HOLLOW-FIBER DEVICE FOR REMOVING IL-1 IN HEMATOPOIESIS

Information

  • Research Project
  • 2221396
  • ApplicationId
    2221396
  • Core Project Number
    R44HL044227
  • Full Project Number
    5R44HL044227-03
  • Serial Number
    44227
  • FOA Number
  • Sub Project Id
  • Project Start Date
    3/1/1992 - 32 years ago
  • Project End Date
    8/31/1994 - 29 years ago
  • Program Officer Name
  • Budget Start Date
    9/1/1993 - 30 years ago
  • Budget End Date
    8/31/1994 - 29 years ago
  • Fiscal Year
    1993
  • Support Year
    3
  • Suffix
  • Award Notice Date
    8/20/1993 - 30 years ago
Organizations

HOLLOW-FIBER DEVICE FOR REMOVING IL-1 IN HEMATOPOIESIS

DESCRIPTION: (Adapted from investigator's abstract) One goal of medical research on hematopoiesis is to be able to duplicate the process in vitro for treatment of disease. However, a major complication of this process is that the same factors that stimulate cell growth (i.e., interleukins and colony-stimulating factors) also stimulate unwanted cell differentiation. The overall goal of this research is to develop a hollow-fiber device that selectively removes growth factors from cell-culture media. Phase I established the technical feasibility of the approach by demonstrating that antibodies for a specific growth factor, Interleukin-1 (IL-I), could be immobilized in a hollow-fiber device and used to remove greater than 99% of the IL-1 from cell-culture media at a practical rate and capacity. The objective of Phase II is to immobilize antibodies for other important growth factors (GM-CSF, IL-4, TFG-beta, IL-7, and G-CSF) on hollow fibers and to use modules made from these fibers to elucidate the effect of these growth factors on stem cell growth and differentiation. Experiments will be conducted in which selected growth factors are removed from culture and the resulting effect on cell growth and differentiation quantified. In addition, long-term (5- to 7-week) tests of marrow cell cultures will be conducted in which specific inhibitory factors are removed, with the objective being to determine the requirements for stem cell proliferation.

IC Name
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
  • Activity
    R44
  • Administering IC
    HL
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    839
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    HEM
  • Study Section Name
    Hematology Subcommittee 2
  • Organization Name
    BEND RESEARCH, INC.
  • Organization Department
  • Organization DUNS
  • Organization City
    BEND
  • Organization State
    OR
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    977018583
  • Organization District
    UNITED STATES