Claims
- 1. Conjugate of two haptens and one protein, coupled through a linker which linker is a compound of formula I ##STR3## wherein, R is an ester activating group;
- m & n are the same or different and are 0-6;
- q & s are 0 or 1; and
- p is 0 when s is 0, and p is 2-4 when s is 1 wherein the haptens are linked to the linker via the maleinimido groups of the linker, and the protein is linked to the linker via the ester-activating group of the linker.
- 2. Conjugate of claim 1, wherein the ester-activating group is a hydroxysuccinimide group.
- 3. Conjugate of claim 2, wherein the protein is an antibody.
- 4. Conjugate of two ED-.beta.-galactosidase units and one antibody, coupled through a linker which linker is a compound of formula I ##STR4## wherein, R is an ester activating group;
- m & n are the same or different and are 0-6;
- q & s are 0 or 1; and
- p is 0 when s is 0, and p is 2-4 when s is 1, wherein the ED-.beta.-galactosidase units are linked to the linker via the maleinimido groups of the linker, and the antibody is linked to the linker via the ester-activating group.
- 5. Conjugate of claim 4, wherein the ester-activating group is a hydroxysuccinimide group.
Priority Claims (1)
Number |
Date |
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Kind |
43 10 141.0 |
Mar 1993 |
DEX |
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Parent Case Info
This is a division, of application Ser. No. 08/219,469 filed on Mar. 29, 1994 now U.S. Pat. No. 5,519,142.
US Referenced Citations (5)
Foreign Referenced Citations (4)
Number |
Date |
Country |
0247866 |
May 1987 |
EPX |
0310361 |
Sep 1988 |
EPX |
0446071 |
Mar 1991 |
EPX |
9222583 |
Dec 1992 |
WOX |
Non-Patent Literature Citations (1)
Entry |
Derwent Abstract, 85-226374 of JP 60146154, cited under 85-226374 (1985). |
Divisions (1)
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Number |
Date |
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Parent |
219469 |
Mar 1994 |
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