Claims
- 1. An isolated polynucleotide comprising a nucleotide sequence which hybridizes under stringent conditions to a sequence selected from the group consisting of SEQ ID NOS:1-2396.
- 2. An isolated polynucleotide comprising at least 15 contiguous nucleotides of a nucleotide sequence having at least 90% sequence identity to a sequence selected from the group consisting of: SEQ ID NOS:1-2396, a degenerate variant of SEQ ID NOS:1-2396, an antisense of SEQ ID NOS:1-2396, and a complement of SEQ ID NOS:1-2396.
- 3. A polynucleotide comprising a nucleotide sequence of an insert contained in a clone deposited as clone number xx of ATCC Deposit Number xx.
- 4. An isolated cDNA obtained by the process of amplification using a polynucleotide comprising at least 15 contiguous nucleotides of a nucleotide sequence of a sequence selected from the group consisting of SEQ ID NOS:1-2396.
- 5. The isolated cDNA of claim 4, wherein amplification is by polymerase chain reaction (PCR) amplification.
- 6. An isolated recombinant host cell containing the polynucleotide according to claims 1, 2, 3, or 4.
- 7. An isolated vector comprising the polynucleotide according to claims 1, 2, 3, or 4.
- 8. A method for producing a polypeptide, the method comprising the steps of:
culturing a recombinant host cell containing the polynucleotide according to claims 1, 2, 3, or 4, said culturing being under conditions suitable for the expression of an encoded polypeptide; recovering the polypeptide from the host cell culture.
- 9. An isolated polypeptide encoded by the polynucleotide according to claims 1, 2, 3, or 4.
- 10. An antibody that specifically binds the polypeptide of claim 9.
- 11. A method of detecting differentially expressed genes correlated with a cancerous state of a mammalian cell, the method comprising the step of:
detecting at least one differentially expressed gene product in a test sample derived from a cell suspected of being cancerous, where the gene product is encoded by a gene comprising an identifying sequence of at least one of SEQ ID NOS:1-2396; wherein detection of the differentially expressed gene product is correlated with a cancerous state of the cell from which the test sample was derived.
- 12. A library of polynucleotides, wherein at least one of the polynucleotides comprises the sequence information of the polynucleotide according to claims 1, 2, 3, or 4
- 13. The library of claim 12, wherein the library is provided on a nucleic acid array.
- 14. The library of claim 12, wherein the library is provided in a computer-readable format.
- 15. A method of inhibiting tumor growth by modulating expression of a gene product, the gene product being encoded by a gene identified by a sequence selected from the group consisting of SEQ ID NOS:1-2396.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of U.S. provisional application serial No. 60/188,609, filed Mar. 9, 2000, which application is incorporated herein by reference in its entirety.
Provisional Applications (1)
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Number |
Date |
Country |
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60188609 |
Mar 2000 |
US |