Claims
- 1. A compound of the formula ##STR6## wherein R.sup.1 and R.sup.2 are the same or different and are methyl or methoxy, or R.sup.1 and R.sup.2 are joined together to form the group of the formula: --CH.dbd.CH--CH.dbd.CH--;
- R.sup.3 is hydrogen or a protecting group selected from the group consisting of acetyl, propionyl, butyryl, benzoyl, nicotinoyl, tetrahydropyranyl, methoxymethyl, ethoxyethyl, methoxyethoxymethyl, methylthiomethyl and trityl;
- X is thienyl unsubstituted or substituted by at least one substituent selected from the group consisting of alkyl of 1-3 carbon atoms, alkoxy of 1-3 carbon atoms and halogen;
- R is a saturated or unsaturated bivalent straight-chain hydrocarbon group having up to 20 carbon atoms or a chemical bond;
- Y is a member selected from the group consisting of
- (1) hydrogen,
- (2) hydroxymethyl,
- (3) methoxymethyloxymethyl,
- (4) acetoxymethyl,
- (5) nitroxymethyl,
- (6) aminocarbonyloxymethyl,
- (7) methylaminocarbonyloxymethyl,
- (8) ethylaminocarbonyloxymethyl,
- (9) dimethylaminocarbonyloxymethyl,
- (10) phenylaminocarbonyloxymethyl,
- (11) morpholinocarbonyloxymethyl
- (12) piperidinocarbonyloxymethyl,
- (13) carboxyl,
- (14) alkoxycarbonyl having 2 to 5 carbon atoms,
- (15) aryloxycarbonyl having 7 to 8 carbon atoms, and
- (16) aminocarbonyl which is unsubstituted or is substituted by
- (a) hydroxyl,
- (b) alkyl of 1 to 4 carbon atoms,
- (c) phenyl or naphthyl each of which is unsubstituted or is substituted by hydroxyl, amino, nitro, halogen, methyl or methoxy,
- (d) morpholinocarbonyl,
- (e) thiomorpholinocarbonyl, or
- (f) piperidinocarbonyl;
- Ph is phenyl; and
- t-Bu is tert-butyl.
- 2. A compound according to claim 1, wherein Y is
- (1) hydroxymethyl,
- (2) carboxyl,
- (3) alkoxycarbonyl having 2 to 5 carbon atoms,
- (4) aryloxycarbonyl having 7 to 8 carbon atoms, or
- (5) aminocarbonyl which is unsubstituted or is substituted by
- (a) hydroxyl,
- (b) alkyl having 1 to 4 carbon atoms,
- (c) phenyl or naphthyl each of which is unsubstituted or is substituted by hydroxyl, amino, nitro, halogen, methyl or methoxy,
- (d) morpholinocarbonyl,
- (e) thiomorpholinocarbonyl, or
- (f) piperidinocarbonyl.
- 3. A compound according to claim 1 wherein R.sup.1 and R.sup.2 are independently methyl or methoxy.
- 4. A compound according to claim 1 wherein R is a saturated or unsaturated bivalent straight-chain hydrocarbon group of 5 to 8 carbon atoms,
Priority Claims (1)
Number |
Date |
Country |
Kind |
4-055007 |
Mar 1992 |
JPX |
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Parent Case Info
This application is a division of application Ser. No. 08/030,880, filed Mar. 12, 1993 (now U.S. Pat. No. 5,436,359).
US Referenced Citations (9)
Non-Patent Literature Citations (1)
Entry |
Stern et al., J. Org. Chem., 52, pp. 2763-2768 (1987). |
Divisions (1)
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Number |
Date |
Country |
Parent |
30880 |
Mar 1993 |
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