mm Chiralpak AD column eluted with 10% ethanol, hexane with 0.1% triethylamine at 2 mL/min with UV detection at 254 nm) and the slower eluting isomer is enantiomer B (HPLC retention time 10.6 miin, 4.6×250 mm Chiralpak AD column eluted with 10% ethanol, hexane with 0.1% triethylamine at 2 mL/min with UV detection at 254 nm). Diasteromer 1 can also be further separated into chiral pure form by similar methodology as that descibed for diastereomer 2 above to provide enantiomers C and D.

7ExampleStructureName(M + H)171

191

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- yl-pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(2-methoxyphenyl)piperazine498172

192

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]-pyrimidin-6-yl]carbo- nyl]-4-[3-(trifluoromethyl)-phenyl]piperazine536173

193

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-nitrophenyl)piperazine513174

194

1-(4-Acetylphenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]piperazine510175

195

1-(2-Chlorophenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]piperazine502176

196

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]-carbo- nyl]-4-(4-methoxyphenyl)piperazine498177

197

1-(3,4-Dichlorophenyl)-4-[[7-(3,4-dichlorophe- nyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]-carbonyl]piperazine537178

198

1-(3,5-Dichlorophenyl)-4-[[7-(3,4-dichlorophe- nyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]-carbonyl]piperazine537179

199

1-(4-Chlorophenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]piperazine502180

200

1-(3-Chlorophenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]piperazine502181

201

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(3-methoxyphenyl)piperazine498182

202

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-methylphenyl)piperazine482183

203

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5a]-pyrimidin-6-yl]car- bonyl]-4-[4-(trifluoromethyl)-phenyl]piperazine536184

204

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(2-fluorophenyl)piperazine486185

205

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(3,4-dimethylphenyl)piperazine496186

206

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(2-pyrimidinyl)piperazine470187

207

7-(3,4-Dichlorophenyl)-N-[2-[(4-fluorophenyl)a- mino]ethyl]-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidine-6-carboxamide460188

208

4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-1-piperazinecarboxylic acid phenylmethyl ester526189

209

7-(3,4-Dichlorophenyl)-N-ethyl-N-[(2-fluoro- phenyl)methyl]-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine-6-carboxamide459190

210

N-[(3-Chloro-4-methoxyphenyl)methyl]-7-(3,4-di- chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midine-6-carboxamide477191

211

1-(1,3-Benzodioxol-5-ylmethyl)-4-[[7-(3,4-di- chlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine526192

212

4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-1-piperazinecarboxylic acid ethyl ester464193

213

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(2-pyridinyl)piperazine469194

214

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine421195

215

1-[Bis(4-fluorophenyl)-methyl]-4-[[7-(3,4-di- chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]piperazine594196

216

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(2-fur- anyl-carbonyl)piperazine486197

217

1-Cyclohexyl-4-[[7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]piperazine474198

218

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(2-methoxy- ethyl)piperazine450199

219

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(9H-fluoren-9-yl)piperazine556200

220

(2R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine421201

221

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(2,3-dimethylphenyl)piperazine496202

222

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-2-piperidinecarboxylic acid ethyl ester463203

223

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-N,N-diethyl-3-piperidinecarboxamide490204

224

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-3-piperidinecarboxylic acid ethyl ester463205

225

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-3-methylpiperidine405206

226

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-3,5-dimethylpiperidine419207

227

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-hydroxypiperidine407208

228

4-(4-Chlorophenyl)-1-[[7-(3,4-dichloro- phenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-hydroxypiperidine517209

229

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-piperidinecarboxylic acid ethyl ester463210

230

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-methylpiperidine405211

231

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-1,2,3,4-tetrahydroquinoline439212

232

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]-pyrimi- din-6-yl]carbonyl]-decahydroquinoline445213

233

2-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-1,2,3,4-tetrahydroisoquinoline439214

234

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-propylpiperidine433215

235

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(hydroxydiphenylmethyl)piperidine573216

236

7-(3,4-Dichlorophenyl)-N-[(2-fluoro- phenyl)methyl]-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine-6-carboxamide431217

237

2-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]in- dole478218

238

7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-N-[2-(phenylamino)-eth- yl]pyrazolo[1,5-a]pyrimidine-6-carboxamide442219

239

(2S)-1-[[7-(3,4-Dichlorophe- nyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-2-[(phenylamino)methyl]pyrrolidine482220

240

N-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-di- hydro-N,5-dimethylpyrazolo[1,5-a]pyri- midine-6-carboxamide419221

241

3-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyri- midin-6-y]carbonyl]thiazole395222

242

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]pyrrolidine377223

243

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-3,4-dihydro-1H-indole425224

244

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]acetidine363225

245

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]hexahydro-1H-azepine405226

246

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]octahydroazocine419227

247

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine389228

248

7-(3,4-Dichlorophenyl)-4,7dihydro-N,5-di- methyl-N-[2-(2-pyridinyl)-ethyl]pyra- zolo[1,5-a]pyrimidine-6-carboxamide442229

249

N-[[7-(3,4-Dichlorophenyl)-4,7dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-N-(phenylmethyl)glycine ethyl ester499230

250

trans-7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-N-(2-phenylcyclopropyl)pyra- zolo[1,5-a]pyrimidine-6-carboxamide439231

251

1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-2-methylpyrrolidine391232

252

1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-2-methylaziridine363233

253

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-2-[[(2,6-dimethyl- phenyl)amino]methyl]pyrrolidine510234

254

7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihy- dro-5-methyl-N-(4-pyridinylmethyl)pyra- zolo[1,5-a]pyrimidine-6-carboxamide442235

255

7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-di- methyl-N-[(1R)-1-phenylethyl]pyra- zolo[1,5-a]pyrimidine-6-carboxamide441236

256

7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-di- methyl-N-[(1S)-1-phenylethyl]pyra- zolo[1,5-a]pyrimidine-6-carboxamide441237

257

6-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-1,3,3-trimethyl-6-azabicyclo[3.2.1]octane459238

258

7-(3,4-Dichlorophenyl)-N-(hexahydro-1H-aze- pin-1-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midine-6-carboxamide420239

259

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]aziridine349240

260

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]octahydro-1H-azonine433241

261

(2R-trans)-1-[[7-(3,4-Dichlorophe- nyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-2,5-bis(methoxymethyl)pyrrolidine465242

262

(2S-trans)-1-[[7-(3,4-Dichlorophe- nyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-2,5-bis(methoxymethyl)pyrrolidine465243

263

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-L-prolinamide420244

264

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-D-prolinamide420245

265

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2,3-dihydro-2-methyl-1H-indole439246

266

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2,3-dihydro-5-nitro-1H-indole470247

267

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2,3-dihydro-6-nitro-1H-indole470248

268

4-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-thiomorpholine409249

269

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-L-proline methyl ester435250

270

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine, enantiomer A421251

271

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine, enantiomer B421252

272

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-L-pro- line 1,1-dimethylether ester477253

273

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-N-(2-naphthalenyl)-L-prolinamide560254

274

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-1,2,3,4-tetrahydro-2-methylquinoline453255

275

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline471256

276

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-L-proline phenylmethyl ester511257

277

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-D-proline phenylmethyl ester511258

278

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-hydroxy-L-proline phenylmethyl ester527259

279

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)-2-methylpiperazine500260

280

3-Chloro-N-cyclohexyl-7-(3,4-dichlorophe- nyl)-4,7-dihydro-N,5-dimethylpyrazolo[1,5-a]pyri- midine-6-carboxamide453261

281

4-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]py- rimidin-6-yl]carbonyl]-thio- morpholine443262

282

1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2,3-dihydro-1H-indole459263

283

1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]hexahydro-1H-azepine439264

284

1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-octahydroazocine453265

285

1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-1,2,3,6-tetrahydropyridine423266

286

3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihy- dro-N,5-dimethyl-N-[(1S)-1-phenylethyl]-py- razolo[1,5-a]pyrimidine-6-carboxamide475267

287

3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihy- dro-N,5-dimethyl-N-[(1R)-1-phenylethyl]-py- razolo[1,5-a]pyrimidine-6-carboxamide475268

288

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]-carbo- nyl]-2-(methoxymethyl)piperidine435269

289

[(3R)-1-[[7-(3,4-Dichlorophe- nyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-3-pyrrolidinyl]carbamic acid 1,1-dimethylethyl ester492270

290

[(3S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-3-pyrrolidinyl]carbamic acid 1,1-dimethylethyl ester492271

291

(3R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-(di- methylamino)pyrrolidine420272

292

N-[1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-pyr- rolidinyl]acetamide434273

293

N-[1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-pyr- rolidinyl]-N-methylacetamide448274

294

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N,N-di- pentylpyrazolo[1,5-a]pyrimidine-6-carboxamide463275

295

7-(3,4-Dichlorophenyl)-N,N-dihexyl-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidine-6-carboxamide491276

296

1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]py- rimidin-6-yl]carbonyl]piperidine425277

297

3-Chloro-7-(3-chlorophenyl)-N-cyclohexyl-4,7-di- hydro-N,5-dimethylpyrazolo[1,5-a]py- rimidine-6-carboxamide419278

298

(2S)-1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine455279

299

1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]py- rimidin-6-yl]carbonyl]-deca- hydroquinoline479280

300

2-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-1,2,3,4-tetrahydroisoquinoline473281

301

4-[[3-Chloro-7-(3-chlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-thiomorpholine409282

302

N-Cyclohexyl-7-(3,4-dichlorohenyl)-4,7-di- hydro-N,5-dimethyl-2-(trifluoromethyl)pyra- zolo[1,5-a]pyrimidine-6-carboxamide487283

303

7-(3,4-Dichlorophenyl)-N,N-diethyl-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide379284

304

N,N-Dibutyl-7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide435285

305

7-(3,4-Dichlorophenyl)-N,N-diheptyl-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide519286

306

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-azacyclotridecane489287

307

9-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-dodecahydro-1H-fluorene485288

308

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methyl-2-(tri- fluoromethyl)pyrazolo-[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine489289

309

1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]piperidine391290

310

1-[[3-Chloro-7-(3-chlorophenyl)-4,7-di- hydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]hexahydro-1H-azepine405291

311

1-[[3-Chloro-7-(3-chlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-octahydroazocine419292

312

1-[[3-Chloro-7-(3-chlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine389293

313

3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-N,5-di- methyl-N-[(1S)-1-phenylethyl]pyra- zolo[1,5-a]pyrimidine-6-carboxamide441294

314

(2S)-1-[[3-Chloro-7-(3-chlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine421295

315

1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-decahydroquinoline445296

316

2-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-1,2,3,4-tetrahydroisoquinoline439297

317

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]hexahydro-1H-azepine439298

318

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine423299

319

(2S)-1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine455300

320

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(tri- fluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2,3-dihydro-1H-indole493301

321

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- yl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]hexahydro-1H-azepine473302

322

7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimeth- yl-N-[(1S)-1-phenylethyl]-2-(trifluoromethyl)pyra- zolo[1,5-a]pyrimidine-6-carboxamide509303

323

7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimeth- yl-N-[(1R)-1-phenylethyl]-2-(trifluoromethyl)pyra- zolo[1,5-a]pyrimidine-6-carboxamide509304

324

7-(3,4-Dichlorohenyl)-4,7-dihydro-N,N-bis(2-meth- oxyethyl)-5-methylpyrazolo[1,5-a]pyrimi- dine-6-carboxamide439305

325

7-(3,4-Dichlorophenyl)-N,N-bis(2-ethoxyethyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide467306

326

7-(3,4-Dichlorophenyl)-4,7-dihydro-N-(2-methoxyeth- yl)-N,5-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxa- mide395307

327

7-(3,4-Dichlorophenyl)-4,7-dihydro-N-(2-methoxyeth- yl)-5-methyl-N-propylpyrazolo[1,5-a]pyrimidine-6-car- boxamide423308

328

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine425309

329

2-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-di- hydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetra- hydroisoquinoline473310

330

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-octahydroazocine453311

331

3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihy- dro-N,5-dimethyl-N-[(1S)-1-phenylethyl]-pyra- zolo[1,5-a]pyrimidine-6-carboxamide475312

332

3-Chloro-N-cyclohexyl-7-(2,3-dichlorophe- nyl)-4,7-dihydro-N,5-dimethylpyrazolo[1,5-a]pyri- midine-6-carboxamide453313

333

3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihy- dro-5-methyl-N-(phenylmethyl)pyrazolo[1,5-a]pyrimi- dine-6-carboxamide447314

334

7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihy- dro-N-(2-methoxyethyl)-5-methylpyrazolo[1,5-a]pyri- midine-6-carboxamide409315

335

N-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-N-methylglycine ethyl ester423316

336

N-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-N-methylglycine 1,1-dimethylethyl ester451317

337

N-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-N-(2-ethoxy-2-oxoethyl)glycine ethyl ester495318

338

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(3-pyridinyl)piperidine468319

339

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-1,2,3,4-tetrahydro-6-methylquinoline453320

340

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-propylpiperidine433321

341

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-[(diethylamino)methyl]piperidine476322

342

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- yl-N-(2-phenoxyethyl)-pyrazolo[1,5-a]pyrimi- dine-6-carboxamide443323

343

1-[(7-Cyclopropyl-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-(4-fluoro- phenyl)piperazine381324

344

1-[[4,7-Dihydro-5-methyl-7-(1-methyl- ethyl)pyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine383325

345

(2S)-1-[[4,7-Dihydro-5-methyl-7-(1-methyl- ethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine318326

346

1-[[4,7-Dihydro-5-methyl-7-(1-methylethyl)pyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-1H-in- dole322327

347

1-[[4,7-Dihydro-5-methyl-7-(1-methylethyl)pyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,6-tetra- hydropyridine286328

348

3-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazolidine, enantiomer A395329

349

3-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazolidine, enantiomer B395330

350

7-(3,4-Dichlorophenyl)-4,7-dihy- dro-N,5-dimethyl-N-(phenyl- methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide427331

351

7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimeth- yl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidine-6-car- boxamide441332

352

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- yl-N-(2-phenylethyl)-N-(phenylmethyl)pyra- zolo[1,5-a]pyrimidine-6-carboxamide517333

353

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(phenoxymethyl)pyrrolidine483334

354

(2R)-1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(phenoxymethyl)pyrrolidine483335

355

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-2-[(4-fluoro- phenoxy)methyl]-pyrrolidine501336

356

(2R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-[(4-fluorophenoxy)methyl]-pyrrolidine501337

357

7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine-6-carboxamide351338

358

N-Butyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine-6-carboxamide379339

359

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-pen- tylpyrazolo[1,5-a]pyrimidine-6-carboxamide393340

360

7-(3,4-Dichlorophenyl)-4,7-dihydro-N-(2-methoxy- ethyl)-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide381341

361

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-2-(hydroxydiphenylmethyl)pyrrolidine559342

362

(2R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(hydroxydiphenylmethyl)pyrrolidine559343

363

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(3-pyridinyl)pyrrolidine454344

364

(2S)-1-[[7-(2,3-Dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(methoxymethyl)pyrrolidine421345

365

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-phenylpyrrolidine453346

366

3-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-phenylthiazolidine471347

367

3-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-thiazolidinecarboxylic acid methyl ester453348

368

7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimeth- yl-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimi- dine-6-carboxamide455349

369

7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihy- dro-5-methyl-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimi- dine-6-carboxamide469350

370

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- yl-N-(3-phenylpropyl)-N-propylpyrazolo[1,5-a]pyri- midine-6-carboxamide483351

371

N-Butyl-7-(3,4-dichlorophenyl)-4,7-dihy- dro-5-methyl-N-(3-phenylpropyl)pyrazolo[1,5-a]pyri- midine-6-carboxamide497352

372

2-(4-Chlorophenyl)-3-[[7-(3,4-dichloro- phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midine-6-yl]carbonyl]thiazolidine505353

373

N-(Cyclopropylmethyl)-7-(3,4-dichloro- phenyl)-4,7-dihydro-5-methyl-N-propyl- pyrazolo[1,5-a]pyrimidine-6-carboxamide419354

374

1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-pyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(2,3-dihydro-2-oxo-1H-ben- zimidazol-1-yl)piperidine523355

375

8-[[7-(2,3-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-1-phenyl-1,3,8-triazaspiro[4.5]de- can-4-one537356

376

4-(4-Chlorophenyl)-1-[[7-(3,4-dichloro- phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine499357

377

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-phenyl- ethyl)pyrrolidine481358

378

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-methoxy- phenyl)pyrrolidine482359

379

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-methoxy- phenyl)pyrrolidine483473

380

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-meth- yl-6-(1-methyl-1H-benzimidazol-2-yl)pyrazolo[1,5-a]py- rimidine410474

381

7-(3,4-Dichlorophenyl)-4,7-dihydro-6-(imida- zo[1,5-a]pyridin-3-yl)-5-methylpyrazolo[1,5-a]pyrimidine510475

382

7-(3,4-Dichlorophenyl)-6-(1-ethyl-5-nitro-1H-benzi- midazol-2-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]py- rimidine469476

383

6-[5-Chloro-1-(1-methyl- ethyl)-1H-benzimidazol-2-yl]-7-(3,4-di- chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]py- rimidine472477

384

6-(5-Chloro-1-ethyl-1H-benzimidazol-2-yl)-7-(3,4-di- chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]py- rimidine458478

385

7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-propyl-1H-ben- zimidazol-2-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]py- rimidine456.35366

386

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-meth- oxyphenyl)pyrrolidine483367

387

(2S)-2-(Butoxymethyl)-1-[[7-(3,4-dichlorophe- nyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]pyrrolidine463368

388

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(2-thienyl)pyrrolidine459369

389

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-(4-pyridinyl)pyrrolidine454370

390

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-2-[(methoxymethoxy)-methyl]pyrrolidine451371

391

(2S)-2-(1H-Benzimidazol-1-ylmethyl)-1-[[7-(3,4-di- chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]pyrrolidine507372

392

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-fura- nyl)pyrrolidine443373

393

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-pyri- dinyl)pyrrolidine454374

394

(3S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car- bonyl]-3-phenoxypyrrolidine469375

395

(3S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car- bonyl]-3-phenoxypyrrolidine488376

396

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyri- midin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine, enantiomer A489377

397

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]-pyri- midin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine, enantiomer B489

EXAMPLE 378

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-L-proline

[0219]

398

[0220] Compound 1: Compound 1 (the compound of Example 252) was prepared in a manner similar to that described in Example 170.

[0221] Title Compound: Hydrochloric acid (5 mL, 4M in Dioxane) was added to compound 1 (0.05 g, 0.1 mmol). The resulting mixture was stirred at room temperature. After 3 h the mixture was concentrated in vacuo. LC/MS analysis of the residue indicated that starting material remained. Additional Hydrochloric acid (5 mL, 4M in Dioxane) was added. The resulting mixture was stirred at room temperature for 7 h. TLC analysis indicated that compound 1 was consumed. The mixture was concentrated in vacuo. The residue was purified by preparative reverse phase HPLC to give the title compound as a mixture of diastereomers. LC/MS indicated that the compound was still impure (50% pure). Reverse Phase LCIMS: YMC S5 ODS 4.6×50 mm Ballistic, UV detection at 220 λ, 4 min. gradient, 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Diastereomer A Rt=3.34, Diastereomer B Rt=3.49 min. MS (M+H: 421). The product was triturated with dichlormethane to give 0.014 g (32% yield) of the title compound (85% pure by HPLC). Reverse Phase LC/MS: YMC 5S 4.6×50 mm combiscreen, UV detection at 220), 4 min. gradient, 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.2% H3PO4, Solvent B: 90% MeOH/H2O with 0.2% H3PO4), 4 mL/min. Diastereomer A Rt=2.82, Diastereomer B Rt=2.97 min.

EXAMPLE 379

7-(3,4-Dichlorophenyl)-4,7-dihydro-N-[(1R)-2,3-dihydro-1H-inden-1-yl]-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide

[0222]

399

[0223] Compound 1: Compound 1 was prepared as described in Example 17.

[0224] Title Compound: To a suspension of polystyrene-supported HOBt resin (NovaBiochem, >1.2 mmol/g, 50 mg, 1.0 eq) in anhydrous CH2Cl2 (1.0 mL) was added Compound 1 (47 mg, 2.0 eq), EDCI (23 mg, 2.0 eq), and DMAP (0.7 mg, 0.1 eq). The suspension was shaken vigorously using a VORTEX-GENIE2 for 1 hr. Solvent was then drained and the resin was washed sequentially with DMF (3×2 mL), THF (3×2 mL), and CH2Cl2 (3×2 mL) with vigorous shaking. The resin was resuspended in CH2Cl2 (1 mL) and to which was added (R)-(−)-Aminoindan 2 (0.006 mL, 0.8 eq). The mixture was shaken for 2 hr. Solvent was drained and the resin was washed with CH2Cl2 (3×1 mL) with vigorous shaking. All the washing solutions were combined and the solvent was removed under reduced pressure. The residue was purified through a silica gel cartridge eluting with 100% EtOAc to give the title compound as a white solid. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.2% H3PO4, Solvent B: 90% MeOH/H2O with 0.2% H3PO4), 4 mL/min. Rt=2.96 min, (diastereomers, 96% pure). MS (M+H): 507.

EXAMPLES 380-391

[0225] The compounds of Examples 380-391, shown in the table provided below, were prepared in a manner similar to that described in Example 379.

8ExampleStructureName(M + H)380

400

7-(3,4-Dichlorophenyl)-N-(2,3-dihydro-1H-in- den-2-yl)-4,7-dihydro-5-methyl-2-(tri- fluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide507381

401

N-[[7-(3,4-Dichlorophenyl)-4,7-dihy- dro-5-methyl-2-(trifluoromethyl)pyrazo- lo[1,5-a]pyrimidin-6-yl]carbonyl]-D-phenylalanine methyl ester553382

402

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- yl-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-2-(tri- fluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide521383

403

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-meth- yl-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-2-(tri- fluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide516384

404

7-(3,4-Dichlorophenyl)-N-(2-furanylmeth- yl)-4,7-dihydro-5-methyl-2-(trifluoro- methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide471385

405

7-(3,4-Dichlorophenyl)-N-[(3,4-dichloro- phenyl)methyl]-4,7-dihydro-5-methyl-2-(tri- fluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide550386

406

7-(3,4-Dichlorophenyl)-4,7-dihydro-N-[(2R)-2-(meth- oxymethyl)-1-pyrrolidinyl]-5-methyl-2-(tri- fluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide504387

407

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(tet- rahydro-2-furanyl)-methyl]-2-(trifluoro- methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide475388

408

7-(3,4-Dichlorophenyl)-4,7-dihydro-N-[(1S)-2,3-di- hydro-1H-inden-1-yl]-5-methyl-2-(trifluoro- methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide507389

409

7-(3,4-Dichlorophenyl)-N-[2-(3,4-dichlorophe- nyl)ethyl]-4,7-dihydro-5-methyl-2-(trifluoro- methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide564390

410

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(tri- fluoromethyl)-N-[[4-[(trifluorometh- yl)thio]-phenyl]methyl]pyrazolo-[1,5-a]pyrimidine-6-car- boxamide581391

411

(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7dihy- dro-5-methyl-2-(trifluoro-methyl)pyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(1-pyrroli- dinylmethyl)-pyrrolidine666

EXAMPLE 392

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(1-naphthalenylsulfonyl)piperazine

[0226]

412

[0227] Compound 1: Compound 1 (the compound of Example 60) was prepared in a manner similar to that described in Example 18, Method 2.

[0228] Step A: HCl (4M in dioxane) was added to solid compound 1 (0.53 g, 1.1 mmol). A gummy precipitate forms immediately. Dichloromethane was added, the gummy precipitate remained. The solvent was decanted and the residue was triturated with ethyl acetate (3×), concentrated to give 0.63 g (130% contains residual dioxane) of the hydrochloride salt compound 2 as a light yellow powder. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=0.57 min, (92% pure). MS (M+H): 392. Compound 2 was used without purification.

[0229] Step B: Compound 2 (0.077 g, 0.18 mmol) and compound 3 (0.049 g, 0.22 mmol) were suspended in dichloromethane (1 mL). Triethylamine (0.05 mL, 0.36 mmol) was added. A clear solution results. TLC after 30 min indicated consumption of starting material. The mixture was loaded directly onto a Worldwide Monitoring CLEAN-UP CARTRIDGE (silica, CUSIL12M6) which had been equilibrated with 100% hexanes. Elution with 100% hexanes (40 mL), followed by 50% Ethyl acetate/hexanes (40 mL) and 100% ethyl acetate (40 mL). The purest fractions (TLC analysis) were combined to give 0.068 g (65% yield) of the title compound as a white solid. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/rnin. Rt=3.46 min, (90% pure). MS (M+H: 582). HMR (CDCl3,400 MHz): 8.60(1H, d, J=8), 8.05(2H, m), 7.95(1H, m), 7.62(4H, m), 7.35(1H, d, J=2 Hz), 7.17(1H, d, J=8 Hz), 7.06(1H, d, J=2 Hz), 6.81(1H, d, J=6 Hz), 6.17(1H, m), 5.54(1H, d, J=2 Hz), 3.23(8H,m), 1.86(3H, s).

EXAMPLES 393-396

[0230] The compounds of Examples 393-396, shown in the table provided below, were prepared in a manner similar to that described in Example 392.

9ExampleStructureName(M + H)393

413

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-[(4-ethyl- phenyl)sulfonyl]-piperazine560394

414

1-[(4-Bromo-5-chloro-2-thienyl)sulfonyl]-4-[[7-(3,4-di- chlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine651395

415

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-[[2-(trifluoromethoxy)phenyl]sulfonyl]piperazine616396

416

1-[(5-Chloro-3-methylbenzo[b]thiophen-2-yl)sul- fonyl]-4-[[7-(3,4-dichlorophenyl)-4,7-di- hydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]piperazine637

EXAMPLE 397

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-[(3-methoxyphenyl)carbonyl]piperazine

[0231]

417

[0232] Compound 1: Compound 1 was prepared as described in Step A of Example 392.

[0233] Title Compound: Compound 1 (0.062 g, 0.15 mmol) and compound 2 (0.025 mL, 0.17 mmol) were suspended in dichloromethane (1 mL). Triethylamine (0.040, 0.29 mmol) was added. A clear solution results. TLC after 30 min indicated consumption of starting material. The mixture was loaded directly onto a Worldwide Monitoring CLEAN-UP CARTRIDGE (CUSIL12M6) which had been equilibrated with 100% hexanes. Elution with 100% hexanes (40 mL), followed by 50% Ethyl acetate/hexanes (100 mL) and 100% ethyl acetate (100 mL). The purest fractions (TLC analysis) were combined to give 0.022 g (29% yield) of the title compound as a white solid. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/mm. Rt=2.69 min, (90% pure). MS (M+H: 526).

EXAMPLES 398 AND 399

[0234] The compounds of Examples 398 and 399, shown in the table provided below, were prepared in a manner similar to that described in Example 397.

10ExampleStructureName(M + H)398

418

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]car- bonyl]-4-(1-oxo-3-phenyl-2-propenyl)-piperazine522399

419

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-pyridinyl- carbonyl)piperazine497

EXAMPLE 400

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine

[0235]

420

[0236] Compound 1: Compound 1 was prepared as described in Example 18.

[0237] Title Compound: Compound 1 (0.08 g, 0.17 mmol) was dissolved in dimethylformarnide (1.0 mL). NaH (0.005 g, 0.22 mmol, 60% in oil) was added and the mixture was stirred for 5 min. Iodomethane (0.012 mL, 0.18 mmol) was added. When TLC (5% methanol/dichloromethane) analysis indicated consumption of starting material the reaction was quenched with water, diluted with ethyl acetate, transferred to a separatory funnel, washed with saturated water and brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 100% dichloromethane followed by 3% methanol/dichloromethane to provide 0.06 g (75%) of the title compound as a amber oil. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=2.99 min, (96% pure). MS (M+H: 482).

EXAMPLES 401-406

[0238] The compounds of Examples 401-406, shown in the table provided below, were prepared in a manner similar to that described in Example 400.

[0239] HPLC resolution of Example 403, Chiralpak AD column (50×500 mm), eluting with 35% isopropanol/hexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ provided enantiomers A (Example 405) and B (Example 404). Chiralpak AD column (4.6×250 mm) eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254 λ, enantiomer A Rt=14.4 min, >99% ee. Enantiomer B Rt=28.7 min, >99% ee.

11ExampleStructureName(M + H)401

421

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine405402

422

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine500403

423

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine500404

424

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer B500405

425

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer A500406

426

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,4,5-trimethyl- pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine514

EXAMPLE 407

1-[[7-(2,3-Dichlorophenyl)-4-[(4-fluorophenyl)methyl]-4,7dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine

[0240]

427

[0241] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0242] Title Compound: Compound 1 (0.10 g, 0.21 mmol) was dissolved in dimethylformamide (1.0 mL). NaH (0.007 g, 0.27 mmol, 60% in oil) was added and the mixture was stirred for 5 min. 4-Fluorobenzyl chloride (0.028 mL, 0.23 mmol) was added. When TLC (5% methanol/ dichloromethane) analysis indicated consumption of starting material the reaction was quenched with water, diluted with ethyl acetate, transferred to a separatory funnel, washed with saturated water and brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 100% dichloromethane followed by 3% methanol/dichloromethane to provide 0.09 g (69%) of the title compound as a amber oil. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H20 with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.20 min, (93% pure). MS (M+H: 608).

EXAMPLE 408

7-(2,3-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-acetic acid ethyl Ester

[0243]

428

[0244] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0245] Title Compound: Compound 1 (0.10 g, 0.21 mmol) was dissolved in dimethylformamide (1.0 mL). NaH (0.006 g, 0.24 mmol, 60% in oil) was added and the mixture was stirred for 5 min. Ethyl bromoacetate (0.029 mL, 0.26 mmol) was added. When TLC (5% methanol/dichloromethane) analysis indicated consumption of starting material the reaction was quenched with water, diluted with ethyl acetate, transferred to a separatory funnel, washed with saturated water and brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 100% dichloromethane followed by 3% methanol/dichloromethane to provide 0.086 g (74%) of the title compound as a yellow glass. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.22 min, (97% pure). MS (M+H: 586).

EXAMPLE 409

7-(2,3-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-N,N ,2,5-tetramethylpyrazolo[1,5-a]pyrimidine-4(7H)-acetamide

[0246]

429

[0247] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0248] Title Compound: Compound 1 (0.08 g, 0.16 mmol) was dissolved in dimethylformamide (0.8 mL). NaH (0.005 g, 0.19 mmol, 60% in oil) was added and the mixture was stirred for 5 min. 2-chloro-N,N-dimethylacetamide (0.021 mL, 0.21 mmol) was added. When TLC (5% methanol/dichloromethane) analysis indicated consumption of starting material the reaction was quenched with water, diluted with ethyl acetate, transferred to a separatory funnel, washed with water and saturated brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 100% dichloromethane followed by 3% methanol/dichloromethane to provide 0.058 g (62%) of the title compound as a yellow oil. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic colunm, UV detection at 220 A, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=2.63 min, (93% pure). MS (M+H: 585).

EXAMPLE 410

1-[[7-(2,3-Dichlorophenyl)-4-[2-(dimethylamino)ethyl]-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine

[0249]

430

[0250] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2

[0251] Title Compound: Compound 1 (0.1 g, 0.21 mmol) was dissolved in dimethylformamide (1.0 mL). Sodium hydride (0.054 g, 0.47 mmol, 60% in oil) was added and the mixture was stirred for 5 min. 1-Chloro-2-dimethylaminoethane hydrochloride (0.040 g, 0.27 mmol) was added. After 25 min the reaction was quenched with water, diluted with ethyl acetate, transferred to a separatory funnel, washed with saturated water and brine, dried over anhydrous sodium sulfate and concentrated. LC/MS analysis of the residue indicated mostly unreacted starting material. The residue was redissolved in dimethylformamide (1.0 mL), Sodium hydride (0.10 g, 4.2 mmol) was added and the mixture was stirred for 5 min. 1-Chloro-2-dimethylarninoethane hydrochloride (0.15 g, 1.05 mmol) was added. When TLC (5% methanol/dichloromethane) analysis indicated consumption of starting material the reaction was quenched with water, diluted with ethyl acetate, transferred to a separatory funnel, washed with saturated water and brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 100% dichloromethane followed by 3% methanol/dichloromethane to provide 0.030 g (25%) of the title compound as a yellow glass. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H20 with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=1.72 min, (92% pure). MS (M+H: 571).

EXAMPLE 411

1-[[4-(Cyclopropylmethyl)-7-(2,3-dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine

[0252]

431

[0253] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0254] Title Compound: Compound 1 (0.11 g, 0.21 mmol) was dissolved in dimethylformamide (1.0 mL). Sodium hydride (0.006 g, 0.25 mmol, 60% in oil) was added and the mixture was stirred for 5 min. (Bromomethyl)cylcopropane(0.0251 mL, 0.27 mmol) was added. When TLC (5% methanol/dichloromethane) analysis indicated consumption of starting material the reaction was quenched with water, diluted with ethyl acetate, transferred to a separatory funnel, washed with saturated water and brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 100% dichloromethane followed by 3% methanol/dichloromethane to provide 0.104 g (89%) of the title compound as a yellow glass. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=2.99 min, (95% pure). MS (M+H: 554).

EXAMPLE 412

7-(2,3-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-N,N,2,5-tetramethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxamide

[0255]

432

[0256] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0257] Title Compound: Compound 1 (0.22 g, 0.44 mmol) was dissolved in tetrahydrofuran (3.0 mL). Sodium hydride (0.106 g, 4.44 mmol, 60% in oil) was added and the mixture was stirred for 5 min. N,N-Dimethylcarbamoyl chloride (0.12 mL, 1.33 mmol) was added. The mixture was stirred overnight. TLC (5% methanol/dichloromethane) analysis indicated consumption of starting material the reaction was quenched with water, diluted with ethyl acetate, transferred to a separatory funnel, washed with saturated water and brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 100% dichloromethane followed by 3% methanol/dichloromethane to provide 0.22 g (87% yield) of the title compound. LC/MS indicated that the compound was impure. The title compound was further purified by silica gel chromatoagraphy eluting with 10% ethyl acetate/hexanes, followed by 50% ethyl acetate/hexanes and 100% ethyl acetate to afford 0.118 g (47% yield) of the title compound as a white glass. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H20 with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=2.45 min, (95% pure). MS (M+H: 571).

EXAMPLE 413

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4-methyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine

[0258]

433

[0259] Step A: Acetic anhydride (0.77 mL, 8.14 mmol) was dropwise added to a solution of 4-(4-fluorophenyl)piperazine 1 (1.17 g, 6.49 nmmol) in dichloromethane (10 mL). TLC after 30 min. indicated reaction was complete. The mixture was transferred to a separatory funnel, washed with water and brine, dried over anhydrous sodium sulfate and concentrated to give 1.28 g (89% yield) of compound 2 as a clear solid. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H20 with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=1.58 min, (92% pure). MS (M+H: 223). HMR (CDCl3, 400 MHz): 6.96(2H, m), 6.89(2H, m), 3.77(2H, m), 3.62(2H, m), 3.07(4H, m), 2.14(3H, s). Compound 2 was used without further purification in the next step.

[0260] Step B: Lithium hexamethyldisilylazide (6.1 mL, 6.1 mmol, 1M in tetrahydrofuran) was dropwise added to a −78° C. solution of compound 2 (1.22 g, 5.5 mmol) in tetrahydrofuran (25 mL). After 40 min. 2,2,2-trifluoroethyl trifluoroacetate (0.9 mL, 6.6 mmol) was added to the yellow solution. The reaction turned from yellow to clear. After an additional 10 min. the cooling bath was removed and the mixture was allowed to warm to room temperature. After 30 min. more the reaction was quenched with saturated ammonium chloride, diluted with ethyl acetate, transferred to a separatory funnel, washed with saturated ammonium chloride, water and brine, dried over anhydrous sodium sulfate and concentrated onto enough silica gel such that a free flowing powder was obtained. The resulting powder was loaded onto a chromatography column prepacked with silica gel and 30% ethylacetate/hexanes. Elution with 30% ethyl acetate/hexanes gave 0.998 g (57% yield) of compound 3 as a yellow solid. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 40-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mmin. Rt=2.87 min, (90% pure). MS (M+H: 319). HMR (CDCl3, 400 MHz): (note compound exists in the enol form) 7.00(2H, m), 6.90(2H, m), 5.80(1H, s), 3.79(4H, m), 3.13(4H, m).

[0261] Step C: Compound 3 and compound 4 were condensed as described in Example 18, Method 2 Step B, to provide compound 5. Compound 5 was used in the next step without further purification.

[0262] Step D: Compound 5 and compound 6 were condensed as described in Example 18, Method 2 Step C 1, to afford compound 7. Reverse Phase LC/MS of crude 6: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/M20 with 0.1% TFA), 4 mL/min. Rt=4.12 min, (58% pure). MS (M+H: 540). Compound 7 was purified by silica gel chromatography eluting with 20-50% ethyl acetate/hexanes followed by recrystallization from ethyl acetate/hexanes to give 0.084 g (6% yield) of compound 7 as a white solid. Reverse Phase LC: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H20 with 0.2% H3PO4, Solvent B: 90% MeOH/H2O with 0.2% H3PO4), 4 mL/min. Rt=4.15 min, (92% pure).

[0263] Step E: Compound 7 (0.08 g, 0.14 mmol) was dissolved in dimethylformamide (1.0 mL). NaH (0.005 g, 0.19 mmol, 60% in oil) was added and the mixture was stirred for 305 min. lodomethane (0.010 mL, 0.16 mmol) was added. The mixture was stirred for 2 h and then quenched with saturated ammonium chloride, diluted with ethyl acetate, transferred to a separatory funnel, washed with saturated water and brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by preparative reverse phase HPLC:YMC S5 ODS 20×100 mm Ballistic column, UV detection at 220 λ, 10 min. gradient 30-100% Solvent B/A (Solvent A: 10% MeOH/H20 with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 20 mL/min. Rt=10.6 min,. to provide 0.037 g (45%) of the title compound. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.83 min. MS (M+H: 568). Reverse Phase LC: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.2% H3PO4, Solvent B: 90% MeOH/H2O with 0.2% H3PO4), 4 mL/min. Rt=4.37 min., 89% pure.

EXAMPLES 414-421

[0264] The compounds of Examples 414-421, shown in the table provided below, were prepared in a manner similar to that described in Example 413.

[0265] HPLC resolution of Example 416, Chiralpak AD column (50×500 mm), eluting with 50% isopropanol/hexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ, provided enantiomers A (Example 418) and B (Example 417). Chiralpak AD column (4.6×250 mm) eluting with 50% isopropanol/hexanes containing 0.1% triethylarnine at 1 mL/min), UV detection at 254 λ, enantiomer A Rt=14.4 min, 89% ee. Enantiomer B Rt=28.7 min, 87% ee.

12ExampleStructureName(M + H)414

434

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-(trifluorometh- yl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine554415

435

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2-methyl-5-(tri- fluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine554416

436

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,4-dimeth- yl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine568417

437

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,4-dimeth- yl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine, enantiomer B568418

438

1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,4-dimeth- yl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine, enantiomer A568419

439

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(tri- fluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-(4-fluorophenyl)piperazine540420

440

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-2-meth- yl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine554

EXAMPLE 421

1-[[1-Benzoyl-7-(2,3-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine

[0266]

441

[0267] Compound 1: Compound 1 was prepared in manner similar to that described in Example 18, Method 2.

[0268] Title Compound: Benzoyl chloride (0.007 mL, 0.06 mmol) and pyridine (0.008 mL, 0.10 mmol) were added to a 0° C. solution of compound 1 (0.08 g, 0.17 mmol) in dichloromethane (5 mL). After 1 h, TLC indicated the reaction was complete. The reaction was quenched with methanol and concentrated. The residue was purified by silica gel chromatography eluting with 80% ethyl acetate/hexanes to afford 0.024 g (81%) of the title compound as a white solid. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=4.05 min, (86% pure). (M+H: 588). HMR (CDCl3, 400 MHz): 8.08(1H, s), 8.06(1H, s), 7.51(1H, m), 7.37(2H, t, J=8 Hz), 7.28(1H, m), 7.18(2H, m), 7.08(1H, m), 6.9-6.7(3H, m), 6.45 (1H, bs), 5.60(1H, bs), 4.15-2.8 (6H, m), 2.20(1H, bs), 1.88(3H, s), 1.45(1H, bs).

EXAMPLES 422-431

[0269] The compounds of Examples 422-431, shown in the table provided below, were prepared in a manner similar to that described in Example 421.

13ExampleStructureName(M + H)422

442

1-[[1-Benzoyl-7-(3,4-dichlorophenyl)-1,2,4,7-tetra- hydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-phenylpiperazine588423

443

1-[[1-Acetyl-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahy- dro-5-methyl-2-oxopyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-phenylpiperazine526424

444

1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-tetrahy- dro-5-methyl-2-oxo-1-(1-oxobutyl)-pyrazo- lo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine554425

445

1-[[1-Cyclopropylcarbonyl)-7-(3,4-dichlorophe- nyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopy- razolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-phenylpiperazine552426

446

1-[[1-(Cyclopropylcarbonyl)-7-(2,3-dichlorophe- nyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine570427

447

1-[[7-(2,3-Dichloro-phenyl)-1,2,4,7-tetra-hy- dro-5-methyl-1-(3-methyl-1-oxobutyl)-2-oxo- pyrazolo[1,5-a]pyri-midin-6-yl]carbonyl]-4-(4-fluoro- phenyl)-piperazine586428

448

1-[[7-(2,3-Dichlorophenyl)-(2,2-dimeth- yl-1-oxopropyl)-1,2,47-tetrahydro-5-meth- yl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbo- nyl]-4-phenylpiperazine568429

449

1-[[1-(Cyclopropylcarbonyl)-7-(3,4-dichloro- phenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine570430

450

1-[[1-(Cyclobutylcarbonyl)-7-(3,4-dichloro- phenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine584431

451

1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-tetrahy- dro-5-methyl-1-(2-methyl-1-oxopropyl)-2-oxopyra- zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine572

EXAMPLE 432

1-[[7-(2,3-Dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-1-[(1-methylethyl)sulfonyl]-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine

[0270]

452

[0271] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0272] Title Compound: Isopropylsulfonyl chloride (0.11 mL, 0.97 mmol) and pyridine (0.12 mL, 1.46 mmol) were added to a 0° C. solution of compound 1 (0.234 g, 0.487 mmol) in dichloromethane (10 mL). The resulting mixture was allowed to warm to room temperature. After 5 h, TLC indicated the reaction was complete. The reaction was quenched with methanol and concentrated. The residue was purified by silica gel chromatography eluting with 5% methanol/ethyl acetate to afford 0.095 g (33%) of the title compound as a pale yellow solid. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H20 with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/mln. Rt=3.57 min, (92% pure). (M+H: 590).

EXAMPLE 433

1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-1-[(1-methylethyl)sulfonyl]-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine

[0273]

453

[0274] The title compound was prepared in a manner similar to that described in Example 432. (M+H) 608.

EXAMPLE 434

7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(1-methylethyl)-2-oxo-6-[(4-phenyl-1-piperazinyl)carbonyl]pyrazolo[1,5-a]pyrimidine-1(2H)-carboxamide

[0275]

454

[0276] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0277] Title Compound: Isopropyl isocyanate (0.034 mL, 0.35 mmol) and pyridine (0.057 mL, 0.706 mmol) were added to a 0° C. solution of compound 1 (0.170 g, 0.350 mmol) in dichloromethane (50 mL). The resulting mixture was allowed to warm to room temperature. After 5 h, TLC indicated the reaction was complete. The reaction was quenched with methanol and concentrated. The residue was purified by silica gel chromatography eluting with 75% ethyl acetate/hexanes to afford 0.027 g (13%) of the title compound as a white solid. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H20 with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.68 min, (95% pure). (M+H: 569).

EXAMPLES 435 AND 436

[0278] The compounds of Examples 435 and 436, shown in the table provided below, were prepared in a manner similar to that described in Example 434.

14ExampleStructureName(M + H)435

455

7-(2,3-Dichlorophenyl)-4,7-dihydro-N,5-di- methyl-2-oxo-6-[(4-phe- nyl-1-piperazinyl)-carbonyl]pyrazolo[1,5-a]pyri- midine-1(2H)-carboxamide541436

456

7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-2-oxo-6-[(4-phe- nyl-1-piperazinyl)carbonyl]-pyrazolo[1,5-a]pyri- midine-1(2H)-carboxamide527

EXAMPLE 437

7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-N, N ,5-trimethyl-2-oxopyrazolo[1,5-a]pyrimidine-1 (2H)-carboxamide

[0279]

457

[0280] Compound 1: Compound 1 was prepared in a manner similar to that dewscribed in Example 18, Method 2.

[0281] Title Compound: Dimethylcarbamoyl chloride (0.10 mL, 1.1 mmol) was added to a 0° C. solution of compound 1(0.52 g, 1.0 mmol) in pyridine (5 mL). The resulting mixture was stirred at 0° C. for 30 mi., the cooling bath was removed, and the mixture was concentrated. The residue was dissolved in ethyl acetate and washed with water and brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 5% methanol/ethyl acetate to afford 0.038 g (6%) of the title compound as a white solid. Reverse phase LC/MS: YMC S5 TurboPack Pro 4.6×33 column, UV detection at 220λ, 2 min gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% mFA), 4 mL/min. Rt=1.97 min, 92% pure). MS (M+H: 573).

EXAMPLE 438

1-[[1-(3-Butenyl)-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine

[0282]

458

[0283] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0284] Title Compound: (Bromomethyl)cyclopropane (0.246 mL, 1.82 mmol) was added to a mixture of compound 1 (0.831 g, 1.66 mmol) and potassium carbonate (g, mmol) in dimethylformamide (10 mL). The resulting mixture was allowed to stir at room temperature for 4 h. The reaction was diluted with ethyl acetate, transferred to a separatory funnel, washed with water and brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 5% methanol/ethyl acetate to afford 0.030 g (3%) of the title compound. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% IFA), 4 mLimin. Rt=2.99 min, (87% pure). (M+H: 556).

EXAMPLES 439 AND 440

[0285]

15

1-[[7-(3,4-Dichlorophenyl)-1,2,
1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-

4,7-tetrahydro-5-methyl-2-oxo-
tetrahydro-5-methyl-2-oxo-1,4-bis

1-(2,2,2-trifluoroethyl)pyrazolo-
(2,2,2-trifluoroethyl)pyrazolo[1,5-a]

[1,5-a]pyrimidin-6-yl]carbonyl]-
pyrimidin-6-yl]carbonyl]-4-

4-(4-fluorophenyl)piperazine
(4-fluorophenyl)piperazine

[0286]

459

[0287] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0288] Title Compounds: 2,2,2-trifluoroethyl trifluormethanesulfonate (0.49 g, 2.1 mmol) was added to a solution of compound 1 (0.967 g, 1.93 mmnol) in dimethylformamide (10 mL). Sodium hydride (0.12 g, 2.89 mmol) was added. TLC (10% methanol/ethyl acetate) indicated consumption of compound 1. The resulting mixture was was diluted with ethyl acetate, transferred to a separatory funnel, washed with water and brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 100% ethyl acetate followed by 10% methanol/ethyl acetate to give a mixture of the title compounds. The title compounds were separated by preparative reverse phase HPLC YMC S5 ODS 20×100 mm column, 25 mL/min, 15 minute gradient eluting with 50%-100% solvent B/A (Solvent A: 10% MeOH/H20 with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA). Compound of Example 439 Rt=11.05 min, Compound of Example 440 Rt=11.88 min. Compound of Example 439: Reverse phase LC/MS: YMC S554.6×50 Ballistic column, UV detection at 220 4, 4 min gradient 0-1 00% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1 % TFA), 4 mL/min. Rt=2.87 min, 95% pure). MS (M+H: 584). Compound of Example 440: Reverse phase LC/MS: YMC S5 4.6×50 Ballistic column, UV detection at 220λ, 4 min gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1 TFA), 4 mL/rmin. Rt=3.25 min, 85% pure). MS (M+H: 666).

EXAMPLE 441

7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidine-1 (2H)-carboxylic acid 1-methylethyl Ester

[0289]

460

[0290] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0291] Title Compound: Isopropyl chloroformate (1.0 mL, 1.0 mmol, 1M in toluene) was added to a 0° C. solution of compound 1 (0.46 g, 0.92 mmol) in pyridine (5 mL). The resulting mixture was stiffed at 0° C. for 30 min., the cooling bath was removed. After 2 h methanol was added to quench the reaction and the mixture was concentrated. The residue was purified by silica gel chromatography eluting with 5% methanol/ethyl acetate to afford 0.057 g (11%) of the title compound as a light pink solid. Reverse phase LC/MS: YMC S5 ODS 4.6×50 column, UV detection at 220 4, 4 min gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90 % MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.67 min, 95% pure). (M+H: 573).

EXAMPLE 442

1-[(4,7-Dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-phenylpiperazine

[0292]

461

[0293] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0294] Step A: Compound 2 (0.6 mL, 4.4 mmol) and acetic anhydride (0.83 mL, 8.8 mmol) were added to a solution of compound 1 (0.72 g, 2.9 mmol) in dimethylformamide (10 mL). The mixture was allowed to stir overnight, poured into water, extracted with dichloromethane. The extracts were combined, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with 50% ethyl acetate/hexanes to 100% ethyl acetate/hexanes to give 0.290 g (38% yield) of compound 3 as a colorless syrup. (M+H: 259).

[0295] Step B: Condensation of compound 3 and compound 4 as described in Example 18, Method 2 Step C provided the title compound. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=1.96 min, (87% pure). (M+H: 323).

EXAMPLE 443

7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxylic Acid

[0296]

462

[0297] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0298] Step A: Lithium hydroxide (0.43 g, 1.8 mmol) was dissolved in water (3 mL) and added slowly to a room temperature solution of compound 1 in tetrahydofuran (9 mL). The resulting mixture was stirred at room temperature for 3 h. TLC indicated that all of compound 1 had been consumed. The mixture was quenched by the addition of acidic Dowex resin. The resin was filtered off. The filtrate was diluted with ethyl acetate, washed with water and brine, dried over anhydrous sodium sulfate and concentrated to give 0.41 g (86% yield) of compound 2 as a light yellow solid. Reverse phase LC/MS: YMC S5 ODS 4.6×50 column, UV detection at 220 λ, 4 min gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.37 min, 96% pure). MS (M+H: 530).

[0299] Step B: EDCI (0.025 g, 0.13 mmol), DMAP (0.003 g, 0.02 mmol) were added to a solution of compound 2 (0.0508 g, 0.1 mmol) and diethylamine (0.014 mL, 0.13 mmol) in dichloromethane (3 mL). The mixture was stirred overnight. TLC indicated some starting material remained. The solvent was removed under reduced pressure. The resulting residue was purified by silica gel chromatography eluting with 5% methanol/ethyl acetate to give the title compound as a white solid. Reverse phase LC/MS: YMC S5 4.6×50 Ballistic column, UV detection at 220λ, 4 min gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.74 min, 91% pure). MS (M+H: 585).

EXAMPLES 444-449

[0300] The compounds of Examples 445-450, shown in the table provided below, were prepared in a manner similar to that described in Example 443.

16ExampleStructureName(M + H)444

463

7-(3,4-Dichlorophenyl)-N,N-die- thyl-6-[[4-(4-fluorophenyl)-1-pipe- razinyl]carbonyl]-4,7-di- hydro-5-methylpyrazolo[1,5-a]py- rimidine-2-carboxamide585445

464

7-(3,4-Dichloro- phenyl)-6-[[4-(4-fluoro- phenyl)-1-pipe- razinyl]carbonyl]-4,7-dihy- dro-N-(4-hydroxy- phenyl)-5-methyl- pyrazolo[1,5-a]pyrimidine-2-car- boxamide621446

465

1-[[7-(3,4-Dichloro- phenyl)-4,7dihydro-5-meth- yl-2-[[(2S)-2-(1-pyrrolidinyl- methyl)-1-pyrrolidinyl]carbo- nyl]-pyrazolo[1,5-a]pyrimi- din-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine666447

466

7-(3,4-Dichloro- phenyl)-6-[[4-(4-fluoro- phenyl)-1-piperazinyl]carbo- nyl]-4,7-dihydro-5-methylpyra- zolo[1,5-a]pyrimidine-2-car- boxamide529448

467

7-(3,4-Dichloro- phenyl)-6-[[4-(4-fluoro- phenyl)-1-piperazinyl]carbo- nyl]-4,7-dihydro-5-meth- yl-N-(phenylmethyl)pyra- zolo-[1,5-a]pyrimidine-2-car- boxamide619449

468

7-(3,4-Dichloro- phenyl)-6-[[4-(4-fluoro- phenyl)-1-piperazinyl]carbo- nyl]-4,7-dihydro-5-meth- yl-N-(2-phenylethyl)-pyra- zolo[1,5-a]pyrimidine-2-car- boxamide633

EXAMPLE 450

1-[[2-Cyano-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine

[0301]

469

[0302] Compound 1: Compound 1 (the compound of Example 447) was prepared in a manner similar to that described in Example 443.

[0303] Title Compound: Triflic anhydride (0.036 mL, 0.21 mmol) was added to a 0° C. solution of compound 1 (0.103 g, 0.19 mmol) and triethylamine (0.054 mL, 0.39 mmol) in dichloromethane (5 mL). After 10 min., TLC (5% methanol/ethyl acetate) indicated that compound 1 remained. Additional Triflic anhydride (0.036 mL, 0.21 mmol) and triethylamine (0.054 mL, 0.39 mmol) were added. After 10 min., TLC (5% methanol/ethyl acetate) indicated that compound 1 remained. The mixture was warmed to room temperature and stirred for an additional 30 min. The reaction was poured into saturated sodium bicarbonate, extracted with dichloromethane. The extracts were combined, dried over anhydrous sodium sulfate and concentrated. The resulting residue was purified by silica gel chromatography eluting with 2% methanol/ethyl acetate to 0.018 g (19% yield) of the title compound as a white solid. Reverse phase LC/MS: YMC S5 4.6×33 column, UV detection at 220λ, 2 min gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.60 min, 81% pure). MS (M+H: 511).

EXAMPLE 451

3-Bromo-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl Ester

[0304]

470

[0305] Compound 1: Compound 1 was prepared as described in Example 4.

[0306] Title Compound: Phenyltrimethylammonium tribromide (0.057 g, 0.14 mmol) was added to a 0° C. solution of compound 1(0.05 g, 0.13 mmol) in dichloromethane (2 nmL). The mixture was allowed to warm to room temperature over 4 h. The solvent was removed under reduced pressure. The resulting residue was purified by preparative TLC (Analtech, silica gel, 20×20 cm, 1000μ). Elution with 25% acetone/hexane provided 0.047 g (79% yield) of the title compound as a white solid. Reverse Phase HPLC: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.2% H3PO4, Solvent B: 90% MeOH/H2O with 0.2% H3PO4), 4 mL/min. Rt=4.67 min, (95% pure). Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=4.19 min. MS (EM, M+1: 458) HMR (CDCl3, 400 MHz): 7.37(1H,d,J=2.0 Hz), 7.36(1H,d,J=8.0 Hz), 7.33(1H,s), 7.12(1H,dd,J=2.2 and 8.4 Hz), 6.38(1H,s), 6.27(1H,s), 2.53(3H,s), 1.36(9H,s).

EXAMPLE 452

1-[[3-Bromo-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine

[0307]

471

[0308] The compound of Example 452 was prepared in a manner similar to that described in Example 451. (M+H) 547.

EXAMPLE 453

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine

[0309]

472

[0310] Compound 1: Compound 1 was prepared in a manner similar to that described in Example 18, Method 2.

[0311] Title Compound: N-chlorosuccinimide (0.0102 g, 0.076 mmol) was added to a 0° C. solution of compound 1 (0.0343 g, 0.073 mmol) in dichloromethane (4 mL). The mixture was allowed to warm to room temperature over 2 h. The solvent was removed under reduced pressure. The resulting residue was purified by preparative TLC (Analtech, silica gel, 20×20 cm, 1000μ). Elution with 50% acetone/hexane provided 0.0287 g (77% yield) of the title compound as a yellow oil which solidified upon standing. Reverse Phase HPLC: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.2% PPA, Solvent B: 90% MeOH/H2O with 0.2% PPA), 4 mL/min. Rt=4.21 min, (91% pure). Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=3.72min. MS (EM, M+1: 501)

EXAMPLES 454-463

[0312] The compounds of Examples 454-463, shown in the table provided below, were prepared in a manner similar to that described in Example 453.

[0313] Example 456 was obtained from the single enantiomer B of Example 30, and Example 457 was obtained from the single enantiomer A of Example 29. Chiralpak AD column (4.6×250 mm) eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254λ, Example 456 Rt=5.9 min, >99% ee. Example 457 Rt=6.3 min, >99% ee.

[0314] Example 458 was obtained from the single enantiomer A of Example 51, and Example 459 was obtained from the single enantiomer B of Example 52. Chiralcel OD column (4.6×250 mm) eluting with 30% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254λ, Example 458 Rt=7.8 min, >99% ee. Example 459 Rt=8.4 min, >99% ee.

[0315] Example 460 was obtained from the single enantiomer A of Example 169, and Example 461 was obtained from the single enantiomer B of Example 168. Chiralpak AD column (4.6×250 mm) eluting with 20% isopropanollhexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254λ, Example 461 Rt=9.2 min, >99% ee. Example 460 Rt=9.4 min, >99% ee.

[0316] Example 462 was obtained from the single enantiomer A of Example 81, and Example 463 was obtained from the single enantiomer B of Example 82. Chiralpak AD column (4.6×250 mm) eluting with 20% isopropanol/hexanes containing 0.1% triethylamine at 1 mnLmin), UV detection at 254λ, Example 462 Rt=8.25 min, >99% ee. Example 463 Rt=8.28 min, >99% ee.

17ExampleStructureName(M + H)454

473

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine520455

474

1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine520456

475

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl- piperazine, enantiomer B502457

476

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl- piperazine, enantiomer A502458

477

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer A520459

478

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-meth- ylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer B520460

479

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-2,5-di- methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer A534461

480

1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-2,5-di- methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer B534462

481

1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-2,5-di- methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer A534463

482

1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-2,5-di- methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro- phenyl)piperazine, enantiomer B534

EXAMPLE 464

3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl Ester

[0317]

483

[0318] Compound 1: Compound 1 was prepared as described in Example 4.

[0319] Title Compound: Pyridine hydrochloride (0.020 g, 0.173 mmol) was added to a 0° C. solution of compound 1 (0.060 g, 0.158 mmol) in dichloromethane (4 ML). After 2 min, N-chlorosuccinimide (0.0231 g, 0.174 mmol) was added. The mixture was allowed to warm to room temperature and was stirred for 13 h. The solvent was removed under reduced pressure. The resulting residue was purified by preparative TLC (Analtech, silica gel, 20×20 cm, 1000μ). Elution with 20% acetone/hexane provided 0.0092 g (14% yield) of the title compound as a yellow oil. Reverse Phase HPLC: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.2% PPA, Solvent B: 90% MeOH/H2O with 0.2% PPA), 4 mLlrnin. Rt=4.61 min, (94% pure). Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220 λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=4.71 min. MS (EM, M+1: 414). HMR (CDCl3, 400 MHz): 7.37(1H,s), 7.36(1H,d,J=1.7 Hz), 7.36(1H,d,J=8.4 Hz), 7.12(1H,dd,J=2.0 and 8.4 Hz), 6.45(1H,brs), 6.24(1H,s), 2.52(3H,s), 1.36(9H,s).

EXAMPLE 465

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(5-phenyl-2-oxazolyl)pyrazolo[1,5-a]pyrimidine

[0320]

484

[0321] Compound 1: Compound 1 was synthesized as described in Example 16.

[0322] Compound 3: Compound 1 (200 mg, 0.62 mmol) was suspended in 2 mL of dichioromethane. Triethylamine (300 μL, 2.2 mmol) and 2-aminoacetophenone 2 (116 mg, 0.68 mmol) were added followed by bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBrOP) (312 mg, 0.68 mmol). All the solid dissolved upon addition of PyBrOP and the reaction was stirred for 4 hrs. The mixture was loaded onto silica gel and purified by flash chromatography on silica gel eluted with 40% acetone, hexane to yield 106 mg (39%) of a pink solid. 1H NMR (400 MHz, CDCl3) 44180-148-16; 1H COSY (400 MHz, CD3OD); 13C NMR (100 MHz, CDCl3); HPLC >99% at 4.0 min (YMC S5 ODS 4.6×50 mm column; 10-90% methanol, water with 0.2% phosphoric acid gradient over 4 min.; 4 mL/min.; uv detection at 220 nm).

[0323] Title Compound: The amide 3 (100 mg, 0.22 mmol) was dissolved in 2 mL phosphorus oxychloride and heated to 112° for 2 h. The mixture was then quenched onto ice and extracted with ethylacetate. The extracts were dried over magnesium sulfate, filtered and the solvent removed to provide 339 mg of a brown oil. The oil was purified by flash chromatography on silica gel eluted with 20-40% acetone, hexane to yield 50 mg (51%) of the title compound as a white powder. mp 229-231°; 1H NMR (400 MHz, CD30D); MS (ESI) m/z 423 (MH+); HPLC >99% at 4.7 min (YMC 5S ODS 4.6×50 mm column; 10-90% methanol, water with 0.2% phosphoric acid gradient over 4 min. then hold at 90% methanol, water; 4 mL/ min.; uv detection at 220 nm).

EXAMPLES 466-469

[0324] The compounds of Examples 466-473, shown in the table provided below, were prepared in a manner similar to that described in Example 465.

18ExampleStructureName(M + H)466

485

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(5-phenyl-1,3,4-oxa- diazol-2-yl)pyrazolo[1,5-a]pyrimidine424467

486

6-(1H-Benzimidazol-2-yl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine396468

487

6-(2-Benzothiazolyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]py- rimidine413469

488

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(1-methyl-1H-benzimida- zol-2-yl)pyrazolo[1,5-a]pyrimidine410

Example 470

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[5-(trifluoromethyl)-1-propyl-1H-benzimidazol-2-yl]pyrazolo[1,5-a]pyrimidine

[0325]

489

[0326] Compound 2: To a solution of acid 1, prepared as described in Example 16, (0.15 g, 0.463 mmol), 2-(n-propylamino)-5-trifluromethylaniline (0.141 g, 0.648 mmol) and DMAP (5 mg, cat.) EDCI (0.124 g, 0.0648 mmol) was added and the solution was stirred at room temperature for 2 hours. The reaction was treated with saturated sodium bicarbonate, the organic solution was dried with magnesium sulfate and the solvent was evaporated. The crude product 2 was used without further purification.

[0327] Title Compound: Compound 2 was dissolved in phosphorus oxychloride (4 mL) and heated to 80° C. for 4 h. TLC indicated the reaction was not complete. Additional phosphorus oxychloride (2 mL) was added and the mixture was heated for 2 h and then left to stand at room temperature overnight. The mixture was then quenched onto ice, made basic with ammonium hydroxide, and extracted with ethyl acetate. The extracts were dried over magnesium sulfate and concentrated. The crude product was purified by preparative reversed phase chromatography (YMC PACK ODSA S3 20×100 mm column 50-100 methanol, water with 0.1% TFA gradient over 10 min.; 20 mL/min.; uv detection at 220 nm.) The appropriate fractions were evaporated, the residue was partitioned between saturated sodium bicarbonate and ethyl acetate, the organic solution was dried and the solvent was removed under vacuum giving the product (27 mg, 11.5%) as a tan glass. [M+H]+m/z 506; HPLC 91.1% at 4.6 min (YMC S5 ODS 4.6×50 mm column; 10-90% methanol, water with 0.2% phosphoric acid gradient over 4 min.; 4 mL/ min.; uv detection at 220 nm).

EXAMPLES 471-482

[0328] The compounds of Examples 471-482, shown in the table provided below, were prepared in a manner similar to that described in Example 470.

[0329] HPLC resolution of Example 480, Chiralcel OD column (50×500 mm), eluting with 25% isopropanol/hexanes containing 0.1% triethylamine at 50 mL/min), UV detection at 254 λ provided enantiomers A (Example 481) and B (Example 482). Analytical Chiralcel OD column (4.6×250 mm) eluting with 25% isopropanol/hexanes containing 0.1% triethylamine at 1 mL/min), UV detection at 254 λ, enantiomer A Rt=7.2 min, >99% ee. Enantiomer B Rt=10.0 min, >99% ee.

19ExampleStructureName(M + H)471

490

6-(5-Butyl-1,3,4- oxadiazol-2-yl)-7-(3,4- dichlorophenyl)- 4,7dihydro-5- methylpyrazolo[1,5-a]pyrimidine404472

491

1-[[7-(3,4-Dichloro- phenyl)-4,7-dihydro-5- methyl-6-(4-methyl-1H- benzimidazol-2-yl)pyrazolo[1,5-a]pyrimidine410473

492

1-[[7-(2,3-Dichloro- phenyl)-4,7-dihydro-5- methyl-6-(1-methyl-1H- benzimidazol-2-yl)pyrazolo[1,5-a]pyrimidine410474

493

7-(3,4-Dichlorophenyl)- 4,7-dihydro-6-(imidazo[1,5-a]- pyridin-3-yl)-5- methylpyrazolo[1,5-a]pyrimidine510475

494

7-(3,4-Dichlorophenyl)- 6-(1-ethyl-5-nitro-1H- benzimidazol-2-yl)-4,7- dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine469476

495

6-[5-Chloro-1-(1- methylethyl)-1H- benzimidazol-2-yl]-7- (3,4-dichlorophenyl)-4,7- dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine472477

496

6-(5-Chloro-1-ethyl-1H- benzimidazol-2-yl)-7- (3,4-dichlorophenyl)-4,7- dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine458478

497

7-(3,4-Dichlorophenyl)- 6-(5-fluoro-1-propyl-1H- benzimidazol-2-yl)-4,7- dihydro-5-methylpyrazolo[1,5-a]pyrimidine456.35479

498

7-(3,4-Dichlorophenyl)- 4,7-dihydro-5-methyl-6- [1-(1-methylethyl)-5- (trifluoromethyl)-1H- benzimidazol-2- yl]pyrazolo[1,5-a]pyrimidine506480

499

7-(3,4-Dichlorophenyl)- 6-(5-fluoro-1-methyl-1H- benzimidazol-2-yl)-4,7- dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine428481

500

7-(3,4-Dichlorophenyl)- 6-(5-fluoro-1-methyl-1H- benzimidazol-2-yl)-4,7- dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine, enantiomer A428482

501

7-(3,4-Dichlorophenyl)- 6-(5-fluoro-1-methyl-1H- benzimidazol-2-yl)-4,7- dihydro-5-methyl- pyrazolo[1,5-a]pyrimidine, enantiomer B428

EXAMPLE 483

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[1-(phenylmethyl)-1H-benzimidazol-2-yl]pyrazolo[1,5-a]pyrimidine

[0330]

502

[0331] Compound 1: Prepared as described in Example 16.

[0332] Compound 2: Prepared from compound 1 and phenylenediamine in a manner similar to that described in Example 470.

[0333] Compound 3: A suspension of 2 (50 mg 0.121 mmol), NaHCO3 (50 mg, 0.6 mmol) and benzyl bromide (20 mg, 0.121 mmol) in DMPU (0.5 mL) was stirred at room temp. overnight. Another equivalent of benzyl bromide was added completing the reaction. The suspension was partitioned between water and ethyl acetate, the organic phase was dried (MgSO4), and the solvent was evaporated. The residue was flash chromatographed through silica eluting with hexane-acetone 2:1 to provide either or both of compounds 3 and 3* (exact structure was not determined) (24.8 mg, 41%) as a white solid. Mp 135-140; [M+H]+m/z 504; HPLC 100% at 4.4 min (YMC S5 ODS 4.6×50 mm column; 10-90% methanol, water with 0.2% phosphoric acid gradient over 4 min.; 4 mL/ min.; uv detection at 220 nm).

[0334] Title Compound: Compound(s) 3/3* was dissolved in phosphorus oxychloride (1.5 mL) and heated to 80° C. for 5 h. Heating was discontinued and the mixture was left to stand at room temperature overnight. The mixture was quenched onto ice, made basic with ammonium hydroxide, and extracted with ethyl acetate. The extracts were dried over magnesium sulfate and concentrated. The residue was purified by flash chromatography (silica gel, 50% acetone/hexanes) to give 6.6 mg of the title compound as a tan solid. Mp 225-230; [M+H]+ m/z 486; HPLC 100% at 3.8 min (YMC S5 ODS 4.6×50 mm column;10-90% methanol, water with 0.2% phosphoric acid gradient over 4 min.; 4 mL/ min.; uv detection at 220 nm).

EXAMPLE 484

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)-N-(2-pyridinylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide

[0335]

503

[0336] Synthesis of 3: A solution of recrystalized (acetone, hexane) 2,2-Dimethyl-1,3-dioxane-4,6-dione (1, 25.0 g, 173.5 mmol) in dichloromethane (350 mL) was treated with pyridine (27.4 g, 346.9 mmol). The reaction mixture was cooled to −5.1° C. To this stirred solution was added a solution of methoxyacetyl chloride (2, 20.7 g, 190.8 mmol) in dichloromethane (150 mL) over 50 mins., maintaining the reaction temperature below 1.5° C. The reaction mixture turned orange and a precipitate formed. The reaction mixture was allowed to warm to 17.5° C. over 40 mins. The reaction mixture turned maroon and the solids dissolved. After TLC (100% ethyl acetate) showed the reaction was complete, the reaction was quenched with 3.7% aqueous hydrochloric acid (500 mL) and the aqueous layer was extracted with dichloromethane). The organic extracts were combined and washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and filtered. The solvent was removed. The resulting oil was dried on high vacuum to constant weight to give 3 (33.11 g) in 88.3% yield.

[0337] Synthesis of 4: To a solution of 3 (33.1 g, 153 mmol) in 100 mL of toluene was added 2-methyl-2-propanol (100 mL, 1.05 mol) and the reaction was heated to reflux. After 1.5 h the reaction was concentrated to give 4 (30.2 g) in 100% yield.

[0338] Synthesis of 5: To the solution of P-ketoester 4 (30.2 g, 160.6 mmol) in dimethylformamide (120 mL) was added 3,4 dichlorobenzaldehyde (28.13 g, 160.6 mmol), followed by 3-aminopyrazole (14.7 g, 176.7 mmol), then sodium hydrogen carbonate (54 g, 642.6 mmol). The reaction mixture was heated at 70° C. for 48 hrs. The reaction mixture was then cooled to 35° C. and transferred into rapidly stirring water (1.5 L) at RT. The resulting off-white solid was filtered. The filtered solid was slurried in water (1 L) and filtered again. The wet cake (165 g) was dissolved into ethyl acetate (1 L), giving a two-phase mixture. The mixture was washed with saturated aqueous sodium chloride (500 mL). The organic layer was dried over anhydrous magnesium sulfate and filtered. The solvent was removed. The resulting crude material was purified by column chromatography using 40% ethyl acetate in hexane as eluent to give 5 (22.6 g, 34.3%) as a white powder.

[0339] Synthesis of 6: To a solution of dihydropyrimidine tert-butyl ester 5 (10.13 g, 24.7 mmol) in dichloromethane (150 mL) was added a solution of trimethylsilyltrifluoromethanesulfonate (11 g, 49.5 mmol) in dichloromethane (11 mL). After 1 hr, hexane (300 mL) was added slowly and the reaction was concentrated to 250 mL. The product formed a gum and supernatant was decanted. Hexane (250 mL) was added and the mixture was allowed to stir for 1 hr. The gum had solidified and fromed a powder. The supernatant was decanted again and another 250 mL of hexane was added. The mixture was stirred for 10 min and filtered. The resulting wet cake was washed with hexane (250 mL)) and a fine off-white powder 6 resulted which was allowed to suction dry.

[0340] Synthesis of 7: To a suspension of dihydropyrimidine acid 6 (100 mg, 0.28 mmol) in dichloromethane (10 mL) was added EDCI (76 mg, 0.39 mmol), followed by a solution of 2-pyridylmethylamine (32.4 mg, 0.39 mmol) in dichloromethane (1 mL). After 2.5 hrs, the reaction was concentrated to dryness and the crude mixture was purified by silica gel chromatography using 10% methanol in dichloromethane as eluent to give the title compound (90 mg, 72.4%) as an off-white powder. Mass Spec m/z (M+Na)+466.

EXAMPLES 485-496

[0341] The following compounds were prepared by the methods described in example 484.

20Ex. #StructureNameMass Spec (m/z)485

504

7-(2,3-Dichlorophenyl)-4,7- dihydro-5-(methoxymethyl)-N-(2- pyridinylmethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide444(M + H)+486

505

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5- (methoxymethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-2-(4- fluorophenyl)pyrrolidine501(M + H)+487

506

7-(3,4-Dichlorophenyl)-4,7- dihydro-5-(methoxymethyl)-N-(3- phenylpropyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide471(M + H)+488

507

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5- (methoxymethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-4-(4- fluorophenyl)piperazine516(M + H)+489

508

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5- (methoxymethyl)pyrazolo[1,5-a]- pyrimidin-6- yl]carbonyl]piperidine421(M + H)+490

509

(2S)-1-[[7-(3,4-Dichlorophenyl)- 4,7-dihydro-5- (methoxymethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-2- (methoxymethyl)pyrrolidine451(M + H)+491

510

7-(3,4-Dichlorophenyl)-4,7- dihydro-5-(methoxymethyl)-N,N- dipropylpyrazolo[1,5-a]pyrimidine- 6-carboxamide437(M + H)+492

511

5-Cyclohexyl-7-(3,4- dichlorophenyl)-4,7-dihydro-N-(3- phenylpropyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide509(M + H)493

512

1-[[5-Cyclohexyl-7-(3,4- dichlorophenyl)-4,7- dihydropyrazolo[1,5-a]pyrimidin-6- yl]carbonyl]-4-(4- fluorophenyl)piperazine554(M + H)494

513

1-[[5-Cyclohexyl-7-(3,4- dichlorophenyl)-4,7- dihydropyrazolo[1,5-a]pyrimidin-6- yl]carbonyl]piperidine459(M + H)495

514

(2S)-1-[[5-Cyclohexyl-7-(3,4- dichlorophenyl)-4,7- dihydropyrazolo[1,5-a]pyrimidin-6- yl]carbonyl]-2- (methoxymethyl)pyrrolidine489(M + H)496

515

5-Cyclohexyl-7-(3,4- dichlorophenyl)-4,7-dihydro-N,N- dipropylpyrazolo[1,5-a]pyrimidine- 6-carboxamide475(M + H)

Example 497

7-(3,4-Dichlorophenyl)-4,7-dihydro-6-(imidazo[1,5-a]pyridin-3-yl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine

[0342]

516

[0343] Synthesis of 1: The synthesis 1 was described in Example 484.

[0344] Synthesis of 2: The title compound was synthesized in a manner described in Example 465. The product was purified by preparative TLC in 10% methanol in dichloromethane. Mass Spec m/z (M+H)+426.

EXAMPLE 498

7-(2,3-Dichlorophenyl)-4,7-dihydro-6-(imidazo[1,5-a]pyridin-3-yl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine

[0345]

517

[0346] The title compound was synthesized in a manner similar to that described in Example 497. Mass Spec m/z (M+H)+426

EXAMPLE 499

7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine

[0347]

518

[0348] Starting with compound 6 from Example 484, the title compound was synthesized in a manner similar to that described in Example 470. Mass Spec m/z (M+H)+458. The title compound can be separated into pure chiral form via preparative chiral HPLC (Chiralpak AD 5 cm×50 cm column eluted with 25% isopropanol in hexane with 0.1% TEA at 50 mL/min with UV detection at 254 nM). The faster eluting isomer (example 503) is enantiomer A (HPLC retention time 6.8 min, 4.6×250 mm Chiralpak AD column eluted with 25% isopropanol, hexane with 0.1% triethylamine at 1 mL/min with UV detection at 220 nm) and the slower eluting isomer (example 504) is enantiomer B (HPLC retention time 12.0 min, 4.6×250 mm Chiralpak AD column eluted with 25% isopropanol, hexane with 0.1% triethylamine at 1 mL/min with UV detection at 254 nm).

EXAMPLES 500-504

[0349] The following examples were synthesized by methods described in Example 499:

21Ex.StructureNameMass Spec500

519

7-(2,3-Dichlorophenyl)-6-(4-fluoro- 1-methyl-1H-benzimidazol-2-yl)- 4,7-dihydro-5- (methoxymethyl)pyrazolo[1,5-a]pyrimidine458(M + H)+501

520

7-(3,4-Dichlorophenyl)-6-(4-fluoro- 1-methyl-1H-benzimidazol-2-yl)- 4,7-dihydro-5- (methoxymethyl)pyrazolo[1,5-a]pyrimidine458(M + H)+502

521

7-(2,3-Dichlorophenyl)-6-(5-fluoro- 1-methyl-1H-benzimidazol-2-yl)- 4,7-dihydro-5- (methoxymethyl)pyrazolo[1,5-a]pyrimidine458(M + H)+503

522

7-(3,4-Dichlorophenyl)-6-(5-fluoro- 1-methyl-1H-benzimidazol-2-yl)- 4,7-dihydro-5- (methoxymethyl)pyrazolo[1,5-a]pyrimidine enantiomer A458(M + H)504

523

7-(3,4-Dichlorophenyl)-6-(5-fluoro- 1-methyl-1H-benzimidazol-2-yl)- 4,7-dihydro-5- (methoxymethyl)pyrazolo[1,5-a]pyrimidine enantiomer B458(M + H)

EXAMPLE 505

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-phenyl-N-(3-phenylpropyl) pyrazolo[1,5-a]pyrimidine-6-carboxamide

[0350]

524

[0351] Synthesis of 1: A solution of benzoic acid (3.05 g, 25 mmol) in tetrahydrofuran (25 mL) was treated with CDI (4.05 g, 25 mmol) at ambient temperature. In a separate flask lithiumdiisopropylamide was generated at −78° C. by treatment of a tetrahydrofuran solution (40 mL) of diisopropyl amine (10.6 mL, 76.0 mmol) with 2.5 M n-butyl lithium in hexanes (30 mL, 75.0 mmol). Tert-butyl acetate was added dropwise and the reaction was stirred at −78° C. for 1 hr. The enolate was transferred at −78° C. to a stirred solution of the imidazoylbenzoate prepared previously. The resulting solution was cooled to −78° C. After the addition of the enolate was complete, a thick slurry resulted, which was broken up by shaking the reaction. The reaction mixture was allowed to stir for 1 h at −78° C. A 1N aqueous solution of hydrochloric acid was added until the pH was 4. The reaction mixture was allowed to warm to ambient temperature with stirring. The reaction mixture was extracted with diethyl ether. The combined organic layer was washed with aqueous 1N hydrochloric acid, aqueous 10% sodium hydrogen carbonate, saturated aqueous sodium chloride, dried over magnesium sulfate, and filtered. The solvent was removed to give 1 (5.0 g, 91%) as an oil.

[0352] Synthesis of 2: Compound 2 was synthesized in a manner similar to that of compound 5 in example 484.

[0353] Synthesis of 3: Compound 3 was synthesized in a manner similar to that of compound 6 in example 484.

[0354] Synthesis of 4: The title compund was synthesized in a manner similar to that of compound 7 in example 484. Mass Spec m/z (M+H)+503.

EXAMPLES 506-509

[0355] The following Examples 506-509 were synthesized in a manner similar to that described in Example 505:

22Ex.StructureNameMass Spec506

525

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5-phenylpyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-4-(4- fluorophenyl)piperazine448(M + H)+507

526

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5-phenylpyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]piperidine459(M + H)+508

527

(2S)-1-[[7-(3,4- Dichlorophenyl)-4,7-dihydro-5- phenylpyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-2- (methoxymethyl)pyrrolidine483(M + H)+509

528

7-(3,4-Dichlorophenyl)-4,7- dihydro-5-phenyl-N,N- dipropylpyrazolo[1,5-a]- pyrimidine-6-carboxamide475(M + H)+

EXAMPLE 510

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-phenylpyrazolidine

[0356]

529

[0357] Preparation of 3: To a solution of dihydropyrimidine acid 1 (0.336 g, 1 mmol) in dichloromethane (10 mL) was added l-phenylpyrazolidine 2 (0.215 g, 1.5 mmol, prepared using the procedure described in Tetrahedron, 1973, 29, 4045) followed by 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.278 g, 1.5 mmol) and the mixture stirred at room temperature for 2 hours. The solvent was evaporated and the residue purified by silica gel chromatography, eluting with ethyl acetate, to give the title compound 3 (0.184 g, 39%) as a white powder. (M+H)+=455.

EXAMPLE 511

6
-(1-Chloro-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-3-yl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine

[0358]

530

[0359] Preparation of B: At 20° C., EDCI (100 mg, 0.52 mmol) was added to a stirred slurry of carboxylic acid A (120 mg, 0.37 mmol) in CH2Cl2. After 5mins, proline amide was added (60 mg, 0.52 mmol) and the reaction mixture was stirred at ambient temperature for 3 h. The resulting yellow slurry was concentrated under reduced pressure, dissolved in 2 mL acetone and applied directly to a preparative silica gel TLC plate, (20×20 cm, 1 mm thickness, 254 nm UV indicator) eluting with 10%MeOH in CH2Cl2. The product B was isolated as a 1:1 ratio of diastereomers (79 mg, 50% yield as a pale yellow glass.) HPLC: RT2.61 and 2.80min (YMC S5 ODS 4.6×50 mm Ballistic column) 10-90% MeOH/water with 0.2% PPA linear gradient over 4min, 4 mL/min, TV Detection at 220 nm. LCMS: RT2.63 and 2.81 min (YMC S5 ODS 4.6×50 mm Ballistic column) 10-90% MeOH/water with 0.1% TFA linear gradient over 4min, 4 mL/min, UV Detection at 220 nm, Mass Spec m/z (M+H)+420.

[0360] Preparation of C: Phosphorus oxychloride (4 mL ) was added to diastereomers B (190 mg, 0.46 mmol). The slurry was heated to 100° C. for 12 h whereupon the precipitate dissolved furnishing an orange colored solution. The cooled reaction mixture was poured cautiously into saturated K2CO3 (ca. 20 mL) and extracted with EtOAc (3×30 mL). The combined organic portions were dried over Na2SO4, decanted and concentrated yielding an orange oil which was purified directly by preparative HPLC: RT28.40min (YMC S5 ODS 30×250 mm Reversed phase C18 column) 30-90% MeOH/water with 0.1% TFA linear gradient over 30min, 25 mL/min, UV Detection at 220 nm. Product C (96 mg, 51% yield) was obtained as a free base after removal of MeOH from the HPLC fractions, addition of 1.0M NaOH and extraction into CH2Cl, (3×30 mL). The enantiomers were separated by chiral preparative HPLC: RT42.4 and 59.0 min (ChiralPak OD 50×500 mm Normal phase column) 15% EtOH/hexane Isocratic, 50 mL/min, UV Detection at 220 nm. Both enantiomers were isolated as pale yellow powders, (34 mg of enantiomer A and 38 mg enantiomer B). ChiralHPLC Enantiomer B: RT 7.36 min (ChiralPak OD 4.6×250 mm Normal phase column) 15% EtOH/hexane Isocratic, 2 mL/min, UV Detection at 220 nm 100% ee. ChiralHPLC Enantiomer A: RT 4.94 min (ChiralPak OD 4.6×250 mm Normal phase column) 15% EtOH/hexane Isocratic, 2 mL/min, UV Detection at 220 nm 100% ee.

EXAMPLE 512

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(-methyl-1H-thieno[3,4-d]imidazol-2-yl)pyrazolo[1,5-a]pyrimidine

[0361]

531

[0362] Preparation of compound 1: as described in example 16.

[0363] Preparation of compound 2: To a suspension of the acid (152.9 mg, 0.47 mmol) in 5 mL of anhydrous dichloromethane were added trichloroacetonitrile (57.0 [tL, 0.67 mmol) and triphenylphosphine (186.2 mg, 0.71 mmol). The mixture became clear and was allowed to stir at room temperature for 1 hour. The reaction mixture was transferred into a solution of 3,4-diaminothiophene hydrochloride (88.5 mg, 0.47 mmol) and triethylamine (198.0 uL, 1.42 mmol) in 5 mL of dichloromethane. The reaction was monitored using TLC or LC/MS. Upon completion of the coupling, the reaction mixture was loaded directly onto silica gel and eluted with 5% methanolvdichloromethane to yield the desired amide as a white solid (132.3 mg, 67%).

[0364] Preparation of compound 3: A suspension of the resulting amide (107 mg, 0.25 mmol) and phosphorus pentachloride (53.1 mg, 0.25 mmol) in chloroform (20 mL) was heated to reflux under anhydrous argon for 5 hours and the mixture was allowed to cool down to room temperature and stir overnight. Solvent was removed under reduced pressure, and the residue was redissolved in ethyl acetate and briefly washed with saturated aqueous sodium bicarbonate solution. The organic layer was separated, dried over sodium sulfate, and concentrated to give the crude thienoimidazole, which was purified by flash chromatograph using 100% ethyl acetate to give a brown solid (73 mg, 71%).

[0365] Preparation of compound 4: To a solution of the thienoimidazole (22.4 mg, 0.06 mmol) in 2 mL of anhydrous DMF was added iodomethane (4.5 μL, 0.07 mmol) and potassium carbonate (15.4 mg, 0.11 mmol). The mixture was allowed to stir at room temperature overnight. The reaction was quenched using methanol. The mixture was diluted with ethyl acetate and washed with 10% LiCl (3×10 mL) and brine (10 mL). The organic layer was separated and dried over sodium sulfate and concentrated to give a residue, which was further purified using flash chromatograph (5% MeOH/ethyl acetate) and (6% MeOH/chloroform) to give the titled compound as a white solid (4.5 mg, 20%).

EXAMPLE 513

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(4-methyl-4H-imidazo[3,4-d][1,2,5]thiadiazol-5-yl)pyrazolo[1,5-a]pyrimidine

[0366]

532

[0367] Preparation of compound 5: To a suspension of the acid (120 mg, 0.37 mmol) in 5 mL of anhydrou dichloromethane were added trichloroacetonitrile (55.9 mL, 0.56 mmol) and triphenylphosphine (146.2 mg, 0.56 mmol). The mixture became clear and was allowed to stir at room temperature for 1 hour. The reaction mixture was transferred into a solution of 3,4-diamino-1,2,5-thiadiazole (51.7 mg, 0.45 mmol, prepared according to J. Heterocycl. Chem. 1976, 13, 13) and triethylamine (103.6 μL, 0.74 mmol) in 5 mL of dichloromethane. The reaction was monitored using TLC or LC/MS. Upon completion of the coupling, the reaction mixture was loaded directly onto silica gel and eluted with 50% ethyl acetate/hexanes to yield the desired amide as a yellow solid (56.4 mg, 30%).

[0368] Preparation of compound 6: A suspension of the resulting amide (80 mg, 0.19 mmol) and phosphorus pentachloride (79 mg, 0.38 mmol) in chloroform (10 mL) was stirred at room temperature under anhydrous argon for one hour and then heated to reflux for 2 hours. The mixture was allowed to cool down to room temperature and solvent was removed under reduced pressure. The residue was redissolved in ethyl acetate and briefly washed with saturated aqueous sodium bicarbonate solution. The organic layer was separated, dried over sodium sulfate, and concentrated to give the crude thiodiazoimidazole, which was purified by flash chromatograph using 80% ethyl acetate/hexanes to give a yellow solid (29 mg, 38%).

[0369] Preparation of compound 7: To a solution of the thiadiazoimidazole (29 mg, 0.07 mmol) in 2 mL of anhydrous DMF was added iodomethane (4.9 gL, 0.08 mmol) and potassium carbonate (19.9 mg, 0.14 mmol). The mixture was allowed to stir at room temperature under dry argon for 3 hours. The reaction was quenched using methanol and diluted with ethyl acetate and washed with 10% LiCl (3×10 mL) and brine (10 mL). The organic layer was separated and dried over sodium sulfate and concentrated to give a residue, which was purified using HPLC to give the titled compound as a white solid (1.6 mg, 5%).

EXAMPLE 514

7-(3,4-Dichlorophenyl)-6-(1,6-dihydro-1,3,6-trimethylimidazo[4,5-c]pyrazol-5-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine

[0370]

533

[0371] Preparation of compound 8: To a suspension of the acid (150 mg, 0.46 mmol) in 5 mL of anhydrou dichloromethane were added trichloroacetonitrile (69.8 μL, 0.70 mmol) and triphenylphosphine (182.7 mg, 0.70 mmol). The mixture became clear and was allowed to stir at room temperature for 1 hour. The reaction mixture was transferred into a solution of the diaminopyrazole (prepared according to J. Med. Chem. 1995, 38, 3524) and triethylamine (129.5 mL, 0.93 mmol) in 5 mL of dichloromethane. The reaction was monitored using TLC or LC/MS. Upon completion of the coupling, the reaction mixture was loaded directly onto silica gel and eluted with 10% methanol/ ethyl acetate to yield the desired amide as a white solid.

[0372] Preparation of compound 9: A suspension of the resulting amide (39.5 mg, 0.09 mmol) in phosphorus oxychloride (10 mL) was stirred at 80° C. under anhydrous argon overnight. The mixture was allowed to cool down to room temperature and solvent was removed under reduced pressure. The residue was redissolved in ethyl acetate and briefly washed with saturated aqueous sodium bicarbonate solution. The organic layer was separated, dried over sodium sulfate, and concentrated to give a residue, which was purified by flash chromatograph using 10% methanol/dichloromethane to give the desired product as a light brown solid (13.9 mg, 37%).

EXAMPLE 515

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-thienyl)pyrrolidine

[0373]

534

[0374] Preparation of compound 1: as described in example 17.

[0375] Preparation of compound 3: To a suspension of polystyrene supported HOBt reagent (5.2 g, 8.0 mmol) in 100 mL of anhydrous dichloromethane in a reaction vessel that has a fritted glass filter at the bottom was added the acid (4.7 g, 12.0 mmol), 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (2.3 g, 12.0 mmol), and 4-dimethylaminopyridine (98 mg, 0.8 mmol). The mixture was shook using an orbital shaker for 3 hours at room temperature. Solvent was drained through filtration, and the resin washed with anhydrous DMF (3×30 mL), anhydrous TF (3×30 mL), and anhydrous dichloromethane (3×30 mL). The resin that contains activated ester was allowed to dry in vacuo overnight. The coupling yield was estimated based on the weight gain to be 84%.

[0376] Preparation of compound 4: Resin containing the HOBt-activated ester (58 mg, 0.05 mmol) was distributed into a well, to which 2-(2′-thienyl)-pyrrolidine (80 μL of 0.5 M, 0.04 mmol) was dispensed. The suspension was allowed to shake at room temperature for 3 hours, and then polystyrene-supported isocyanate reagent was added (83 mg, 0.08 mmol) and the suspension was shook for 2 hours. Solvent was collected through filtration, and the resin was washed with dichloromethane (2×0.5 mL). All filtrates were combined and concentrated under reduced pressure to give the desired product as a white solid (18 mg). The purity of the product was checked using LC/MS to be 100%, and m/z is 527.

EXAMPLES 516-587

[0377] The following compounds were synthesized using the procedure as described in Example 515. Those compounds that have low purity were purified using preparative HPLC to give the corresponding desired products.

23Ex.StructureNameMass Spec516

535

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]pyrimidin- 6-yl]carbonyl]-2-(4- methoxyphenyl)pyrrolidine551(M + H)+517

536

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-2-(3- furanyl)pyrrolidine511(M + H)+518

537

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-2-(2- pyridinyl)pyrrolidine522(M + H)+519

538

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-2-(4- pyridinyl)pyrrolidine522(M + H)520

539

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-2- (phenylmethyl)pyrrolidine535(M + H)521

540

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-2-(2- methoxyphenyl)pyrrolidine551(M + H)522

541

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-2-(2- phenylethyl)pyrrolidine549(M + H)523

542

7-(3,4-Dichlorophenyl)-N-(2,3- dimethylcyclohexyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide501(M + H)524

543

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[1-(1- naphthalenyl)ethyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide545(M + H)525

544

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[2-(1-piperidinyl)ethyl]- 2-(trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide502(M + H)526

545

7-(3,4-Dichlorophenyl)-N-(2,2- diphenylethyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide571(M + H)527

546

N-[2-(1-Cyclohexen-1-yl)ethyl]-7- (3,4-dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide499(M + H)528

547

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[2-(phenylthio)ethyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide527(M + H)529

548

N-([1,1′-Bicyclohexyl]-2-yl)-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide555(M + H)530

549

7-(3,4-Dichlorophenyl)-N-[2-[[(2,6- dichlorophenyl)methyl]thio]ethyl]- 4,7-dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide610(M + H)531

550

N-[(2-Chloro-6- methylphenyl)methyl]-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide529(M + H)532

551

N-(Bicyclo[2.2.1]heptan-2-yl)-7- (3,4-dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide485(M + H)533

552

N-Cyclobutyl-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide445(M + H)534

553

N-Cyclopentyl-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide458(M + H)535

554

N-Cyclohexyl-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide473(M + H)536

555

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-(2-methylcyclohexyl)-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide487(M + H)537

556

N-(Cyclohexylmethyl)-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide487(M + H)538

557

N-(2-Cyanoethyl)-7-(3,4- dichlorophenyl)-4,7-dihydro-N,5- dimethyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide458(M + H)539

558

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[2-(1-methyl-2- pyrrolidinyl)ethyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide502(M + H)540

559

7-(3,4-Dichlorophenyl)-N-[(1-ethyl- 2-pyrrolidinyl)methyl]-4,7-dihydro- 5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide502(M + H)541

560

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[2-(1-pyrrolidinyl)ethyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide488(M + H)542

561

N-Cyclohexyl-7-(3,4- dichlorophenyl)-N-ethyl-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide501(M + H)543

562

N-Cycloheptyl-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide487(M + H)544

563

7-(3,4-Dichlorophenyl)-4,7-dihydro- [(1S,2S)-1-(hydroxymethyl)-2- methylbutyl]-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide491(M + H)545

564

3-[[7-(3,4-Dichlorophenyl)- 4,7dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]thiazolidine463(M + H)546

565

1-[[7-(3,4-Dichlorophenyl)- 4,7dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]pyrrolidine445(M + H)547

566

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-(2-thienylmethyl)-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide487(M + H)548

567

1-[[7-(3,4-Dichlorophenyl)- 4,7dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-4- methylpiperazine474(M + H)549

568

8-[[7-(3,4-Dichlorophenyl)- 4,7dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-1,4- dioxa-8-azaspiro[4.5]decane517(M + H)550

569

1-[[7-(3,4-Dichlorophenyl)-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidin-6-yl]carbonyl]-4- (phenylmethyl)piperidine549(M + H)551

570

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[4-(4- morpholinyl)phenyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide552(M + H)552

571

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[3-(4- morpholinyl)propyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide518(M + H)553

572

7-(3,4-Dichlorophenyl)-4,7-dihydro- N,5-dimethyl-N-[2-(2- pyridinyl)ethyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide510(M + H)554

573

7-(3,4-Dichlorophenyl)-N-(2,3- dihydro-1,4-benzodioxin-6-yl)-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide525(M + H)555

574

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-(1-phenylethyl)-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide495(M + H)556

575

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-(1-methylpropyl)-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide447(M + H)557

576

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-(phenylmethyl)-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide481(M + H)558

577

7-(3,4-Dichlorophenyl)-N-[(2- fluorophenyl)methyl]-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide499(M + H)559

578

N-[(2-Chlorophenyl)methyl]-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide515(M + H)560

579

7-(3,4-Dichlorophenyl)-N-[(4- fluorophenyl)methyl]-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide499(M + H)561

580

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-(2-phenylethyl)-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide495(M + H)562

581

N-[2-(4-Chlorophenyl)ethyl]-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide530(M + H)563

582

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N,N-bis(2-methylpropyl)- 2-(trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide503(M + H)564

583

7-(3,4-Dichlorophenyl)-N-[(3,4- dichlorophenyl)methyl]-4,7-dihydro- N,5-dimethyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide564(M + H)565

584

N-[(2-Chlorophenyl)methyl]-7-(3,4- dichlorophenyl)-4,7-dihydro-N,5- dimethyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide530(M + H)566

585

7-(3,4-Dichlorophenyl)-N-ethyl-4,7- dihydro-5-methyl-N-(1- methylethyl)-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide461(M + H)567

586

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-(phenylmethyl)-N- propyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide523(M + H)568

587

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[[4-(1- methylethyl)phenyl]methyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide523(M + H)569

588

7-(3,4-Dichlorophenyl)-N-[2- [ethyl(3-methylphenyl)amino]ethyl]- 4,7-dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide552(M + H)570

589

N-(Cyclopropylmethyl)-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide445(M + H)571

590

7-(3,4-Dichlorophenyl)-N-[2-(6- fluoro-1H-indol-3-yl)ethyl]-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide552(M + H)572

591

N-[2-(Butylethylamino)ethyl]-7- (3,4-dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide518(M + H)573

592

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[1-(phenylmethyl)-3- pyrrolidinyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide550(M + H)574

593

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[[4- (trifluoromethoxy)phenyl]methyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide565(M + H)575

594

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[[3- (trifluoromethoxy)phenyl]methyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide565(M + H)576

595

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[(1R)-1-(1- naphthalenyl)ethyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide545(M + H)577

596

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[(1S)-1-(1- naphthalenyl)ethyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide545(M + H)578

597

N-[(1S)-1-Cyclohexylethyl]-7-(3,4- dichlorophenyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide501(M + H)579

598

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N- (tricyclo[3.3.1.1<3,7]decan-1-ylmethyl)-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide539(M + H)580

599

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[(1R,2S,5R)-5-methyl- 2-(1-methylethyl)cyclohexyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide529(M + H)581

600

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[2-(4- phenoxyphenyl)ethyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide587(M + H)582

601

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[[4-(1,2,3-thiadiazol-4- yl)phenyl]methyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide565(M + H)583

602

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-(1-methyl-1- phenylethyl)-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide509(M + H)584

603

7-(3,4-Dichlorophenyl)-4,7-dihydro- 5-methyl-N-[(5-methyl-2- furanyl)methyl]-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide584(M + H)585

604

7-(3,4-Dichlorophenyl)-N-[[(2S)-1- ethyl-2-pyrrolidinyl]methyl]-4,7- dihydro-5-methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide502(M + H)586

605

7-(3,4-Dichlorophenyl)-N-(4,6- dimethyl-2-pyridinyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide596(M + H)587

606

7-(3,4-Dichlorophenyl)-N-(1,1- dimethylethyl)-4,7-dihydro-5- methyl-2- (trifluoromethyl)pyrazolo[1,5-a]- pyrimidine-6-carboxamide447(M + H)

EXAMPLE 588

1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidine

[0378]

607

[0379] Synthesis of 3: A mixture of N-(tert-butoxycarbonyl)-L-proline 1 (0.5 g, 2.3 mmol), hydroxyamidine 2 (0.172 g, 2.3 mmol, prepared using the procedure outlined in J. Fluor. Chem. 1999, 95, 127) and 1-hydroxybenzotriazole hydrate (0.323 g, 2.4 mmol) in 22% dimethyl formamide in dichloromethane (9 mL) was stirred at room temperature for 0.5 hours. Then 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.757 g, 3.9 mmol) was added and the mixture stirred further at room temperature for 2 hours when HPLC indicated completion of the reaction. The reaction mixture was diluted with water and extracted with dichloromethane. The organic layers were washed successively with saturated aqueous sodium bicarbonate solution, saturated aqueous sodium chloride solution and dried over magnesium sulfate. Evaporation of the solvent provided a white solid with an (M+H)+ of 272 consistent for the coupled product 3.

[0380] Preparation of 4: The solid 3 was dissolved in tetrahydrofuran (17 mL), cesium carbonate (1.6 g) added and the mixture heated at 50-70° C. for 18 hours after which HPLC indicated the complete consumption of 3. The reaction was diluted with water and extracted with ethyl acetate. The organic layers were dried over magnesium sulfate and evaporated to give a light-green colored oil that had an (M+H)+ of 254 consistent with the desired oxadiazole 4 which was used without any further purification.

[0381] Synthesis of 5: To a solution of 4 (0.288 g, 1.1 mmol) in dichloromethane (9 mL) was added 0.9 mL of trifluoroacetic acid and the solution stirred at room temperature for 18 hours when HPLC indicated the absence of 4. The reaction mixture was concentrated and the residue purified by ion-exchange chromatography (using BioRad AG-50W-X2 resin, 200-400 mesh, hydrogen form) eluting with 2N ammonia in methanol to give the deprotected pyrrolidine 5 as an oil (0.122 g, 70%). (M+H)+=154

[0382] Synthesis of 6: To a solution of dihydropyrimidine acid (0.21 gram, 0.65 mmol) in dichloromethane (10 mL) was added pyrrolidine 5 (0.139 gram, 0.9 mmol) followed by 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.174 gram, 0.9 mmol) and the reaction stirred at room temperature for 1.5 hours. The solvent was evaporated and the residue purified by silica gel chromatography, eluting with ethyl acetate, to give two diastereomers- a fast moving, less polar diastereomer-1 and a slow moving, more polar diastereomer-2, both as white amorphous solids with an (M+H)+ of 460.

EXAMPLE 589

1-1-[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine

[0383]

608

[0384] Synthesis of 4: A mixture of (+/−) N-(tert-butoxycarbonyl)-pipecolinic acid 1 (0.8 gram, 3.5 mmol), 1-hydroxybenzotriazole hydrate (1.14 gram, 5.9 mmol) and 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.49 gram, 3.6 mmol) in 22% dimethyl formamide in dichloromethane (20 mL) was stirred at room temperature for 0.5 hours. Then hydroxyamidine 2 (0.26 gram, 3.5 mmol, prepared using the procedure outlined in J. Fluor. Chem. 1999, 95, 127) was added and the mixture stirred further at room temperature for 18 hours when HPLC indicated completion of the reaction. The reaction mixture was diluted with water and extracted with dichloromethane. The organic layers were washed successively with saturated aqueous sodium bicarbonate solution, saturated aqueous sodium chloride solution and dried over magnesium sulfate. Evaporation of the solvent provided a clear oil with an (M+H)+ of 285 consistent for the coupled product 3. The oil 3 was dissolved in tetrahydrofuran (25 mL), cesium carbonate (2.5 g) added and the mixture heated at 50-70° C. for 18 hours after which HPLC indicated the complete consumption of 3. The reaction was diluted with water and extracted with ethyl acetate. The organic layers were dried over magnesium sulfate and evaporated to give a clear oil that had an (M+H)+ of 267 consistent with the desired oxadiazole 4 which was used without any further purification.

[0385] Synthesis of 5: To a solution of 4 (0.82 gram, 3.1 mmol) in dichloromethane (20 mL) was added 2 mL of trifluoroacetic acid and the solution stirred at room temperature for 18 hours when HPLC indicated the absence of 4. The reaction mixture was concentrated and the residue purified by ion-exchange chromatography (using BioRad AG-50W-X2 resin, 200-400 mesh, hydrogen form) eluting with 2N ammonia in methanol to give the deprotected pyrrolidine 5 as an oil (0.46 gram, 89%). (M+H)+=167

[0386] Synthesis of title compound: To a solution of dihydropyrimidine acid (0.64 gram, 2.0 mmol) in dichloromethane (30 mL) was added pyrrolidine 5 (0.462 gram, 2.8 mmol) followed by 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.53 gram, 2.8 mmol) and the reaction stirred at room temperature for 2.5 hours. The solvent was evaporated and the residue purified by silica gel chromatography, eluting with ethyl acetate, to give two diastereomers- a minor and less polar diastereomer (diastereomer 1) and a major more polar diastereomer (diastereomer 2), both as white amorphous solids with an (M+H)+ of 473.

Claims

1. A method of treating atrial arrhythmias comprising administering to a patient in need thereof an effective amount of at least one compound of formula I
2. A method of treating atrial fibrillation comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
3. A method of treating atrial flutter comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
4. A method of selectively treating supraventricular arrhythmias comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
5. A method of controlling heart rate comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
6. A method of treating gastrointensinal disorders comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
7. The method of claim 6 wherein the gastrointestinal disorder is reflux esauphagitis.
8. The method of claim 6 wherein the gastrointestinal disorder is motility disorders.
9. A method of treating inflammatory or immunological disease comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
10. The method of claim 9 wherein the disease is chronic obstructive pulmonary disease.
11. A method of treating diabetes comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
12. A method of treating cognitive disorders comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
13. A method of treating migraine comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
14. A method of treating epilepsy comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
15. A method of treating IKur-associated conditions comprising administering to a patient in need thereof an effective amount of at least one compound of claim 1.
16. The method of claim 1 where in formula I R1 is hydrogen R2 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo or substituted carbocyclo R3 is —(CH2)n—Z2, —(CH2)—C(O)Z3—(CH2)p—Z2, or —(CH2)n—C(O)NZ4—(CH2)p—Z2; R4 is alkyl or substituted alkyl; R5 is hydrogen, or —(CH2)n—Z2; and X1, X2 and X3, together with the atoms to which they are bonded, form a ring selected from: 610 wherein the ring substituents are the same or different.
17. The method of claim 16 where in formula I R3 is —(CH2)n—Z2, —(CH2)n—C(O)Z3—(CH2)p—Z2, or —(CH2)n—C(O)NZ4—(CH2)p—Z2 wherein Z2 is selected from —C(O)NZ5Z6, —CO2Z5, —SO2Z5, —NZ5Z6, —NZ5CO2Z6, —NZ5C(O)Z6, OZ5, aryl, substituted aryl, heterocyclo, substituted heterocyclo, aikyl or substituted alkyl; Z3 is heterocyclo or substituted heterocycle; and n and p are independently selected from integers 0 to 3; R5 is hydrogen, or —(CH2)n—Z2 wherein Z2 is selected from —C(O)NZ5Z6, —CO2Z5, —NZ5Z6, aryl, substituted aryl, alkyl, or substituted alkyl; and X1, X2 and X3, together with the atoms to which they are bonded, form a ring selected from: 611
18. The method of claim 17 where in formula I R3 is heterocyclo or substituted heterocyclo, —C(O)NZ5Z6, C(O)Z3—CONZ5Z6, —C(O)Z Z2, or —C(O)Z3CO2Z5, wherein Z3 is heterocyclo or substituted heterocyclo, and Z2 is aryl or substituted aryl.
19. The method of claim 1 wherein the compound of formula I is selected from: 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid methyl ester; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid methyl ester; 7-(4-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid methyl ester; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 7-(3,4- Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethylester enantiomer A; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethylester, enantiomer B; 7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 7-(2,3-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin e-6-carboxylic acid 1,1-dimethylethyl ester; 7-(3,4-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 4,7-Dihydro-5-methyl-7-(1-methylethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 7-Cyclopropyl-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-propylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-phenyl-pyrazolo[1,5-a]pyrimidine-6-carboxamide; 4-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]morpholine; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N-propylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N-phenylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-3-pyridinylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine, enantiomer A; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine, enantiomer B; 1-[[7-(4-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]morpholine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-methyl-piperazine; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(4-Chlorophenyl)-4,7-dihydro-5-methyl-N-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 4-[[7-(4-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]morpholine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[5-(3,4-Dichlorophenyl)-5,8-dihydro-7-methyl-imidazo[1,2-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(phenyl-methyl)piperidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(phenyl-methyl)piperazine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N,N-dipropylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-(4-Fluorophenyl)-4-[(4,7-dihydro-5-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]piperazine; 1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer A; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; 1-[[5-(2,3-Dichlorophenyl)-5,8-dihydro-7-methyl-imidazo[1,2-ajpyrimidin-6-yl]carbonyl]-4-phenyl-piperazine; 1-(4-Fluorophenyl)-4-[[7-(3-fluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine; 1-[[7-(3,5-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[(7-Cyclohexyl-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-phenylpiperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-phenyl-piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[(4-phenyl- l-piperazinyl)carbonyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; 1-[[4-(2,3-Dichlorophenyl)-4,6,7,8-tetrahydro-2-methyl-1H-pyrimido[1,2-a]pyrimidin-3-yl]carbonyl]-4-phenyl-piperazine; 4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1-pipera-zinecarboxylic acid 1,1-dimethylethyl ester; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(2,3-Dichlorophenyl)-2-(1,1-dimethylethyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[[(3-phenylpropyl)amino]carbonyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[(4-phenyl-1-piperazinyl)-carbonyl]pyrazolo[1,5-a]pyrimidine-2-carboxylic acid ethyl ester; 1-[[3-Cyano-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer B; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(3-phenylpropyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-pipera-zinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midine-2-carboxylic acid methyl ester; 2S)-1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine; 1-[[7-(2,3-Dichlorophenyl)-2-fluoro-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; (2S)-1-[[2-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo 1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrro-lidine; (2S)-1-[[2-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrroli-dine; (2S)-1-[[7-(2,3-Dichloro-phenyl)-2-fluoro-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxy-methyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N,N-dipropylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 4-[6-[[4-(4-Fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]benzoic acid methyl ester; 1-(4-Fluorophenyl)-4-[[7-(2-fluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine; 1-[[7-(2-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(2-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dimethoxyphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,3-Dimethoxyphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,5-Dimethoxyphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[2-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-methylphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dimethoxyphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(3,5-Dimethoxyphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[3-(phenylmethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-7-(3-hydroxyphenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbony]3-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-methylphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(4-Cyanophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-(4-Fluorophenyl)-4-[[7-(4-fluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-pipera; N-[4-[6-[[4-(4-Fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide; 1-[[7-[4-(Dimethyl-amino)phenyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(4-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyt]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[4-(phenylmethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(4-Butoxyphenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-thienyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-thienyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-nitrophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(4-nitrophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,6-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,4-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,5-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,5-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[2-(phenylmethoxy)phenyl]pyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(3,4-Dimethylphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[4-(trifluoromethoxy)phenyl]py-razolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[3-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(3-Cyanophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(3-methoxyphenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(4-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-nitrophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(5-methyl-2-furanyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(1H-imidazol-2-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(1H-pyrrol-2-yl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-pyridinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3-Chloro-4-methoxy-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(4-methoxy-1,3-benzodioxol-6-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-[5-(hydroxymethyl)-2-furanyl]-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(1H-indol-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-pyridinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-quinolinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(4-quinolinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dihydro-1,4-benzodioxin-6-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2,3,5-trichloro-phenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,5-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-(4-Fluorophenyl)-4-[[7-(3-furanyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine; 1-[[7-(2-Benzofuranyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-methyibenzo[b]thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-quinolinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-thiazolyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-(4-Fluorophenyl)-4-[[7-(2-furanyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine; 1-[[4,7-Dihydro-7-[3-methoxy-4-(phenylmethoxy)phenyl]-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-[4-methoxy-3-(phenylmethoxy)phenyl]-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-naphthalenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-[3,4-Bis(phenyl-methoxy)phenyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(1,3-Benzodioxol-5-yl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-[3,5-Bis(trifluoro-methyl)phenyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; -1-[[7-(5-Ethyl-2-furanyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dihydro-5-benzofuranyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3-Bromophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[4-(1-pyrrolidinyl)-phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-methyl-2-thienyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(5-methyl-2-thienyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(1,3-Benzodioxol-4-yl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(5-Chloro-2-thienyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,5-Dimethylphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer A; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer A; S8-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-ylcarbonyl]-1,4-dioxa-8-azaspiro[4.5]decane; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(2-methoxy-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]-pyrimidin-6-yl]carbonyl]-4-[3-(trifluoromethyl)-phenyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-nitrophenyl)piperazine; 1-(4-Acetylphenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-(2-Chlorophenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]-carbonyl]-4-(4-methoxy-phenyl)piperazine; 1-(3,4-Dichlorophenyl)-4-[[7-(3,4-dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]-carbonyl]piperazine; 1-(3,4-Dichlorophenyl)-4-[[7-(3,4-dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]-carbonyl]piperazine; 1-(3,4-Dichlorophenyl)-4-[[7-(3,4-dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]-carbonyl]piperazine; 1-3-Chlorophenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(3-methoxy-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-methyl-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5a]-pyrimidin-6-yl]car-bonyl]-4-[4-(trifluoromethyl)-phenyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(2-fluoro-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(3,4-dimethyl-phenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(2-pyrimidinyl)piperazine; 7-(3,4-Dichlorophenyl)-N-[2-[(4-fluoro-phenyl)amino]ethyl]-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; 4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1-piperazinecarboxylic acid phenylmethyl ester; 7-(3,4-Dichlorophenyl)-N-ethyl-N-[(2-fluorophenyl)methyl]-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; N-[(3-Chloro-4-methoxyphenyl)methyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; 1-(1,3-Benzodioxol-5-ylmethyl)-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1-piperazinecarboxylic acid ethyl ester; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(2-pyridinyl)piperazine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine; 1-[Bis(4-fluorophenyl)-methyl]-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(2-furanyl-carbonyl)piperazine; 1-Cyclohexyl-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(2-methoxyethyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(9H-fluoren-9-yl)piperazine; (2R)-1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(methoxy-methyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(2,3-dimethyl-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-piperidine-carboxylic acid ethyl ester; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-N,N-diethyl-3-piperidinecarboxamide; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-3-piperidine-carboxylic acid ethyl ester; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-methyl-piperidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-3,5-dimethyl-piperidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-hydroxy-piperidine; 4-(4-Chlorophenyl)-1-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midin-6-yl]carbonyl]-4-hydroxypiperidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-piperidine-carboxylic acid ethyl ester; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-methylpiperidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroquinoline; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]-pyrimidin-6-yl]carbonyl]-decahydroquinoline; 2-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroisoquinoline; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-l]carbonyl]-4-propylpiperidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-l]carbonyl]-4-(hydroxydiphenylmethyl)piperidine; 7-(3,4-Dichlorophenyl)-N-[(2-fluoro-phenyl)methyl]-4,7-dihydro-5-methyl-yrazolo[1,5-a]pyri-midine-6-carboxamide; 2-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(phenylamino)-ethyl]pyrazolo[1,5-a]pyri-midine-6-carboxamide; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[(phenyl-amino)methyl]pyrrolidine; N-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; 3-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazole; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3,4-dihydro-1H-indole; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]azetidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]hexahydro-1H-azepine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]octahydroazocine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine; 7-(3,4-Dichlorophenyl)-4,7dihydro-N,5-dimethyl-N-[2-(2-pyridinyl)-ethyl]pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[[7-(3,4-Dichlorophenyl)-4,7dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-N-(phenylmethyl)glycine ethyl ester; trans-7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenylcyclopropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamde; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-methylpyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-methylaziridine; (2S)- -[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[[(2,6-dimethylphenyl)amino]methyl]pyrrolidine; 7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihydro-5-methyl-N-(4-pyridinylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(IR)-1-phenylethyl]pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1S)-1-phenylethyl]pyrazolo[1,5-a]pyrimidine-6-carboxamide; 6-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl-1,3,3-trimethyl-6-azabicyclo[3.2.1 ]octane; 7-(3,4-Dichlorophenyl)-N-(hexahydro-1H-azepin-1-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]aziridine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]octahydro-1H-azonine; (2R-trans)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,5-bis(methoxymethyl)-pyrrolidine; (2S-trans)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,5-bis-(methoxymethyl)pyrro-lidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-L-prolinamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimnidin-6-yl]carbonyl]-D-prolinamide′1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-2-methyl-1H-indole; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl3-2,3-dihydro-5-nitro-1H-indole; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-6-nitro-1H-indole; 4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-thiomorpholine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-L-proline methyl ester; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrro-lidine, enantiomer A; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine, enantiomer B; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-L-proline 1,l-dimethylethyl ester; -[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-N-(2-naphthalenyl)-L-prolinamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydro-2-methylquinoline; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-L-proline phenylmethyl ester; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-D-proline phenylmethyl ester; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-hydroxy-L-proline phenylmethyl ester; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbony]-4-(4-fluorophenyl)-2-methylpiperazine; 3-Chloro-N-cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; 4-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-thiomorpholine; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-1H-indole; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]hexahydro-1H-azepine; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-octahydroazocine; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine; 3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1S)-1-phenylethyl]-pyrazolo[1,5-a]pyrimidine-6-carboxarnide; 3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1 R)-1-phenylethyl]-pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]-carbonyl]-2-(methoxy-methyl)piperidine; [(3R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-pyrrolidinyl]carbamic acid 1,l-dimethylethyl ester; [(3S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-pyrrolidinyl]carbamic acid 1,l-dimethylethyl ester; (3R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-(di-methylamino)pyrrolidine; N-[1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-pyrrolidinyl]acetamide; N-[1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-pyrrolidinyl]-N-methylacetamide, 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N,N-dipentyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N,N-dihexyl-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine; 3-Chloro-7-(3-chlorophenyl)-N-cyclohexyl-4,7-dihydro-N,5-dimethyl-pyrazolo[1,5-a]pyrimidine-6-carboxamide; (2S)-1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxy-methylpyrrolidine; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-decahydroquinoline; 2-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroisoquinoline; 4-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-thiomorpholine; N-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N,N-diethyl-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; N,N-Dibutyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N,N-diheptyl-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-azacyclotridecane; 9-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-dodecahydro-1H-fluorene; (2S)-1-[[7-(3,4-Di-chlorophenyl)-4,7-dihydro-5-methyl-2-(tri-fluoromethyl)pyrazolo-[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(methoxy-methyl)pyrrolidine; 1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine; 1-[[3-Chloro-7-(3-chloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]hexahydro-1H-azepine; 1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-octahydroazocine; 1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyt]-1,2,3,6-tetrahydropyridine; 3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1 S)-1-phenyl-ethyl]pyrazolo[1,5-a]pyrimidine-6-carboxa-mide; (2S)-1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrro-lidine; 1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-decahydroquinoline; 2-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroisoquinoline; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]hexahydro-1H-azepine; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine; (2S)-1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimi-din-6-yl]carbonyl]-2-(methoxymethyl)pyrroli-dine; -[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-1H-indole; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]hexahydro-1H-azepine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-di-methyl-N-[(1S)-1-phenylethyl]-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1R)- l-phenylethyl]-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carbox; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,N-bis(2-methoxyethyl)-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N,N-bis(2-ethoxyethyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-(2-methoxyethyl)-N,5-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-(2-methoxyethyl)-5-methyl-N-propylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine; 2-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroisoquinoline; 2-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroisoquinoline; 3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1S)-1-phenylethyl]-pyrazolo[1,5-a]pyrimi-dine-6-carboxamide; 3-Chloro-N-cyclohexyl-7-(2,3-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-pyrazolo[1,5-a]pyrim-dine-6-carboxamide; 3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-N-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihydro-N-(2-methoxyethyl)-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrirnidin-6-yl]carbonyl]-N-methylglycine ethyl ester; N-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-N-methylglycine 1,1-dimethylethyl ester; N-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-N-(2-ethoxy-2-oxoethyl)glycine ethyl ester; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-pyridinyl)piperidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydro-6-methylquinoline; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl l-2-propylpiperidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[(diethylamino)methyl]piperidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenoxyethyl)-pyrazolo[1,5-a]pyrimi-dine-6-carboxamide; 1-[(7-Cyclopropyl-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(1-methyl-ethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; (2S)-1-[[4,7-Dihydro-5-methyl-7-(1-methyl-ethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxy-methyl)pyrrolidine; 1-[[4,7-Dihydro-5-methyl-7-(1-methyl-ethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-1H-indole; 1-[[4,7-Dihydro-5-methyl-7-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine; 3-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazolidine, enantiomer A; 3-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazolidine, enantiomer B; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-(phenyl-methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenylethyl)-N-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(phe-noxymethyl)pyrrolidine; (2R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(phenoxymethyl)pyrro-lidine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[(4-fluorophenoxy)methyl]-pyrrolidine; (2R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[(4-fluorophenoxy)methyl]-pyrrolidine; 7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihydro-5-methylpyrazolo[1,5-a]pyriinidine-6-carboxamide; N-Butyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-pentylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-(2-methoxyethyl)-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(hydroxydiphenylmethyl)pyrrolidine; (2R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(hydroxydiphenylmethyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-pyridinyl)pyrrolidine; (2S)-1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrro-lidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-phenylpyrrolidine; 3-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-phenylthia-zolidine; 3-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-thiazolidinecarboxylic acid methyl ester; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-(3-phenyl-propyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihydro-5-methyl-N-(3-phenyl-propyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(3-phenylpropyl)-N-propylpyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Butyl-7-(3,4-dichloro-phenyl)-4,7-dihydro-5-methyl-N-(3-phenyl-propyl)pyrazolo[1,5-a]pyrimidine-6-carbo-xamide; 2-(4-Chlorophenyl)-3-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazolidine; N-(Cyclopropylmethyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-N-propylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine; 8-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; 4-(4-Chlorophenyl)-1-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-vllcar-bonyl]-1,2,3,6-tetrahydropyridine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(2-phenyl-ethyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(4-methoxy-phenyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(2-methoxy-phenyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine diastereomer 1; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine diastereomer 2; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer A; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazoloL 1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer B; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer C; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer D; (3R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-phenoxypyrrolidine; (2S)-2-[(Cyclohexyl-oxy)methyl]-1-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(phenyl-methyl)pyrrolidine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(phenoxymethyl)pyrro-lidine, diastereomer A; (2S)- -[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(phenoxymethyl)pyrro-lidine, diastereomer B; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(3-methoxy-phenyl)pyrrolidine; (2S)-2-(Butoxymethyl)-1-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-thienyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-pyridinyl)pyrrolidine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[(methoxymethoxy)-methyl]pyrrolidine; (2S)-2-(1H-Benzimidazol-1-ylmethyl)-1-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-furanyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-pyridinyl)pyrrolidine; (3S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-phenoxypyrrolidine; (3S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-phenoxypyrrolidine; (2S)-1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine, enantiomer A; (2S)-1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]-pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrro-lidine, enantiomer B; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-L-proline; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-[(I R)-2,3-dihydro-1H-inden-1-yl]-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(2,3-dihydro-1H-inden-2-yl)-4,7-dihydro-5-methyl-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrirmidine-6-carboxamide; N-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-D-phenylalanine methyl ester; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-2-(trifluoro-methyl)pyra-zolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(2-furanylmethyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyra-zolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[(3,4-dichloro-phenyl)methyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyra-zolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-[(2R)-2-(methoxymethyl)-1-pyr-rolidinyl]-5-methyl-2-(trifluoromethyl)pyra-zolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(tetrahydro-2-furanyl)-methyl]-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carbo-xamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-[(1S)-2,3-dihydro-1H-inden-1-yl]-5-methyl-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimnidine-6-carboxarnide; 7-(3,4-Dichlorophenyl)-N-[2-(3,4-dichloro-phenyl)ethyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyra-zolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyt)-4,7-dihydro-5-methyl-2-(trifluoromethyl)-N-L[4-[(trifluoromethyl)thio]-phenyl]methyl]pyrazolo-[1,5-a]pyrirridine-6-carboxamide; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7di-hydro-5-methyl-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(1-pyrrolidinylmethyl)-pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(1-naphthalenylsulfonyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-[(4-ethylphenyl)sulfonyl]-piperazine; 1-[(4-Bromo-5-chloro-2-thienyl)sulfonyl]-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimi-din-6-yl]carbonyl]-piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-[[2-(trifluoro-methoxy)phenyl]sul-fonylipiperazine; 1-[(5-Chloro-3-methyl-benzo[b]thiophen-2-yl)sulfonyl]-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-[(3-methoxyphenyl)carbonyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(1-oxo-3-phenyl-2-propenyl)-piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-pyridinylcarbonyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer B; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer A; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,4,5-trimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4-[(4-fluorophenyl)methyl]-4,7dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 7-(2,3-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-acetic acid ethyl ester; 7-(2,3-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-N,N,2,5-tetramethylpyrazolo[1,5-a]pyrimidine-4(7H)-acetamide; 1-[[7-(2,3-Dichlorophenyl)-4-[2-(dimethylamino)ethyl]-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4-(Cyclopropylmethyl)-7-(2,3-dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]4-(4-fluorophenyl)piperazine; 7-(2,3-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-N,N,2,5-tetramethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxamide; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4-methyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-2-methyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-2,4-dimethyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-2,4-dimethyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-2,4-dimethyl-5-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer A; 1-[[7-(3,4-Dichlo-rophenyl)-4,7-dihydro-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenylpiperazinie; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-2-methyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[1-Benzoyl-7-(2,3-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[1-Benzoyl-7-(3,4-dichlrophenyl)-1,2,4,7-tetrahydro-5- methyl -2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-phenyl-piperazine; 1-[[1-Acetyl-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-ylIcar-bonyl]-4-phenyl-piperazine; 1-[[7-(3,4-Dichloro-phenyl)-1,2,4,7-tetrahydro-5-methyl-oxo-1-(1-oxobutyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[1-(Cyclopropyl-carbonyl)-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-phenyl-piperazine; 1-[[1-(Cyclopropyl-carbonyl)-7-(2,3-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-1,2,4,7-tetra-hydro-5-methyl-1-(3-methyl-1-oxobutyl)-2-oxopyra-zolo[1,5-a]pyri-midin-6-yl]carbonyl]-4-(4-fluorophenyl)-piperazine; 1-[[7-(2,3-Dichloro-phenyl)-(2,2-dimethyl-1-oxopropyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-phenyl-piperazine; 1-[[1-(Cyclopropyl-carbonyl)-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[1-(Cyclobutyl-carbonyl)-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-1,2,4,7-tetrahydro-5-methyl-1-(2-methyl-1-oxopropyl)-2-oxopyrazoo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-1-[(1-methylethyl)sulfonyl]-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-1-[(1-methylethyl)sulfonyl]-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(1-methylethyl)-2-oxo-6-[(4-phenyl-1-piperazinyl)carbonyl]pyrazolo[1,5-a]pyrimidine-1(2H)-carboxamide; 7-(2,3-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-2-oxo-6-[(4-phenyl-1-piperazinyl)-carbonyl]pyrazolo[1,5-a]pyrimidine-1(2H)-carboxamide; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-2-oxo-6-[(4-phenyl-1-piperazinyl)carbonyl]-pyrazolo[1,5-a]pyri-midine-1(2H)-carboxa-mide; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-N,N,5-trimethyl-2-oxopyrazolo[1,5-a]pyrimidine-1 (2H)-carboxamide; 1-[[1-(3-Butenyl)-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-1,2,4,7- tetrahydro-5-methyl-2-oxo-1-(2,2,2-trifluoroethyl)pyrazolo-[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxo-1,4-bis(2,2,2-trifluoroethyl)pyrazolo[1,5-a]pyrimidin-6- yl]carbonyl]-4-(4-fluorophenyl)piperazine; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidine-1(2H)-carboxylic acid 1-methylethyl ester; 1-[(4,7-Dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-phenylpiperazine; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyt)-1-piperazinyl]carbonyl-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxylic acid; 7-(3,4-Dichlorophenyl)-N,N-diethyl-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxamide; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-N-(4-hydroxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxamide; 1-[[7-(3,4-Dichloro-phenyl)-4,7dihydro-5-methyl-2-[[(2S)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxamide; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methyl-N-(phenylmethyl)pyrazolo-[1,5-a]pyrimidine-2-carboxamide; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methyl-N-(2-phenylethyl)-pyrazolo[1,5-a]pyri-midine-2-carboxamide; 1-[[2-Cyano-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 3-Bromo-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 1-[[3-Bromo-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine, enantiomer B; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine, enantiomer A; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer A; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer B; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer A; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer B; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer A; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer B; 3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(5-phenyl-2-oxazolyl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(5-phenyl-1,3,4-oxa-diazol-2-yl)pyrazolo[1,5-a]pyrimidine; 6-(1H-Benzimidazol-2-yl)-7-(3,4-dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine; 6-(2-Benzothiazolyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(1-methyl-1H-benzimi-dazol-2-yl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[5-(trifluoromethyl)-1-propyl-1H-benzimidazol-2-yl]pyrazolo[1,5-a]pyrimidine; 6-(5-Butyl-1,3,4-oxadiazol-2-yl)-7-(3,4-dichlorophenyl)-4,7dihydro-5-methylpyrazolo[1,5-a]pyrimidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-6-(4-methyl-1H-benzimidazol-2-yl)pyra-zolo[1,5-a]pyrimidine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-5-methyl-6-(1-methyl-1H-benzimidazol-2-yl)pyra-zolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-6-(imida-zo[1,5-a]pyridin-3-yl)-5-methylpyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(1-ethyl-5-nitro-1H-benzimidazol-2-yl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine; 6-[5-Chloro-1-(1-methylethyl)-1H-benzimidazol-2-yl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidine; 6-(5-Chloro-1-ethyl-1H-benzimidazol-2-yl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-propyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-methylpyra-zolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[1-(1-methylethyl)-5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine, enantiomer A; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine, enantiomer B; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[1-(phenylmethyl)-1H-benzimidazol-2-yl]pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)-N-(2-pyridinylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)-N-(2-pyridinylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluorophenyl)pyrrolidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)-N,N-dipropylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 5-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[5-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[S-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine; (2S)-1-[[5-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine; 5-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-N,N-dipropylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-6-(imidazo[1,5-a]pyridin-3-yl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(2,3-Dichlorophenyl)-4,7-dihydro-6-(imidazo[1,5-a]pyridin-3-yl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(2,3-Dichlorophenyl)-6-(4-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(4-fluoro-1-methyl- 1H-benzimidazol-2-yl)4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(2,3-Dichlorophenyt)-6-(5-fluoro-1-methyl- H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine enantiomer A; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine enantiomer B; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-phenyl-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-phenylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-phenylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperidine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-phenylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-phenyl-N,N-dipropylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-phenylpyrazolidine; 6-(1-Chloro-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-3-yl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(1-methyl-1H-thieno [3,4-d]imidazol-2-yl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(4-methyl-4H-imidazo[3,4-d][1,2,5]thiadiazol-5-yl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(1,6-dihydro-1,3,6-trimethylimidazo[4,5-c]pyrazol-5-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-thienyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-methoxyphenyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-furanyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-pyridinyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-pyridinyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(phenylmethyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-methoxyphenyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-phenylethyl)pyrrolidine; 7-(3,4-Dichlorophenyl)-N-(2,3-dimethylcyclohexyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[1-(1-naphthalenyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(1-piperidinyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(2,2-diphenylethyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[2-(1-Cyclohexen-1-yl)ethyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(phenylthio)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-([1,1′-B icyclohexyl]-2-yl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[2-[[(2,6-dichlorophenyl)methyl]thio]ethyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[(2-Chloro-6-methylphenyl)methyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-(Bicyclo[2.2.1]heptan-2-yl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Cyclobutyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Cyclopentyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-methylcyclohexyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-(Cyclohexylmethyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-(2-Cyanoethyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(1-pyrrolidinyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Cyclohexyl-7-(3,4-dichlorophenyl)-N-ethyl-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Cycloheptyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-[(1S ,2S)-1-(hydroxymethyl)-2-methylbutyl]-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 3-[[7-(3,4-Dichlorophenyl)-4,7dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazolidine; 3-[[7-(3,4-Dichlorophenyl)-4,7dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazolidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-thienylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-methylpiperazine; 8-[[7-(3,4-Dichlorophenyl)-4,7dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,4-dioxa-8-azaspiro[4.5]decane; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(phenylmethyl)piperidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[4-(4-morpholinyl)phenyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[3-(4-morpholinyl)propyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[2-(2-pyridinyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(1-phenylethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(1-methylpropyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(phenylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[(2-fluorophenyl)methyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[(2-Chlorophenyl)methyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[(4-fluorophenyl)methyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenylethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[2-(4-Chlorophenyl)ethyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N,N-bis(2-methylpropyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[(3,4-dichlorophenyl)methyl]-4,7-dihydro-N,5-dimethyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[(2-Chlorophenyl)methyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihydro-5-methyl-N-(1-methylethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(phenylmethyl)-N-propyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[[4-(1-methylethyl)phenyl]methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[2-[ethyl(3-methylphenyl)amino]ethyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-(Cyclopropylmethyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[2-(6-fluoro-1H-indol-3-yl)ethyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[2-(Butylethylamino)ethyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[[4-(trifluoromethoxy)phenyl]methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[[3-(trifluoromethoxy)phenyl]methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(1 S)-1-(1-naphthalenyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[(1S)-1-Cyclohexylethyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(tricyclo[3.3.1.1<3,7]decan-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(4-phenoxyphenyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[[4-(1,2,3-thiadiazol-4-yl)phenyl]methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(1-methyl-1-phenylethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(5-methyl-2-furanyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(4,6-dimethyl-2-pyridinyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(1,1-dimethylethyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-al pyrimidin-6-yl]carbonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine diastereomer 1; and 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine diastereomer 2 enantiomers, diastereomers and pharmaceutically acceptable salts thereof.
20. A compound of the formula I*
21. A compound of claim 20 wherein R3* is heterocyclo; substituted heterocyclo; —C(O)NZ5*Z6*, —C(O)Z3*—C(O)NZ5Z6, —C(O)Z3*—CO2Z5, C(O)Z3*-(aryl), —C(O)Z3*-(substituted aryl), C(O)Z3*-(heterocyclo), or —C(O)Z3*(substituted heterocyclo).
22. A compound of claim 21 wherein R1 is H; R2 is aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo or substituted carbocyclo; R4 is alkyl or substituted alkyl; and X1, X2 and X3, together with the atoms to which they are bonded, form a ring selected from: 614where the ring substituents are the same or different.
23. A compound of claim 20 wherein R3* is heterocyclo or substituted heterocyclo.
24. A compound of claim 23 wherein R1 is H; R2 is aryl, substituted aryl, heterocyclo, substituted heterocyclo, carbocyclo or substituted carbocyclo; R4 is alkyl or substituted alkyl; and X1, X2 and X3, together with the atoms to which they are bonded, form a ring selected from: 615where the ring substituents are the same or different.
25. A compound of claim 20 selected from 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-3-pyridinylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine, enantiomer A; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine, enantiomer B; 1-[[7-(4-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-methyl-piperazine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[5-(3,4-Dichlorophenyl)-5,8-dihydro-7-methyl-imidazo[1,2-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(phenyl-methyl)piperidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(phenyl-methyl)piperazine; 1-[[7-(3-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-(4-Fluorophenyl)-4-[(4,7-dihydro-5-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]piperazine; 1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer A; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; 1-[[5-(2,3-Dichlorophenyl)-5,8-dihydro-7-methyl-imidazo[1,2-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine; 1-(4-Fluorophenyl)-4-[[7-(3-fluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine; 1-[[7-(3,5- Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[(7-Cyclohexyl-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-phenylpiperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-phenyl-piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[(4-phenyl-1-piperazinyl)-carbony]-1-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; 1-[[4-(2,3-Dichlorophenyl)-4,6,7,8-tetrahydro-2-methyl-1H-pyrimido[1,2-a]pyrimidin-3-yl]carbonyl]-4-phenyl-piperazine; 4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1-pipera-zinecarboxylic acid 1,1-dimethylethyl ester; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(2,3-Dichlorophenyl)-2-(1,1-dimethylethyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[[(3-phenylpropyl)amino]carbonyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; 7-(2,3- Dichlorophenyl)-4,7-dihydro-5-methyl-6-[(4-phenyl-1-piperazinyl)carbonyl]pyrazolo[1,5-a]pyrimidine-2-carboxylic acid ethyl ester; 1-[[3-Cyano-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1 5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer B; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(3-phenylpropyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-pipera-zinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midine-2-carboxylic acid methyl ester; (2S)-1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine; 1-[[7-(2,3-Dichlorophenyl)-2-fluoro-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; (2S)-1-[[2-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrro-lidine; (2S)-1-[[2-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrroli-dine; (2S)-1-[[7-(2,3-Dichloro-phenyl)-2-fluoro-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxy-methyl)pyrrolidine; -[[7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-d imethylpyrazolo[1 5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer A; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Difluorophenyl)-4,7-dihydro-5- methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 4-[6-[[4-(4-Fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]benzoic acid methyl ester; 1-(4-Fluorophenyl)-4-[[7-(2-fluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine; 1-[[7-(2-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7- Dihydro-7-(2-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dimethoxyphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,4-Dimethoxyphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,5-Dimethoxyphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; -[[4,7- Dihydro-5-methyl-7-[2-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-methylphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dimethoxyphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(3,5-Dimethoxyphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[3-(phenylmethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-7-(3-hydroxyphenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yilcarbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[3-(trifluoromethyl) phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-methylphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(4-Cyanophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-(4-Fluorophenyl)-4-[[7-(4-fluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine; N-[4-[6-[[4-(4-Fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide; 1-[[7-[4-(Dimethyl-amino) phenyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(4-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[4-(phenylmethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(4-Butoxyphenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-thienyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-thienyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7- Dihydro-5-methyl-7-(4-methylphenyl) pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-nitrophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(4-nitrophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,6-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,4-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,5-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,5-Difluorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[2-(phenylmethoxy)phenyl]pyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(3,4-Dimethylphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[4-(trifluoromethoxy)phenyl]py-razolo[1,5-a]pyrimidin-6-ylIcarbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[3-(trifluoromethoxy)phenyl]py-razolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(3-Cyanophenyl)-4,7-dihydro-5-m ethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(3-methoxyphenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(4-Chlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-nitrophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(5-methyl-2-furanyl) pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(1H-imidazol-2-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(1H-pyrrol-2-yl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-pyridinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3-Chloro-4-methoxy-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(4-methoxy-1,3-benzodioxol-6-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-[5-(hydroxymethyl)-2-furanyl]-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-(1H-indol-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-pyridinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-quinolinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7- Dihydro-5-methyl-7-(4-quinolinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dihydro-1,4-benzodioxin-6-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2,3,5-trichloro-phenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,5-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-(4-Fluorophenyl)-4-[[7-(3-furanyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine; 1-[[7-(2-Benzofuranyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(3-methylbenzo[b]thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-quinolinyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-thiazolyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-(4-Fluorophenyl)-4-[[7-(2-furanyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-piperazine; 1-[[4,7-Dihydro-7-[3-methoxy-4-(phenylmethoxy)phenyl]-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-7-[4-methoxy-3-(phenylmethoxy)phenyl]-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(2-naphthalenyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-[3,4-Bis(phenyl-methoxy)phenyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(1,3-Benzodioxol-5-yl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-[3,5-Bis(trifluoro-methyl)phenyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(5-Ethyl-2-furanyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dihydro-5-benzofuranyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3-Bromophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[4-(1-pyrrolidinyl)-phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-[4-(1-pyrrolidinyl)-phenyl]pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine 1-[[4,7-Dihydro-5-methyl-7-(5- methyl-2-thienyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(1,3-Benzodioxol-4-yl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(5-Chloro-2-thienyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,5-Dimethylphenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer A; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer A; 8-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,4-dioxa-8-azaspiro[4.5]decane; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(2-methoxy-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]-pyrimidin-6-yl]carbonyl]-4-[3-(trifluoromethyl)-phenyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-nitrophenyl)piperazine; 1-(4-Acetylphenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-(2-Chlorophenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]-carbonyl]-4-(4-methoxy-phenyl)piperazine; 1-(3,4-Dichlorophenyl)-4-[[7-(3,4-dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]-carbonylipiperazine; 1-(3,5-Dichlorophenyl)-4-[[7-(3,4-dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]-carbonyl]piperazine; 1-(4-Chlorophenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-(3-Chlorophenyl)-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(3-methoxy-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-methyl-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5a]-pyrimidin-6-yl]car-bonyl]-4-[4-(trifluoromethyl)-phenyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(2-fluoro-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(3,4-dimethyl-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(3,4-dimethyl-phenyl)piperazine; 7-(3,4-Dichlorophenyl)-N-[2-[(4-fluoro-phenyl)amino]ethyl]-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; 4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1-piperazinecarboxylic acid phenylmethyl ester; 7-(3,4-Dichlorophenyl)-N-ethyl-N-[(2-fluorophenyl)methyl]-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; N-[(3-Chloro-4-methoxyphenyl)methyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; 1-(1,3-Benzodioxol-5-ylmethyl)-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1-piperazinecarboxylic acid ethyl ester; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(2-pyridinyl)piperazine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine; 1-[Bis(4-fluorophenyl)-methyl]-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(2-furanyl-carbonyl)piperazine; 1-Cyclohexyl-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(2-methoxyethyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(9H-fluoren-9-yl)piperazine; (2R)-1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(methoxy-methyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(2,3-dimethyl-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-piperidine-carboxylic acid ethyl ester; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-N,N-diethyl-3-piperidinecarboxamide; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-3-piperidine-carboxylic acid ethyl ester; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-3-methyl-piperidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-3,5-dimethyl-piperidine; -[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-hydroxy-piperidine; 4-(4-Chlorophenyl)-1-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midin-6-yl]carbonyl]-4-hydroxypiperidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-piperidine-carboxylic acid ethyl ester; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-methylpiperidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroquinoline; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]-pyrimidin-6-yl]carbonyl]-decahydroquinoline; 2-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroisoquinoline; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-propylpiperidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(hydroxydiphenylmethyl)piperidine; 7-(3,4-Dichlorophenyl)-N-[(2-fluoro-phenyl)methyl-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; 2-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(phenylamino)-ethyl]pyrazolo[1,5-a]pyrimidine-6-carboxamide; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[(phenyl-amino)methyl]pyrrolidine; N-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; 33-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazole; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3,4-dihydro-1H-indole; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]azetidine; -[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]hexahydro-1H-azepine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]octahydroazocine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine; 7-(3,4-Dichlorophenyl)-4,7dihydro-N,5-dimethyl-N-[2-(2-pyridinyl)-ethyl]pyrazolo[1,5-a]pyrimidine-6-carboxanide; N-[[7-(3,4-Dichlorophenyl)-4,7dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-N-(phenylmethyl)glycine ethyl ester; trans-7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenylcyclopropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamde; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-methylpyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-methylaziridine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[[(2,6-dimethylphenyl)amino]methyl]pyrrolidine; 7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihydro-5-methyl-N-(4-pyridinylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1R)-1-phenylethyl]pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1S)-1-phenylethyl]pyrazolo[1,5-a]pyrimidine-6-carboxamide; 6-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,3,3-trimethyl-6-azabicyclo[3.2.1]octane; 7-(3,4-Dichlorophenyl)-N-(hexahydro-1H-azepin-1-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]aziridine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]octahydro-1H-azonine; (2R-trans)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,5-bis(methoxymethyl)-pyrrolidine; (2S-trans)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,5-bis-(methoxymethyl)pyrro-lidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-L-prolinamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-D-prolinamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-2-methyl-1H-indole; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-5-nitro-1H-indole; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-6-nitro-1H-indole; 4-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-thiomorpholine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-L-proline methyl ester; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrro-lidine, enantiomer A; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine, enantiomer B; 1-[1-[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-L-proline 1,1-dimethylethyl ester; 1-[[7-(3,4-Dichlorophenyl)4,7-dihydro-5-methylpyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-N-(2-naphthalenyl)-L-prolinamide; 1-1-[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydro-2-methylquinoline; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,S-a]pyrimidin-6-yl]carbonyl]-6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-L-proline phenylmethyl ester; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-rnethylpyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-D-proline phenylmethyl ester; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-hydroxy-L-proline phenylmethyl ester; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)-2-methylpiperazine; 3-Chloro-N-cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-pyrazolo[1,5-a]pyri-midine-6-carboxamide; 4-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-thiomorpholine; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-1H-indole; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]hexahydro-1H-azepine; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-octahydroazocine; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine; 3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1S)-1-phenylethyl]-pyrazolo[1,5-a]pyrimidine-6-carboxamide; 3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1R)-1-phenylethyl]-pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]-carbonyl]-2-(methoxy-methyl)piperidine; [(3R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-pyrrolidinyl]carbamic acid 1,1-dimethylethyl ester; [(3 S) 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-pyrrolidinyl]carbamic acid 1,1-dimethylethyl ester; (3R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-(di-methylamino)pyrrolidine; N-[1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-pyrrolidinyl]acetamide; N-[1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-pyrrolidinyl]-N-methylacetamide; 3-Chloro-7-(3-chlorophenyl)-N-cyclohexyl-4,7-dihydro-N,5-dimethyl-pyrazolo[1,5S-a]pyrimidine-6-carboxamide; (2S)-1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxy-methyl)pyrrolidine; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-decahydroquinoline; 2-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroisoquinoline; 4-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-thiomorpholine; N-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-azacyclotridecane; 9-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-dodecahydro-1H-fluorene; (2S)-1-[[7-(3,4-Di-chlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(methoxymethyl)pyrrolidine; 1-[[3-Chloro-7-(3-chloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]hexahydro-1H-azepine; 1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-octahydroazocine; 1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine; 3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1 S)-1-phenylethyl]pyrazolo[1,5-a]pyrimidine-6-carboxa-mide; (2S)-1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrro-lidine; 1-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-decahydroquinoline; 2-[[3-Chloro-7-(3-chlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroisoquinoline; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-ylJcarbonyl]hexahydro-1H-azepine; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine; (2S)-1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimi-din-6-yl]carbonyl]-2-(methoxymethyl)pyrroli-dine; 1-[[7-(3,4-Dichioro-phenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-1H-indole; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]hexahydro-1H-azepine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-di-methyl-N-[(S)-1-phenylethyl]-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1R)-1-phenylethyl]-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,N-bis(2-methoxyethyl)-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N,N-bis(2-ethoxyethyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-(2-methoxyethyl)-N,5-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-(2-methoxyethyl)-5-methyl-N-propylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 2-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydroisoquinoline; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-octahydroazocine; 3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[(1S)-1-phenylethyl]-pyrazolo[1,5-a]pyrimi-dine-6-carboxamide; 3-Chloro-N-cyclohexyl-7-(2,3-dichlorophenyl)-4,7-dihydro-N,5-dimethylpyrazolo[1,5-a]pyrim-dine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihydro-N-(2-methoxyethyl)-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-N-methylglycine ethyl ester; N-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-N-methylglycine 1,1-dimethylethyl ester; N-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-N-(2-ethoxy-2-oxoethyl)glycine ethyl ester; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-pyridinyl)piperidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,4-tetrahydro-6-methylquinoline; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-propylpiperidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[(diethylamino)methyl]piperidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenoxyethyl)pyrazolo[1,5-a]pyrimi-dine-6-carboxamide; 1-[(7-Cyclopropyl-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4,7-Dihydro-5-methyl-7-(1-methyl-ethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; (2S)-1-[[4,7-Dihydro-5-methyl-7-(1-methyl-ethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxy-methyl)pyrrolidine; -[[4,7-Dihydro-5-methyl-7-(1-methyl-ethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2,3-dihydro-1H-indole; 1-[[4,7-Dihydro-5-methyl-7-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,2,3,6-tetrahydropyridine; 3-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazolidine, enantiomer A; 3-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazolidine, enantiomer B; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-(2-phenylethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenylethyl)-N-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(phenoxymethyl)pyrrolidine; (2R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(phenoxymethyl)pyrro-lidine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[(4-fluorophenoxy)methyl]-pyrrolidine; (2R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[(4-fluorophenoxy)methyl]-pyrrolidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-(2-methoxyethyl)-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(hydroxydiphenylmethyl)pyrrolidine; (2R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(hydroxydiphenylmethyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-ylicarbonyl]-2-(3-pyridinyl)pyrrolidine; (2S)-1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrro-lidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-phenylpyrrolidine; 3-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-phenylthia-zolidine; 3-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-thiazolidinecarboxylic acid methyl ester; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,S-dimethyl-N-(3-phenyl-propyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-ethyl-4,7-dihydro-5-methyl-N-(3-phenyl-propyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(3-phenylpropyl)-N-propylpyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Butyl-7-(3,4-dichloro-phenyl)-4,7-dihydro-5-methyl-N-(3-phenyl-propyl)pyrazolo[1,5-a]pyrimidine-6-carbo-xamide; 2-(4-Chlorophenyl)-3-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]thiazolidine; N-(Cyclopropylmethyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-N-propylpyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine; 8-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; 4-(4-Chlorophenyl)-1-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-1,2,3,6-tetrahydropyridine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-phenyl-ethyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-methoxy-phenyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(2-methoxy-phenyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine diastereomer 1; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine diastereomer 2; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer A; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer B; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer C; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer D; (3R)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-phenoxypyrrolidine; (2S)-2-[(Cyclohexyl-oxy)methyl]-1-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(phenyl-methyl)pyrrolidine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(phenoxymethyl)pyrro-lidine, diastereomer A; (2S)1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(phenoxymethyl)pyrro-lidine, diastereomer B; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-2-(3-methoxy-phenyl)pyrrolidine; (2S)-2-(Butoxymethyl)-1-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-thienyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-pyridinyl)pyrrolidine(2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-[(methoxymethoxy)-methyl]pyrrolidine; (2S)-2-(1H-Benzimidazol-1-ylmethyl)-1-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-furanyl)pyrrolidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-pyridinyl)pyrrolidine; Ad (3S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-phenoxypyrrolidine; (3S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-3-phenoxypyrrolidine; (2S)-1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine, enantiomer A; (2S)-1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]-pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrro-lidine, enantiomer B; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-ylcarbonyl]-L-proline; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-[(1R)-2,3-dihydro-1H-inden-1-yl]-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(2,3-dihydro-1H-inden-2-yl)-4,7-dihydro-5-methyl-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-D-phenylalanine methyl ester; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-2-(trifluoro-methyl)pyra-zolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(2-furanylmethyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyra-zolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[(3,4-dichloro-phenyl)methyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyra-zolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-[(2R)-2-(methoxymethyl)-1-pyrrolidinyl]-5-methyl-2-(trifluoromethyl)pyra-zolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(tetrahydro-2-furanyl)-methyl]-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carbo-xamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N-[(1S)-2,3-dihydro-1H-inden-1-yl]-5-methyl-2-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[2-(3,4-dichloro-phenyl)ethyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyra-zolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)-N-[[4-[(trifluoromethyl)thio]-phenyl]methyl]pyrazolo-[1,5-a]pyrimidine-6-carboxamide; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7di-hydro-5-methyl-2-(trifluoromethyl)pyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(1-naphthalenylsulfonyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-[(4-ethylphenyl)sulfonyl]-piperazine; 1-[(4-Bromo-5-chloro-2-thienyl)sulfonyl]-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimi-din-6-yl]carbonyl]-piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-[[2-(trifluoro-methoxy)phenyl]sulfonyl]piperazine; 1-[(5-Chloro-3-methyl-benzo[b]thiophen-2-yl)sulfonyl]-4-[[7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyra-zolo[1,5-a]pyrimidin-6-yl]carbonyl]piperazine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-[(3-methoxyphenyl)carbonyl]piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(1-oxo-3-phenyl-2-propenyl)-piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-pyridinylcar-bonyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer B; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer A; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-2,4,5-trimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4-[(4-fluorophenyl)methyl]-4,7dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 7-(2,3-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4(7H)-acetic acid ethyl ester; 7-(2,3-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-N,N,2,5-tetramethylpyrazolo[1,5-a]pyrimidine-4(7H)-acetamide; 1-[[7-(2,3-Dichlorophenyl)-4-[2-(dimethylamino)ethyl]-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[4-(Cyclopropylmethyl)-7-(2,3-dichlorophenyl)-4,7-dihydro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 7-(2,3-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-N,N,2,5-tetramethylpyrazolo[1,5-a]pyrimidine-4(7H)-carboxamide; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-4-methyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-4,7-dihydro-5-(trifluoro-methyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-2-methyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-2,4-dimethyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-2,4-dimethyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer B; -[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-2,4-dimethyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine, enantiomer A; 1-[[7-(3,4-Dichlo-rophenyl)-4,7-dihydro-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-2-methyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[1-Benzoyl-7-(2,3-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[1-Benzoyl-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-phenyl-piperazine; 1-[[1-Acetyl-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-phenyl-piperazine; 1-[[7-(3,4-Dichloro-phenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxo-1-(1-oxobutyl)-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[1-(Cyclopropyl-carbonyl)-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine; 1-[[1-(Cyclopropyl-carbonyl)-7-(2,3-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(2,3-Dichloro-phenyl)-1,2,4,7-tetra-hydro-5-methyl-1-(3-methyl-1-oxobutyl)-2-oxopyra-zolo[1,5-a]pyri-midin-6-yl]carbonyl]-4-(4-fluorophenyl)-piperazine; 1-[[7-(2,3-Dichloro-phenyl)-(2,2-dimethyl-1-oxopropyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-phenyl-piperazine; 1-[[1-(Cyclopropyl-carbonyl)-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[1-(Cyclobutyl-carbonyl)-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluoro-phenyl)piperazine; 1-[[7-(3,4-Dichloro-phenyl)-1,2,4,7-tetrahydro-5-methyl-1-(2-methyl-1-oxopropyl)-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]car-bonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(2,3-Dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-1-[(1-methylethyl)sulfonyl]-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-1-[(1-methylethyl)sulfonyl]-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(1-methylethyl)-2-oxo-6-[(4-phenyl-1-piperazinyl)carbonyl]pyrazolo[1,5-a]pyrimidine-1 (2H)-carboxamide; 7-(2,3-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-2-oxo-6-[(4-phenyl-1-piperazinyl)-carbonyl]pyrazolo[1,5-a]pyrimidine-1(2H)-carboxamide; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-methyl-2-oxo-6-[(4-phenyl-1-piperazinyl)carbonyl]-pyrazolo[1,5-a]pyri-midine-1 (2H)-carboxa-mide; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-N,N,5-trimethyl-2-oxopyrazolo[1,5-a]pyrimidine-1 (2H)-carboxamide; 1-[[1-(3-Butenyl)-7-(3,4-dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-1,2,4,7-tetrahydro-5-methyl-2-oxo-1-(2,2,2-trifluoroethyl)pyrazolo-[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[7-(3,4-Dichlorophenyl)-1,2,4,7tetrahydro-5-methyl-2-oxo-1,4-bis(2,2,2-trifluoroethyl)pyrazolo[1,5-a]pyrimidin-6- yl]carbonyl]-4-(4-fluorophenyl)piperazine; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methyl-2-oxopyrazolo[1,5-a]pyrimidine-1(2H)-carboxylic acid 1-methylethyl ester; 1-[(4,7-Dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-phenylpiperazine7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxylic acid; 7-(3,4-Dichlorophenyl)-N,N-diethyl-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxamide; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-N-(4-hydroxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxamide; 1-[[7-(3,4-Dichloro-phenyl)-4,7dihydro-5-methyl-2-[[(2S)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxamide; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methyl-N-(phenylmethyl)pyrazolo-[1,5-a]pyrimidine-2-carboxamide; 7-(3,4-Dichlorophenyl)-6-[[4-(4-fluorophenyl)-1-piperazinyl]carbonyl]-4,7-dihydro-5-methyl-N-(2-phenylethyl)-pyrazolo[1,5-a]pyri-midine-2-carboxamide; 1-[[2-Cyano-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[3-Bromo-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl) piperazine; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenylpiperazine, enantiomer B; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-phenyl-piperazine, enantiomer A; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer A; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer B; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer A; 1-[[3-Chloro-7-(2,3-dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer A; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer A; 1-[[3-Chloro-7-(3,4-dichlorophenyl)-4,7-dihydro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine, enantiomer B; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(5-phenyl-2-oxazolyl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-m ethyl-6-(5-phenyl-1,3,4-oxa-diazol-2-yl)pyrazolo[1,5-a]pyrimidine; 6-(1H-Benzimidazol-2-y)-7-(3,4-dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine; 6-(2-Benzothiazolyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(1-methyl-1H-benzimi-dazol-2-yl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[5-(trifluoromethyl)-1-propyl-1H-benzimidazol-2-yl]pyrazolo[1,5-a]pyrimidine; 6-(5-Butyl-1,3,4-oxadiazol-2-yl)-7-(3,4-dichlorophenyl)-4,7dihydro-5-methylpyrazolo[1,5-a]pyrimidine; 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methyl-6-(4-methyl-1H-benzimidazol-2-yl)pyrazolo[1,5-a]pyrimidine; 1-[[7-(2,3-Dichloro-phenyl)-4,7-dihydro-5-methyl-6-(1-methyl-1H-benzimidazol-2-yl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-6-(imida-zo[1,5-a]pyridin-3-yl)-5-methylpyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(1-ethyl-5-nitro-1H-benzimidazol-2-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midine; 6-[5-Chloro-1-(1-methylethyl)-1H-benzimidazol-2-yl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidine; 6-(5-Chloro-1-ethyl-1H-benzimidazol-2-yl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midine; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-propyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-methylpyra-zolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[1-(1-methylethyl)-5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midine; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midine, enantiomer A; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H -benzimidazol-2-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyri-midine, enantiomer B; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-[1-(phenylmethyl)-1H-benzimidazol-2-yl]pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)-N-(2-pyridinylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(2,3-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)-N-(2-pyridinylmethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluorophenyl)pyrrolidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine; 5-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-N-(3-phenylpropyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[5-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; (2S)-1-[[5-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yilcarbonyl]-2-(methoxymethyl)pyrrolidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-6-(imidazo[1,5-a]pyridin-3-yl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(2,3-Dichlorophenyl)-4,7-dihydro-6-(imidazo[1,5-a]pyridin-3-yl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(2,3-Dichlorophenyl)-6-(4-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(4-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(2,3-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine enantiomer A; 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine enantiomer B; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-phenyl-N-(3-phenylpropy)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-phenylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine; (2S)-1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-phenylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(methoxymethyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-phenylpyrazolidine; 6-(1-Chloro-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-3-yl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(1-methyl-1H-thieno[3,4-d]imidazol-2-yl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-6-(4-methyl-4H-imidazo[3,4-d][1,2,5]thiadiazol-5-yl)pyrazolo[1,5-a]pyrimidine; 7-(3,4-Dichlorophenyl)-6-(1,6-dihydro-1,3,6-trimethylimidazo[4,5-c]pyrazol-5-yl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-thienyl)pyrrolidine; 1-[[7- (3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-methoxyphenyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-furanyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-pyridinyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-pyridinyl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(phenylmethyl) pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(2-methoxyphenyl)pyrrolidine; 1-[[7- (3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[5-a]pyrimidin-6-yl]carbonyl]-2-(2-phenylethyl)pyrrolidine; 7-(3,4-Dichlorophenyl)- N-(2,3-dimethylcyclohexyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[1-(1-naphthalenyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(1-piperidinyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(2,2-diphenylethyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[2-(1-Cyclohexen-1-yl)ethyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(phenylthio)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-([1,1′-Bicyclohexyl]-2-yl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[2-[[(2,6-dichlorophenyl)methyl]thio]ethyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[(2-Chloro-6-methylphenyl)methyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-(Bicyclo[2.2.1]heptan-2-yl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Cyclobutyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Cyclopentyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Cyclohexyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-methylcyclohexyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-(Cyclohexylmethyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-(2-Cyanoethyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-N ,5-dimethyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[(1-ethyl-2-pyrrolidinyl) methyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[2-(1-pyrrolidinyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Cyclohexyl-7-(3,4-dichlorophenyl)-N-ethyl-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-Cycloheptyl-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 3-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2(trifluoromethyl)pyrazolo[1,5a]-pyrimidin-6-yl]carbonyl]thiazolidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-thienylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7dihydro-5-methyl-2(trifluoromethyl)pyrazolo[1,5a]-pyrimidin-6-yl]carbonyl]-4-methylpiperazine; 8-[[7-(3,4-Dichlorophenyl)-4,7dihydro-5methyl-2(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-1,4-dioxa-8-azaspiro[4.5]decane; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-2(trifluoromethyl)pyrazolo[1,5a]-pyrimidin-6-yl]carbonyl]-4-(phenylmethyl)piperidine; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[4-(4morpholinyl)phenyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[3-(4-morpholinyl)propyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-N,5-dimethyl-N-[2-(2-pyridinyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(1-phenylethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(phenylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[(2-fluorophenyl)methyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl) pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[(2-Chlorophenyl)methyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[(4-fluorophenyl)methyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(2-phenylethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[2-(4-Chlorophenyl)ethyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[(3,4-dichlorophenyl)methyl]-4,7-dihydro-N,5-dimethyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[(2-Chlorophenyl)methyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-N,5-dimethyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(phenylmethyl)-N-propyl-2-(trifluoromethyl) pyrazolo[1 5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[[4-(1-methylethyl)phenyl]methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[2-[ethyl (3-methylphenyl)am ino]ethyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-(Cyclopropylmethyl)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[2-(6-fluoro-1H-indol-3-yl)ethyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1N-[2-(Butylethylamino)ethyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[[4-(trifluoromethoxy)phenyl]methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N -[[3-(trifluoromethoxy)phenyl]methyl]-2-7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(1 S)-1-(1-naphthalenyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; N-[(1S)-1-Cyclohexylethyl]-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(tricylo[3.3.1.1<3)7]decan-1-ylmethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]-2-(trifluoromethyl)pyrazol[[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5- methyl-N -[2- (4-phenoxyphenyl)ethyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[[4-(1,2,3-thiadiazol-4-yl)phenyl]methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-(1-methyl-1-phenylethyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methyl-N-[(5-methyl-2-furanyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 7-(3,4-Dichlorophenyl)-N-(4,6-dimethyl-2-pyridinyl)-4,7-dihydro-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5- methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine; 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine diastereomer 1; and 1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine diastereomer 2 enantiomers, diastereomers and pharmacuetically acceptable salts thereof.
26. A pharmaceutical composition comprising a therapeutically effective amount of at least one compound of claim 20 and a pharmaceutically acceptable vehicle or carrier thereof.
27. The pharmaceutical composition of claim 26 further comprising at least one other anti-arrhythmic agent.
28. The pharmaceutical composition of claim 27 wherein the other anti-arrhythmic agent is selected from sotalol, dofetilide, diltiazem and verapamil.
29. The pharmaceutical composition of claim 26 further comprising at least one calcium channel blocker.
30. The pharmaceutical composition of claim 26 further comprising at least one anti-platelet agent.
31. The pharmaceutical composition of claim 30 wherein the anti-platelet agent is selected from clopidogrel, ifetroban and aspirin.
32. The pharmaceutical composition of claim 26 further comprising at least one anti-hypertensive agent.
33. The pharmacuetical composition of claim 32 where the anti-hypertensive agent is selected from beta adrenergic blockers, ACE inhibitors, A II antagonists, ET antagonists, Dual ET/A II antagonists, and vasopepsidase inhibitors.
34. The pharmaceutical composition of claim 33 wherein the ACE inhibitors are selected from captopril, zofenopril, fosinopril, enalapril, ceranopril, cilazopril, delapril, pentopril, quinapril, ramipril, and lisinopril.
35. The pharmaceutical composition of claim 33 wherein the vasopepsidase inhibitors are selected from omapatrilat and gemopatrilat.
36. The pharmaceutical composition of claim 26 further comprising at least one anti-thrombotic/anti-thrombolytic agent.
37. The pharmaceutical composition of claim 36 wherein the anti-thrombotic/anti-thrombolytic agent is selected from tPA, recombinant tPA, TNK, nPA, factor Vila inhibitors, factor Xa inhibitors and thrombin inhibitors.
38. The pharmaceutical composition of claim 26 further comprising at least one anti-coagulant.
39. The pharmaceutical composition of claim 38 wherein the anti-coagulant is selected from warfarin and heparins.
40. The pharmaceutical composition of claim 26 further comprising at least one HMG-CoA reductase inhibitor.
41. The pharmaceutical composition of claim 40 wherein the HMG-CoA reductase inhibitor is selected from pravastatin, lovastatin, atorvastatin, simvastatin, NK-104 and ZD-4522.
42. The pharmaceutical composition of claim 26 further comprising at least one anti-diabetic agent.
43. The pharmacuetical composition of claim 42 wherein the anti-diabetic agent is selected from biguanides and biguanide/glyburide combinations.
44. The pharmaceutical composition of claim 26 further comprising at least one thyroid mimetic.
45. The pharmaceutical composition of claim 26 further comprising at least one mineralocorticoid receptor antagonist.
46. The pharmaceutical composition of claim 45 wherein the mineralocorticoid receptor antagonist is selected from spironolactone and eplerinone.
47. The pharmaceutical composition of claim 26 further comprising at least one cardiac glycoside.
48. The pharmaceutical composition of claim 47 wherein the cardiac glycoside is selected from digitalis and ouabain.
49. The compound7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimdine.
50. The compound 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine enantiomer A.
51. The compound 7-(3,4-Dichlorophenyl)-6-(5-fluoro-1-methyl-1H-benzimidazol-2-yl)-4,7-dihydro-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidine enantiomer B.
52. The compound 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine.
53. The compound 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine diasteriomer 1.
54. The compound 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine diastereomer 2.
55. The compound 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer A.
56. The compound 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer B.
57. The compound 1-[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer C.
58. The compond 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluoro-phenyl)pyrrolidine enantiomer D.
59. A method of treating cardiac arrhythmias comprising administering to a patient in need thereof an effective amount of at least one compound of claim 20.
60. A method of treating cardiac arrhythmias comprising administering to a patient in need thereof an effective amount of at least one compound of claim 50.

Parent Case Info

[0001] This application claims priority to U.S. Provisional application Serial No. 60/236,037 filed Sep. 28, 2000 and U.S. Provisional application Serial No. 60/169,091 filed Dec. 6, 1999. The entirety of each of these applications is incorporated herein by reference.

Provisional Applications (2)

	Number	Date	Country
	60236037	Sep 2000	US
	60169091	Dec 1999	US

Heterocyclic dihydropyrimidine compounds

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Provisional Applications (2)