Claims
- 1. A microporous drug delivery membrane having a hydrophilic, polymeric shell, comprising:
- a supporting structure having a complex geometric configuration and surfaces about said structure and an extremely thin, self-interlocking, tactic, hydrophilic poly(vinyl alcohol) shell enveloping at least a portion of said surfaces while substantially retaining said complex geometric configuration.
- 2. The membrane according to claim 1, wherein said membrane is a polyolefin rendered hydrophilic and having pores of from about 0.01 .mu.m to about 20 .mu.m.
- 3. The membrane according to claim 1, wherein said membrane has a complex geometric configuration and said shell substantially retains said complex geometric configuration of said membrane.
- 4. The membrane according to claim 1, wherein said shell is between about an average of 10 monolayers to about an average of 4000 monolayers thick on said surfaces.
- 5. The membrane according to claim 1, wherein said shell is substantially insoluble in solvents having a solubility parameter differential to a solubility parameter of poly(vinyl alcohol) of greater than about 0.4.
- 6. The membrane according to claim 1, wherein pores of said structure are larger than the mean free path of flowing molecules of the drug.
- 7. The membrane according to claim 1, wherein said polymeric membrane is hydrophobic.
- 8. The membrane according to claim 1, wherein said shell has a sufficient pore wetting surface energy to permit spontaneous wetting of the drug delivery membrane with water containing a drug and an optimal excipient.
- 9. A drug delivery device, comprising: a hypoallergenic pressure sensitive adhesive layer, a therapeutic agent, and a membrane of claim 1 contacting said adhesive layer and in communication with said therapeutic agent.
- 10. The drug delivery device according to claim 9, wherein said membrane is a polyolefin rendered hydrophilic and has pores of from about 0.01 .mu.m to about 20 .mu.m.
- 11. The drug delivery device according to claim 9, wherein said shell is between about an average of 10 monolayers to about an average of 4000 monolayers thick on said surfaces.
- 12. The drug delivery device according to claim 9, wherein said shell is substantially insoluble in solvents having a solubility parameter differential to a solubility parameter of poly(vinyl alcohol)of greater than about 0.4.
- 13. The drug delivery device according to claim 9, wherein pores of said structure are larger than the mean free path of flowing molecules of the drug.
- 14. The drug delivery device according to claim 9, wherein said membrane is between said therapeutic agent and said pressure sensitive adhesive layer.
- 15. The drug delivery device according to claim 9, wherein said membrane comprises a porous depot for said therapeutic agent.
- 16. The drug delivery device according to claim 9, wherein said transdermal delivery device further comprises an excipient in communication with said therapeutic agent and said membrane.
- 17. A drug delivery device, comprising: a hypoallergenic pressure sensitive adhesive layer, a therapeutic agent, optionally an excipient in a reservoir, and a membrane according to claim 1 contacting said adhesive layer and contacting the reservoir.
- 18. The drug delivery device according to claim 17, wherein said membrane is between said therapeutic agent and said pressure sensitive adhesive layer.
- 19. The drug delivery device according to claim 17, wherein said pressure sensitive adhesive layer is absent from a pathway from said reservoir to skin of a patient.
- 20. The drug delivery device according to claim 9, wherein the membrane is hydrated for use in iontophoresis.
RELATED APPLICATIONS
This application is a division of U.S. patent application Ser. No. 08/122,807 filed Sep. 16, 1993, now U.S. Pat. No. 5,443,727, which is a continuation of U.S. patent application Ser. No. 07/775,969 filed Nov. 8, 1991, abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 07/605,834 filed Oct. 30, 1990, abandoned, and a continuation-in-part of U.S. patent application Ser. No. 07/605,754 filed Oct. 30, 1990, abandoned, and a continuation-in-part of U.S. patent application Ser. No. 07/605,948 filed Oct. 30, 1990, abandoned, and a continuation-in-part of Ser. No. 07/605,921 filed Oct. 30, 1990, abandoned, and a continuation-in-part of Ser. No. 07/605,828 filed Oct. 30, 1990, abandoned, and a continuation-in-part of Ser. No. 07/605,757 filed Oct. 30, 1990, abandoned. All prior related applications are incorporated by reference herein.
US Referenced Citations (55)
Foreign Referenced Citations (9)
Number |
Date |
Country |
0203459 |
May 1986 |
EPX |
0272923 |
Jun 1988 |
EPX |
0359925 |
Jul 1989 |
EPX |
0370657 |
Nov 1989 |
EPX |
2817854 |
Jan 1979 |
DEX |
50-139184 |
Jun 1975 |
JPX |
62-14903 |
Jan 1987 |
JPX |
62-277106 |
Dec 1987 |
JPX |
1601529 |
Oct 1981 |
GBX |
Non-Patent Literature Citations (6)
Entry |
Harris, Polymer Sci., Part A-1, vol. 4, 665-677 (1965). |
Haas et al., J. Polymer Sci., vol. 22, 291-302 (1956). |
Ikada et al., "Blood Compatibility of Hydrophilic Polymers,", J. Biomedical Materials Research, 15:697-718 (1981). |
Sato et al., "Study on Interactions Between Plasma Proteins and Polymer Surface", Polymer Journal, 16: No. 1 pp. 1-8 (1984). |
Saito, "On Food Quality Preservation By Means of Free Oxygen Absorber", Journal Yukaqaku, 28, No. 1, pp. 45-54 (1979) (Translated with pagination 1-23). |
Labuza et al., "Applications of Active Packaging for Improvement of Shelf Life and Nutritional Quality of CAP/MAP Foods", J. Food Processing and Preservation, 13:1-69 (1989). |
Related Publications (5)
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Date |
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605754 |
Oct 1990 |
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605948 |
Oct 1990 |
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605921 |
Oct 1990 |
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605828 |
Oct 1990 |
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605757 |
Oct 1990 |
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Divisions (1)
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Number |
Date |
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Parent |
122807 |
Sep 1993 |
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Continuations (1)
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Number |
Date |
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Parent |
775969 |
Nov 1991 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
605834 |
Oct 1990 |
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