HUMAN AND MURINE HYBRIDOMA ANTIBODIES IN ACUTE LEUKEMIAS

Information

• Research Project
• 3172843

• ApplicationId

  3172843

• Core Project Number

  R01CA035227

• Full Project Number

  5R01CA035227-03

• Serial Number

  35227

• FOA Number

• Sub Project Id

• Project Start Date

  9/15/1983 - 41 years ago

• Project End Date

  8/31/1986 - 38 years ago

• Program Officer Name

• Budget Start Date

  9/1/1985 - 39 years ago

• Budget End Date

  8/31/1986 - 38 years ago

• Fiscal Year

  1985

• Support Year

  3

• Suffix

• Award Notice Date

  -

Organizations

• COPENHAGEN, UNIVERSITY OF

The goal of this research is the characterization of human myeloid leukemia cells using murine and human monoclonal antibody techniques to provide reagents that will be useful in the diagnosis and treatment of human myeloid leukemia. Monoclonal antibodies will be produced against cell surface antigens on normal and malignant myeloid cells with emphasis on myeloid precursor cells and their differentiation products. This technology also includes recently developed procedures to expand normal antibody-producing B-lymphocyte cultures in large quantities by demethylation of cytosin in certain nucleotide sequences. The antigenic determinants for such antibodies will be biochemically characterized. Also included will be studies on the modulation potential of such antigens. (2)

IC Name

• Activity

  R01

• Administering IC

  CA

• Application Type

  5

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  394

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  EI

• Study Section Name

  Experimental Immunology Study Section

• Organization Name

  UNIVERSITY OF COPENHAGEN

• Organization Department

• Organization DUNS

• Organization City

  COPENHAGEN

• Organization State

• Organization Country

  DENMARK

• Organization Zip Code

• Organization District

  DENMARK