High-Resolution Ion Beam Probe for Biological Research

Information

• Research Project
• 6550912

• ApplicationId

  6550912

• Core Project Number

  R43EB000387

• Full Project Number

  1R43EB000387-01

• Serial Number

  387

• FOA Number

• Sub Project Id

• Project Start Date

  8/1/2002 - 23 years ago

• Project End Date

  7/31/2003 - 22 years ago

• Program Officer Name

  SWAIN, AMY L

• Budget Start Date

  8/1/2002 - 23 years ago

• Budget End Date

  7/31/2003 - 22 years ago

• Fiscal Year

  2002

• Support Year

  1

• Suffix

• Award Notice Date

  7/19/2002 - 23 years ago

Organizations

• FM TECHNOLOGIES, INC.

DESCRIPTION (provided by applicant): Mapping the distribution of targeted chemical species in tissues is important in many areas of biology and medicine. These measurements require a highly sensitive methodology giving an accurate measure of the minute quantities of material in cells as well as the spatial resolution distinguishing organelles. Secondary Ion Mass Spectroscopy (SIMS) has intrinsic merits to serve this purpose. Much higher resolution, than the currently available value of 0.5 micrometer, is desired to make a strong headway with SIMS for ultra-fine imaging at cellular and sub-cellular level. The primary demand to achieve this goal is a high-brightness ion beam probe at low energy, using either oxygen or cesium species.The proposed work aims at developing a novel, high-brightness ion-optical column for SIMS and achieving a target spot size of about 10-20 nanometer and a current density of -1 ampere per square centimeter for oxygen ions.Success of this work will cross the present technological barrier for addressing several fundamental problems in cell biology relevant to the studies of carcinogenesis, toxicology, neurochemistry and the diagnosis of several diseases including cancer. Additionally, this project will immediately benefit many other areas in biology and medicine and nanotechnology overall.

IC Name

• Activity

  R43

• Administering IC

  EB

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  100560

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  286

• Ed Inst. Type

• Funding ICs

  NIBIB:100560\

• Funding Mechanism

• Study Section

  ZRG1

• Study Section Name

  Special Emphasis Panel

• Organization Name

  FM TECHNOLOGIES, INC.

• Organization Department

• Organization DUNS

• Organization City

  CHANTILLY

• Organization State

  MD

• Organization Country

  UNITED STATES

• Organization Zip Code

  201514010

• Organization District

  UNITED STATES