Claims
- 1. A thienodiazepine of the formula Ib: ##STR56## wherein U is a single bond, branched or unbranched C.sub.1-4 -alkylene, C.sub.3-4 -alkenylene or C.sub.3-4 -alkynylene;
- V is methylene or ethylene;
- R.sub.5 is hydrogen or methyl;
- R.sub.6 is hydrogen, cyclopropyl or a group of formula ##STR57## wherein K is hydrogen, CF.sub.3 or halogen; and
- .alpha. is an integer selected from 1, 2, 3, 4 and 5
- R.sub.7 is a group of formula ##STR58## wherein L is hydrogen, F, Cl, Br, methyl, CF.sub.3, CH.sub.3 O.sub.2 S, alkoxy or hydroxy; and
- .beta. is an integer selected from 1, 2, 3, 4, and 5,
- wherein if .alpha. or .beta. is greater than 1, all the Ks or Ls may be identical, partially identical or different.
- 2. The thienodiazepine:
- s-(-)-3-((4-trifluoromethylbenzyl)propylaminocarbonyl)-5-(2-chlorophenyl)-10-methyl-7H-cyclopenta�4,5!thieno-�3,2-f!�1,2,4!-triazolo-�4,3-a!�1,4!-diazepine.
- 3. A pharmaceutical composition of matter comprising a compound as recited in claim 1 or 2 and a pharmaceutically acceptable carrier.
- 4. A method of treating diseases in a warm-blooded animal induced by endogenously formed PAF which comprises administering to said animal a therapeutically effective amount of a compound as recited in claim 1 or 2.
Priority Claims (1)
Number |
Date |
Country |
Kind |
40 27 470.5 |
Aug 1990 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 08/290,169, filed Aug. 15, 1994, now abandoned which is a continuation of application Ser. No. 08/071,159, filed Jun. 2, 1993 (abandoned), which is a continuation of application Ser. No. 07/927,096, filed Aug. 7, 1992 (abandoned), which is a continuation of application Ser. No. 07/750,374 filed Aug. 27, 1991 (abandoned).
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Number |
Name |
Date |
Kind |
4621083 |
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Nov 1986 |
|
4900729 |
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Feb 1990 |
|
4937240 |
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Jun 1990 |
|
4968794 |
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Nov 1990 |
|
5104543 |
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|
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Country |
2012411 |
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CAX |
254245 |
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EPX |
407955 |
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EPX |
Non-Patent Literature Citations (9)
Entry |
US patent application 821,640 (Weber et al.), filed 23, Jan. 1986 (now abandoned). |
US patent application 005,992 (Stransky et al.), filed 21 Jan. 1987 (now abandoned). |
US patent application 076,515(Weber et al.), filed 22 Jul. 1987 (now abandoned). |
US patent application 346,862 (Heuer et al.), filed 3 May 1989 (now abandoned). |
US patent application 348,364 (Heuer et al.), filed 8 May 1989 (now abandoned). |
US patent application 433,075 (Weber et al.), filed 6 Nov. 1989 (now abandoned). |
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Divisions (1)
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Number |
Date |
Country |
Parent |
290169 |
Aug 1994 |
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Continuations (3)
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Number |
Date |
Country |
Parent |
71159 |
Jun 1993 |
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Parent |
927096 |
Aug 1992 |
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Parent |
750374 |
Aug 1991 |
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