Claims
- 1. A compound of the formula: ##STR3## wherein X is selected from the group consisting of O, and S;
- Z is selected from the group consisting of H, halogen, C1-C6 alkyl with an attached phenyl, C1-C6 fluorinated alkyl, C1-C6 fluorinated alkoxy, C1-C6 alkoxy with an attached phenyl, benzyloxy, 4-fluorobenzyloxy, --OCH2C6H4--R' (2-substituent), --OCH2C6H4--R' (3-substituent), --OCH2C6H4--R' (4-substituent), --OCH2C6H3--(R')2 (2,3-substituents), --OCH2C6H3--(R')2 (2,4-substituents), --OCH2C6H3--(R')2 (2,5-substituents), --OCH2C6H3--(R')2 (2,6-substituents), --OCH2C6H3--(R')2 (3,4-substituents), --OCH2C6H3--(R')2 (3,5-substituents);
- R' is selected from the group consisting of H, halogen, trifluoromethyl, NO2, cyano, methyl, methoxy, acetyl, carboxyl, OH, and amino;
- Y is selected from the group consisting of H, halogen, trifluoromethyl, methyl, OH, and methoxy, and
- R is selected from the group consisting of H, --NH--C(NH--NH2, C1-C6 fluorinated alkoxy, C1-C6 alkyl, and C1-C6 alkyl amino.
- 2. A compound of the formula: ##STR4## wherein X is selected from the group consisting of O, and S;
- Z is selected from the group consisting of H, halogen, C1-C6 alkyl with an attached phenyl, C1-C6 fluorinated alkyl, C1-C6 fluorinated alkoxy, C1-C6 alkoxy with an attached phenyl, benzyloxy, 4-fluorobenzyloxy, --OCH2C6H4--R' (2-substituent), --OCH2C6H4--R' (3-substituent), --OCH2C6H4--R' (4-substituent), --OCH2C6H3--(R')2 (2,3-substituents), --OCH2C6H3--(R')2 (2,4-substituents), --OCH2C6H3--(R')2 (2,5-substituents), --OCH2C6H3--(R')2 (2,6-substituents), --OCH2C6H3--(R')2 (3,4-substituents), --OCH2C6H3--(R')2 (3,5-substituents);
- R' is selected from the group consisting of H, halogen, trifluoromethyl, NO2, cyano, methyl, methoxy, acetyl, carboxyl, OH, and amino;
- Y is selected from the group consisting of H, halogen, trifluoromethyl, methyl, OH, and methoxy, and
- R is selected from the group consisting of OCH3 and OH.
- 3. A compound of the formula: ##STR5## wherein X is selected from the group consisting of O, and S;
- Z is selected from the group consisting of H, halogen, C1-C6 alkyl with an attached phenyl, C1-C6 fluorinated alkyl, C1-C6 fluorinated alkoxy, C1-C6 alkoxy with an attached phenyl, benzyloxy, 4-fluorobenzyloxy, --OCH2C6H4--R' (2-substituent), --OCH2C6H4--R' (3-substituent), --OCH2C6H4--R' (4-substituent), --OCH2C6H3--(R')2 (2,3-substituents), --OCH2C6H3--(R')2 (2,4-substituents), --OCH2C6H3--(R')2 (2,5-substituents), --OCH2C6H3--(R')2 (2,6-substituents), --OCH2C6H3--(R')2 (3,4-substituents), --OCH2C6H3--(R')2 (3,5-substituents);
- R' is selected from the group consisting of H, halogen, trifluoromethyl, NO2, cyano, methyl, methoxy, acetyl, carboxyl, OH, and amino;
- Y is selected from the group consisting of H, halogen, trifluoromethyl, methyl, OH, and methoxy, and
- R is selected from the group consisting of NH2 and NO2.
- 4. A compound of the formula: ##STR6## wherein X is selected from the group consisting of O, and S;
- Z is halogen;
- Y is selected from the group consisting of H, halogen, trifluoromethyl, methyl, OH and methoxy, and
- R is selected from the group consisting of OH, NH2, NO2, halogen, --NH--C(NH)--NH2, --C(NH)NH2, C1-C6 alkoxy, c1-C6 fluorinated alkoxy, c1-C6 alkyl, C1-C6 alkylamino, M--AA--NH--, M--AA--O--, M--AA--S-- and M--NH,
- wherein AA is selected from the group consisting of alanine, valine, leucine, isoleucine, proline, methionine, phenylalanine, tryptophan, glycine, serine, threonine, cysteine, tyrosine, asparagine, glutamine, aspartic acid, glutamic acid, lysine arginine, histidine, beta-alanine, norleucine, norvaline, alphaaminobutyric acid, epsilon-aminocaproic acid, citrulline, hydroxyproline, ornithine, and sarcosine,
- wherein M is selected from the group consisting of H, lower alkanoyl having 1 to 6 carbons, carboxylalkanoyl, hydroxyalkanoyl, amino-alkanoyl, benzenesulfonyl, tosyl, benzoyl, and lower alkyl sulfonyl having 1 to 6 carbons.
- 5. A compound of the formula: ##STR7## wherein R1 is selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 alkyl with an attached phenyl, C1-C6 fluorinated alkyl, C1-C6 alkoxy, C1-C6 fluorinated alkoxy, C1-C6 alkoxy with an attached phenyl, benzyloxy, 4-fluorobenzyloxy, --OCH2C6H4--R' (2-substituent), --OCH2C6H4--R' (3-substituent), --OCH2C6H4--R' (4-substituent), --OCH2C6H3--(R')2 (2,3-substituents), --OCH2C6H3--(R')2 (2,4-substituents), --OCH2C6H3--(R')2 (2,5-substituents), --OCH2C6H3--(R')2 (2,6-substituents), --OCH2C6H3--(R')2 (3,4-substituents), --OCH2C6H3--(R')2 (3,5-substituents);
- R' is selected from the group consisting of H, halogen, trifluoromethyl, NO2, cyano, methyl, methoxy, acetyl, carboxyl, OH, and amino;
- R2 is selected from the group consisting of H, OH, NH2, NO2, halogen, --NH--C(NH)--NH2, --C(NH)NH2, C1-C6 alkoxy, C1-C6 fluorinated alkoxy, C1-C6 alkyl, and C1-C6 alkyl amino.
RELATED APPLICATIONS
This application is a divisional of Ser. No. 07/499,561, filed on Mar. 26, 1990, now U.S. Pat. No. 5,109,018, issued on Apr. 28, 1992, which in turn is a file-wrapper continuation of Ser. No. 07/215,994, filed on Jul. 7, 1988, now abandoned, which in turn is a continuation of Ser. No. 06/874,459, filed on Jun. 13, 1986, now abandoned, which in turn is a continuation of Ser. No. 06/642,995, filed on Aug. 20, 1984, now U.S. Pat. No. 4,596,822, issued on Jun. 24, 1986.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5089633 |
Powers et al. |
Feb 1992 |
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5089634 |
Powers et al. |
Feb 1992 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
499561 |
Mar 1990 |
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Continuations (3)
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Number |
Date |
Country |
Parent |
215994 |
Jul 1988 |
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Parent |
874459 |
Jun 1986 |
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Parent |
642995 |
Aug 1984 |
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