Claims
- 1. Hydrogel which has a three dimensional crosslinked polymer network structure, formed by the free radical polymerization of a hydrogel-forming system which comprises from 0.01 to 99.99% by weight of (A) a hydrophobic macromer with unsaturated group terminated ends, and from 99.99 to 0.01% by weight of (B) a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, and wherein the total of the percentages of (A) and (B) is 100%, said hydrogel having composition comprising a drug of weight average molecular weight ranging from 200 to 1,000 entrapped in the three dimensional crosslinked polymer network structure.
- 2. The hydrogel as claimed in claim 1 wherein said drug is indomethacin.
- 3. The hydrogel of claim 1 where the unsaturated group introducing compound is selected from the group consisting of acryloyl chloride, methacryloyl chloride, acrylic acid, methacrylic acid and isocyanate having unsaturated group at one end of the molecule.
- 4. The hydrogel of claim 1, where the hydrophobic macromer is made from aliphatic polyester starting material.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a division of U.S. patent application Ser. No. 10/096,435, filed Mar. 13, 2002, and now U.S. Pat. No. 6,583,219 which, in turn is a continuation and a division of U.S. patent application Ser. No. 09/531,451, filed Mar. 20, 2000, and now U.S. Pat. No. 6,388,047 which claims the benefit of U.S. Provisional Application No. 60/128,803, filed Apr. 12, 1999.
US Referenced Citations (25)
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 0012619 |
Mar 2000 |
WO |
Non-Patent Literature Citations (2)
Entry |
Kurisawa, M., et al., J. Biomater. Sci. Polymer Edn., Vol 8, No. 9; 691-708 (1997). |
Zhang, Y., et al., J. Polym. Sci., Polymer Chemistry 37, 4554-4569 (Dec. 15, 1999). |
Provisional Applications (1)
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Number |
Date |
Country |
|
60/128803 |
Apr 1999 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
09/531451 |
Mar 2000 |
US |
Child |
10/096435 |
|
US |