Claims
- 1. A compound of the formula:
- 2. The compound of claim 1 wherein R1 is substituted or unsubstituted thiazolyl.
- 3. The compound of claim 2 wherein R1 is substituted thiazolyl.
- 4. The compound of claim 3 wherein R1 is thiazolyl substituted with —(R5)n-C(O)—OR6.
- 5. The compound of claim 4 wherein R2 is cyclopentyl or cyclohexyl.
- 6. The compound of claim 5 wherein R3 is cyclopentyl or cyclohexyl and R4 is hydrogen.
- 7. The compound of claim 6 wherein n is 0.
- 8. A compound of claim 7 which is (S,S)-2-[[2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidin-1-yl)-3-cyclopentylpropanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 9. A compound of claim 7 which is (S,S)-2-[[3-cyclopentyl-2-[4-(cyclopentyl)methyl-2,5-dioxoimidazolidin-1-yl]propanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 10. A compound of claim 7 which is (S,S)-2-[[3-cyclohexyl-2-[4-(cyclopentyl)methyl-2,5-dioxoimidazolidin-1-yl]propanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 11. A compound of claim 7 wherein R2 and R3 are cyclohexyl.
- 12. A compound of claim 11 which is (S,S)-2-[[3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidin-1-yl]propanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 13. A compound of claim 6 wherein R2 and R3are cyclohexyl.
- 14. A compound of claim 13 which is (S,S)-[2-[[3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidin-1-yl]propanoyl]amino]thiazol-4-yl]oxoacetic acid ethyl ester.
- 15. A compound of claim 13 which is (S,S)-[2-[[3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidin-1-yl]propanoyl]amino]thiazol-4-yl]acetic acid ethyl ester.
- 16. A compound of claim 5 wherein R3 is substituted or unsubstituted phenyl and R4 is hydrogen.
- 17. A compound of claim 16 which is (S,S)-2-[[2-(4-benzyl-2,5-dioxoimidazolidin-1-yl)-3-cyclohexylpropanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 18. A compound of claim 16 which is 2-[[(S)-2-[(R)-4-(4-chlorobenzyl)-2,5-dioxoimidazolidin-1-yl]-3 -cyclohexylpropanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 19. A compound of claim 16 which is (S,S)-2-[[3-cyclohexyl-2-[2,5-dioxo-4-(4-hydroxybenzyl)imidazolidin-1-yl]propanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 20. A compound of claim 16 which is (S,S)-2-[[3-cyclohexyl-2-[2,5-dioxo-4-(3-hydroxybenzyl)imidazolidin-1-yl]propanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 21. A compound of claim 16 which is 2-[[(S)-3-cyclohexyl-2-[(R,S)-2,5-dioxo-4-(4-fluorobenzyl)imidazolidin-1-yl]propanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 22. A compound of claim 5 wherein at least one of R3 and R4 are lower alkyl.
- 23. A compound of claim 22 which is (S)-2-[[3-cyclohexyl-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)propanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 24. A compound of claim 22 which is 2-[[(S)-3-cyclohexyl-2-[(R)-2,5-dioxo-4-propylimidazolidin-1-yl]propanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 25. A compound of claim 5 wherein R3 is naphthyl and R4 is hydrogen.
- 26. A compound of claim 25 which is (S,S)-2-[[3-cyclohexyl-2-[2,5-dioxo-4-(naphthalen-2-yl)methylimidazolidin-1-yl]propanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 27. A compound of claim 5 wherein R3 and R4 together with the carbon atoms to which they are attached form a cycloalkyl ring containing 5 to 7 carbon atoms.
- 28. A compound of claim 27 which is (S)-2-[[3-cyclohexyl-2-(2,4-dioxo-1,3-diazaspiro[4.4]non-3-yl)propanoyl]amino]thiazole-4-carboxylic acid methyl ester.
- 29. A compound of claim 5 wherein R3 is an unsubstituted five- or six-membered aromatic heterocyclic ring having one or two heteroatoms selected from nitrogen, oxygen, and sulfur.
- 30. A compound of claim 29 which is (S,S)-2-[[3 -cyclohexyl-2-[2,5-dioxo-4-(thiophen-2-yl)methylimidazolidin-1-yl]propanoyl] amino] thiazole-4-carboxylic acid methyl ester.
- 31. A compound of claim 2 wherein R1 is unsubstituted thiazolyl.
- 32. A compound of claim 31 wherein R2 and R3 are cyclohexyl and R4 is hydrogen.
- 33. A compound of claim 32 which is (S,S)-3 -cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidin-1-yl]-N-(thiazole-2-yl)propanamide.
- 34. A compound of claim 1 wherein R1 is substituted or unsubstituted pyridine.
- 35. A compound of claim 34 wherein R2 is cyclohexyl.
- 36. A compound of claim 35 wherein R3 is cyclohexyl and R4 is hydrogen.
- 37. A compound of claim 36 wherein R1 is substituted pyridine.
- 38. A compound of claim 37 wherein the pyridine is substituted with —(R5)n-C(O)—OR6.
- 39. A compound of claim 38 wherein n is 0 and R6 is lower alkyl.
- 40. A compound of claim 39 which is (S,S)-6-[[3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidin-1-yl]propanoyl]amino]nicotinic acid methyl ester.
- 41. A compound of claim 37 which is (S,S)-3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidin-1-yl]-N-(5-methylpyridin-2-yl)propanamide.
- 42. A compound of claim 37 which is (S,S)-N-(5-chloropyridin-2-yl)-3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidin-1-yl]propanamide.
- 43. A compound of claim 36 wherein R1 is unsubstituted pyridine.
- 44. A compound of claim 43 which is (S,S)-3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidin-1-yl]-N-(pyridin-2-yl)propanamide.
CROSS-REFERENCE TO RELATED APPLICATIONS This application is related to U.S. Ser. No. 09/526,143 filed Mar. 15, 2000 and U.S. Ser. No. 09/532,506 filed Mar. 21, 2000.
[0001] This application claims priority under 35 U.S.C. § 119(e) of provisional application Serial No. 60/201,498, filed May 3, 2000.
Provisional Applications (1)
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Number |
Date |
Country |
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60201498 |
May 2000 |
US |