Holographic Decoding of Biochemical Libraries

Information

  • Research Project
  • 6642628
  • ApplicationId
    6642628
  • Core Project Number
    R43EB000926
  • Full Project Number
    1R43EB000926-01
  • Serial Number
    926
  • FOA Number
  • Sub Project Id
  • Project Start Date
    5/1/2003 - 22 years ago
  • Project End Date
    4/30/2004 - 21 years ago
  • Program Officer Name
    KORTE, BRENDA
  • Budget Start Date
    5/1/2003 - 22 years ago
  • Budget End Date
    4/30/2004 - 21 years ago
  • Fiscal Year
    2003
  • Support Year
    1
  • Suffix
  • Award Notice Date
    -
Organizations

Holographic Decoding of Biochemical Libraries

[unreadable] DESCRIPTION (provided by applicant): Nanohmics has developed a platform for decoding signatures of biochemical library compounds from randomly ordered arrays. The approach uses a novel holographic imaging technique to identify positive reactions with any compounds during a single image acquisition of the entire immobilized library. The premise for the method is three-dimensional contouring of micro/nanoparticle-labeled complements, or analyzes within the boundaries of a templated signature pattern. Signature patterns are generated on millions of copies of the same library compound using microlithographic processes to define the pattern. A single copy of each signature is liberated from the template surface into freestanding support structures able to diffuse into solution. Batch fabrication of the support structures can occur in parallel for different signature compounds in the library. The support structures for different compounds can be mixed to form libraries without the need for rebuilding the array or synthesizing new sequences each time a library is constructed. The method of holographic imaging has recently been demonstrated for defect detection in the semiconductor industry. Nanohmics plans to apply the method of digital holographic imaging for the analysis of bound biochemical species for the first time. This technique will enable ultra high throughput screening as the ability to simultaneous decode all the compounds in the library for a randomly ordered array offers superior advantage to serial microarraying processes. [unreadable] [unreadable]

IC Name
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
  • Activity
    R43
  • Administering IC
    EB
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    111345
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    287
  • Ed Inst. Type
  • Funding ICs
    NIBIB:111345\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    NANOHMICS, INC.
  • Organization Department
  • Organization DUNS
    100651798
  • Organization City
    AUSTIN
  • Organization State
    TX
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    78741
  • Organization District
    UNITED STATES