Claims
- 1. A method of providing a substrate with a hydrophilic coating which becomes lubricous when contacted with an aqueous fluid, comprising:
a) coating said substrate with a first aqueous coating composition comprising an aqueous dispersion or emulsion of a first polymer having organic acid functional groups and a first polyfunctional crosslinking agent having functional groups being capable of reacting with organic acid groups, and drying said first coating composition to obtain a substantially water-insoluble coating layer still including functional groups being reactive with organic acid groups; and b) contacting said dried coating layer with a second aqueous coating composition comprising an aqueous solution or dispersion of a hydrophilic polymer having organic acid functional groups, a second polymer having organic acid functional groups, and a second polyfunctional crosslinking agent having functional groups being capable of reacting with organic acid groups, and drying to effectuate covalent bonding of said hydrophilic polymer and said second polymer to said first polymer of the first coating composition through said first or said second crosslinking agents to form a hydrophilic coating; wherein said first polymer and said second polymer may be the same or different, and further wherein said first crosslinking agent and said second crosslinking agent may be the same or different.
- 2. A method of claim 1, wherein said second polymer is present in said second coating composition in an amount of up to 10 weight percent of said second coating composition.
- 3. A method of claim 1 wherein said second polymer in the second aqueous coating composition is the same as said first polymer in the first aqueous coating composition.
- 4. A method of claim 1 wherein said second crosslinking agent in the second aqueous coating composition is the same as said first crosslinking agent in the first aqueous coating composition.
- 5. A method of claim 1 further comprising:
providing a quantity of said second polyfunctional crosslinking agent in said second aqueous coating composition so that said hydrophilic coating still includes functional groups being reactive with organic acid groups.
- 6. A method of claim 5 further comprising:
contacting said hydrophilic coating with a third aqueous coating composition comprising an aqueous solution or dispersion of a second hydrophilic polymer having organic acid functional groups, and drying the combined coatings to effectuate covalent bonding of the second hydrophilic polymer to said first hydrophilic polymer or said second polymer of said hydrophilic coating through said second crosslinking agent; wherein said second hydrophilic polymer in the third aqueous coating composition and said hydrophilic polymer in the second aqueous coating composition may be the same or different.
- 7. A method of claim 6, wherein said second hydrophilic polymer in the third aqueous coating composition is the same as said hydrophilic polymer in the second aqueous coating composition.
- 8. A method of claim 1, wherein the organic acid functional groups are selected from free carboxylic or sulfonic acid groups, metal salts of such acid groups, particularly alkali metal salts, and quaternary amine salts of such acid groups.
- 9. A method of claim 1, wherein said first or said second polyfunctional crosslinking agent is selected from polyfunctional aziridines, polyfunctional carboimides and combinations thereof.
- 10. A method of claim 1, wherein said first or said second polyfunctional crosslinking agent is a crosslinking agent having more than two functional groups per molecule.
- 11. A method of claim 1, wherein said first or said second polymer is selected from homo- and copolymers having a substantial amount of organic acid functional groups in their structure.
- 12. A method of claim 1, wherein said first or said second polymer is selected from the group consisting of polyurethanes, polyacrylates, polymethacrylates, polyisocrotonates, epoxy resins, acrylate-urethane copolymers and combinations thereof.
- 13. A method according to claim 12, wherein said first or said second polymer comprises an acrylate-urethane copolymer and/or a polyurethane.
- 14. A method of claim 6, wherein said hydrophilic polymer in said second coating composition or said second hydrophilic polymer in said third coating composition comprises monomer units from at least one monomer having organic acid functional groups.
- 15. A method according to claim 14, wherein said hydrophilic polymer in said second coating composition or said second hydrophilic polymer in said third coating composition is selected from the group consisting of acrylic acid, methacrylic acid, isocrotonic acid and combinations thereof.
- 16. A method according to claim 14, wherein said hydrophilic polymer in said second coating composition or said second hydrophilic polymer in said third coating composition further comprises monomer units without any organic acid functional groups.
- 17. A method according to claim 14, wherein said hydrophilic polymer in said second coating composition or said second hydrophilic polymer in said third coating composition comprises an acrylamide-acrylic acid copolymer.
- 18. A method of claim 6, wherein the hydrophilic polymer in said second coating composition or said second hydrophilic polymer in said third coating composition have a molecular weight in the range from about 100,000 to about 15 million.
- 19. A method of claim 6, wherein the concentration of said hydrophilic polymer in said second coating composition or the concentration of said second hydrophilic polymer in said third coating composition is from about 0.1 to about 5% by weight solids content.
- 20. A method of claim 1, wherein the concentration of said first polymer in said first coating composition is from about 2 to about 60% by weight solids content.
- 21. A method of claim 1, wherein the concentration of said first crosslinking agent in said first coating composition is in the range from about 0.2 to about 30% by weight of said first coating composition and the concentration of said second crosslinking agent in the second coating composition is in the range from about 0.01 to about 10% by weight of said second coating composition.
- 22. A method of claim 6, wherein the functional groups of said first crosslinking agent and of said second crosslinking agent are capable of reacting with the organic acid functional groups of said first polymer, said second polymer, said hydrophilic polymer and said second hydrophilic polymer at a temperature below 120° C.
- 23. A medical device intended for introduction to the body comprising:
a substrate suitable for introduction into the body, the surface of said substrate being coated with a cured polymeric composition, said composition comprising a first polymeric layer formed from at least a partial reaction of an aqueous dispersion or emulsion of a polymer having reactive organic acid functional groups present and two hydrophilic polymeric layers each having organic acid functional groups present, wherein said first polymer layer and at least one of the hydrophilic layers have a polyfunctional crosslinking agent capable of reacting with said organic acid functional groups; wherein said first hydrophilic polymeric layer coats said first polymeric layer and said second hydrophilic polymeric layer coats said first hydrophilic polymeric layer.
- 24. A medical device of claim 23, wherein said first polymeric layer, said first hydrophilic polymeric layer, and said second hydrophilic polymeric of the cured polymeric composition are an integral coating.
- 25. A medical device of claim 23, wherein said first hydrophilic polymeric layer further includes a polymer having reactive organic acid functional groups.
- 26. A reactive film coating useful for bonding hydrophilic polymers having organic acid functional groups, said film coating being the reaction product of an aqueous dispersion or emulsion of a polymer having organic acid functional groups, a hydrophilic polymer having organic acid functional groups, and a polyfunctional crosslinking agent capable of reacting with said organic acid functional groups, whereby said reaction product still includes reactive functional groups from said polyfunctional crosslinking agent.
- 27. A hydrophilic polymeric coating capable of becoming lubricous when in contact with an aqueous medium, said coating comprising at least three polymeric layers having adjacent layers covalently bonded together to form a cross-linked network, said cross-linked network being the reaction product of:
a) a first polymeric layer comprising an aqueous dispersion or emulsion of a first polymer having organic acid functional groups and a polyfunctional crosslinking agent capable of reacting with said organic acid functional groups; b) a second aqueous polymeric layer comprising an aqueous solution or dispersion of a first hydrophilic polymer having organic acid functional groups, a second polymer having organic acid functional groups, and a second polyfunctional crosslinking agent having functional groups being capable of reacting with organic acid groups; and c) a third aqueous polymeric layer comprising an aqueous solution or dispersion of a second hydrophilic polymer having organic acid functional groups; wherein said first polymer and said second polymer may be the same or different; wherein said first crosslinking agent and said second crosslinking agent may be the same or different; and further wherein said hydrophilic polymer and said second hydrophilic polymer may be the same or different.
- 28. The hydrophilic polymeric coating of claim 27 wherein said first polymer or said second polymer is selected from the group consisting of water-borne polyurethane and polyacrylic acid polymers; and said first or said second hydrophilic polymer is selected from the group consisting of polyacrylic acid polymer and acrylamide-acrylic acid copolymers.
- 29. A medical device being at least partially coated with the polymeric coating of claim 27.
- 30. The product of claim 29 wherein the medical device is an angioplasty balloon.
- 31. A hydrophilic polymeric coating capable of becoming lubricous when in contact with an aqueous medium, said coating comprising at least three polymeric layers having adjacent layers covalently bonded together to form a cross-linked network, said cross-linked network being the reaction product of:
a) a first aqueous polymeric layer comprising an aqueous dispersion or emulsion of a first polymer having organic acid functional groups; b) a second aqueous polymeric layer comprising an aqueous solution or dispersion of a first hydrophilic polymer having organic acid functional groups or a second polymer having organic acid functional groups; and c) a third aqueous polymeric layer comprising an aqueous solution or dispersion of a second hydrophilic polymer having organic acid functional groups; wherein said first polymer and said second polymer may be the same or different; wherein said hydrophilic polymer and said second hydrophilic polymer may be the same or different; and further wherein at least one of said aqueous polymeric layers contain a polyfunctional crosslinking agent having functional groups being capable of reacting with organic acid groups.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation-in-part of U.S. Ser. No. 09/457,955, filed Dec. 9, 1999, which is a continuation-in-part of U.S. Ser. No. 08/929,948, filed Sep. 15, 1997, now U.S. Pat. No. 6,048,620, which is a Divisional of U.S. Ser. No. 08/392,141, filed Feb. 22, 1995, now U.S. Pat. No. 5,702,754, all of which are incorporated by reference herein.
Divisions (2)
|
Number |
Date |
Country |
Parent |
09876556 |
Jun 2001 |
US |
Child |
10387380 |
Mar 2003 |
US |
Parent |
08392141 |
Feb 1995 |
US |
Child |
08929948 |
Sep 1997 |
US |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
09457955 |
Dec 1999 |
US |
Child |
09876556 |
Jun 2001 |
US |
Parent |
08929948 |
Sep 1997 |
US |
Child |
09457955 |
Dec 1999 |
US |