Krantz et al. (1990) J. Med. Chem. 33:464-479. |
H. Carp et al., Potential mechanism of emphysema: .alpha..sub.1 -Proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity, Proc. Natl. Acad. Sci. 770:2041-2045 (1982). |
L. J. Copp, et al. , Kinetics and mechanism of human leukocyte elastase inactivation by ynenol lactones Biochemistry 26:169-178 (1987). |
P. D. Edwards, Design, synthesis, and kinetic evaluation of a unique class of elastase inhibitors, the peptidyl .alpha.-Ketobenzoxazoles, and the X-ray crystal structure of the covalent complex between porcine pancreatic elastase and Ac-Ala-Pro-Val-2-Benzoxazole, J. Am. Chem. Soc. 114:1854-1863 (1992). |
L. Eskerot et al., Interactions of granulocyte proteases with inhibitors in rheumatoid arthritis, Adv. Exp. Med. Biol. 167:335-344 (1984). |
P. E. Finke, et al., Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol, J. Med. Chem. 35:3731-3744 (1992). |
J. W. Harper, et al., Reaction of serine proteases with substituted 3-Alkoxy-4-chloroisocoumarins and 3-Alkoxy-7-amino-4-chloroisocoumarins: New reactive mechanism-based inhibitors, Biochemistry 24:7200-7213 (1985). |
J. W. Harper, et al., Reaction of serine proteases with substituted isocoumarins: Discovery of 3,4-Dichloroisocoumarin, a new general mechanism based serine protease inhibitor, Biochemistry 24:1831-1841 (1985). |
C. H. Hassal et al., A new class of inhibitors of human leucocyte elastase, FEBS Lett. 183:201-205 (1985). |
M. A. Hernandez, et al., Effect of the 7-Amino substituent on the inhibitory potency of mechanism-based isocoumarin inhibitors for porcine pancreatic and human neutrophil elastases: A 1.85-.ANG.-X-ray structure of the complex between porcine pancreatic elastase and 7-[(N-Tosylphenylalanyl)amino]-4-chloro-3-methoxyisocoumarin, J. Med. Chem. 35:1121-1129 (1992). |
A. H. Jackson et al., Sputum sol-phase proteins and elastase activity in patients with systic fibrosis, J. Respir. Dis. 65:114-124 (1984). |
A. Janoff, Elastase in tissue injury, Annu. Rev. Med. 36:207-216 (1985). |
A. Janoff, Elastases and emphysema; Current assessment of the protease-antiprotease hypothesis, Am. Rev. Respir. Dis. 132:417-433 (1985). |
D. H. Kinder et al., Acylamino boronic acids and difluoroborane analogues of amino acids: Potent inhibitors of chymotrypsin and elastase, J. Med. Chem. 28:1917-1925 (1985). |
A. Krantz et al., Design and synthesis of 4H-3,1-Benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase, J. Med. Chem. 33:464-479 (1990). |
C.-B. Laurell et al., The electrophoretic .alpha..sub.1 -Antitrypsin deficiency, Scand. J. Clin. Lab. Invest. 15:132-140 (1963). |
S. Mehdi et al., The inhibition of human neutrophil elastase and cathepsin G by peptidyl 1,2-Dicarbonyl derivatives, Biochem. Biophys. Res. Commun. 166:201-205 (1990). |
T. A. Merritt et al., Elastase and .alpha..sub.1 -Proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome, J. Clin. Invest. 72:656-666 (1983). |
H. P. Schnebli, Recombinant elastase inhibitors for therapy, Ann. N.Y. Acad. Sci. 624:212-218 (1991). |
S. K. Shah, et al., Orally active .beta.-Lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-Diethyl-2-azetidinones, J. Med. Chem. 35:3745-3754 (1992). |
J. W. Skiles et al., Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones, J. Med. Chem. 35:641-662 (1992). |
R. A. Stockley et al., Proteinases in chronic lung infection Ann. N.Y. Acad. Sci. 624:257-266 (1991). |
J. C. Taylor et al., Pulmonary emphysema and proteolysis, New York: Academic Press, (1987). |
R. A. Wildonger et al., The in vitro and in vivo inhibition of human leukocyte elastase by .alpha.,.alpha.-difluoro-.beta.-ketoamides, in Eleventh American Symposium Abstracts, poster 87, presented at the University of California, San Diego, Jul. 9-14, 1989. |