Claims
- 1. A method for administering hydrocodone to a patient in need of hydrocodone therapy, which method comprises orally admitting into the gastrointestinal tract of the patient a sustained delivery bilayer comprising a hydrocodone layer comprising up to 1250 mg of hydrocodone, 10 mg to 350 mg of poly(alkylene oxide), 5 to 50 mg of a hydroxyalkylcellulose, and 0.01 to 5 mg of a lubricant; and a push layer comprising 25 mg to 300 mg of a poly(alkylene oxide), 5 to 150 mg of an osmagent, and 1 to 30 mg of a hydroxypropylalkylcellulose, which bilayer through the combined operation of the bilayer imbibes fluid and releases hydrocodone, thereby delivers the hydrocodone at a controlled rate of 0.5 mg to 10 mg per hour over a period of 30 hours to the gastrointestinal tract of the patient in need of hydrocodone therapy.
Parent Case Info
application is a division of application Ser. No. 08/277,399, filed Sept. 16, 1994, and benefit of the filing date of said earlier filed application is claimed under 35 U.S.C. .sctn. 120.
US Referenced Citations (12)
Foreign Referenced Citations (4)
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0220805 |
May 1987 |
EPX |
0367746 |
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EPX |
0377518 |
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WOX |
Non-Patent Literature Citations (3)
Entry |
Hiemenz in Polymer Chemistry, pp. 34-43. Marcel Dekker, 1984. |
Fried in Polymer Science and Technology, "1.3 Molecular Weight", pp. 16-18. Prentice Hall, 1995. |
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Divisions (1)
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Number |
Date |
Country |
Parent |
277399 |
Sep 1994 |
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