Claims
- 1. A compound of the formula: ##STR21## wherein: Y is an alkylene bridge of 3-9 carbon atoms; Z in N; R is lower-alkyl of 1-5 carbon atoms;
- R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; and
- Het is selected from the group consisting of: ##STR22## where n is 2 or 3; and R.sub.3, R.sub.4 and R.sub.5 are hydrogen or lower-alkyl of 1-5 carbon atoms;
- R.sub.6 is hydrogen, lower-alkyl of 1.5 carbon atoms or chloro;
- R.sub.7 is hydrogen, or alkyl or hydroxyalkyl of 1-5 carbon atoms; or pharmaceutically acceptable acid-addition salts of basic members thereof.
- 2. A compound according to claim 1 of the formula ##STR23## wherein R.sub.1, R.sub.2 and Het have the meanings given in claim 1.
- 3. A compound according to claim 2 wherein Het is a furanyl group.
- 4. 5-{5-[2,6-Dichloro-4-(2-furanyl)phenoxy]pentyl}-3-methylisoxazole, according to claim 3.
- 5. 5-{5-[2,6-Dimethyl-4-(5-methyl-2-furanyl)phenoxy]pentyl}-3-methylisoxazole, according to claim 3.
- 6. A compound according to claim 2 wherein Het is a thienyl group.
- 7. 5-{5-[2,6-Dichloro-4-(2-thienyl)phenoxy]pentyl}-3-methylisoxazole, according to claim 6.
- 8. A compound according to claim 2 wherein Het is a tetrazolyl group.
- 9. 5-{5-[2,6-Dichloro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy]pentyl}-3-methylisoxazole, according to claim 8.
- 10. 5-{5-[2,6-Dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenoxy]pentyl}-3-methylisoxazole, according to claim 8.
- 11. 5-{5-[2,6-Dichloro-4-(2-ethyl-2H-tetrazol-5-yl)phenoxy]pentyl}-3-methylisoxazole, according to claim 8.
- 12. 5-{5-[2,6-Dimethyl-4-(2-ethyl-2H-tetrazol-5-yl)phenoxy]pentyl}-3-methylisoxazole, according to claim 8.
- 13. A composition for combating picornaviruses which comprises an antivirally effective amount of a compound according to claim 1, in admixture with a suitable carrier or diluent.
- 14. A composition according to claim 13 for combating rhinoviruses.
- 15. A composition according to claim 14 wherein the antivirally effective compound is 5-{5-[2,6-dichloro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy]pentyl}-3-methylisoxazole.
- 16. A composition according to claim 14 wherein the antivirally effective compound is 5-{5-[2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenoxy]pentyl}-3-methylisoxazole.
- 17. A method for combating picornaviruses which comprises contacting the locus of said viruses with a compound according to claim 1.
- 18. A method according to claim 17 for combating rhinoviruses.
- 19. A method according to claim 18 wherein the compound used is 5-{5-[2,6-dichloro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy]pentyl}-3-methylisoxazole.
- 20. A method according to claim 18 wherein the compound used is 5-{5-[2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenoxy]pentyl}-3-methylisoxazole.
- 21. A method for combating an picornaviral infection in a mammalian host which comprises administering to said host an antivirally effective amount of a compound according to claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
512258 |
Jun 1986 |
CAX |
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Parent Case Info
This application is a continuation-in-part of application Ser. No. 751,348, filed July 2, 1985 now abandoned, in turn a continuation-in-part of application Ser. No. 624,302, filed June 25, 1984, now abandoned, in turn a continuation-in-part of application Ser. No. 527,583, filed Aug. 29, 1983, now abandoned.
US Referenced Citations (6)
Foreign Referenced Citations (1)
Number |
Date |
Country |
137242 |
Apr 1985 |
EPX |
Non-Patent Literature Citations (2)
Entry |
Maier et al., Chemical Abstracts, vol. 77, No. 61979n (1972). |
Diana et al., Chemical Abstracts, vol. 106, No. 213931y (1987). |
Continuation in Parts (3)
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Number |
Date |
Country |
Parent |
751348 |
Jul 1985 |
|
Parent |
624302 |
Jun 1984 |
|
Parent |
527583 |
Aug 1983 |
|