Stationary tomosynthesis may be performed using a multi-source x-ray tube. Such a multi-source x-ray tube may include multiple emitters, such as nanotube emitters. While tomosynthesis may be performed using a multi-source x-ray tube, the dose may be insufficient to perform certain higher dose two-dimensional (2D) imaging.
Some embodiments relate to x-ray sources with multiple x-ray fluxes (representing different doses). Embodiments described herein may allow for tomosynthesis used in lower dose three-dimensional (3D) imaging (e.g., “3D” mammography) and either or both of higher dose two-dimensional (2D) imaging and magnification imaging. Different electron emitters—anode configurations may be used in an x-ray source with different x-ray fluxes appropriate for the different applications.
The emitters 102 and 104 may be any variety of emitters. For example, each of the emitters 102 and 104 may include a filament (e.g., coil filament emitter), a low work function (LWF) emitter, a field emitter, a dispenser cathode, a photo emitter, or the like. The emitters 102 and 104 may be the same or different types of emitters. For example, emitters 102 may be field emitters used in tomosynthesis while emitter 104 may be a filament used in 2D and/or magnification imaging.
The target 106 is a structure configured to generate x-rays in response to incident electron beams such as electron beams 108 and 110. The target 106 may include materials such as tungsten (W), molybdenum (Mo), rhodium (Rh), silver (Ag), rhenium (Re), palladium (Pd), or the like. In some embodiments, the target 106 is a linear target where the target length is 2 times, 5 times, 10 times, 20, or 50 times the target width (or height) with a length:width (or length:height) aspect ratio. In some embodiments, the linear target may be flat or in a curve, such as a continuous curve, a piecewise-linear curve, a combination of such curves, or the like. In some embodiments, the electron beams 108 and 110 from each of the emitters 102 and 104 may strike a different sections or portions of the target 106. In some embodiments, the electron beams 108 and 110 from the emitters 102 and 104 may strike at least three, five, or ten different sections or portions of the target 106.
In some embodiment, the x-rays emitted from the x-ray sources 101 may be directed towards a common location. For example, the x-ray source 101 may be oriented in a housing, gantry, or other structure such that the x-rays are directed towards a single point or region. When the system 100a is installed the point or region may be a location where an object, specimen, patient, or the like is placed. In some embodiments, the system may be mounted on a stationary structure or gantry. The placement and orientation of the x-ray source 101 may alleviate a need to rotate the system around an object, specimen, patient, or the like.
The combination of an emitter 102 or 104 and the target 106 forms an x-ray source 101a. For example, x-ray source 101a-0 includes emitter 104 and the target 106. X-ray sources 101a-1 to 101a-n each includes the corresponding emitter 102-1 to 102-n and the target 106. While a single target 106 has been illustrated as an example, as will be described in further detail below, each x-ray source 101 may include a different region of the target 106 or separate targets 106. As will be described in further detail below, the x-ray sources 101 may have other aspects such as different configurations of emitters 102 or 104, different targets 106 and/or regions of targets 106, or the like such that at least one of the x-ray sources 101 is different from another one of the x-ray sources 101. Here, x-ray source 101a-0 is different from the x-ray sources 101a-1 to 101a-n in that the emitters 102 are different from the emitter 104. In some embodiments, the emitters 102 may be identical. Thus, only one of the x-ray sources 101a, namely, the x-ray source 101a-0, is different from the others. However, in some embodiments, each of the x-ray sources 101 may be different. In other embodiments, different combinations of the emitters 102 and 104 may be the same while others are different.
While the emitters 102 and 104 may be similar, emitters 102 and 104 are configured such that a maximum current of a first electron beam 108 from one of the emitters 102 on a first focal spot on the target 106 is different from a second maximum current of a second electron beam 110 on a second focal spot on the target 106.
The maximum current is the maximum current achievable by the individual emitter 102 or 104 and the configuration of the corresponding portion of the target 106. While in some embodiments, the emitters 102 and 104 may be operated to have the same operating current, the emitters 102 and 104 and/or the target 106 are configured such that the maximum current achievable by the emitter 104 and target 106 can also be different. For example, one or more of the emitters 102 may have a maximum current that is not achievable with the configuration of the emitter 104 or the emitter 104 may have a maximum current that is not achievable by one or more of the emitters 102.
In some embodiments, the system 100a includes at least one emitter 102 and a single emitter 104. As will be described in further detail below, the emitters 102 and 104 may have some similarities; however, in operation and in combination with the corresponding focal spot and portion of the target 106, the emitter-target combination has a maximum current.
In some embodiments, the maximum current due to the emitter 104 and the corresponding portion of the target 106 is greater than the maximum current of a single emitter 102, such as emitter 102-1, and the corresponding portion of the target 106. In other embodiments, the relative maximum currents are reversed, so maximum currents of emitter 102 is greater than emitter 104. The maximum currents may be related by a factor of 1.5, 2, 10, 100, or more.
In some embodiments, the maximum current of the electron beam 110 may be greater or less than the maximum current of one of the electron beams 108. Accordingly, even with an identical portion of the target 106, the electron beams 108 may generate a different maximum current on the target 106 than the electron beam 110. For example, a maximum current of the electron beams 108 may be about 30 milliamperes (mA) while a maximum current of the electron beam 110 may be about 100 mA. In an example, the maximum current (e.g., first maximum current) of the electron beam (e.g., 110) from a first electron source (e.g., 101a-0) is at least twice (2 times), 3 times, 5 times, 10 times, 20 times, 50 times, or 100 times greater than the maximum current (e.g., second maximum current) of the electron beam (e.g., 108) from a second electron source (e.g., 101a-1). For example, the electron beams 108 from emitters 102 may be used in lower dose tomosynthesis while electron beam 110 from emitter 104 may be used in higher dose 2D and/or magnification imaging.
The system 100a may include any number of emitters 102, represented by emitters 102-1 to 102-n where n is any integer greater than one. In some embodiments, the number of emitters 102 is one or at least two. In some embodiments, the number of emitters 102 may be about 25. In other embodiments, the number may be different, based on a variety of factors such as layout, configuration, application, or the like.
In some embodiments, the emitters 102 and 104 may be disposed in a flat, one dimensional array. In other embodiments, the emitters 102 and 104 may be disposed in a curve, such as a continuous curve, a piecewise-linear curve, a combination of such curves, or the like. In some embodiments, the emitters 102 and 104 may be disposed in a two-dimensional array or a combination of one and two-dimensional arrays. In some embodiments, an arc of the emitters may extend from about +/−15 degrees to about +/−90 degrees around a central point. The target 106 may be shaped in a manner corresponding to the one or two-dimensional array of the emitters 102 and 104.
In some embodiments, the emitter 104 is disposed in a center of the emitters 102. However, in other embodiments, the emitter 104 may be disposed in different locations. For example, the emitter 104 may be disposed at an end of an array of the emitters 104, offset from the center of the emitters 104, or the like.
In some embodiments, the system 100a may be used for different applications. For example, in one set of operations, each of the emitters 102 and 104 may be operated to generate substantially the same current on the target 106. Such an application may be used to generate tomographic images. However, in other operations, such as two-dimensional mammography, a two-dimensional projection image may be desired. For such images, a higher x-ray intensity may be desired. As the emitter 104 is configured differently than the emitters 102, the system 100a may be used in both types of operations.
In some embodiments, one of the emitters 104 such as emitter 104-1 may be similar to the emitters 102. However, the emitter 104-2 may be different, such as by being larger or smaller. As a result, the maximum current on the target may be different due to the different emitter 104-2.
In some embodiments, both the emitters 104-1 and 104-2 may be different from the emitters 102. For example, the emitter 104-1 may be smaller and/or configured to generate a smaller focal spot on the target 106 while the emitter 104-1 may be larger and/or configured to generate a larger focal spot on the target. In some operations, the emitter 104-1 with a smaller focal spot may be used for high resolution imaging while the larger emitter 104-2 may be used for two-dimensional imaging such as for mammography.
However, in other operations, the focusing electrodes 112 may be controlled to focus the electron beams 110 on a single focal spot as illustrated in
While some embodiments have been described where the focusing electrodes 112 may be controlled to focus the electron beams 110 on a single focal spot or multiple focal spots on the target 106, in other embodiments, the focusing may be fixed. For example, the focusing may be set to focus the electron beams 110 on the single focal spot. In operation, any number of the emitters 104 from zero to all emitters 104 may be controlled, such as by focusing electrodes 112 (which combination can be referred to as a grid) or other component specific to the type of the emitter 104, to selectively emit the electron beams 110. As a result, the effective current on the single focal spot may be controlled by controlling which emitters 104 emit electron beams 110 towards the single focal spot.
Many variations of emitter configurations have been described above that result in different maximum current on the target 106. As will be described in further detail below, the target 106 may include different configurations for different portions of the target 106 to achieve the different maximum current. While embodiments will be described where the emitters 102 and 104 have electron beams 108 and 110 with the same or similar current, in other embodiments, the different maximum current may be achieved through various combinations of emitter configurations and target configurations.
While the regions 106f-0 to 106f-n are illustrated as adjacent, in some embodiments, the spacing between regions may be different. In addition, in some embodiments, focal spots created by the electron beams 108 or 110 may be separated rather than overlapping.
While a shallower slope in region 106f-0 has been used as an example, in other embodiments, the configurations may be different. For example, region 106f-0 may have a steeper slope relative to the regions 106f-1 to 106f-n.
Referring back to
In a particular example, the region 106f-0 may be formed of tungsten (W). The regions 106f-1 to 106f-n may be formed from a tungsten-rhodium alloy. As described above, in some embodiments, the maximum current of the beam 110 on the target 106f-0 may be greater than the other regions 106f-1 to 106f-n. Accordingly, a material, such as tungsten, having a higher thermal performance, such as having a higher melting point, may be used in that region 106f-0. However, rhodium (Rh) may have a more desirable x-ray spectrum for particular applications, such as mammography. Accordingly, rhodium may be used as part of the regions 106f-1 to 106f-n that will not receive electron beams 108 with the higher maximum current. Accordingly, in some embodiment, the materials may be selected based on the thermal performance and/or the x-ray emission spectrum.
In some embodiments, the regions 106f may be spaced apart from each other. For example, the spacing between the regions 106f may be a fraction for the length of the region 106f, such as about 5%, 10%, or more. In some embodiments, the spacing between the regions 106f may be the same or different. In some embodiments, the spacing between region 106f-0 and other regions 106f may be different than the spacing between those other regions 106f.
In some embodiments, the ability of two different configurations in one system 100, such as x-ray sources 100a-100g may result in a reduced cost. Regardless of whether the desired operation is a higher or lower maximum current, the combination into a single system 100 may reduce complexity, include more uniform parts, reduce cost, or the like. In addition, the combination may allow for additional uses while maintaining previous uses of other x-rays sources. For example, users that were used to using a particular x-ray source for two-dimensional imaging may continue to use that operation while obtaining the additional benefits described above, such as tomographic imaging, improved image quality from reduced motion blur, higher resolution imaging, or the like.
In some embodiments, a first x-ray source strikes a different target or region of the target than the second x-ray source. The first x-rays source may share the same control electronics, power supply, or the like.
In some embodiments, the targets described above are part of a stationary anode. In some embodiments the targets described above are part of a linear anode.
A collimator 220a is configured to shape the x-ray beam 270. The shaped x-ray beam 270 includes a central axis 272, a portion 274 closer to the electron source 205 and a portion 276 further from electron source 205. The central axis 272 is the direction of x-rays in the x-ray beam 270 that are generated at an angle perpendicular to the incoming electron beam 210. The portions 274 and 276 are formed at least in part by the edges 220a-1 and 220a-2 of the collimator 220a. In particular, the edge 220a-1 is closer to the electron source 205 than the central axis 272. The edge 220a-2 is further from the electron source 205 than the central axis 272. Due to the heel effect in the generation of the x-ray beam 270, the intensity in the portion 274 may be higher and more uniform than the portion 276. In the portion 276, the intensity may fall off faster closer to the edge 220a-2 of the collimator 220a.
Anode heel effect or heel effect refers to a lower field intensity or x-ray flux in a portion of the x-ray beam 720 closer to the anode in comparison to the cathode or electron source 205 due to lower x-ray emissions from the target material at angles perpendicular or greater to the electron beam. The conversion of the electron beam 210 into x-rays doesn't simply occur at the surface of the target 206 material but also occurs within target 206 material. Because x-rays are produced deeper in the target 206 material, those x-rays also traverse back out of the target 206 material before x-rays can proceed to the detector 230. More target 206 material needs to be traversed at emission angles that are perpendicular to the electron beam 210 (closer to the target 206) than at those more parallel to the electron beam 210 (closer to the cathode or electron source 205). The increase in target 206 material leads to more resorption of the x-rays by the target 206 material resulting in fewer x-rays reaching the field at angles perpendicular to the electron beam 210. By contrast, the x-rays emitted to angles closer to the incident electron beam 210 travel through less target 206 material and fewer are resorbed. The end result is that the field intensity and x-ray flux towards the cathode or electron source 205 is more than that towards the target 206. This nonuniform beam effect or heel effect may have a negative influence on the results of detection in x-ray imaging.
In some embodiments, an x-ray filter 260 may be disposed in the x-ray beam 270. The x-ray filter 260 is illustrated as being downstream from the collimator 220a; however, in other embodiments, the x-ray filter 260 may be disposed in other locations. The x-ray filter 260 may include materials such as molybdenum (Mo), rhodium (Rh), silver (Ag) and aluminum (Al), copper (Cu), stainless steel, combinations of such materials, or the like at various thicknesses. The x-ray filter 260 may be configured to adjust the intensity of the x-ray beams 270 such that the portions 274 and 276 are more uniform, thus mitigating the heel effect.
In some embodiments, the x-ray source 200a is used with a detector 230 to generate an image based on a portion 240 of a patient 250. For example, the portion 240 may be the breast of a patient 250. Due to the positioning of the patient 250 relative to the x-ray beam 270, a portion 240′ may not be imaged. However, the remainder may be imaged with an x-ray beam where a variation in the intensity due to the heel effect has a reduced impact (e.g., heel effect applied on narrower portion of the breast with lower mass density). For example, the variation due to the heel effect may range from 80% to 100% with a 15 degree angle of the surface 205a. Accordingly, for a given image quality during an operation of the x-ray source 200a, the patient may receive a reduced dose. In addition, the use of substantially the full field of the x-ray beam 270 may allow for a reduced source-to-image distance (SID), increasing the imaging x-ray dose, allow for a reduced power for the same imaging x-ray dose, or the like.
In some embodiments, a smaller angle may be used on the surface 206a of the target 206. For example, a nanotube (NT) emitter with size of w1 (width)×l1 (length) results in an electric focal spot size (FSS) of w2 (width)×l2 (length) on the surface 206a after electron beam focusing. The electron FSS on surface 206a depends on focusing electrode design where smaller the NT emitter size (w1×l1), the smaller electron FSS on the surface (w2×l2). X-ray FSS of w3 (width)×l3 (length) is determined by electron FSS and the angle (θ) of the surface 206a. W3 is equal to w2 and l3 is equal to l2×sin(θ). At a given x-ray FSS, a smaller anode angle allows for a larger electron FSS and a larger emitter. A larger NT emitter can produce larger emission current. A larger electron FSS on the surface 206a distributes the heat load in a larger area, which allows for higher tube power and x-ray dose output.
Accordingly, as the impact of the heel effect is reduced, a smaller angle on the surface 206a may be used. The smaller angle allows for an increased current or size of the emitters in the electron source 205. For example, a larger size of a field emitter may provide a larger current; however, the larger size would lead to a larger x-ray FSS. However, the angle of the surface 206a may be reduced to maintain the x-ray FSS while still increasing the dose at the same or similar SID.
In some embodiments, the imaging system 200b allows for the patient 250 to be on a side of the system 200b opposite to that of
Referring to
Referring to
In some embodiments, the emission of the x-ray beam may be the result of differently sized emitters emitting electron beams 110 towards a target 106.
Some embodiments include a system, comprising: a plurality of x-ray sources (101), each x-ray source (101) including: an electron source (102, 104) configured to generate an electron beam (108, 110); and a target (106) configured to receive the electron beam (108, 110) and convert the electron beam (108, 110) into an x-ray beam; wherein at first x-ray source (101) of the x-ray sources (101) is different from a second x-ray source (101) of the x-ray sources (101).
In some embodiments, the targets (106) of the x-ray sources (101) are part of a linear target (106).
In some embodiments, an aspect ratio of the linear target (106) is greater than or equal to at least one of 2:1, 10:1, and 20:1.
In some embodiments, the linear target (106) is a flat, curved, or piecewise linear target (106).
In some embodiments, the x-ray sources (101) are disposed such that the corresponding x-ray beams substantially converge on a single point.
In some embodiments, a first plurality of the x-ray sources (101) include at least one field emitter; and another x-ray source (101) of the x-ray sources (101) includes a filament, a low work function emitter, a dispenser cathode, or a photo emitter.
In some embodiments, the system further comprises a collimator (220) configured to collimate the x-ray beam from each of the x-ray sources (101).
In some embodiments, the first x-ray source (101) of the x-ray sources (101) includes a first electron source (102, 104) including at least one emitter; the second x-ray source (101) of the x-ray sources (101) includes a second electron source (102, 104) including at least one emitter; and wherein: the first electron source (102, 104) and the second electron source (102, 104) are configured such that a first maximum current of a first electron beam (108, 110) from one of the emitters of the first electron source (102, 104) on a first focal spot on the corresponding target (106) is different from a second maximum current of a second electron beam (108, 110) from the second electron source (102, 104) on a second focal spot on the corresponding target (106).
In some embodiments, the first maximum current is greater than the second maximum current.
In some embodiments, the first maximum current is greater than the second maximum current by a factor of at least one of 2, 10, and 100.
In some embodiments, at least some of the x-ray sources (101) are substantially the same.
In some embodiments, at least three of the x-ray sources (101) are substantially the same.
In some embodiments, the first x-ray source (101) comprises a first emitter and a second emitter; and the first emitter is configured to generate a maximum current higher than a maximum current of the second emitter.
In some embodiments, the first x-ray source (101) comprises: a plurality of emitters; and a plurality of focus electrodes (112) configured to focus electron beams (108, 110) from the emitters on a single focal spot.
In some embodiments, the first x-ray source (101) comprises: a plurality of emitters; and a plurality of focus electrodes (112) configured to controllably focus electron beams (108, 110) from the emitters on a single focal spot and controllably focus the electron beams (108, 110) from the emitters on multiple focal spots.
In some embodiments, the system further comprises a first vacuum enclosure (120, 282) including the at first x-ray source (101); a second vacuum enclosure (120, 282) separate from the first vacuum enclosure (120, 282) including the second x-ray source (101).
In some embodiments, for at least one of the x-ray sources (101): a surface of the target (106) is disposed at an angle relative to the associated electron beam (108, 110) that is different from perpendicular; and a first edge of the collimator (220) closest to the electron source (102, 104) is closer to the electron source (102, 104) than a central axis (272) of the x-ray beam before entering the collimator (220).
In some embodiments, a second edge of the collimator (220) opposite to the first edge is at or closer to the electron source (102, 104) than the central axis (272) of the x-ray beam before entering the collimator (220).
In some embodiments, a position of the collimator (220) relative to the x-ray beam is adjustable.
In some embodiments, the target (106) of the first x-ray source (101) has a configuration different from the target (106) of the second x-ray source (101).
In some embodiments, the target (106) of the first x-ray source (101) has a slope different from the target (106) of the second x-ray source (101).
In some embodiments, the target (106) of the first x-ray source (101) has a material different from a material of the target (106) of the second x-ray source (101).
In some embodiments, the system further comprises a cooling system configured to cool the target (106) of the first x-ray source (101) differently from the target (106) of the second x-ray source (101).
Some embodiments include a method, comprising: emitting a first x-ray beam from a first x-ray source (101) including at least part of a target (106); and emitting a second x-ray beam from a second x-ray source (101) including at least part of the target (106); wherein the first x-ray source (101) is different from the second x-ray source (101).
In some embodiments the target is a linear target.
In some embodiments, emitting the first x-ray beam comprises emitting the first x-ray beam through a collimator (220); and emitting the second x-ray beam comprises emitting the second x-ray beam through the collimator (220).
In some embodiments, emitting the first x-ray beam comprises emitting a first electron beam (108, 110) from a first electron source (102, 104) including multiple emitters towards a target (106); and emitting the second x-ray beam comprises emitting a second electron beam (108, 110) from a second electron source (102, 104) including at least one emitter towards the target (106); wherein a first maximum current of the first electron beam (108, 110) on a first focal spot on the target (106) is different from a second maximum current of a second electron beam (108, 110) on a second focal spot on the target (106).
In some embodiments, the at least one emitter of the second electron source (102, 104) comprises a first emitter and a second emitter; and further comprising: emitting the second electron beam (108, 110) from the first emitter of the second electron source (102, 104) with a first current during a first operation; and emitting the second electron beam (108, 110) from the second emitter of the second electron source (102, 104) with a second current greater than the first current density during a second operation.
In some embodiments, the first operation is a three-dimensional imaging operation; and the second operation is a two-dimensional imaging operation.
In some embodiments, the at least one emitter of the second electron source (102, 104) comprises a plurality of emitters; and further comprising focusing electron beams (108, 110) from the emitters of the second electron source (102, 104) on the second focal spot.
In some embodiments, the first maximum current is less than the second maximum current.
In some embodiments, collimating an x-ray beam generated in response to the second electron beam (108, 110) with a collimator (220) such that at least part of the x-ray beam between an edge of the collimator (220) and a central axis (272) of the x-ray beam that is closer to the second electron source (102, 104) is passed by the collimator (220).
Some embodiments include a system, comprising: a plurality of means for emitting electron beams; and means for generating x-rays in response to the electron beams; wherein a first combination of a first means for emitting electron beams and the means for generating x-rays in response to the electron beams is different from a second combination of a second means for emitting electron beams and the means for generating x-rays in response to the electron beams. Examples of the means for emitting electron beams include the electron sources 102 and 104, or the like. Examples of the means for generating x-rays in response to the electron beams include the target 106 or the like.
In some embodiments, a first maximum current on the means for generating x-rays of a first electron beam from one of the means for emitting electron beams is different from a second maximum current of a second electron beam from another one of means for emitting electron beams.
In some embodiments, the system further comprises means for collimating the x-ray beam. Examples of the means for collimating the x-ray beam include the collimator 220.
Some embodiments include a system, comprising: an electron source (102, 104) including multiple emitters; a target (106); wherein: the emitters of the electron source (102, 104) are configured to emit electrons towards a plurality of focal spots on separate regions of the target (106); at least one of the separate regions of the target (106) has a configuration different from at least one other region of the separate regions.
Some embodiments include a system, comprising: a first electron source (102, 104) including at least one emitter; a second electron source (102, 104) including at least one emitter; and a target (106); wherein: each of the emitters of the first electron source (102, 104) and the second electron source (102, 104) are configured to emit electrons towards the target (106); and the first electron source (102, 104) and the second electron source (102, 104) are configured such that a first maximum current of a first electron beam (108, 110) from one of the emitters of the first electron source (102, 104) on a first focal spot on the target (106) is different from a second maximum current of a second electron beam (108, 110) from the second electron source (102, 104) on a second focal spot on the target (106).
Although the structures, devices, methods, and systems have been described in accordance with particular embodiments, one of ordinary skill in the art will readily recognize that many variations to the particular embodiments are possible, and any variations should therefore be considered to be within the spirit and scope disclosed herein. Accordingly, many modifications may be made by one of ordinary skill in the art without departing from the spirit and scope of the appended claims.
The claims following this written disclosure are hereby expressly incorporated into the present written disclosure, with each claim standing on its own as a separate embodiment. This disclosure includes all permutations of the independent claims with their dependent claims. Moreover, additional embodiments capable of derivation from the independent and dependent claims that follow are also expressly incorporated into the present written description. These additional embodiments are determined by replacing the dependency of a given dependent claim with the phrase “any of the claims beginning with claim [x] and ending with the claim that immediately precedes this one,” where the bracketed term “[x]” is replaced with the number of the most recently recited independent claim. For example, for the first claim set that begins with independent claim 1, claim 4 can depend from either of claims 1 and 3, with these separate dependencies yielding two distinct embodiments; claim 5 can depend from any one of claim 1, 3, or 4, with these separate dependencies yielding three distinct embodiments; claim 6 can depend from any one of claim 1, 3, 4, or 5, with these separate dependencies yielding four distinct embodiments; and so on.
Recitation in the claims of the term “first” with respect to a feature or element does not necessarily imply the existence of a second or additional such feature or element. Elements specifically recited in means-plus-function format, if any, are intended to be construed to cover the corresponding structure, material, or acts described herein and equivalents thereof in accordance with 35 U.S.C. § 112(f). Embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows.
Number | Date | Country | Kind |
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21157470.2 | Feb 2021 | EP | regional |
Number | Date | Country | |
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63133036 | Dec 2020 | US |