The invention is directed to the field of posterior capsule opacification.
The human eye often suffers from aberrations such as defocus and astigmatism that must be corrected to provide acceptable vision to maintain a high quality of life. Correction of these defocus and astigmatism aberrations can be accomplished using a lens. The lens can be located at the spectacle plane, at the corneal plane (a contact lens or corneal implant), or within the eye as a phakic (crystalline lens intact) or aphakic (crystalline lens removed) intraocular lens (IOL).
In addition to the basic aberrations of defocus and astigmatism, the eye often has higher-order aberrations such as spherical aberration and other aberrations. Chromatic aberrations, aberrations due to varying focus with wavelength across the visible spectrum, are also present in the eye. These higher-order aberrations and chromatic aberrations negatively affect the quality of a person's vision. The negative effects of the higher-order and chromatic aberrations increase as the pupil size increases. Vision with these aberrations removed is often referred to as high definition (HD) vision.
Presbyopia is the condition where the eye loses its ability to focus on objects at different distances. Aphakic eyes have presbyopia. A standard monofocal IOL implanted in an aphakic eye will restore vision at a single focal distance. To provide good vision over a range of distances, a variety of options can be applied, among them, using a monofocal IOL combined with bi-focal or progressive addition spectacles. A monovision IOL system is another option to restore near and distance vision—one eye is set at a different focal length than the fellow eye, thus providing binocular summation of the two focal points and providing blended visions.
Monovision is currently the most common method of correcting presbyopia by using IOLs to correct the dominant eye for distance vision and the non-dominant eye for near vision in an attempt to achieve spectacle-free binocular vision from far to near. Additionally IOLs can be bifocal or multifocal. Most IOLs are designed to have one or more focal regions distributed within the addition range. However, using elements with a set of discrete foci is not the only possible strategy of design: the use of elements with extended depth of field (EDOF), that is, elements producing a continuous focal segment spanning the required addition, can also be considered. These methods are not entirely acceptable as stray light from the various focal regions degrade a person's vision.
What is needed in the art is an improved virtual aperture IOL to overcome these limitations.
Disclosed is a virtual aperture integrated into an intraocular lens (IOL). The construction and arrangement permit optical rays which intersect the virtual aperture and are widely scattered across the retina, causing the light to be virtually prevented from reaching detectable levels on the retina. The virtual aperture helps remove monochromatic and chromatic aberrations, yielding high-definition retinal images. For a given definition of acceptable vision, the depth of field is increased over a larger diameter optical zone IOL. Eyes with cataracts can have secondary issues due to injury, previous eye surgery, or eye disorder that would not be well corrected with normal IOL designs. Examples of eyes with complications include: asymmetric astigmatism, keratoconus, postoperative corneal transplant, asymmetric pupils, very high astigmatism, and the like. Because of its ability to remove unwanted aberrations, our virtual aperture IOL design would be very effective in provided enhanced vision compared to normal large optic IOLs.
An objective of the invention is to teach a method of making thinner IOLs since the optical zone can have a smaller diameter, which allows smaller corneal incisions and easier implantation surgery. Eyes with cataracts can have secondary issues due to injury, previous eye surgery, or eye disorder that would not be well corrected with normal IOL designs. Examples of eyes with complications include: asymmetric astigmatism, keratoconus, postoperative corneal transplant, asymmetric pupils, very high astigmatism, and the like. Because of its ability to remove unwanted aberrations, the disclosed virtual aperture IOL design is effective in providing enhanced vision compared to normal large optic IOLs.
Another objective of the invention is to teach a virtual aperture IOL that exhibits reduced monochromatic and chromatic aberrations, as well as an extended depth of field, while providing sufficient contrast for resolution of an image over a selected range of distances.
Still another objective of the invention is to teach a virtual aperture IOL that provides a smaller central thickness compared to other equal-powered IOLs.
Another objective of the invention is to teach a virtual aperture that can be realized as alternating high-power positive and negative lens profiles.
Yet still another objective of the invention is to teach a virtual aperture that can be realized as high-power negative lens surfaces.
Another objective of the invention is to teach a virtual aperture that can be realized as high-power negative lens surfaces in conjunction with alternating high-power positive and negative lens profiles.
Yet another objective of the invention is to teach a virtual aperture that can be realized as prism profiles in conjunction with alternating high-power positive and negative lens profiles.
Still another objective of the instant invention is to overcome these limitations by providing a phakic or aphakic IOL which simultaneously: provides correction of defocus and astigmatism, decreases higher-order and chromatic aberrations, and provides an extended depth of field to improve vision quality.
Another objective of the invention is to teach a virtual aperture that can be employed in phakic or aphakic IOLs, a corneal implant, a contact lens, or used in a cornea laser surgery (LASIK, PRK, etc.) procedure to provide an extended depth of field and/or to provide high-definition vision.
Yet another objective is to provide an IOL for eyes with complications such as asymmetric astigmatism, keratoconus, postoperative corneal transplant, asymmetric pupils, very high astigmatism, and the like.
Still another objective is to provide an IOL capable of removing unwanted aberrations to provide enhanced vision compared to normal large optic IOLs.
Another objective of the invention is to teach replacement of the virtual aperture with an actual opaque aperture and realize the same optical benefits as the virtual aperture.
Other objectives and further advantages and benefits associated with this invention will be apparent to those skilled in the art from the description, examples and claims which follow.
Detailed embodiments of the instant invention are disclosed herein; however, it is to be understood that the disclosed embodiments are merely exemplary of the invention, which may be embodied in various forms. Therefore, specific functional and structural details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a representation basis for teaching one skilled in the art to variously employ the present invention in virtually any appropriately detailed structure.
The optical principle represented here is that as the height of parallel incident rays is reduced, the corresponding blur circle is also reduced. This simple relationship is applicable to the human eye. Stated another way, for a given amount of defocus (dioptric error) in the eye, vision is improved as the height of incident rays is reduced. This principle is used when someone squints in an attempt to see an out-of-focus object more clearly.
The tracing in
In the preferred embodiment, the virtual aperture zone is a sequence of high-power positive and negative lens profiles. Thus, light rays which intersect this region are dispersed widely downstream from the IOL. These profiles could be realized as sequential conics, polynomials (such as Bezier functions), rational splines, diffractive profiles, or other similar profiles, as long as the entire region properly redirects and/or disperses the refracted rays. The preferred use is smooth high-power profiles over diffractive profiles as this simplifies manufacturing the IOL on a high-precision lathe or with molds. As known to those skilled in the art, the posterior side of the haptic should include a square edge to inhibit cell growth leading to posterior capsule opacification.
Taken together, these characteristics of an IOL which incorporates the virtual aperture can accurately be described as high definition (HD) and extended depth of field (EDOF).
The basic layout of the virtual aperture IOL is illustrated in
Spherical, Toric and zero aberrations optic zone. A significant portion of cataract patients have astigmatism in their cornea. After removal of the crystalline lens, the remaining optical system of the astigmatic cornea eye is ideally corrected with a toric, or astigmatic lens. For these patients, the central optical portion of our lens is made toric to provide improved visual correction. In addition, even though the optical portion is small, there is still some amount of spherical aberrations that could be corrected. Thus, the optimally corrected optical zone would provide spherical aberration correction for all lenses and toric correction for those patients who have corneal astigmatism.
The toric correction is easily made by those skilled in the art by providing two principle powers at two principle directions which would be aligned with the eye's corneal astigmatic powers.
The spherical aberrations for either the spherical or toric lens are corrected by employing a conic profile on one or more surfaces of the lens. Such a lens is said to have zero aberrations as there are zero monochromatic aberrations in the lens for an on-axis, distant object. The apical radius Ra of the conic profile is computed as usual for the desired paraxial power of the lens. A conic constant K is then selected based upon the lens material index of refraction, the lens center thickness, and the shapes of the front and back surface of the lens.
In the case where the correction is to be astigmatic, at least one of the lens surface shapes is biconic, having a conic profile in two orthogonal principal directions. In the preferred embodiment, the toric optic has an equal biconvex surface design where each surface is biconic. The non-toric optic has an equal biconvex surface design where each surface is conic. In both the biconic or conic surface case, the optimal conic constant K for the surfaces is determined using optical ray tracing known to those skilled in the art.
Multiple focal points. Some patients may prefer a multi-focal point optic providing vision correction for specific distances. One example is a bifocal optic which generally provides focusing power for both near and distant vision. Another example is a trifocal optic which provides focusing power for near, intermediate, and distant vision. In either case, to implement the multi-focal points IOL, the optical zone is modified to yield these focal zones using refractive or diffractive optical regions and the virtual aperture remains outside the last focal zone.
In some applications, the virtual aperture can appear as an annular region with optical zones on each side of the annular region. The shape of the annular virtual aperture can also be free form, for example to accommodate an astigmatic optical zone or non-symmetric haptic region. This is illustrated in
The IOL designs contemplated here can be made of any biocompatible optical material normally used for IOLs including hard and soft materials. They also can be manufactured using CNC machines or molds or other methods used to manufacture IOLs. The virtual aperture can be implemented as a one-dimensional profile that is symmetric in the azimuthal direction or a two-dimensional profile that implements tiny lens regions.
In
In
Alternatively, the two-dimensional high-power lenses could be all positive or all negative lenses. In this case, the high-power lenses are separated by small smooth transition regions (for example, a continuous polynomial interpolator such as a Bezier curve) to prevent visual artifacts. This is the preferred two-dimensional high-power lens structure when there is more than one lens sample rate in the azimuth direction. In this case, the individual lenses look like small pillows where the pillows are above the base surface for positive power lenses and are below the surface for negative power lenses.
The central optical zone can be designed using standard IOL design concepts to provide sphere, cylinder, and axis correction, as well as higher-order correction such as spherical aberration control. These design concepts are known to those skilled in the art.
The preferred virtual aperture profiles illustrated in
Using the preferred virtual aperture profiles illustrated in
The IOL design provides very good, high-definition, distance vision and the range of “clear vision” can be controlled by specification of what is meant by “clear vision” (e.g., 20/40 acuity), and the relative size of the central optic zone and the virtual aperture width. A simple equation [Smith G, Relation between spherical refractive error and visual acuity, Optometry Vis. Sci. 68, 591-8, 1991] for estimating the acuity given the pupil diameter and spherical refractive error is given in equation (1a and 1b).
A=kDE (1A)
A=√{square root over (1+(kDE)2)} (1b)
The second equation is postulated as being more accurate for low levels of refractive error, and gives a reasonable result.
For E=0, A=1 min of arc or 20/20.
Solving (1b) for E yields equation (2).
Equation (1b) tells us the acuity A given the range of depth of field (E×2) in diopters and the pupil diameter D.
Equation (2) tells the range of depth of field in diopters given the acuity A and the pupil diameter D. For example, for:
Acuity of 20/40, A=40/20=2 min arc
D=3.0 mm
k=0.65
Depth of field=2E=1.8 D. Using (1b),
A=√{square root over (1+(0.65×3.0×0.89)2)}=2
The concept of the virtual aperture can be employed in phakic or aphakic IOLs, a corneal implant, a contact lens, or used in a cornea laser surgery (LASIK, PRK, etc.) procedure to provide an extended depth of field and/or to provide high-definition vision. Also, it would be possible to replace the virtual aperture with an actual opaque aperture and realize the same optical benefits as the virtual aperture.
It is to be understood that while a certain form of the invention is illustrated, it is not to be limited to the specific form or arrangement herein described and shown. It will be apparent to those skilled in the art that various changes may be made without departing from the scope of the invention and the invention is not to be considered limited to what is shown and described in the specification and any drawings/figures included herein.
One skilled in the art will readily appreciate that the present invention is well adapted to carry out the objectives and obtain the ends and advantages mentioned, as well as those inherent therein. The embodiments, methods, procedures and techniques described herein are presently representative of the preferred embodiments, are intended to be exemplary and are not intended as limitations on the scope. Changes therein and other uses will occur to those skilled in the art which are encompassed within the spirit of the invention and are defined by the scope of the appended claims. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention which are obvious to those skilled in the art are intended to be within the scope of the following claims.
In accordance with 37 C.F.R. § 1.76 a claim of priority is included in an Application Data Sheet filed concurrently herewith. Accordingly, the present invention is a Continuation-in-Part of U.S. patent application Ser. No. 14/686,233 entitled “HIGH DEFINITION AND EXTENDED DEPTH OF FIELD INTRAOCULAR LENS” filed Apr. 14, 2015. The contents of the above referenced application are incorporated herein by reference.
Number | Name | Date | Kind |
---|---|---|---|
4976732 | Vorosmarthy | Dec 1990 | A |
5121980 | Cohen | Jun 1992 | A |
5628794 | Lindstrom | May 1997 | A |
5662706 | Legerton et al. | Sep 1997 | A |
5693094 | Young et al. | Dec 1997 | A |
5965330 | Evans et al. | Oct 1999 | A |
5980040 | Xu et al. | Nov 1999 | A |
6221067 | Peyman | Apr 2001 | B1 |
6874886 | Miller et al. | Apr 2005 | B2 |
6949093 | Peyman | Sep 2005 | B1 |
7287852 | Fiala | Oct 2007 | B2 |
7350918 | Clough et al. | Apr 2008 | B2 |
7491350 | Silvestrini | Feb 2009 | B2 |
7628810 | Christie et al. | Dec 2009 | B2 |
7976577 | Silvestrini | Jul 2011 | B2 |
8079706 | Silvestrini et al. | Dec 2011 | B2 |
D656526 | Christie et al. | Mar 2012 | S |
8241354 | Hong et al. | Aug 2012 | B2 |
8287592 | Silvestrini | Oct 2012 | B2 |
8343215 | Miller et al. | Jan 2013 | B2 |
D681086 | Christie et al. | Apr 2013 | S |
8460374 | Christie et al. | Jun 2013 | B2 |
8740978 | Weeber et al. | Jun 2014 | B2 |
8747466 | Weeber et al. | Jun 2014 | B2 |
8752958 | Miller et al. | Jun 2014 | B2 |
8858624 | Christie et al. | Oct 2014 | B2 |
8864824 | Silvestrini et al. | Oct 2014 | B2 |
8974526 | Bogaert | Mar 2015 | B2 |
9005281 | Christie et al. | Apr 2015 | B2 |
9138142 | Christie et al. | Sep 2015 | B2 |
9204962 | Silvestrini | Dec 2015 | B2 |
9427311 | Christie et al. | Aug 2016 | B2 |
9427922 | Reboul et al. | Aug 2016 | B2 |
9492272 | Christie et al. | Nov 2016 | B2 |
9545303 | Vilupuru et al. | Jan 2017 | B2 |
9573328 | Reboul et al. | Feb 2017 | B2 |
9603704 | Silvestrini | Mar 2017 | B2 |
9636215 | Rosen et al. | May 2017 | B2 |
9844919 | Reboul et al. | Dec 2017 | B2 |
9848979 | Vilupuru et al. | Dec 2017 | B2 |
9943403 | Webb et al. | Apr 2018 | B2 |
10004593 | Webb et al. | Jun 2018 | B2 |
10183453 | Reboul et al. | Jan 2019 | B2 |
10765510 | Sarver et al. | Sep 2020 | B2 |
20010050750 | Breger | Dec 2001 | A1 |
20030144733 | Brady et al. | Jul 2003 | A1 |
20030199976 | Portney | Oct 2003 | A1 |
20040230299 | Simpson et al. | Nov 2004 | A1 |
20050046794 | Silvestrini et al. | Mar 2005 | A1 |
20050125055 | Deacon et al. | Jun 2005 | A1 |
20060113054 | Silvestrini | Jun 2006 | A1 |
20060184243 | Yilmaz | Aug 2006 | A1 |
20060235428 | Silvestrini | Oct 2006 | A1 |
20060265058 | Silvestrini | Nov 2006 | A1 |
20060271184 | Silvestrini | Nov 2006 | A1 |
20070198084 | Cumming et al. | Aug 2007 | A1 |
20080269886 | Simpson et al. | Oct 2008 | A1 |
20080269890 | Simpson | Oct 2008 | A1 |
20080269891 | Hong et al. | Oct 2008 | A1 |
20090033863 | Blum et al. | Feb 2009 | A1 |
20090069817 | Peyman | Mar 2009 | A1 |
20090268155 | Weeber | Oct 2009 | A1 |
20090306773 | Silversrini et al. | Dec 2009 | A1 |
20110172675 | Danta et al. | Jul 2011 | A1 |
20120330415 | Callahan et al. | Dec 2012 | A1 |
20130053953 | Silvestrini | Feb 2013 | A1 |
20130238091 | Danta et al. | Sep 2013 | A1 |
20130289668 | Nirenberg et al. | Oct 2013 | A1 |
20140052245 | Zickler et al. | Feb 2014 | A1 |
20140131905 | Webb | May 2014 | A1 |
20140172088 | Carson et al. | Jun 2014 | A1 |
20150025627 | Christie et al. | Jan 2015 | A1 |
20150366658 | Christie et al. | Dec 2015 | A1 |
20160157997 | Gerlach | Jun 2016 | A1 |
20160193037 | Pinto et al. | Jul 2016 | A1 |
20160302916 | Sarver et al. | Oct 2016 | A1 |
20170143477 | Christie et al. | May 2017 | A1 |
20170156850 | Silvestrini | Jun 2017 | A1 |
20180125639 | Vilupuru et al. | May 2018 | A1 |
20180296322 | Webb et al. | Oct 2018 | A1 |
20180338826 | Link et al. | Nov 2018 | A1 |
20190076235 | Webb et al. | Mar 2019 | A1 |
20190076242 | Pinto | Mar 2019 | A1 |
20190307556 | Sarver et al. | Oct 2019 | A1 |
20210228337 | Sarver et al. | Jul 2021 | A1 |
20210298893 | Sarver et al. | Sep 2021 | A1 |
Number | Date | Country |
---|---|---|
WO0115635 | Mar 2001 | WO |
WO2006054178 | May 2006 | WO |
WO2008137425 | Nov 2008 | WO |
WO-2010100523 | Sep 2010 | WO |
WO-2016142736 | Sep 2016 | WO |
WO2016167906 | Oct 2016 | WO |
Entry |
---|
Nishi, Y. et al. (2015). “Visual Simulation of Retinal Images with Various Designs of Pinhole Contact Lenses.” JSM Ophthalmol. 3(1):1025 (5 pages). |
Yaish, S.B. et al. (2010). “Intraocular Omni-focal Lens With Increased Tolerance to Decentration and Astigmatism.” J Refract Surg. 26(1):71-76. |
Smith, George (1991) “Relation between Spherical Refractive Error and Visual Acuity” Optometry Vis. Sci., vol. 68, No. 8, pp. 591-598. |
Number | Date | Country | |
---|---|---|---|
20190231518 A1 | Aug 2019 | US |
Number | Date | Country | |
---|---|---|---|
Parent | 14686233 | Apr 2015 | US |
Child | 16380622 | US |