Claims
- 1. A method for making an isolated antibody specific for the variable region of the alpha subunit of a mammalian T lymphocyte receptor, wherein the antibody is produced by the method comprising:
- expressing the variable region of the alpha subunit of the T lymphocyte receptor in a genetically engineered host selected from the group consisting of procaryotic and eucaryotic cells;
- immunizing with the variable region; and
- isolating antibody specific for the variable region of the alpha subunit.
- 2. The method of claim 1 wherein the variable region of the alpha subunit of the mammalian T lymphocyte receptor is an immunoglobulin-like domain.
- 3. The method of claim 1 wherein the animal is immunized with the isolated variable region of the alpha subunit or a portion thereof.
- 4. The method of claim 1 wherein cells producing the antibody are isolated and used to make hybridomas expressing monoclonal antibodies specific for the variable region of the alpha subunit of a mammalian T lymphocyte receptor.
- 5. The method of claim 1 wherein the antibody is a human antibody.
Parent Case Info
This application is a divisional of U.S. patent application Ser. No. 07/943,296, filed Sep. 10, 1992, by Haruo Saito, David M. Kranz, Herman N. Eisen, and Susumu Tonegawa, entitled "Heterodimeric T Lymphocyte Receptor", now abandoned, which is a continuation of U.S. Ser. No. 07/271,216, filed Nov. 14, 1988, now U.S. Pat. No. 5,189,147, which is a divisional of U.S. Ser. No. 06/666,988, filed Oct. 31, 1984, now U.S. Pat. No. 4,873,190, which is a continuation-in-part of U.S. Ser. No. 06/620,122, filed Jun. 13, 1984, now U.S. Pat. No. 4,874,845.
Government Interests
The U.S. government has rights in this invention by virtue of Grant No. NIH-5-PO1-CA28900-04, NIH-5-P30-CA14051-13 and the Arthritis Foundation.
Non-Patent Literature Citations (4)
Entry |
Berzofsky, Immunology Today 4: 299-301, 1983. |
Haskins et al, J. Exp. Med. 157: 1149-1169, 1983. |
Acuto et al. Cell 34: 717-726 Oct. 1983. |
Kapler et al. Cell 34: 727-737, 1983. |
Divisions (2)
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943296 |
Sep 1992 |
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Parent |
666988 |
Oct 1984 |
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Continuations (1)
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271216 |
Nov 1988 |
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Continuation in Parts (1)
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620122 |
Jun 1984 |
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