Claims
- 1. A two-stage method for preparing an acrylic, high refractive index ophthalmic device material, wherein the ophthalmic device material comprises
(i) at least one aryl acrylic hydrophobic monomer of the formula
2wherein: X is H or CH3; m is0-10; Y is nothing, O, S, or NR wherein R is H, CH3, CnH2n+1 (n=1-10) iso OC3H7, C6H5, or CH2C6H5; Ar is any aromatic ring which can be unsubstituted or substituted with CH3, C2H5, n-C3H7, iso-C3H7, OCH3, C6H11, Cl, Br, C6H5, or CH2C6H5; (ii) a first stage polymerization initiator selected from the group consisting of photoinitiators and thermal free radical initiators having a 10 hr t½ of about 55° C. or less; and (iii) a second stage cross-linking agent where the second stage cross-linking agent is a thermal free radical initiator having a 10 hr t1/2 of about 50° C. or greater if the first stage polymerization initiator is a photoinitiator and the second stage cross-linking agent is a thermal free radical initiator having a 10 hr t½ of about 65° C. or greater if the first stage polymerization initiator is a thermal free radical initiator having a 10 hr t1/2 of about 55° C. or less, wherein the first stage of the method comprises polymerizing the ophthalmic device material by activating the first stage polymerization initiator without activating the second stage cross-linking agent; and the second stage of the method comprises cross-linking the ophthalmic device material by activating the second stage cross-linking agent.
- 2. The method of claim 1 wherein the aryl acrylic hydrophobic monomers is selected from the group consisting of 2-phenoxyethyl acrylate; 2-phenylethylthio acrylate; 2-phenylethylamino acrylate; phenyl acrylate; benzyl acrylate; 2-phenylethyl acrylate; 3-phenylpropyl acrylate; 3-phenoxypropyl acrylate; 4-phenylbutyl acrylate; 4-phenoxybutyl acrylate; 4-methylphenyl acrylate; 4-methylbenzyl acrylate; 2-2-methylphenylethyl acrylate; 2-3-methylphenylethyl acrylate; 2-4-methylphenylethyl acrylate; and their corresponding methacrylate compounds.
- 3. The method of claim 1 wherein m is 2-4; Y is nothing or O; and Ar is phenyl.
- 4. The method of claim 1 wherein the ophthalmic device material comprises at least two aryl acrylic hydrophobic monomers of Formula (I) and further wherein at least one of the aryl acrylic hydrophobic monomers is a methacrylate monomer and at least one of the aryl acrylic hydrophobic monomers is an acrylate monomer.
- 5. The method of claim 4 wherein the ophthalmic device materials comprise a total of at least 50% (w/w) of aryl acrylic hydrophobic monomers of Formula (I).
- 6. The method of claim 5 wherein the ophthalmic device materials comprise a total of at least 70% (w/w) of aryl acrylic hydrophobic monomers of Formula (I).
- 7. The method of claim 1 wherein the ophthalmic device material further comprises one or more monomers selected from the group consisting of C1-C8 alkylacrylates; C1-C8 cycloalkylacrylates; C1-C8 N-alkylacrylamides; C1-C8 phenoxyalkylacrylates; and their corresponding methacrylates.
- 8. The method of claim 1 wherein the first stage polymerization initiator is selected from group consisting of thermal free radical initiator having a 1 0 hr t½ of about 50° C. or less; UV-photoinitiators; and blue-light photoinitiators.
- 9. The method of claim 1 wherein the first stage polymerization initiator is a blue-light photoinitiator.
- 10. The method of claim 1 wherein the amount of the first stage polymerization initiator is about 3% (w/w) or less.
- 11. The method of claim 9 wherein the second stage cross-linking agent is selected from the group consisting of dibenzoyl peroxide; 2, 4-dichlorodibenzoylperoxide; and dicumyl peroxide.
- 12. The method of claim 1 wherein the amount of the second stage cross-linking agent is about 2-5% (w/w).
- 13. The method of claim 1 wherein the ophthalmic device material further comprises one or more ingredients selected from the group consisting of UV absorbing compounds and blue-light absorbing compounds.
Parent Case Info
[0001] This application is a continuation-in-part application of co-pending U.S. patent application Ser. No. 09/283,592, filed Apr. 1, 1999, which claims priority from U.S. Provisional Patent Application Serial No. 60/081,874, filed Apr. 15, 1998.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60081874 |
Apr 1998 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09283592 |
Apr 1999 |
US |
Child |
09766493 |
Jan 2001 |
US |