Claims
- 1. A hydrogel forming system which comprises hydrophobic and hydrophilic components (A) and (B) which are convertible into a one phase crosslinked network structure by free radical polymerization, where the hydrophobic and hydrophilic components constitute different compounds from one another, the hydrophobic component (A) being a hydrophobic macromer with unsaturated group terminated ends, and the hydrophilic component (B) being a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, the unsaturated group introducing compound being selected from the group consisting of acryloyl chloride, methacryloyl chloride, acrylic acid, methacrylic acid and isocyanate having unsaturated group at one end of the molecule, the hydrogel-forming system comprising from 0.01 to 99.00% by weight of (A) and from 99.99 to 0.01% of (B), with the total of the percentages of (A) and (B) being 100%.
- 2. Hydrogel formed by the free radical polymerization of the hydrogel-forming system of claim 1 which has a three dimensional crosslinked polymer network structure containing hydrophobic and hydrophilic components.
- 3. The hydrogel of claim 2 where the hydrophobic macromer is made from aliphatic polyester starting material.
- 4. The hydrogel of claim 2 where the hydrophobic macromer is made from poly (lactic acid) starting material.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation/division of U.S. patent application Ser. No. 09/531,451, filed Mar. 20, 2000, and now U.S. Pat. No. 6,388,047 which claims the benefit of U.S. Provisional Application No. 60/128,803, filed Apr. 12, 1999.
US Referenced Citations (23)
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 0012619 |
Mar 2000 |
WO |
Non-Patent Literature Citations (2)
Entry |
Kurisawa, M., et al., J. Biomater. Sci. Polymer Edn., vol. 8, No. 9; 691-708 (1997). |
Zhang, Y., et al., J. Polym. Sci., Polymer Chemistry 37, 4554-4569 (Dec. 15, 1999. |
Provisional Applications (1)
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Number |
Date |
Country |
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60/128803 |
Apr 1999 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
09/531451 |
Mar 2000 |
US |
Child |
10/096435 |
|
US |