Claims
- 1. A hydrazinopyridazine compound represented by the formula: ##STR25## wherein R.sup.1 represents a hydrogen atom; a halogen atom; a cyano group; a C.sub.1 -C.sub.5 alkyl group which may optionally be substituted by a halogen atom, a C.sub.1 -C.sub.5 alkoxy or tetrahydrofurfuryloxy group; a C.sub.1 -C.sub.5 alkoxy group which may optionally be substituted by a C.sub.1 -C.sub.5 alkoxy group; an allyl group; an allyloxy group; or an ethynyl group;
- R.sup.2 represents a hydrogen, a halogen atom, a C.sub.1 -C.sub.5 alkyl group, a C.sub.1 -C.sub.5 alkoxy group, or an allyl group,
- R.sup.3, R.sup.4, and R.sup.5, independently from each other, represent a hydrogen atom, a halogen atom, or a C.sub.1 -C.sub.5 alkyl group which may optionally be substituted by a C.sub.1 -C.sub.5 alkoxy group,
- R.sup.6 and R.sup.7, both represent a methyl group,
- Y represents --NH.sub.2, --NH--COOC.sub.2 H.sub.5, or ##STR26## Z represents --O--, --S--, or ##STR27## in which R.sup.8 represents a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group, and
- n is 1 or 2
- or its salt
- with the proviso that at least three of R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are hydrogen atoms, said alkyl groups are straight chain alkyl groups and the alkyl groups in said alkoxy groups are straight chain alkyl groups.
- 2. The compound of claim 1 wherein Z represents --O--.
- 3. The compound of claim 1 wherein R.sup.1 represents a chlorine atom or a methyl, trifluoromethyl or ethynyl group.
- 4. The compound of claim 1 which is 1-(2-chlorophenoxy)-3-[1,1-dimethyl-2-(3-hydrazino-6-pyridazinyloxy)-ethylamino]-2-propanol, 1-(2-methylphenoxy)-3-[1,1-dimethyl-2-(3-hydrazino-6-pyridazinyloxy)ethylamino]-2-propanol, 1-(2-trifluoromethylphenoxy)-3-[1,1-dimethyl-2-(3-hydrazino-6-pyridazinyloxy)ethylamino]-2-propanol, or 1-(2-ethynylphenoxy)-3-[1,1-dimethyl-2-(3-hydrazino-6-pyridazinyloxy)ethylamino]-2-propanol.
- 5. A pharmaceutical composition comprising a hydrazino-pyridazine compound of the formula ##STR28## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6, Y, Z and n are as defined in claim 1,
- or its pharmaceutically acceptable salt, and a pharmaceutically acceptable carrier or diluent.
- 6. A method for the treatment of hypertension which comprises administering an anti-hypertensive amount of the compound the formula (I) as defined in claim 1 or a pharmaceutically acceptable salt thereof, to a patient suffering from hypertension.
- 7. The compound of claim 1 wherein n is 1.
- 8. The compound according to claim 2 wherein n is 1.
- 9. The compound of claim 3 wherein n is 1.
- 10. The compound of claim 4 which is 1-(2-chlorophenoxy)-3-[1,1-dimethyl-2-(3-hydrazino-6-pyridazinyloxy)ethylamino]-2-propanol.
- 11. The compound according to claim 4 which is 1-(2-methylphenoxy)-3-[1,1-dimethyl-2-(3-hydrazino-6-pyridazinyloxy)ethylamino]-2-propanol.
Parent Case Info
This application is a continuation of now abandoned application Ser. No. 388,476, filed June 14, 1982.
US Referenced Citations (6)
Foreign Referenced Citations (3)
Number |
Date |
Country |
959845 |
Dec 1974 |
CAX |
1071205 |
May 1976 |
CAX |
0092945 |
Nov 1983 |
EPX |
Continuations (1)
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Number |
Date |
Country |
Parent |
388476 |
Jun 1982 |
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