Claims
- 1. A medical or surgical implant, film, or graft composition comprising:
- a non-polymeric, non-water soluble, high viscosity liquid carrier material having a viscosity of at least 5000 cP at 37.degree. C. that does not crystallize neat under ambient or physiological conditions.
- 2. The medical or surgical implant, film, or graft composition according to claim 1, wherein the non-polymeric, non-water soluble, high viscosity liquid carrier material is sucrose acetate isobutyrate.
- 3. The medical or surgical implant, film, or graft composition according to claim 1, wherein the non-polymeric, non-water soluble, high viscosity liquid carrier material has a viscosity of at least 10,000 cP at 37.degree. C.
- 4. The medical or surgical implant, film, or graft composition according to claim 3, wherein the non-polymeric, non-water soluble, high viscosity liquid carrier material has a viscosity of at least 15,000 cP at 37.degree. C.
- 5. The medical or surgical implant, film, or graft composition according to claim 4, wherein the non-polymeric, non-water soluble, high viscosity liquid carrier material has a viscosity of at least 20,000 cP at 37.degree. C.
- 6. The medical or surgical implant, film, or graft composition according to claim 5, wherein the non-polymeric, non-water soluble, high viscosity liquid carrier material has a viscosity of at least 25,000 cP at 37.degree. C.
- 7. The medical or surgical implant, film, or graft composition according to claim 6, wherein the non-polymeric, non-water soluble, high viscosity liquid carrier material has a viscosity of at least 50,000 cP at 37.degree. C.
- 8. The medical or surgical implant, film, or graft composition according to claim 1, wherein the non-polymeric, non-water soluble, high viscosity liquid carrier material further comprises an additive.
- 9. The medical or surgical implant, film, or graft composition according to claim 8, wherein the additive is selected from the group consisting of biodegradable polymers, non-biodegradable polymers, natural oils, synthetic oils, carbohydrates, carbohydrate derivatives, inorganic salts, and inert organic compounds.
- 10. The medical or surgical implant, film, or graft composition according to claim 1, further comprising a biologically active substance for controlled delivery.
- 11. The medical or surgical implant, film, or graft composition according to claim 1, which is a block for surgical adhesions.
- 12. The medical or surgical implant, film, or graft composition according to claim 1, which is a void filler in biological tissue.
- 13. The medical or surgical implant, film, or graft composition according to claim 1, which is a guide for tissue regeneration.
- 14. The medical or surgical implant, film, or graft composition according to claim 1, which is a hemostat.
- 15. The medical or surgical implant, film, or graft composition according to claim 1, which is a tissue adhesive.
- 16. The medical or surgical implant, film, or graft composition according to claim 1, which is a biological tissue scaffold.
- 17. The medical or surgical implant, film, or graft composition according to claim 1, which is a wound dressing.
- 18. The medical or surgical implant, film, or graft composition according to claim 2, wherein the non-polymeric non-water soluble liquid carrier material is present in an amount from about 99.5 percent to about 10 percent by weight, relative to the total weight of the composition.
- 19. The medical or surgical implant, film, or graft composition according to claim 2, wherein the non-polymeric non-water soluble liquid carrier material is present in an amount from about 99.5 percent to about 25 percent by weight, relative to the total weight of the composition.
- 20. A medical or surgical implantable or sprayable composition comprising a mixture of:
- (a) a non-polymeric, non-water soluble, high viscosity liquid carrier material having a viscosity of at least 5000 cP at 37.degree. C. that does not crystallize neat under ambient or physiological conditions; and
- (b) a solvent in which the non-polymeric, non-water soluble liquid carrier material is soluble;
- wherein the mixture has a viscosity of less than approximately 1000 cP at 37.degree. C.
- 21. The medical or surgical implantable or sprayable composition according to claim 20, wherein the solvent is selected from the group consisting of ethanol, dimethylsulfoxide, ethyl lactate, ethyl acetate, benzyl alcohol, triacetin, 2-pyrrolidone, N-methylpyrrolidone, propylene carbonate, glycofurol, and any aerosol propellant.
- 22. The medical or surgical implantable or sprayable composition according to claim 20, wherein the solvent in which the non-polymeric, non-water soluble liquid carrier material is soluble is present in an amount of from about 10 to about 50% by weight, relative to the weight of the implantable or sprayable composition.
- 23. A method for the in vivo formation an implant, film, or graft in a patient in need thereof, comprising:
- (1) contacting a mixture comprising:
- (a) a non-polymeric, non-water soluble, high viscosity liquid carrier material having a viscosity of at least 5000 cP at 37.degree. C. that does not crystallize neat under ambient or physiological conditions; and
- (b) a solvent in which the non-polymeric, non-water soluble liquid carrier material is soluble;
- wherein the mixture has a viscosity of less than approximately 1000 cP at 37.degree. C.
- with the tissue of the patient; and
- (2) allowing the solvent to dissipate or diffuse into the tissue of the patient, thereby forming an implant, film, or graft of the non-polymeric, non-water soluble, high viscosity liquid carrier material.
- 24. The method according to claim 23, wherein said contacting comprises coating a vascular graft with said mixture and implanting said vascular graft in the patient.
- 25. The method according to claim 23, wherein said contacting comprises injection said mixture into a vessel or cavity in the tissue of the patient.
- 26. The method according to claim 23, wherein said contacting comprises spraying the mixture onto the tissue of the patient.
- 27. The method according to claim 23, wherein said contacting comprises spreading a paste comprising the mixture onto the tissue of the patient.
Parent Case Info
This application is a continuation-in-part of U.S. Ser. No.: 08/478,450, filed Jun. 7, 1995, now abandoned, and a continuation-in-part of U.S. Ser. No. 08/474,337, filed Jun. 7, 1995, now U.S. Pat. No. 5,747,058.
US Referenced Citations (11)
Foreign Referenced Citations (1)
Number |
Date |
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1 569 231 |
Aug 1969 |
DEX |
Continuation in Parts (1)
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Number |
Date |
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Parent |
478450 |
Jun 1995 |
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