Hydroxphenyl-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical comositions comprising them

BACKGROUND OF THE INVENTION

[0001] 1. Field of the Invention

[0002] The present invention relates to pyrazole derivatives active as kinase inhibitors and, more in particular, it relates to hydroxyphenyl-pyrazole derivatives, to a process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of diseases linked to disregulated protein kinases.

[0003] 2. Discussion of the Background

[0004] The malfunctioning of protein kinases (PKs) is the hallmark of numerous diseases. A large share of the oncogenes and proto-oncogenes involved in human cancers code for PKs. The enhanced activities of PKs are also implicated in many non-malignant diseases such as benign prostate hyperplasia, familial adenomatosis, polyposis, neuro-fibromatosis, psoriasis, vascular smooth cell proliferation associated with atherosclerosis, pulmonary fibrosis, arthritis glomerulonephritis and post-surgical stenosis and restenosis. PKs are also implicated in inflammatory conditions and in the multiplication of viruses and parasites. PKs may also play a major role in the pathogenesis and development of neurodegenerative disorders.

[0005] For a general reference to PKs malfunctioning or disregulation see, for instance, Current Opinion in Chemical Biology 1999, 3, 459-465.

SUMMARY OF THE INVENTION

[0006] The present inventors have now discovered that some hydroxyphenyl-pyrazoles are endowed with multiple protein kinase inhibiting activity and are thus useful in therapy in the treatment of diseases caused by and/or associated with disregulated protein kinases.

[0007] As such, it is an object of the invention to provide compounds which are useful as therapeutic agents against a host of diseases caused by a disregulated protein kinase activity.

[0008] It is another object to provide compounds endowed with multiple protein kinase inhibiting activity.

[0009] More specifically, the hydroxyphenyl-pyrazoles of this invention are useful in the treatment of a variety of cancers including, but not limited to: carcinoma such as bladder, breast, colon, kidney, liver, lung, including small cell lung cancer, esophagus, gall-bladder, ovary, pancreas, stomach, cervix, thyroid, prostate, and skin, including squamous cell carcinoma; hematopoietic tumors of lymphoid lineage, including leukemia, acute lymphocitic leukemia, acute lymphoblastic leukemia, B-cell lymphoma, T-cell-lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, hairy cell lymphoma and Burkett's lymphoma; hematopoietic tumors of myeloid lineage, including acute and chronic myelogenous leukemias, myelodysplastic syndrome and promyelocytic leukemia; tumors of mesenchymal origin, including fibrosarcoma and rhabdomyosarcoma; tumors of the central and peripheral nervous system, including astrocytoma, neuroblastoma, glioma and schwannomas; other tumors, including melanoma, seminoma, teratocarcinoma, osteosarcoma, xeroderma pigmentosum, keratocanthoma, thyroid follicular cancer and Kaposi's sarcoma.

[0010] Due to the key role of PKs in the regulation of cellular proliferation, these hydroxyphenyl-pyrazoles are also useful in the treatment of a variety of cell proliferative disorders such as, for instance, benign prostate hyperplasia, familial adenomatosis, polyposis, neuro-fibromatosis, psoriasis, vascular smooth cell proliferation associated with atherosclerosis, pulmonary fibrosis, arthritis glomerulonephritis and post-surgical stenosis and restenosis.

[0011] The compounds of the invention can be useful in the treatment of Alzheimer's disease, as suggested by the fact that cdk5 is involved in the phosphorylation of tau protein (J. Biochem., 117,741-749, 1995).

[0012] The compounds of this invention, as modulators of apoptosis, may also be useful in the treatment of cancer, viral infections, prevention of AIDS development in HIV-infected individuals, autoimmune diseases and neurodegenerative disorders.

[0013] The compounds of this invention may be useful in inhibiting tumor angiogenesis and metastasis.

[0014] The compounds of the invention are useful as cyclin dependent kinase (cdk) inhibitors and also as inhibitors of other protein kinases such as, for instance, protein kinase C in different isoforms, Met, PAK-4, PAK-5, ZC-1, STLK-2, DDR-2, Aurora 1, Aurora 2, Bub-1, PLK, Chk1, Chk2, HER2, raf1, MEK1, MAPK, EGF-R, PDGF-R, FGF-R, IGF-R, VEGF-R, PI3K, weel kinase, Src, Abl, Akt, ILK, MK-2, IKK-2, Cdc7, Nek, and thus be effective in the treatment of diseases associated with other protein kinases.

[0015] Accordingly, the present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a hydroxyphenyl-pyrazole derivative represented by formula (I):

[0016] wherein R1 to R4 independently represent

[0017] hydrogen or halogen atom, hydroxy, nitro or NR8R9 group, wherein R8 and R9 independently represent hydrogen or an optionally substituted group selected from C1-C6 alkyl, aryl, aryl C1-C6 alkyl, C3-C7 cycloalkyl and saturated or unsaturated heterocyclyl group, or a residue of formula COR10, CONHR10 or SO2R10 in which R10 is hydrogen atom or an optionally substituted group selected from C1-C6 alkyl, aryl, aryl C1-C6 alkyl, saturated or unsaturated C3-C7 cycloalkyl or saturated or unsaturated heterocyclyl group, or

[0018] an optionally substituted group selected from a straight or branched C1-C6 alkyl, aryl, aryl C1-C6 alkyl, a saturated or unsaturated C3-C7 cycloalkyl or cycloalkoxy group, saturated or unsaturated heterocyclyl, C1-C6 alkoxy, aryloxy, aryl C1-C6 alkoxy;

[0019] R5 and R6 independently represent hydrogen or an optionally substituted group selected from C1-C6 alkyl, aryl, aryl C1-C6 alkyl, C3-C7 cycloalkyl and saturated or unsaturated heterocyclyl,

[0020] R7 is a substituent attached at one of the two nitrogen atoms of the pyrazole ring having the formula CONHR10, CSNHR10, SO2R10, COR10 or COOR10, in which R10 is as above defined, or a pharmaceutically acceptable salt thereof.

[0021] In a preferred embodiment of the method described above, the disease caused by and/or associated with an altered protein kinase activity is selected from the group consisting of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

[0022] Specific types of cancer that may be treated according to the invention include carcinoma, squamous cell carcinoma, hematopoietic tumors of myeloid or lymphoid lineage, tumors of mesenchymal origin, tumors of the central and peripheral nervous system, melanoma, seminoma, teratocarcinoma, osteosarcoma, xeroderoma pignentosum, keratoxanthoma, thyroid follicular cancer and Kaposi's sarcoma.

[0023] In another preferred embodiment of the method described above, the cell proliferative disorder is selected from the group consisting of benign prostate hyperplasia, familial adenomatosis polyposis, neuro-fibromatosis, psoriasis, vascular smooth cell proliferation associated with atherosclerosis, pulmonary fibrosis, arthritis glomerulonephritis and post-surgical stenosis and restenosis. In addition, the method object of the present invention, provides tumor angiogenesis and metastasis inhibition.

[0024] The present invention also provides a hydroxyaryl-pyrazole derivative represented by formula (I):

[0025] wherein R1 to R4 independently represent

[0026] hydrogen or halogen atom, hydroxy, nitro or NR8R9 group, wherein R8 and R9 independently represent hydrogen or an optionally substituted group selected from C1-C6 alkyl, aryl, aryl C1-C6 alkyl, C3-C7 cycloalkyl and saturated or unsaturated heterocyclyl group, or a residue of formula COR10, CONHR10 or SO2R10 in which R10 is hydrogen atom or an optionally substituted group selected from C1-C6 alkyl, aryl, aryl C1-C6 alkyl, saturated or unsaturated C3-C7 cycloalkyl or saturated or unsaturated heterocyclyl group, or

[0027] an optionally substituted group selected from a straight or branched C1-C6 alkyl, aryl, aryl C1-C6 alkyl, a saturated or unsaturated C3-C6 cycloalkyl or cycloalkoxy group, saturated or unsaturated heterocyclyl, C1-C6 alkoxy, aryloxy, aryl C1-C6 alkoxy;

[0028] R5 and R6 independently represent hydrogen or an optionally substituted group selected from C1-C6 alkyl, aryl, aryl C1-C6 alkyl, C3-C7 cycloalkyl and saturated or unsaturated heterocyclyl,

[0029] R7 is a substituent attached at one of the two nitrogen atoms of the pyrazole ring having the formula CONHR10, CSNHR10, SO2R10, COR10 or COOR10, in which R10 is as above defined, with the following provisos:

[0030] when R7 is CONH2 or CSNH2 and R5 is H or CH3, then R6 is not H, CH3 or phenyl group,

[0031] when R7 is CO R111 in which R′11 is an optionally substituted C1-C6 alkyl, phenyl, or saturated or unsaturated heterocyclyl group, and R5 is H or phenyl group, then R6 is not H, CH3 or an optionally substituted phenyl,

[0032] when R7 is CO2C(CH3)3 or CO2CH3 and R5 is H, then R6 is not an optionally substituted phenyl group;

[0033] or a pharmaceutically acceptable salt thereof.

[0034] The hydroxyphenyl-pyrazole derivatives of formula (I), object of the invention, are obtainable through a synthetic process comprising well known reactions carried out according to conventional techniques, as well as through a new and extremely versatile solid-phase combinatorial process, being both comprised within the scope of the invention. The present invention also provides a pharmaceutical composition comprising the hydroxyaryl-pyrazole derivatives of formula (I) and at least one pharmaceutically acceptable excipient, carrier or diluent.

[0035] A more complete appreciation of the invention and many of the attendant advantages thereof will be readily obtained as the same becomes better understood by reference to the following detailed description.

DETAILED DESCRIPTION OF THE INVENTION

[0036] Some hydroxyphenyl-pyrazole derivatives structurally close to the compounds of formula (I) are known in the art. Among them are, as an example, certain pyrazoles active as antibacterial agents were studied (Mogilaiah et al, Indian J. Chem., B, 2001, 40B(1), p.43-48; Naik, S. M. et al. Asian J. Chem., 11(4), 1537-1539 and 1522-1524, 1999), and the reactivity of other derivatives was for instance discussed in Hamed, Ashraf et al., An. Quim. (1994), 90(5-6), 359-64 and in Rampey, Mary E.et al. Photochem. Photobiol., 70(2), 176-183, 1999.

[0037] The compounds of formula (I), object of the present invention, may have asymmetric carbon atoms and may therefore exist either as racemic admixtures or as individual optical isomers. Accordingly, all the possible isomers and their admixtures and of both the metabolites and the pharmaceutically acceptable bio-precursors (otherwise referred to as pro-drugs) of the compounds of formula (I), as well as any therapeutic method of treatment comprising them, are also within the scope of the present invention.

[0038] As stated above, as will be readily appreciated, the R7 substituent on the pyrazole ring may be on one of the two nitrogens in the compounds of the invention:

[0039] wherein R1 to R4, R5, R6 and R7 are as defined above.

[0040] Accordingly, in the present invention and unless otherwise indicated, the general formula I comprises both the compounds of formula (I′) and the other of formula (I″). As used herein, unless otherwise specified, with the term straight or branched C1-C6 alkyl, we intend a group such as, for instance, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, neopentyl, n-hexyl, isohexyl, and the like.

[0041] With the term aryl we intend an aromatic carbocycle such as, for instance, phenyl, biphenyl, 1-naphthyl, 2-naphthyl, and the like.

[0042] With the term saturated or unsaturated C3-C7 cycloalkyl group we intend, for instance, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopentenyl, cyclohexenyl, and the like.

[0043] Unless otherwise specified, saturated or unsaturated cycloalkyl groups can be further condensed with 1 or 2 benzene rings are, for instance, 1,2,3,4-tetrahydro-naphthalene-2-yl, fluorene-9-yl, and the like.

[0044] The term “heterocyclyl” as used herein refers to a 3- to 7-membered, substituted or unsubstituted, saturated or unsaturated heterocyclyl ring, containing at least one heteroatom selected from O, S and N, any ring carbon may be oxidized as a carbonyl, and wherein said heterocyclyl ring may be optionally fused to a second 5- or 6-membered, saturated or unsaturated heterocyclyl ring, or to a C3-C7 cycloalkyl ring, or to a benzene or naphthalene ring. With the term 3- to 7-membered heterocycle with at least one heteroatom selected among nitrogen, oxygen or sulphur, we intend a saturated, partly unsaturated or fully unsaturated either aromatic or non aromatic heterocycle such as, for instance, thiophene, furan, pyrrole, imidazole, pyrazole, thiazole, isothiazole, oxazole, isoxazole, pyridine, pyrazine, pyrimidine, pyridazine, pyrrolidine, pyrroline, imidazolidine, imidazoline, piperidine, piperazine, morpholine, tetrahydrofuran, tetrahydropyran, tetrahydrothiopyran, and the like.

[0045] With the term optionally fused heterocycle and unless otherwise indicated we intend any of the above defined heterocycles further condensed, through any one of the available bonds, with 5- or 6-membered, saturated or unsaturated heterocyclyl ring, or to a C3-C7 cycloalkyl ring, or to a benzene or naphthalene ring such as, for instance, quinoline, isoquinoline, chroman, chromene, thionaphthene, indoline, and the like.

[0046] The term “aryl C1-C6 alkyl” refer to a straight or branched chain alkyl moiety having from 1 to 6 carbon atoms substituted with at least one aryl group as defined above, such as, for instance, benzyl, phenylethyl, benzhydryl, benzyloxy and the like.

[0047] With the term halogen atom, we intend fluoro, bromo, chloro or iodo atom.

[0048] The term “optionally substituted” means that the group may be substituted or unsubstituted; the substituents which may be present in the alkyl, cycloalkyl, aryl, arylcycloalkyl, alkoxy, aryloxy, cycloalkoxy, alkenyl or heterocyclyl groups in any of the above definitions of R1-R10 include the following:

[0049] halo (i.e., fluoro, bromo, chloro or iodo);

[0050] hydroxy;

[0051] nitro;

[0052] azido;

[0053] mercapto (i.e., —SH), and acetyl or phenylacetyl esters thereof (i.e., —SCOCH3 and —SCOCH2C6H5);

[0054] amino (i.e., —NH2 or —NHRI or —NRIRII, wherein RI and RII, which are the same or different, are straight or branched C1-C6 alkyl, phenyl, biphenyl (i.e., —C6H4—C6H5), or benzyl groups, optionally substituted by hydroxy, methoxy, methyl, amino, methylamino, dimethylamino, chloro or fluoro; or RI and RII taken together with the nitrogen atom to which they are attached form a heterocyclic ring such as morpholino, pyrrolidino, piperidino, pyperazino or N-methylpyperazino;

[0055] guanidino, i.e., —NHC(═NH)NH2;

[0056] formyl (i.e. —CHO);

[0057] cyano;

[0058] carboxy (i.e. —COOH), or esters thereof (i.e., —COORI), or amides thereof (i.e., —CONH2, —CONHRI or —CONHRIRII), wherein RI and RII are as defined above, and including morpholino-amides, pyrrolidino-amides, and carboxymethylamides —CONHCH2COOH;

[0059] sulfo (i.e., —SO3H);

[0060] acyl, i.e., —C(O)RI, wherein RI is as defined above, including monofluoroacetyl, difluoroacetyl, trifluoroacetyl;

[0061] carbamoyloxy (i.e., —OCONH2) and N-methylcarbamoyloxy;

[0062] acyloxy, i.e., —OC(O)RI wherein RI is as defined above, or formyloxy;

[0063] acylamino, i.e., —NHC(O)RI, or —NHC(O)ORI, wherein RI is as defined above or is a group —(CH2)tCOOH where t is 1, 2 or 3;

[0064] ureido, i.e., —NH(CO)NH2, —NH(CO)NHRI, —NH(CO)NRIRII, wherein RI and RII are as defined above, including —NH(CO)-(4-morpholino), —NH(CO)-(1-pyrrolidino), —NH(CO)-(1-piperazino), —NH(CO)-(4-methyl-1-piperazino);

[0065] sulfonamido, i.e., —NHSO2RI wherein RI is as defined above;

[0066] a group —(CH2)tCOOH, and esters and amides thereof, i.e., —(CH2)tCOORI and —(CH2)tCONH2, —(CH2)tCONHRI, —(CH2)tCONRIRII, wherein t, RI and RII are as defined above;

[0067] a group —NH(SO2)NH2, —NH(SO2)NHRI, —NH(SO2)NRIRII, wherein RI and RII are as defined above, including —NH(SO2)-(4-morpholino), —NH(SO2)-(1-pyrrolidino), —NH(SO2)-(1-piperazino), —NH(SO2)-(4-methyl-1-piperazino);

[0068] a group —OC(O)ORI, wherein RI is as defined above;

[0069] a group —ORI, wherein RI is as defined above, including —OCH2COOH;

[0070] a group —O—CH2—O—, methylendioxy or —CH2—CH2—O—, ethylendioxy,

[0071] a group —SRI, wherein RI is as defined above, including —SCH2COOH;

[0072] a group —S(O)RI, wherein RI is as defined above;

[0073] a group —S(O2)RI, wherein RI is as defined above;

[0074] a group —SO2NH2, —SO2NHRI, or —SO2NRIRII, wherein RI and RII are as defined above;

[0075] C1-C6 alkyl or C2-C6 alkenyl;

[0076] C3-C7 cycloalkyl;

[0077] substituted methyl selected from chloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, aminomethyl, N,N-dimethylaminomethyl, azidomethyl, cyanomethyl, carboxymethyl, sulfomethyl, carbamoylmethyl, carbamoyloxymethyl, hydroxymethyl, methoxycarbonylmethyl, ethoxycarbonylmethyl, tert-butoxycarbonylmethyl and guanidinomethyl.

[0078] Most preferred substituents are methoxy, trifluoromethyl, methylendioxy, dimethylamino, and ethoxycarbonyl groups.

[0079] When present, carboxy, hydroxy, mercapto and amino groups may be either free or in a protected form. Protected forms of said groups are any of those generally known in the art. Preferably, carboxy groups are protected as esters thereof, in particular methyl, ethyl, tert-butyl, benzyl, and 4-nitrobenzyl esters. Preferably, hydroxy groups are protected as silyl-ethers, ethers or esters thereof, in particular trimethyl silyl, tert-butyldiphenyl silyl, triethyl silyl, triisopropyl silyl or tert-butyldimethylsilyl ethers, methoxymethyl ethers, tetrahydropyranyl ethers, benzyl ethers, acetates or benzoates. Preferably, mercapto groups are protected as thioethers or thioesters, in particular tert-butyl thioethers, thioacetates or thiobenzoates. Preferably, amino groups are protected as carbamates, e.g. tert-butoxycarbonyl derivatives, or as amides, e.g. acetamides and benzamides.

[0080] Furthermore, hydrates, solvates of compounds of formula (I), and physiologically hydrolyzable derivatives (i.e., prodrugs) of compounds of formula (J) are included within the scope of the present invention.

[0081] With the term oxo we intend a carbonyl (>C═O) group.

[0082] With the term perfluorinated alkyl we intend any alkyl group as above defined being substituted by two or more fluorine atoms such as, for instance, trifluoromethyl, 2,2,2-trifluoroethyl, 1,1-difluoroethyl, and the like.

[0083] From all of the above, it is clear to the skilled man that any of the groups or substituents being defined, for instance, as arylalkyl, alkoxy, cycloalkoxy, aryloxy, arylalkyloxy and the like, have to be construed from the names of the groups from which they originate.

[0084] As an example, unless specifically noted otherwise, any arylalkyloxy group has to be intended as an alkyloxy wherein the alkyl moiety is substituted by at least one aryl, both aryl and alkyl being as above defined.

[0085] Pharmaceutically acceptable salts of the compounds of formula (I) are the acid addition salts with inorganic or organic, e.g. nitric, hydrochloric, hydrobromic, sulphuric, perchloric, phosphoric, acetic, trifluoroacetic, propionic, glycolic, lactic, oxalic, malonic, malic, maleic, tartaric, citric, benzoic, cinnamic, mandelic, methanesulphonic, isethionic and salicylic acid, as well as the salts with inorganic or organic bases, e.g. alkali or alkaline-earth metals, especially sodium, potassium, calcium or magnesium hydroxides, carbonates or bicarbonates, acyclic or cyclic amines, preferably methylamine, ethylamine, diethylamine, triethylamine or piperidine.

[0086] Within the compounds of formula (I) object of the invention, the R7 group can be on one of the two nitrogen atoms of the pyrazole ring; preferably, the said R7 is on the nitrogen in position meta with respect to the hydroxy-phenyl ring, as depicted in the formula I′ above.

[0087] Preferred compounds of formula (I) are the compounds wherein R1, R4 and R5 are hydrogen atoms.

[0088] Other preferred compounds of formula (I) are the compounds wherein R2 and R3 are independently selected from

[0089] hydrogen or halogen atom,

[0090] an optionally substituted straight or branched C1-C6 alkyl or C1-C6 alkoxy, and —NR8R9 group, wherein R8 and R9 independently represent hydrogen atom or a residue of formula COR10 wherein R10 is an optionally substituted group selected from aryl and saturated or unsaturated heterocyclyl group.

[0091] Still more preferred, within this class, are the compounds of formula (I) wherein R2 and R3 are selected from hydrogen, chlorine or fluorine atom, optionally substituted straight or branched C1-C6 alkyl or C1-C6 alkoxy and NR8R9 group, wherein R8 and R9 independently represent hydrogen atom or a residue of formula COR10 wherein R10 is an optionally substituted group selected from phenyl, 1-naphthyl, 2-naphtyl, biphenyl, pyridyl, pyrazolyl, thienyl, isoxazolyl, thiazolyl, pyrazolyl, fluorene-9-yl, piperidine or tetrahydroquinoline.

[0092] Another preferred class of compounds of formula (I) are the compounds wherein R6 is an optionally substituted group selected from C1-C6 alkyl, aryl, C3-C7 cycloalkyl and saturated or unsaturated heterocyclyl group.

[0093] Still more preferred, within this class, are the compounds of formula (I) wherein R6 is an optionally substituted group selected from straight or branched C1-C6 alkyl, C3-C7 cycloalkyl, phenyl, 1-naphthyl, 2-naphtyl, biphenyl, pyridyl, pyrazolyl, thienyl, isoxazolyl, thiazolyl, pyrazolyl, fluorene-9-yl, piperidine or tetrahydroquinoline.

[0094] According to another preferred embodiment of the invention, the compounds of formula (I) are pyrazole derivatives wherein R7 represents a group of formula CONHR10, in which R10 is hydrogen atom or an optionally substituted group selected from C1-C6 alkyl, aryl, aryl C1-C6 alkyl, C2-C8 alkenyl, C3-C7 cycloalkyl or saturated or unsaturated heterocyclyl group. More preferably, R7 represents a group of formula CONHR10, in which R10 is C1-C6alkyl, phenyl, 1-naphthyl, 2-naphtyl, biphenyl, benzyl, allyl or phenethyl group.

[0095] Specific, not limiting, examples of the compounds of formula (I) of the invention, whenever appropriate in the form of pharmaceutically acceptable salts, are the following:

[0096] Ia. 5-Cyclopropyl-3-[2-hydroxy-4-(4-methoxy-benzoylamino)-phenyl]-pyrazole-1-carboxylic acid butylamide;

[0097] Ib. N-ethyl-3-(2-hydroxyphenyl)-5-pyridin-4-yl-1H-pyrazole-1-carboxamide;

[0098] Ic. 5-cyclopropyl-3-(2-hydroxyphenyl)-N-propyl-1H-pyrazole-1-carboxamide;

[0099] Id. ethyl N-{[5-cyclopropyl-3-(2-hydroxyphenyl)-1H-pyrazol-1-yl]carbonyl}glycinate;

[0100] Ie. N-allyl-5-cyclopropyl-3-(2-hydroxyphenyl)-1H-pyrazole-1-carboxamide;

[0101] If. N-cyclohexyl-5-cyclopropyl-3-(2-hydroxyphenyl)-1H-pyrazole-1-carboxamide;

[0102] Ig. 5-cyclopropyl-N-ethyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide;

[0103] Ih. ethyl-N-{[5-[2-(dimethylamino)ethyl]-3-(2-hydroxyphenyl)-1H-pyrazol-1-yl]carbonyl}glycinate;

[0104] Ii. 5-cyclopropyl-N-ethyl-3-(2-hydroxy-4-methoxyphenyl)-1H-pyrazole-1-carboxamide;

[0105] Ij. ethyl-N-{[5-cyclopropyl-3-(2-hydroxy-4-methoxyphenyl)-1H-pyrazol-1-yl]carbonyl}glycinate;

[0106] Ik. 5-cyclopropyl-N-ethyl-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazole-1-carboxamide;

[0107] Il. 5-cyclopropyl-N-ethyl-3-(2-hydroxy-5-methylphenyl)-1H-pyrazole-1-carboxamide;

[0108] Im. ethyl-N-{[5-cyclopropyl-3-(2-hydroxy-5-methylphenyl)-1H-pyrazol-1-yl]carbonyl}glycinate;

[0109] In. N-butyl-5-cyclopropyl-3-(2-hydroxy-4-methoxyphenyl)-1H-pyrazole-1-carboxamide:

[0110] Io. N-butyl-5-cyclopropyl-3-(2-hydroxy-5-methylphenyl)-1H-pyrazole-1-carboxamide;

[0111] Ip. N-(3-{1-[(butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide;

[0112] Iq. N-(4-{1-[(butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide;

[0113] Ir. 3-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-butyl-5-cyclobutyl-1H-pyrazole-1-carboxamide;

[0114] Is. 3-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-butyl-5-cyclopentyl-1H-pyrazole-1-carboxamide;

[0115] It. N-allyl-5-cyclopropyl-3-(4-fluoro-2-hydroxyphenyl)-1H-pyrazole-1-carboxamide;

[0116] Iu. 5-(3,4-dimethoxyphenyl)-N-ethyl-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazole-1-carboxamide;

[0117] Iv. N-allyl-5-[2-(dimethylamino)ethyl]-3-(2-hydroxy-5-methylphenyl)-1H-pyrazole-1-carboxamide;

[0118] Iw. 5-[2-(dimethylamino)ethyl]-3-(2-hydroxy-5-methoxyphenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide;

[0119] Ix. ethyl-N-{[5-(3,4-dimethoxyphenyl)-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazol-1-yl]carbonyl}glycinate;

[0120] Iy. 5-cyclopropyl-N-ethyl-3-(4-fluoro-2-hydroxyphenyl)-1H-pyrazole-1-carboxamide

[0121] Iz. ethyl-N-{[3-(5-chloro-2-hydroxyphenyl)-5-cyclopropyl-1H-pyrazol-1-yl]carbonyl}glycinate;

[0122] Iaa. 5-cyclopropyl-3-(2-hydroxy-5-methoxyphenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide;

[0123] Ibb. 5-cyclopropyl-N-ethyl-3-(2-hydroxyphenyl)-1H-pyrazole-1-carboxamide;

[0124] Icc. N-allyl-5-(3,4-dimethoxyphenyl)-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazole-1-carboxamide;

[0125] Idd. N-benzyl-5-(3,4-dimethoxyphenyl)-3-(2-hydroxy-5-methylphenyl)-1H-pyrazole-1-carboxaamide;

[0126] Iee. N-allyl-5-cyclopropyl-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazole-1-carboxamide;

[0127] Iff. N-benzyl-5-[2-(dimethylamino)ethyl]-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazole-1-carboxamide;

[0128] Igg. 5-cyclopropyl-3-(2-hydroxy-5-methylphenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide;

[0129] Ihh. 5-[2-(dimethylamino)ethyl]-N-ethyl-3-(2-hydroxyphenyl)-1H-pyrazole-1-carboxamide;

[0130] Iii. Ethyl N-[(5-cyclobutyl-3-{2-hydroxy-4-[(3-methoxybenzoyl)amino]phenyl}-1H-pyrazol-1-yl)carbonyl]glycinate and

[0131] Ijj. Ethyl N-[(5-cyclopropyl-3-{2-hydroxy-4-[(3-methoxybenzoyl)amino]phenyl}-1H-pyrazol-1-yl)carbonyl]glycinate.

[0132] As formerly indicated, it is a further object of the invention a process for preparing the compounds of formula (I) and pharmaceutically acceptable salts thereof, which process comprises:

[0133] a) removing Q from a compound of formula (II)

[0134] wherein R1 to R7 are as defined above and Q is a hydroxy-phenyl protecting group or a solid support, so as to obtain the compound of formula (I) as defined above and, if desired,

[0135] b) converting the resultant compound of formula (I) into another compound of formula (I) and/or into a salt or free form thereof.

[0136] The above process is an analogy process which can be carried out according to well known methods. It is clear to the person skilled in the art that if a compound of formula (I), prepared according to the above process, is obtained as an admixture of isomers, their separation into the single isomers of formula (I), carried out according to conventional techniques, is still within the scope of the present invention.

[0137] Likewise, the salification of a compound of formula (I) or the conversion of its salt into the free compound (I), carried out according to well-known procedures in the art, are still within the scope of the invention.

[0138] According to step a) of the process, the removal of Q as defined above from a compound of formula (II) is preferably carried out under acidic conditions, that is in the presence of suitable acids such as, for instance, hydrochloric, trifluoroacetic, methanesulphonic or p-toluensulphonic acid, as well as by using conventional acid ion exchange resins.

[0139] The reaction is carried out under conventional methods, for instance by using a solution of the acid, e.g. a 10% to 100% (v/v) of trifluoroacetic acid in dichlorometane, at a temperature ranging from about 0° C. to reflux, and for a suitable time, for instance from about 5 minutes to about 2 hours.

[0140] From the above it is clear to the skilled man that the optional conversion of a compound of formula (I) into another compound of formula (I) may be carried out by conventional methods. Likewise, a compound of formula (II) may be converted into another compound of formula (II) before undergoing deprotection. The conversion of a compound of formula I or II into another different compound of formula I or II may be carried out in several ways, depending on the meanings of the substituents and the presence of other substituents in the molecule.

[0141] For example, a conversion can be a hydrolysis, an oxidation, a reduction, a condensation with an appropriate reagent or a combination of these reactions.

[0142] Also the optional salification of a compound of formula (I) or the conversion of its salt into the free compound, as well as the separation of a mixture of isomers into the single isomers, may be all carried out by conventional methods.

[0143] The compound of formula (II) with a suitable hydroxy-phenyl protecting group or a solid support may be prepared by

[0144] i) reacting the compound of formula (E)

[0145] wherein R1 to R5 are as above defined, with a suitable hydroxy-phenyl protecting agent or a solid support, so as to obtain a compound of formula (IV)

[0146] wherein R1 to R5 are as above defined and Q is the said hydroxy-phenyl protecting group or a solid support;

[0147] ia) optionally converting the compound of formula (IV) wherein one of R1 to R4 is an amino group into a different compound of formula (IV) wherein one of R1 to R4 is a group of formula NHCOR10, NHCONHR10 or NHSO2R10 wherein R10 is as defined above, by reaction with any one of the compounds of the formula (V), (VI) or (VII):

R10—COX (V);

R10—N═C═O (VI);

R10—SO2X′ (II)

[0148] wherein R10 is as above defined, X is hydroxy or a suitable leaving group and X′ is a suitable leaving group;

[0149] ii) reacting the compound of formula (IV) with a derivative of formula (VIII)

[0150] wherein Ra is a C1-C6 alkyl group, so as to obtain a compound of formula (IX)

[0151] wherein Q, R1 to R6 are as above defined;

[0152] iii) reacting the compound of formula (IX) with hydrazine hydrate so as to obtain the compound of formula (X)

[0153] wherein Q, R1 to R6 are as above defined;

[0154] iv) reacting the compound of formula (X) with any one of the compounds of formula (V), (VI), (VII), (XI) or (XII):

R10—COX (V);

R10—N═C═O (VI);

R10—SO2X′ (VII);

R10—N═C═S (XI)

R10—OCOX (XII)

[0155] wherein R10, X′ and X are as above defined, so as to obtain the compound of formula (II) as defined above.

[0156] According to step i) of the process, the compound of formula (III) is reacted with a suitable hydroxy-phenyl protecting agent such as, for instance, benzyl group; or with a solid support such as, for instance, a benzyloxy-polystyrene resin.

[0157] Preferably, the oxygen-phenol protecting agent or the solid support is selected from benzyl or a benzyloxy-polystyrene resin.

[0158] The reaction is carried out in the presence of a base such as cesium carbonate or potassium carbonate and a salt as tetrabutilamonium iodide or sodium iodide to enhance the solubility of carbonate, in a suitable solvent such as, for instance, N,N-dimethylacetamide or N,N-dimethylformamide, at a temperature ranging from about 0° C. to room temperature and for a suitable time, for instance from about 30 minutes to about 96 hours.

[0159] According to the optional step ia) of the process, the compound of formula (IV) is reacted with any one of the compounds of formula (V), (VI) or (VII), so as to obtain the corresponding different derivative of formula (IV). In this respect, it is clear to the skilled man that a carboxamido derivative of formula (IV) wherein one of R1 to R4 is NHCOR10 is obtained through reaction with a compound of formula (V); an ureido derivative of formula (IV) wherein one of R1 to R4 is NHCONHR10 is obtained through reaction with a compound of formula (VI) and a sulphonamido derivative of formula (VII) wherein one of R1 to R4 is NHSO2R10 is obtained through reaction with a compound of formula (VII). As formerly indicated, within the compound of formula (V) X is a hydroxy group or a suitable leaving group such as, for instance, a halogen atom. Preferably, in the reaction with a compound of formula (V) X is hydroxy, chlorine or bromine.

[0160] The reaction between a compound of formula (IV) and a carboxylic acid derivative of formula (V) wherein X is hydroxy group can be carried out in the presence of a coupling agent such as, for instance, benzotriazol-1-yloxytrispyrrolidino)phosphonium hexafluorophosphate carbo diimide, 1,3-dicyclohexylcarbodiimide, bromo-tris-pyrrolidino-phosphonium hexafluorophosphate, 1,3-diisopropylcarbodiimide, o-benzotriazol-1-yl-n,n,n′,n′-tetramethyluronium tetrafluoroborate, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, N-cyclohexylcarbodiimide-N′-propyloxymethyl polystyrene or N-cyclohexylcarbodiimide-N′-methyl polystyrene, in a suitable solvent such as, for instance, dichloromethane, chloroform, tetrahydrofuran, diethyl ether, 1,4-dioxane, acetonitrile, toluene or N,N-dimethylformamide, at a temperature ranging from about −10° C. to reflux and for a suitable time ranging from about 30 minutes to about 96 hours.

[0161] The said reaction is optionally carried out in the presence of a suitable catalyst, for instance 4-dimethylaminopyridine, or in the presence of a further coupling agent such as N-hydroxybenzotriazole. The reaction between a compound of formula (IV) and a compound of formula (V) can also be carried out through a mixed anhydride method, that is by using an alkyl chloroformate such as ethyl, isobutyl, or isopropyl chloroformate, in the presence of a tertiary base such as triethylamine, N,N-diisopropylethylamine or pyridine, in a suitable solvent such as toluene, dichloromethane, chloroform, tetrahydrofuran, acetonitrile, diethyl ether, 1,4-dioxane or N,N-dimethylformamide, and at a temperature ranging from about −30° C. to room temperature.

[0162] The reaction between a compound of formula (IV) and a compound of formula (V) wherein X is a suitable leaving group, for instance chlorine or bromine, can be carried out in the presence of a tertiary base such as triethylamine, N,N-diisopropylethylamine or pyridine, in a suitable solvent such as toluene, dichloromethane, chloroform, diethyl ether, tetrahydrofuran, acetonitrile or N,N-dimethylformamide, and at a temperature ranging from about −10° C. to reflux.

[0163] The reaction of the compound of formula (IV) with an isocyanate derivative of formula (VI) can be carried out in the presence of a suitable catalyst, for instance 4-dimethylaminopyridine or a tertiary base such as N,N-diisopropylethylamine, in a suitable solvent such as toluene, diethyl ether, tetrahydrofuran, acetonitrile, or N,N-dimethylformamide, and at a temperature ranging from about 20° C. to 60° C.

[0164] As per step ia) of the process, within the compound of formula (VII) X′ is a suitable leaving group such as, for instance, a halogen atom. Preferably, X′ is chlorine or bromine. The reaction between a compound of formula (IV) and a sulphonyl derivative of formula (VI) can be carried out in the presence of a tertiary base such as triethylamine, N,N-diisopropylethylamine or pyridine, in a suitable solvent such as toluene, dichloromethane, chloroform, diethyl ether, tetrahydrofuran, acetonitrile or N,N-dimethylformamide, at a temperature ranging from about −10° C. to reflux.

[0165] According to step ii) of the process, the compound of formula (VIR) is reacted with the compound of formula (IV) under basic conditions, for instance in the presence of a base such as sodium hydryde or potassium ter-butoxide.

[0166] The reaction is carried out in a suitable solvent such as, for instance, N,N-dimethylformamide, N,N-dimethylacetamide at a temperature comprised from about 70° C. to 100° C. and for a suitable time, for instance from about 30 minutes to about 5 hours. According to step iii) of the process, the reaction between a compound of formula (IX) and hydrazine hydrate is carried out in a suitable solvent such as, for instance, tetrahydrofuran, acetonitrile, 1,4-dioxane, N,N-dimethylacetamide or N,N-dimethylformamide, and at a temperature ranging from about 60° C. to 90° C.

[0167] According to step iv) of the process, the reaction between a compound of formula (X) and a derivative of formula (V), (VI) or (VII) can be carried out as described in the detailed reaction description under step ia) above.

[0168] The reaction of a compound of formula (X) with an or isothiocyanate derivative of formula (XI) can be carried out in the presence of a suitable catalyst, for instance 4-dimethylaminopyridine or a tertiary base such as N,N-diisopropylethylamine, in a suitable solvent such as toluene, diethyl ether, tetrahydrofuran, acetonitrile, or N,N-dimethylformamide, and at a temperature ranging from about 20° C. to 60° C. The reaction of a compound of formula (X) with a derivative of formula (XII) can be carried out analogously to that between compound of formula (X) and the derivative of formula (V). As it will be really appreciated by the man skilled in the art, when preparing the compounds of formula (I) object of the invention, optional functional groups within both the starting materials or the intermediates thereof which could give rise to unwanted side reactions, need to be properly protected according to conventional techniques. Likewise, the conversion of these latter into the free deprotected compounds may be carried out according to known procedures.

[0169] The compounds of formula (III), (V), (VI), (VII), (VIII), (XI) and (XII) of the process are known or can be prepared according to known methods.

[0170] In addition to the above, it is also clear to the skilled man that the compounds of formula (I) of the invention can be advantageously prepared by combining the above described reactions in a combinatorial fashion, for example according to solid-phase-synthesis (SPS) techniques, so as to get a combinatorial chemical library of compounds of formula (I).

[0171] It is therefore a further object of the invention a library of two or more compounds of formula (I):

[0172] wherein R1 to R7 are as defined above.

[0173] As such, it is a further object of the present invention a compound of formula (I) which is obtainable, for instance through a combinatorial chemistry technique, as depicted in the following scheme, wherein Pol and Pol-Y are respectively a solid support and its activated form, X, X′, Ra, R1, R2, R3, R4, R5, R6, R7 and R10 are as defined above and the steps are carried out preferably under the reaction conditions set forth herein above. More preferably, one of R2 and R3 represents a group of formula NHCOR10, NHCONHR10 or NHSO2R10, wherein R10 is as defined above, and the resultant compound has one of the following formula:

[0174] wherein R6, R7 and R10 are as defined above.

[0175] Each of the compounds of formula (IV)—obtained from the reaction between the solid support and a derivative of formula (III), as set forth in table I, is optionally reacted with any one of the derivatives of formula (V) or (VI) of table II and IV, and subsequently operating as per the process of the invention by reacting any one of the resultant derivatives of formula (IV) with any one of the derivatives of formula (VIII) as set forth in table III; reacting the resultant compounds (IX) with hydrazine hydrate and subsequently reacting the resultant compounds (X) with any one of the derivatives of formula (V) or (VI) as set forth in tables II and IV.

1TABLE I2-hydroxyacetophenones derivatives of formula (III)14-amino-2-hydroxyacetophenone25-amino-2-hydroxyacetophenone

[0176]

2

TABLE II

Acyl chlorides derivatives of formula (V)

1
2-CHLOROBENZOYL CHLORIDE

2
2,6-DICHLOROBENZOYL CHLORIDE

3
2-METHOXYBENZOYL CHLORIDE

4
O-TOLUOYL CHLORIDE

5
3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE

6
4-CHLOROBENZOYL CHLORIDE

7
4-ETHOXYBENZOYL CHLORIDE

8
4-TERT-BUTYLBENZOYL CHLORIDE

9
P-TOLUOYL CHLORIDE

10
4-ETHYLBENZOYL CHLORIDE

11
ISOBUTYRYL CHLORIDE

12
ACETYL CHLORIDE

13
ISOVALERYL CHLORIDE

14
PROPIONYL CHLORIDE

15
CYCLOPROPANECARBONYL CHLORIDE

16
2-FUROYL CHLORIDE

17
THIOPHENE-2-CARBONYL CHLORIDE

18
2-QUINOXALOYL CHLORIDE

19
NICOTINOYL CHLORIDE HYDROCHLORIDE

20
ISONICOTINOYL CHLORIDE HYDROCHLORIDE

21
3,4-METHYLENEDIOXYBENZOYL CHLORIDE

22
2-ETHYLBUTYRYL CHLORIDE

23
BENZO[B]THIOPHENE-2-CARBONYL CHLORIDE

24
2-CHLORONICOTINOYL CHLORIDE

25
4-(TRIFLUOROMETHOXY)BENZOYL CHLORIDE

26
ISOXAZOLE-5-CARBONYL CHLORIDE

27
1-METHYLPYRROLE-2-CARBONYL CHLORIDE

[0177]

3

TABLE III

Esters derivatives of formula (VIII)

1
ETHYL CYCLOPROPANECARBOXYLATE

2
ETHYL CYCLOBUTANECARBOXYLATE

3
METHYL CYCLOPENTANECARBOXYLATE

[0178]

4

TABLE IV

Isocyanates derivatives of formula (VI)

1
ISOPROPYL ISOCYANATE

2
ETHYL ISOCYANATE

3
ALLYL ISOCYANATE

4
N-PROPYL ISOCYANATE

5
BENZYL ISOCYANATE

6
PHENETHYL ISOCYANATE

7
2-METHYLBENZYL ISOCYANATE

8
3-METHYLBENZYL ISOCYANATE

9
4-METHYLBENZYL ISOCYANATE

10
2-CHLOROBENZYL ISOCYANATE

11
4-FLUOROBENZYL ISOCYANATE

12
3,4-DICHLOROBENZYL ISOCYANATE

13
4-METHOXYBENZYL ISOCYANATE

14
SEC-BUTYL ISOCYANATE

15
2-FLUOROBENZYL ISOCYANATE

16
3-FLUOROBENZYL ISOCYANATE

17
CYCLOPROPYL ISOCYANATE

[0179] All of the compounds of formula (I) which are prepared according to combinatorial chemistry techniques, for instance as reported in the examples, whenever appropriate in the form of pharmaceutically acceptable salts, are herewith conveniently indicated and defined as “products by process”, that is as compounds of formula (I) which are obtainable through a given process.

[0180] As such, it is a further object of the present invention a compound of formula (I) which is obtainable, for instance through a combinatorial chemistry technique, by reacting each of the derivatives obtained from a compound of formula (III), as set forth in table I, with any one of the carboxylic acid derivatives of formula (VIII), as set forth in table II, and by subsequently operating as per the process of the invention.

[0181] It is a further object of the present invention a compound of formula (I) which is obtainable, for instance through a combinatorial chemistry technique, by reacting each of the derivatives obtained from a compound of formula (II) wherein R2 or R3 is an amino group, as set forth in table I, with any one of the acyl chloride or isocyanate derivatives of formula (V) and (VI), as set forth in tables II and IV, and by subsequently operating as per the process of the invention.

[0182] Pharmacology

[0183] The compounds of formula (I) are active as protein kinase inhibitors and are therefore useful, for instance, to restrict the unregulated proliferation of tumor cells.

[0184] In therapy, they may be used in the treatment of various tumors such as, for instance, carcinomas, e.g. mammary carcinoma, lung carcinoma, bladder carcinoma, colon carcinoma, ovary and endometrial tumors, sarcomas, e.g. soft tissue and bone sarcomas, and the hematological malignancies such as, e.g., leukemias.

[0185] In addition, the compounds of formula (I) are also useful in the treatment of other cell proliferative disorders such as psoriasis, vascular smooth cell proliferation associated with atherosclerosis and post-surgical stenosis and restenosis and in the treatment of Alzheimer's disease.

[0186] The inhibiting activity of putative protein kinase inhibitors and the potency of selected compounds was determined through a method of assay based on the use of the MultiScreen-PH 96 well plate (Millipore), in which a phosphocellulose filter paper was placed at each well bottom allowing binding of positive charged substrate after a washing/filtration step.

[0187] When a radioactivity labeled phosphate moiety was transferred by the ser/threo kinase to the filter-bound histone, light emitted was measured in a scintillation counter.

[0188] Inhibition Assay of cdk2/Cyclin A activity

[0189] Kinase reaction: 1.5 μM histone H1 substrate, 25 μM ATP (0.2 uCi P33□-ATP), 30 ng of baculovirus co-expressed cdk2/Cyclin A, 10 μM inhibitor in a final volume of 100 μl buffer (TRIS HCl 10 mM pH 7.5, MgCl2 10 mM, 7.5 mM DTT) were added to each well of a 96 U bottom well plate. After 10 min at 37° C. incubation, reaction was stopped by 20 μl EDTA 120 mM.

[0190] Capture: 100 μl were transferred from each well to MultiScreen plate, to allow substrate binding to phosphocellulose filter. Plates were then washed 3 times with 150 μl/well PBS Ca++/Mg++ free and filtered by MultiScreen filtration system.

[0191] Detection: filters were allowed to dry at 37° C., then 100 μl/well scintillant were added and 33P labeled histone H1 was detected by radioactivity counting in the Top-Count instrument.

[0192] Results: data were analyzed and expressed as % inhibition referred to total activity of enzyme (=100%).

[0193] All compounds showing inhibition ≧50% were further analyzed in order to study and define potency (IC50) as well as the kinetic-profile of inhibitor through Ki calculation.

[0194] IC50 determination: the protocol used was the same described above, where inhibitors were tested at different concentrations ranging from 0.0045 to 10 μM. Experimental data were analyzed by the computer program GraphPad Prizm using the four parameter logistic equation:

y
=bottom+(top−bottom)/(1+10{circumflex over ( )}((logIC50−x)*slope))

[0195] where x is the logarithm of the inhibitor concentration, y is the response; y starts at bottom and goes to top with a sigmoid shape.

[0196] Ki calculation: either the concentration of ATP and histone H1 substrate were varied: 4, 8, 12, 24, 48 μM for ATP (containing proportionally diluted P33γ-ATP) and 0.4, 0.8, 1.2, 2.4, 4.8 μM for histone were used in absence and presence of two different, properly chosen inhibitor concentrations.

[0197] Experimental data were analyzed by the computer program “SigmaPlot” for Ki determination, using a random bireactant system equation:

v = \frac{V \max \frac{(A) (B)}{aKAKB}}{1 + \frac{(A)}{KA} + \frac{(B)}{KB} + \frac{(A) (B)}{aKAKB}}

[0198] where A=ATP and B=histone H1.

[0199] In addition the selected compounds have been characterized on a panel of ser/threo kinases strictly related to cell cycle (cdk2/cyclin E, cdk1/cyclin B1, cdk4/Cyclin D1), and also for specificity on MAPK, PKA, EGFR, IGF1-R, Cdc7/dbf4 and aurora-2.

[0200] Inhibition assay of cdk2/Cyclin E Activity

[0201] Kinase reaction: 1.5 μM histone H1 (Sigma #H-5505) substrate, 25 μM ATP (0.2 □Ci P33γ-ATP), 15 ng of baculovirus co-expressed cdk2/GST-Cyclin E, suitable concentrations of inhibitor in a final volume of 100 μl buffer (TRIS HCl 10 mM pH 7.5, MgCl2 10 mM, 7.5 mM DTT+0.2 mg/ml BSA) were added to each well of a 96 U bottom well plate. After 10 min at 37° C. incubation, reaction was stopped by 20 μl EDTA 120 mM.

[0202] Capture: 100 μl were transferred from each well to MultiScreen plate, to allow substrate binding to phosphocellulose filter. Plates were then washed 3 times with 150 □l/well PBS Ca++/Mg++ free and filtered by MultiScreen filtration system.

[0203] Detection: filters were allowed to dry at 37° C., then 100 μl/well scintillant were added and 33P labeled histone H1 was detected by radioactivity counting in the Top-Count instrument.

[0204] Inhibition Assay of cdkl/Cyclin B1 Activity

[0205] Kinase reaction: 1.5 μM histone H1 (Sigma # H-5505) substrate, 25 μM ATP (0.2 μCi P33γ-ATP), 30 ng of baculovirus co-expressed cdkl/Cyclin B1, suitable concentrations of inhibitor in a final volume of 100 μl buffer (TRIS HCl 10 mM pH 7.5, MgCl2 10 mM, 7.5 mM DTT+0.2 mg/ml BSA) were added to each well of a 96 U bottom well plate. After 10 min at 37° C. incubation, reaction was stopped by 20 μl EDTA 120 mM.

[0206] Capture: 100 μl were transferred from each well to MultiScreen plate, to allow substrate binding to phosphocellulose filter. Plates were then washed 3 times with 150 μl/well PBS Ca++/Mg++ free and filtered by MultiScreen filtration system.

[0207] Detection: filters were allowed to dry at 37° C., then 100 μl/well scintillant were added and 33P labeled histone H1 was detected by radioactivity counting in the Top-Count instrument.

[0208] Inhibition assay cdk4/Cyclin D1 Activity

[0209] Kinase reaction: 0,4 μM μM mouse GST-Rb(769-921) (# sc-4112 from Santa Cruz) substrate, 10 μM ATP (0.5 μCi P33γ-ATP), 100 ng of baculovirus expressed GST-cdk4/GST-Cyclin D1, suitable concentrations of inhibitor in a final volume of 50 μl buffer (TRIS HCl 10 mM pH 7.5, MgCl2 10 mM, 7.5 mM DTT+0.2 mg/ml BSA) were added to each well of a 96 U bottom well plate. After 40 min at 37° C. incubation, reaction was stopped by 20 μl EDTA 120 mM.

[0210] Capture: 60 μl were transferred from each well to MultiScreen plate, to allow substrate binding to phosphocellulose filter. Plates were then washed 3 times with 150 □l/well PBS Ca++/Mg++ free and filtered by MultiScreen filtration system.

[0211] Detection: filters were allowed to dry at 37° C., then 100 μl/well scintillant were added and 33P labeled Rb fragment was detected by radioactivity counting in the Top-Count instrument.

[0212] Inhibition assay of MAPK Activity

[0213] Kinase reaction: 10 μM MBP (Sigma #M-1891) substrate, 25 μM ATP (0.2 tCi P33γ-ATP), 25 ng of bacterially expressed GST-MAPK (Upstate Biotechnology #14-173), suitable concentrations of inhibitor in a final volume of 100 μl buffer (TRIS HCl 10 mM pH 7.5, MgCl2 10 mM, 7.5 mM DTT+0.1 mg/ml BSA) were added to each well of a 96 U bottom well plate. After 15 min at 37° C. incubation, reaction was stopped by 20 μl EDTA 120 mM.

[0214] Capture: 100 μl were transferred from each well to MultiScreen plate, to allow substrate binding to phosphocellulose filter. Plates were then washed 3 times with 150 μl/well PBS Ca++/Mg++ free and filtered by MultiScreen filtration system.

[0215] Detection: filters were allowed to dry at 37° C., then 100 μl/well scintillant were added and 33P labeled MBP was detected by radioactivity counting in the Top-Count instrument.

[0216] Inhibition Assay of PKA Activity

[0217] Kinase reaction: 10 μM histone Hi (Sigma #H-5505) substrate, 10 μM ATP (0.2 μCi P33γ-ATP), 1U of bovine heart PKA (Sigma # 2645), suitable concentrations of inhibitor in a final volume of 100 μl buffer (TRIS HCl 10 mM pH 7.5, MgCl2 10 mM, 7.5 mM DTT+0.2 mg/ml BSA) were added to each well of a 96 U bottom well plate. After 5 min at 37° C. incubation, reaction was stopped by 20 μl EDTA 120 mM.

[0218] Capture: 100 μl were transferred from each well to MultiScreen plate, to allow substrate binding to phosphocellulose filter. Plates were then washed 3 times with 150 μl/well PBS Ca++/Mg++ free and filtered by MultiScreen filtration system.

[0219] Detection: filters were allowed to dry at 37° C., then 100 μl/well scintillant were added and 33P labeled histone H1 was detected by radioactivity counting in the Top-Count instrument.

[0220] Inhibition Assay of EGFR Activity

[0221] Kinase reaction: 25 nM in house biotinylated PolyGluTyr (Sigma # 0275) substrate, 2,5 μM ATP (0.3 μCi P33γ-ATP), 80 ng baculovirus expressed GST-EGFR, suitable concentrations of inhibitor in a final volume of 100 μl buffer (Hepes 50 mM pH 7,5, MnCl2— MgCl2 3 mM, 1 mM DTT+3 μM NaVO3, 0.1 mg/ml BSA) were added to each well of a 96 U bottom well plate. After 5 min. at 37° C. incubation, reaction was stopped by 20 μl EDTA 120 mM.

[0222] Capture: 100 μl were transferred from each well to streptavidin-Flashplate, to allow biotinylated-substrate binding to plate. Plates were then washed 3 times with 150 μl/well PBS Ca++/Mg++ free.

[0223] Detection: radioactivity counting in the Top-Count instrument.

[0224] Inhibition Assay of IGF1-R Activity

[0225] The inhibition assay of IGFI—R activity was performed according to the following protocol.

[0226] Kinase reaction: 10 μM biotinylated MBP (Sigma cat. #M-1891) substrate, 0-20 μM inhibitor, 6 μM cold ATP, 2 nM 33P-ATP, and 22.5 ng IGF1-R (pre-incubated for 30 min at room temperature with cold 60 μM cold ATP) in a final volume of 30 μl buffer (50 mM HEPES pH 7.9, 3 mM MnCl2, 1 mM DTT, 3 μM NaVO3) were added to each well of a 96 U bottom well plate. After incubation for 35 min at room temperature, the reaction was stopped by addition of 100 μl PBS buffer containing 32 mM EDTA, 500 μM cold ATP, 0.1% Triton X100 and 10 mg/ml streptavidin coated SPA beads. After 15 min incubation, 110 μl of suspension were withdrawn and transferred into 96-well OPTIPLATEs containing 100 μl of 5M CsCl. After 4 hours, the plates were read for 2 min in a Packard TOP-Count radioactivity reader.

[0227] Results: Experimental data were analyzed with the program GraphPad Prizm.

[0228] In addition, the inhibiting activity of putative protein kinase inhibitors and the potency of selected compounds was also determined through a method of assay based on the use of a SPA (Scintillation Proximity Assay) 96 well plate assay. The assay is based on the ability of streptavidin coated SPA beads to capture a biotinylated peptide derived from a phosphorylation site of histone.

[0229] When a radioactivity labeled phosphate moiety was transferred by the ser/threo kinase to the biotinylated histone peptide, light emitted was measured in a scintillation counter.

[0230] Inhibition Assay of cdk5/p25 Activity

[0231] The inhibition assay of cdk5/p25 activity was performed according to the following protocol.

[0232] Kinase reaction: 1.0 μM biotinylated histone peptide substrate, 0.25 uCi P33 g-ATP, 4 nM cdk5/p25 complex, 0-100 μM inhibitor in a final volume of 100 μl buffer (Hepes 20 mM pH 7.5, MgCl2 15 mM, 1 mM DTT) were added to each well of a 96 U bottom well plate. After 20 min at 37° C. incubation, the reaction was stopped by the addition of 500 ug SPA beads in phosphate-buffered saline containing 0.1% Triton X-100, 50 uM ATP and 5 mM EDTA. The beads were allowed to settle, and the radioactivity incorporated in the 33P-labelled peptide was detected in a Top Count scintillation counter.

[0233] Results: Data were analyzed and expressed as % Inhibition using the formula:

100×(1−(Unknown−Bkgd)/(Enz. Control−Bkgd))

[0234] IC50 values were calculated using a variation of the four parameter logistics equation:

Y=100/[1+10{circumflex over ( )}((LogEC50−X)*Slope)]

[0235] Where X=log(uM) and Y=% Ihibition.

[0236] Inhibition Assay of Cdc7/dbf4 Activity

[0237] The inhibition assay of Cdc7/dbf4 activity was performed according to the following protocol.

[0238] The Biotin-MCM2 substrate is trans-phosphorylated by the Cdc7/Dbf4 complex in the presence of ATP traced with γ33-ATP. The phosphorylated Biotin-MCM2 substrate is then captured by Streptavidin-coated SPA beads and the extent of phosphorylation evaluated by β counting.

[0239] The inhibition assay of Cdc7/dbf4 activity was performed in 96 wells plate according to the following protocol.

[0240] To each well of the plate were added:

[0241] 10 μl substrate (biotinylated MCM2, 6 μM final concentration)

[0242] 10 μl enzyme (Cdc7/Dbf4, 12.5 nM final concentration)

[0243] 10 μl test compound (12 increasing concentrations in the nM to μM range to generate a dose-response curve)

[0244] 10 μl of a mixture of cold ATP (10 μM final concentration) and radioactive ATP ({fraction (1/2500)} molar ratio with cold ATP) was then used to start the reaction which was allowed to take place at 37° C.

[0245] Substrate, enzyme and ATP were diluted in 50 mM HEPES pH 7.9 containing 15 mM MgCl2, 2 mM DTT, 3 μM NaVO3, 2 mM glycerophosphate and 0.2 mg/ml BSA. The solvent for test compounds also contained 10% DMSO.

[0246] After incubation for 20 minutes, the reaction was stopped by adding to each well 100 □l of PBS pH 7.4 containing 50 mM EDTA, 1 mM cold ATP, 0.1% Triton X100 and 10 mg/ml streptavidin coated SPA beads.

[0247] After 15 minutes of incubation at room temperature to allow the biotinylated MCM2-streptavidin SPA beads interaction to occur, beads were trapped in a 96 wells filter plate (UnfilterR GF/B™) using a Packard Cell Harvester (Filtermate), washed with distilled water and then counted using a Top Count (Packard).

[0248] Counts were blank-subtracted and then the experimental data (each point in triplicate) were analyzed for IC50 determination using a non-linear regression analysis (Sigma Plot).

[0249] Inhibition Assay of Aurora-2 Activity

[0250] The inhibiting activity and the potency of selected compounds was determined through a method of assay based on the use of the streptavidin scintillation proximity assay beads (amershampharmacia biotech) run in a 96 well plates. At the end of the reaction, the biotinylated peptide substrate was captured with the beads and subsequently allowed to stratify using CsCl2.

[0251] When a radioactivity labeled phosphate moiety was transferred by the kinase to the beads-bound peptide, light emitted was measured in a scintillation counter.

[0252] The inhibition assay of Aurora-2 activity was performed in 96 wells plate according to the following protocol.

[0253] Kinase reaction: 8 μM biotinylated peptide (4 repeats of LRRWSLG), 10 MM ATP (0.5 uCi P33 g-ATP), 10 nM Aurora2, 10 inhibitor in a final volume of 60μ buffer (HEPES 50 mM pH 7.0, MgCl2 10 mM, 1 mM DTT, 0.125 mg/ml BSA, 3 μM orthovanadate) were added to each well of a 96 U bottom well plate. After 30 minutes at room temperature incubation, reaction was stopped and biotinylated peptide captured by adding 100 μl of bead suspension.

[0254] Stratification: 100 μl of CsCl2 7.5 M were added to each well and let stand one hour before radioactivity was counted in the Top-Count instrument.

[0255] Results: data were analyzed and expressed as % inhibition referred to total activity of enzyme (=1100%).

[0256] All compounds showing inhibition ≧60% were further analyzed in order to study the potency of the inhibitor through IC50 calculation.

[0257] The protocol used was the same described above, except that serial dilution of the inhibitor was used. Experimental data were fitted by nonlinear regression using the following equation:

v = v_{0} + \frac{(v_{0} - v_{b})}{1 + 10^{n (\log {IC}_{50} - \log [I])}}

[0258] With vb as the baseline velocity, v as the observed reaction velocity, v0 as the velocity in the absence of inhibitors, and [I] as the inhibitor concentration.

[0259] The compounds of formula (I) of the present invention, suitable for administration to a mammal, e.g. to humans, can be administered by the usual routes and the dosage level depends upon the age, weight, conditions of the patient and the administration route.

[0260] For example, a suitable dosage adopted for oral administration of a compound of formula (I) may range from about 10 to about 500 mg pro dose, from 1 to 5 times daily.

[0261] The compounds of the invention can be administered in a variety of dosage forms, e.g. orally, in the form of tablets, capsules, sugar or film coated tablets, liquid solutions or suspensions; rectally in the form of suppositories; parenterally, e.g. intramuscularly, or by intravenous and/or intrathecal and/or intraspinal injection or infusion.

[0262] In addition, the compounds of the invention can be administered either as single agents or, alternatively, in combination with known anticancer treatments such as radiation therapy or chemotherapy regimen in combination with cytostatic or cytotoxic agents, antibiotic-type agents, alkylating agents, antimetabolite agents, hormonal agents, immunological agents, interferon-type agents, cyclooxygenase inhibitors (e.g. COX-2 inhibitors), metallomatrixprotease inhibitors, telomerase inhibitors, tyrosine kinase inhibitors, anti-growth factor receptor agents, anti-HER agents, anti-EGFR agents, anti-angiogenesis agents, farnesyl transferase inhibitors, ras-raf signal transduction pathway inhibitors, cell cycle inhibitors, other cdks inhibitors, tubulin binding agents, topoisomerase I inhibitors, topoisomerase R1 inhibitors, and the like.

[0263] As an example, the compounds of the invention can be administered in combination with one or more chemotherapeutic agents such as, for instance, exemestane, formestane, anastrozole, letrozole, fadrozole, taxane, taxane derivatives, encapsulated taxanes, CPT-11, camptothecin derivatives, anthracycline glycosides, e.g., doxorubicin, idarubicin, epirubicin, etoposide, navelbine, vinblastine, carboplatin, cisplatin, estramustine, celecoxib, tamoxifen, raloxifen, Sugen SU-5416, Sugen SU-6668, Herceptin, and the like, optionally within liposomal formulations thereof.

[0264] If formulated as a fixed dose, such combination products employ the compounds of this invention within the dosage range described above and the other pharmaceutically active agent within the approved dosage range.

[0265] Compounds of formula (I) may be used sequentially with known anticancer agents when a combination formulation is inappropriate.

[0266] It is therefore a further object of the invention a product or kit comprising the compound of formula (I) of the invention and one or more chemotherapeutic agents for simultaneous, separate or sequential use in anticancer therapy or for the treatment of cell proliferative disorders.

[0267] The present invention also includes pharmaceutical compositions comprising an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable excipient, carrier or diluent.

[0268] The pharmaceutical compositions containing the compounds of the invention are usually prepared following conventional methods and are administered in a pharmaceutically suitable form.

[0269] For example, the solid oral forms may contain, together with the active compound, diluents, e.g. lactose, dextrose, saccharose, sucrose, cellulose, corn starch or potato starch; lubricants, e.g. silica, talc, stearic, magnesium or calcium stearate, and/or polyethylene glycols; binding agents, e.g. starches, arabic gum, gelatine, methylcellulose, carboxymethylcellulose or polyvinyl pyrrolidone; disaggregating agents, e.g. a starch, alginic, alginates or sodium starch glycolate; effervescing mixtures; dyestuffs; sweeteners; wetting agents such as lecithin, polysorbates, laurylsulphates; and, in general, non-toxic and pharmacologically inactive substances used in pharmaceutical formulations. Said pharmaceutical preparations may be manufactured in known manner, for example, by means of mixing, granulating, tabletting, sugar-coating, or film-coating processes.

[0270] The liquid dispersions for oral administration may be e.g. syrups, emulsions and suspensions.

[0271] The syrups may contain as carrier, for example, saccharose or saccharose with glycerine and/or mannitol and/or sorbitol.

[0272] The suspensions and the emulsions may contain as carrier, for example, a natural gum, agar, sodium alginate, pectin, methylcellulose, carboxymethylcellulose, or polyvinyl alcohol.

[0273] The suspension or solutions for intramuscular injections may contain, together with the active compound, a pharmaceutically acceptable carrier, e.g. sterile water, olive oil, ethyl oleate, glycols, e.g. propylene glycol, and, if desired, a suitable amount of lidocaine hydrochloride. The solutions for intravenous injections or infusions may contain as carrier, for example, sterile water or preferably they may be in the form of sterile, aqueous, isotonic saline solutions or they may contain as a carrier propylene glycol.

[0274] The suppositories may contain together with the active compound a pharmaceutically acceptable carrier, e.g. cocoa butter, polyethylene glycol, a polyoxyethylene sorbitan fatty ester surfactant or lecithin.

EXAMPLES

[0275] The following examples are herewith intended to better illustrate the present invention without posing any limitation to it.

[0276] General Methods

[0277] Flash chromatografy was performed on silica gel (Merck grade 9385, 60A). SPE (Solid Phase Extraction) was performed using prepacked cartridges with silica gel available from several vendors. FT-IR was obtained using a Perkin-Elmer spectrophotometer with the micropellets. HPLC/MS was performed on a Waters X Terra RP 18 (4.6×50 mm, 3.5 μm) column using a Waters 2790 HPLC system equipped with a 996 Waters PDA detector and a Micromass mod. ZQ single quadrupole mass spectrometer, equipped with an electrospray (ESI) ion source. Mobile phase A was ammonium acetate 5 mM buffer (pH 5.5 with acetic acid/acetonitrile 95:5), and Mobile phase B was H2O/acetonitrile (5:95). Gradient from 10 to 90% B in 8 minutes, hold 90% B 2 min. UV detection at 220 nm and 254 nm. Flow rate 1 ml/min. Injection volume 10 μl. Full scan, mass range from 100 to 800 amu. Capillary voltage was 2.5 KV; Source temp. was 120° C.; Cone was 10 V. Retention Times (HPLC r.t.) are given in minutes at 220 nm or 254 nm. Mass are given as m/z ratio.

[0278] When necessary compounds have been purified by Preparative HPLC on a Waters Symmetry C18 (19×50 mm, 5 um) column using a Waters preparative HPLC 600 equipped with a 996 Waters PDA detector and a Micromass mod. ZMD single quadrupole mass spectrometer, electrospray ionisation, positive mode. Mobile phase A was water 0.01% TFA, and Mobile phase B was acetonitrile. Gradient from 10 to 90%B in 8 min, hold 90%B 2 min. Flow rate 20 ml/m.

[0279]

1
H-NMR spectroscopy was performed on a Mercury VX 400 operating at 400.45 MHz equipped with a 5 mm double resonance probe (1H {15N-31P} ID_PFG Varian).

Example 1

[0280] 1-[4-Amino-2-(4-benzyloxy-benzyloxy)-phenyl]-ethanone

[0281] To 0.83 mmol of resin 2 (1 g) in 15 ml of DMA were added 6.64 mmol of 4-amino-2-hydroxyacetophenone (8 eq 1.0 g), 4.15 mmol of cesium carbonate (5 eq 1.35 g), and 0.83 mmol of tetrabutylammonium iodide (1 eq 0.3 g). The slurry was left under magnetic stirring for 24 h at room temperature, then the resin was filtered, washed with DMF (2×), MeOH, THF, MeOH, DCM (3×) and dried in vacuo to give 1.1 g of resin.

[0282] FT-IR KBr micropellet □ cm−1: 1675 (C═O, s, st).

Example 2

[0283] N-[4-Acetyl-3-(4-benzyloxy-benzyloxy-polystyrene)-phenyl]-4-methoxy-benzamide

[0284] 1-[4-Amino-2-(4-benzyloxy-benzyloxy)-phenyl]-ethanone (0.166 mmol, 0.2 g) was suspended with 0.5 ml of DiPEA (excess), 10 mg of DMAP in 5 ml of DCM. To the slurry was added under argon, 0.49 mmol of p-anisoyl chloride (3 eq, 85 mg). The mixture was stirred at room temperature for 18 h. The slurry was filtered and the resin washed with DMF, MeOH, DMF, MeOH, THF, MeOH, DCM (3×). The resin was dried under vacuum to give 0.22 g of product.

[0285] FT-IR KBr micropellet □ cm−1: 1679 (C═O, s, b, st).

Example 3

[0286] N-[4-Acetyl-3-(4-benzyloxy-benzyloxy-polystyrene)-phenyl]-4-methoxy-benzamide

[0287] N-[4-Acetyl-3-(4-benzyloxy-benzyloxy-polystyrone)-phenyl]-4-methoxy-benzamide,

[0288] (0.166 mmol, 0.2 g) was suspended in a solution of 3.32 mmol of ethyl cyclopropyl carboxylate (20 eq, 568 mg) in 5 ml of DMA. To the slurry was added under argon, 4.98 mmol of sodium hydride (30 eq, 199 mg as 60% dispersion in paraffin oil). The mixture was heated under stirring at 90° for 1 h. The slurry was filtered and the resin washed with DMF, AcOH 20%, H2O, DMF, MeOH, THF, MeOH, DCM (3×).

[0289] The resin was dried under vacuum and 0.22 g was obtained.

[0290] FT-IR KBr micropellet □cm−1: 1603 (C═O, s, b, st).

Example 4

[0291] N-[3-(4-Benzyloxy-benzyloxypolystyrene)-4-(3-cyclopropyl-3-oxo-propionyl)-phenyl]-4-methoxy-benzamide

[0292] N-[3-(4-Benzyloxy-benzyloxypolystyrene)-4-(3-cyclopropyl-3-oxo-propionyl)-phenyl]-4-methoxy-benzamide (0.166 mmol, 0.2 g) was swelled in a solution of 16 mmol of hydrazine hydrate (100 eq), in 3 ml of DMA. The suspension was heated at 80° under magnetic stirring overnight. The resin was filtered and washed with DMF (2×), MeOH, THF, MeOH, DCM (3×) consecutively.

[0293] The resin was dried under vacuum and 0.21 g was obtained.

[0294] FT-IR KBr micropellet □ cm−1: 3442 (N—H, b, st).

[0295] As further analytical investigation an aliquot of resin was incubated with TFA/DCM 50% for one hour, then filtered off and the solution was evaporated under nitrogen to dryness.

[0296] We obtained from 5 mg of resin (loading 0.83 mMol/g) 0.76 mg of N-[4-(5-Cyclopropyl-1H-pyrazol-3-yl)-3-hydroxy-phenyl]-4-methoxy-benzamide. The final product was obtained in 80% yield with 95% HPLC purity (according to HPLC analysis at 220 nm). [M+H]+=350 [M]−=348, HPLC r.t. 5.35. 1H-NMR (DMSO-d6), (ppm): 10.06 (s, 1H), 9.79 (s, 1H), 7.94 (d, 2H), 7.73 (d, 1H), 7.55 (s, 1H), 7.26 (d, 1H), 7.04 (d, 2H), 6.60 (s, 1H), 3.83 (s, 3H), 2.82 (m, 1H), 1.02 (m, 2H), 0.74 (m, 2H).

Example 5

[0297] 3-[2-(4-Benzyloxy-benzyloxypolystyrene)-4-(4-methoxy-benzoylamino)-phenyl]-5-cyclopropyl-pyrazole-1-carboxylic Acid Butylamide

[0298] N-[3-(4-Benzyloxy-benzyloxypolystyrene)-4-(5-cyclopropyl-1H-pyrazol-3-yl)-phenyl]-4-methoxy-benzamide (0.124 mmol 0.15 g) was suspended in a solution of 0.124 mmol of DiPEA (1 eq, 22 μL) in 3 ml of toluene and to the suspension was added 1.2 mmol of n-butylisocyanate (10 eq, 100 μL) and stirred at 60° overnight. The resin was filtered and washed with DMF (2×), MeOH, THF, MeOH, DCM (3×) and dried in vacuo, to obtain 0.124 mg of resin.

[0299] FT-IR KBr micropellet □ cm−1: 3442 (N-H, b, st,),1745 (C═O uerea, s, st) 1679 (C═O amide, s, st,).

Example 6

[0300] 5-Cyclopropyl-3-[2-hydroxy-4-(4-methoxy-benzoylamino)-phenyl]-pyrazole-1-carboxylic Acid Butylamide

[0301] 0.124 mmol, of 3-[2-(4-Benzyloxy-benzyloxypolystyrene)-4-(4-methoxy-benzoylamino)-phenyl]-5-cyclopropyl-pyrazole-1-carboxylic acid butylamide resin were swelled in 2 ml of 50% TFA in DCM. The resulting suspension was gently stirred or shaken at 22° C. for 1 h. The resin was filtered and washed with DCM, the solution was collected in a test tube and evaporated to dryness under nitrogen.

[0302] We obtained 20 mg (yield 40%) of product. LC/MS analysis showed 50% purity (254 nm. After filtration through 250 mg of silica gel packed in a 3 ml cartridge was recovered 11.5 mg.

[0303] LC/MS analysis gave 90% of purity HPLC r.t. 8.24 [M+H]+=449, [M−H]−=447.

[0304]

1
H-NMR (DMSO-d6), (ppm): 10.06 (s, 1H), 9.79 (s, 1H), 8.56 (t, 1H), 7.94 (d, 2H), 7.73 (d, 1H), 7.55 (s, 1H), 7.26 (d, 1H), 7.04 (d, 2H), 6.60 (s, 1H), 3.83 (s, 3H), 3.25 (m, 2H), 2.82 (m, 1H), 1.54 (m, 2H), 1.33 (m, 2H), 1.02 (m, 2H), 0.91 (t, 3H), 0.74 (m, 2H).

[0305] By working in an analogous way and by using the appropriate 2-hydroxyacetophenones derivatives, the appropriate carboxylic ester derivatives and the appropriate isocyanates derivatives, the following compounds were prepared:

[0306] N-ethyl-3-(2-hydroxyphenyl)-5-pyridin-4-yl-1H-pyrazole-1-carboxamide,

[0307] [M+H]+=309. 1H-NMR (DMSO d6) diagnostic signals (ppm): 8.73 (d, 2H), 7.20 (dd, 1H), 6.92 (d, 1H), 6.91 (dd, 1H), 2.81 (q, 2H), 1.12 (t, 3H).

[0308] 5-Cyclopropyl-3-(2-hydroxyphenyl)-N-propyl-1H-pyrazole-1-carboxamide,

[0309] [M+H]+=285. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.78 (s, 1H), 8.67 (t, 1H), 7.78 (d, 1H), 7.21 (m, 1H), 6.84 (m, 2H), 6.63 (s, 1H), 3.22 (m, 2H), 2.75 (m, 1H), 1.58 (m, 1H), 1.01 (m, 2H), 0.89 (t, 3H), 0.74 (m, 2H).

[0310] Ethyl N-{[5-cyclopropyl-3-(2-hydroxyphenyl)-1H-pyrazol-1-yl]carbonyl}glycinate

[0311] [M+H]+=330. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.78 (s, 1H), 8.95 (t, 1H) 7.8 (d, 1H), 7.22 (dd, 1H), 6.93 (m, 2H), 6.68 (s, 1H), 4.15 (q, 2H), 4.01 (d, 2H), 2.73 (m, 1H), 1.21 (t, 3H), 1.01 (m, 2H), 0.76 (m, 2H).

[0312] N-allyl-5-cyclopropyl-3-(2-hydroxyphenyl)-1H-pyrazole-1-carboxamide,

[0313] [M+H]+=284. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.85 (s, 1H), 8.82 (t, 1H), 7.81 (d, 1H), 7.2 (dd, 1H), 6.92 (m, 2H), 6.65 (s, 1H), 5.92 (m, 1H) 5.2 (d, 1H), 5.12 (d, 1H), 3.88 (dd, 2H), 2.75 (m, 1H), 1.02 (m, 2H), 0.75 (m, 2H).

[0314] N-cyclohexyl-5-cyclopropyl-3-(2-hydroxyphenyl)-1H-pyrazole-1-carboxamide

[0315] [M+H]+=326. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.88 (s, 1H), 8.23 (d, 1H), 7.79 (d, 1H), 7.2 (dd, 1H), 6.91 (d, 1H), 6.87 (dd, 1H), 6.62 (s, 1H), 3.62 (m, 1H), 2.75 (m, 1H), 1.82-1.15 (m, 10H), 1.02 (m, 2H), 0.75 (m, 2H).

[0316] 5-Cyclopropyl-N-ethyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide,

[0317] [M+H]+=459. 1H-NMR (DMSO d6) diagnostic signals (ppm): 10.41 (s, 1H), 9.82 (s, 1H), 8.57 (t, 1H), 8.25 (s, 1H), 8.22 (d, 1H), 7.95 (d, 1H), 7.80 (d, 1H), 7.57 (s, 1H), 7.27 (d, 1H), 6.62 (s, 1H), 3.28 (m, 2H), 2.75 (m, 1H), 1.16 (t, 3H), 1.02 (m, 2H), 0.75 (m, 2H).

[0318] Ethyl-N-{[5-[2-(dimethylamino)ethyl]-3-(2-hydroxyphenyl)-1H-pyrazol-1-yl]carbonyl}glycinate,

[0319] [M+H]+=361 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.02 (s, 1H), 9.05 (t, 1H), 7.90 (d, 1H), 7.22 (dd, 1H), 6.97 (s, 1H), 6.95 (d, 1H), 6.9 (dd, 1H), 4.13 (q, 2H), 4.02 (d, 2H), 3.41 (bs, 4H), 2.83 (s, 6H), 1.21 (t, 3H).

[0320] 5-Cyclopropyl-N-ethyl-3-(2-hydroxy-4-methoxyphenyl)-1H-pyrazole-1-carboxamide,

[0321] [M+H]+=302. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.91 (s, 1H), 8.55 (t, 1H), 7.67 (d, 1H), 6.56 (s, 1H), 6.46 (m, 2H), 3.74 (s, 3H), 3.22 (m, 2H), 2.75 (m, 1H), 1.15 (t, 3H), 1.02 (m, 2H), 0.75 (m, 2H).

[0322] Ethyl-N-{[5-cyclopropyl-3-(2-hydroxy-4-methoxyphenyl)-1H-pyrazol-1-yl]carbonyl}glycinate,

[0323] [M+H]+=360. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.89 (s, 1H), 8.94 (t, 1H), 7.66 (d, 1H), 6.61 (s, 1H), 6.48 (m, 2H), 4.13 (q, 2H), 4.02 (d, 2H), 3.74 (s, 3H), 2.75 (m, 1H), 1.21 (t, 3H), 1.02 (m, 2H), 0.75 (m, 2H).

[0324] 5-Cyelopropyl-N-ethyl-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazole-1-earboxamide,

[0325] [M+H]+=302. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.33 (s, 1H), 8.58 (t, 1H), 7.34 (d, 1H), 6.82 (m, 2H), 6.68 (s, 1H), 3.72 (s, 3H), 3.22 (m, 2H), 2.74 (m, 1H), 1.15 (t, 3H), 1.02 (m, 2H), 0.75 (m, 2H).

[0326] 5-Cyclopropyl-N-ethyl-3-(2-hydroxy-5-methylphenyl)-1H-pyrazole-1-carboxamide,

[0327] [M+H]+=286. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.33 (s, 1H), 8.57 (t, 1H), 7.34 (d, 1H), 6.81 (m, 2H), 6.68 (s, 1H), 3.22 (m, 2H), 2.74 (m, 1H), 2.22(s, 3H), 1.15 (t, 3H), 1.02 (m, 2H), 0.75 (m, 2H).

[0328] Ethyl-N-{[5-cyclopropyl-3-(2-hydroxy-5-methylphenyl)-1H-pyrazol-1-yl]carbonyl}glycinate,

[0329] [M+H]+=344. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.52 (s, 1H), 8.58 (t, 1H), 7.59 (d, 1H), 7.02 (d, 1H), 6.81 (d, 1H), 6.62 (s, 1H), 3.22 (m, 2H), 2.75 (m, 1H), 2.23 (s, 3H), 1.15 (t, 3H), 1.02 (m, 2H), 0.75 (m, 2H).

[0330] N-butyl-5-cyclopropyl-3-(2-hydroxy-4-methoxyphenyl)-1H-pyrazole-1-carboxamide,

[0331] [M+H]+=330. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.82 (s, 1H), 8.57 (t, 1H), 7.67 (d, 1H), 6.56 (s, 1H), 6.47 (m, 2H), 3.74 (s, 3H), 3.25 (m, 2H), 2.75 (m, 1H), 1.55 (m, 2H), 1.33 (m, 2H), 1.02 (m, 2H), 0.90 (t, 3H), 0.75 (m, 2H).

[0332] N-butyl-S-cyclopropyl-3-(2-hydroxy-5-methylphenyl)-1H-pyrazole-1-carboxamide,

[0333] [M+H]+=314. 1H-NNMR (DMSO d6) diagnostic signals (ppm): 9.55 (s, 1H), 8.58 (t, 1H), 7.58 (d, 1H), 7.0 (d, 1H), 6.81 (d, 1H), 6.63 (s, 1H), 3.25 (m, 2H), 2.75 (m, 1H), 2.23 (s, 3H),1.56 (m, 2H), 1.34 (m, 2H), 1.01 (m, 2H), 0.91 (t, 3H), 0.75 (m, 2H).

[0334] N-(3-{1-[(butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide,

[0335] [M+H]+=420. 1H-NMR (DMSO d6) diagnostic signals (ppm): 9.68 (s, 1H), 8.78 (d, 1H), 8.52 (t, 1H), 8.02 (s, 1H), 7.86 (d, 1H), 7.55 (dd, 1H), 6.94 (d, 1H), 6.51 (s, 1H), 3.25 (m, 2H), 2.75 (m, 1H), 1.56 (m, 2H), 1.34 (m, 2H), 1.01 (m, 2H), 0.87 (t, 3H), 0.75 (m, 2H).

[0336] N-(4-{1-[(butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide,

[0337] [M+H]+=420. 1H-NMR (DMSO d6) diagnostic signals (ppm): 10.48 (s, 1H), 9.87 (s, 1H), 8.78 (d, 1H), 8.55 (t, 1H), 7.86 (d, 2H), 7.78 (d, 1H), 7.55 (s, 1H), 7.27 (dd, 1H), 6.61 (s, 1H), 3.23 (m, 2H), 2.76 (m, 1H), 1.56 (m, 2H), 1.34 (m, 2H), 1.01 (m, 2H), 0.91 (t, 3H), 0.75 (m, 2H).

[0338] 3-{4-[(3-Benzodioxol-5-ylcarbonyl)amino]-2-hydroxypheny}-N-butyl-5-cyclobutyl-1H-pyrazole-1-carboxamide,

[0339] [M+H]+=477. 1H-NMR (DMSO d6) diagnostic signals ppm): 10.0 (s, 1H), 8.52 (t, 1H), 7.61 (d, 1H), 7.59 9d, 1H), 7.56 (d, 1H), 7.45 (d, 1H), 7.27 (d, 1H), 7.05 (d, 1H) 6.65 (s, 1H), 6.11 (s, 2H), 3.58 (m, 1H), 3.23 (m, 2H), 2.31 (m, 2H), 2.19 (m, 2H), 1.97 (m, 2H), 1.56 (m, 2H), 1.34 (m, 2H), 0.91 (t, 3H).

[0340] 3-{4-[(1,3-Benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-butyl-5-cyclopentyl-1H-pyrazole-1-carboxamide,

[0341] [M+H]+=491. 1H-NMR (DMSO d6) diagnostic signals (ppm): 10.05 (s, 1H), 8.52 (t, 1H), 7.60 (d, 1H), 7.58 (d, 1H), 7.48 (d, 1H), 7.42, (s, 1H), 7.04 (d, 1H), 6.58 (s, 1H), 6.11 (s, 2H), 3.23 (m, 2H), 3.11 (m, 1H), 2.1 (m, 2H), 1.75 (m, 2H), 1.6 (m, 4H), 1.56 (m, 2H), 1.34 (m, 2H), 0.91 (t, 3H).

[0342] N-Allyl-5-cyclopropyl-3-(4-fluoro-2-hydroxyphenyl)-1H-pyrazole-1-carboxamide,

[0343] [M+H]+=302. HPLC r.t.=6.21-5-(3,4-Dimethoxyphenyl)-N-ethyl-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazole-1-carboxamide,

[0344] [M+H]+=398. HPLC r.t.=4.59

[0345] N-Allyl-5-[2-(dimethylamino)ethyl]-3-(2-hydroxy-5-methylphenyl)-1H-pyrazole-1-carboxamide,

[0346] [M+H]+=329 HPLC r.t.=3.75.

[0347] 5-[2-(Dimethylamino)ethyl]-3-(2-hydroxy-5-methoxyphenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide,

[0348] [M+H]+=409. HPLC r.t.=4.39.

[0349] Ethyl-N-{[5-(3,4-dimethoxyphenyl)-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazol-1-yl]carbonyl}glycinate,

[0350] [M+H]+=456. HPLC r.t.=4.69

[0351] 5-Cyclopropyl-N-ethyl-3-(4-fluoro-2-hydroxyphenyl)-1H-pyrazole-1-carboxamide,

[0352] [M+H]+=290. HPLC r.t.=6.01

[0353] Ethyl-N-{[3-(5-chloro-2-hydroxyphenyl)-5-cyclopropyl-1H-pyrazol-1-yl]carbonyl}glycinate,

[0354] [M+H]+=364. HPLC r.t.=6.21

[0355] 5-Cyclopropyl-3-(2-hydroxy-5-methoxyphenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide,

[0356] [M+H]+=377. HPLC r.t.=6.55.

[0357] 5-Cyclopropyl-N-ethyl-3-(2-hydroxyphenyl)-1H-pyrazole-1-carboxamide,

[0358] [M+H]+=271. HPLC r.t.=5.76.

[0359] N-allyl-5-(3,4-dimethoxyphenyl)-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazole-1-carboxamide,

[0360] [M+H]+=410. HPLC r.t.=4.71.

[0361] N-benzyl-5-(3,4-dimethoxyphenyl)-3-(2-hydroxy-5-methylphenyl)-1H-pyrazole-1-carboxamide,

[0362] [M+H]+=444. HPLC r.t.=5.41.

[0363] N-allyl-5-cyclopropyl-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazole-1-carboxamide,

[0364] [M+H]+=314. HPLC r.t.=5.80.

[0365] N-benzyl-5-[2-(dimethylamino)ethyl]-3-(2-hydroxy-5-methoxyphenyl)-1H-pyrazole-1-1-carboxamide,

[0366] [M+H]+=394. HPLC r.t. 4.20.

[0367] 5-Cyclopropyl-3-(2-hydroxy-5-methylphenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide,

[0368] [M+H]+=362. HPLC r.t.=6.90.

[0369] 5-[2-(Dimethylamino)ethyl]-N-ethyl-3-(2-hydroxyphenyl)-1H-pyrazole-1-carboxamide,

[0370] [M+H]+=302. HPLC r.t.=3.24.

[0371] Ethyl N-[(5-cyclobutyl-3-{2-hydroxy-4-[(3-methoxybenzoyl)amino]phenyl}-1H-pyrazol-1-yl)carbonyl]glycinate,

[0372] [M+H]+=493. HPLC r.t.=7.27.

[0373] Ethyl N-[(5-cyclopropyl-3-{2-hydroxy-4-[(3-methoxybenzoyl)amino]phenyl}-1H-pyrazol-1-yl)carbonyl]glycinate,

[0374] [M+H]+=479. HPLC r.t.=6.87.

[0375] Operting in an analogous way, the following compounds are also obtained:

513-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide23-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide3N-allyl-3-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide43-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide5N-benzyl-3-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide63-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide73-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide83-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide93-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide103-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide113-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide123-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide133-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide14N-(sec-butyl)-3-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide153-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide163-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide173-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide183-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide193-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide20N-allyl-3-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide213-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide22N-benzyl-3-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide233-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide243-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide253-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide263-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide273-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide283-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide293-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide303-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide31N-(sec-butyl)-3-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide323-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide333-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide343-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide353-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide363-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide37N-allyl-3-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide383-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide39N-benzyl-3-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide403-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide413-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide423-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide433-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide443-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide453-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide465-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide473-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide48N-(sec-butyl)-3-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide493-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide503-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide513-{4-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide525-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide535-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide54N-allyl-5-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide555-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide56N-benzyl-5-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide575-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide585-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide595-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide605-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide61N-(2-chlorobenzyl)-5-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide625-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide635-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide645-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide65N-(sec-butyl)-5-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide665-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide675-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide68N,5-dicyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide695-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide705-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide71N-allyl-5-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide725-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide73N-benzyl-5-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide745-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide755-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide765-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide775-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide78N-(2-chlorobenzyl)-5-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide795-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide805-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide815-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide82N-(sec-butyl)-5-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide835-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide845-cyclobutyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide855-cyclobutyl-N-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide865-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide875-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide88N-allyl-5-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide895-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide90N-benzyl-5-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide915-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide925-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide935-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide945-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide95N-(2-chlorobenzyl)-5-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide965-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide975-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide985-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide99N-(sec-butyl)-5-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide1005-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide1015-cyclopentyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide1025-cyclopentyl-N-cyclopropyl-3-{4-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide1035-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide1045-cyclopropyl-N-ethyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide105N-allyl-5-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1065-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide107N-benzyl-5-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1085-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide1095-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide1105-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide1115-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide112N-(2-chlorobenzyl)-5-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1135-cyclopropyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1145-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1155-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide116N-(sec-butyl)-5-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1175-cyclopropyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1185-cyclopropyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide119N,5-dicyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1205-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide1215-cyclobutyl-N-ethyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide122N-allyl-5-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1235-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide124N-benzyl-5-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1255-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide1265-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide1275-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide1285-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide129N-(2-chlorobenzyl)-5-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1305-cyclobutyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1315-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1325-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide133N-(sec-butyl)-5-cyclobutyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1345-cyclobutyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1355-cyclobutyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1365-cyclobutyl-N-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1375-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide1385-cyclopentyl-N-ethyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide139N-allyl-5-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1405-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide141N-benzyl-5-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1425-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide1435-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide1445-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide1455-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide146N-(2-chlorobenzyl)-5-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1475-cyclopentyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1485-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1495-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide150N-(sec-butyl)-5-cyclopentyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1515-cyclopentyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1525-cyclopentyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1535-cyclopentyl-N-cyclopropyl-3-{2-hydroxy-4-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1545-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide1555-cyclopropyl-N-ethyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide156N-allyl-5-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1575-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide158N-benzyl-5-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1595-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide1605-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide1615-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide1625-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide163N-(2-chlorobenzyl)-5-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1645-cyclopropyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1655-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1665-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide167N-(sec-butyl)-5-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1685-cyclopropyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1695-cyclopropyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide170N,5-dicyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1715-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide1725-cyclobutyl-N-ethyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide173N-allyl-5-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1745-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide175N-benzyl-5-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1765-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide1775-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide1785-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide1795-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide180N-(2-chlorobenzyl)-5-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1815-cyclobutyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1825-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1835-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide184N-(sec-butyl)-5-cyclobutyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1855-cyclobutyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1865-cyclobutyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1875-cyclobutyl-N-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1885-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide1895-cyclopentyl-N-ethyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide190N-allyl-5-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1915-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide192N-benzyl-5-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1935-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide1945-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide1955-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide1965-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide197N-(2-chlorobenzyl)-5-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1985-cyclopentyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1995-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide2005-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide201N-(sec-butyl)-5-cyclopentyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide2025-cyclopentyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide2035-cyclopentyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide2045-cyclopentyl-N-cyclopropyl-3-{2-hydroxy-4-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide2055-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide2065-cyclopropyl-N-ethyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide207N-allyl-5-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2085-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide209N-benzyl-5-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2105-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide2115-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide2125-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide2135-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide214N-(2-chlorobenzyl)-5-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2155-cyclopropyl-N-(4-fluorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2165-cyclopropyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2175-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide218N-(sec-butyl)-5-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2195-cyclopropyl-N-(2-fluorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide220N-allyl-5-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide221N,5-dicyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2225-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide2235-cyclobutyl-N-ethyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide224N-allyl-5-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2255-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide226N-benzyl-5-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2275-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide2285-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide2295-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide2305-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide231N-(2-chlorobenzyl)-5-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2325-cyclobutyl-N-(4-fluorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2335-cyclobutyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2345-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide235N-(sec-butyl)-5-cyclobutyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2365-cyclobutyl-N-(2-fluorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2375-cyclobutyl-N-(3-fluorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2385-cyclobutyl-N-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2395-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide2405-cyclopentyl-N-ethyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide241N-allyl-5-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2425-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide243N-benzyl-5-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2445-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide2455-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide2465-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide2475-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide248N-(2-chlorobenzyl)-5-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2495-cyclopentyl-N-(4-fluorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2505-cyclopentyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2515-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide252N-(sec-butyl)-5-cyclopentyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2535-cyclopentyl-N-(2-fluorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2545-cyclopentyl-N-(3-fluorobenzyl)-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2555-cyclopentyl-N-cyclopropyl-3-(2-hydroxy-4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2563-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide2573-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide258N-allyl-3-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide2593-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide260N-benzyl-3-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide2613-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide2623-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide2633-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide2643-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2653-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide2663-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide2673-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide2683-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide269N-(sec-butyl)-3-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide2703-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide2713-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide2723-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide2733-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide2743-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide275N-allyl-3-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide2763-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide277N-benzyl-3-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide2783-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide2793-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide2803-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide2813-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2823-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide2833-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide2843-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide2853-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide286N-(sec-butyl)-3-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide2873-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide2883-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide2893-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide2903-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide2913-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide292N-allyl-3-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide2933-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide294N-benzyl-3-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide2953-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide2963-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide2973-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide2983-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2993-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide3003-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide3013-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide3023-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide303N-(sec-butyl)-3-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide3043-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide3053-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide3063-{4-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide3075-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide3085-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide309N-allyl-5-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3105-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide311N-benzyl-5-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3125-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide3135-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide3145-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide3155-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide316N-(2-chlorobenzyl)-5-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3175-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide3185-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3195-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide320N-(sec-butyl)-5-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3215-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide3225-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide323N,5-dicyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3245-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide3255-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide326N-allyl-5-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3275-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide328N-benzyl-5-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3295-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide3305-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide3315-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide3325-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide333N-(2-chlorobenzyl)-5-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3345-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide3355-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3365-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide337N-(sec-butyl)-5-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3385-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide3395-cyclobutyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide3405-cyclobutyl-N-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3415-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide3425-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide343N-allyl-5-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3445-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide345N-benzyl-5-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3465-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide3475-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide3485-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide3495-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide350N-(2-chlorobenzyl)-5-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3515-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide3525-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3535-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide354N-(sec-butyl)-5-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3555-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide3565-cyclopentyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide3575-cyclopentyl-N-cyclopropyl-3-{4-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide3583-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide3593-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide360N-allyl-3-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide3613-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide362N-benzyl-3-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide3633-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide3643-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide3653-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide3663-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide3673-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide3683-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide3693-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide3703-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide371N-(sec-butyl)-3-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide3723-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide3733-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide3743-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide3753-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide3763-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide377N-allyl-3-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide3783-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide379N-benzyl-3-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide3803-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide3813-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide3823-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide3833-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide3843-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide3853-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide3863-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide3873-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide388N-(sec-butyl)-3-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide3893-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide3903-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide3913-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide3923-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide3933-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide394N-allyl-3-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide3953-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide396N-benzyl-3-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide3973-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide3983-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide3993-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide4003-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide4013-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide4023-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide4033-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide4043-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide405N-(sec-butyl)-3-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide4063-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide4073-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide4083-{4-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide4095-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide4105-cyclopropyl-N-ethyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide411N-allyl-5-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4125-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide413N-benzyl-5-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4145-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide4155-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide4165-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide4175-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide418N-(2-chlorobenzyl)-5-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4195-cyclopropyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4205-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4215-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide422N-(sec-butyl)-5-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4235-cyclopropyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4245-cyclopropyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide425N,5-dicyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4265-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide4275-cyclobutyl-N-ethyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide428N-allyl-5-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4295-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide430N-benzyl-5-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4315-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide4325-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide4335-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide4345-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide435N-(2-chlorobenzyl)-5-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4365-cyclobutyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4375-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4385-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide439N-(sec-butyl)-5-cyclobutyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4405-cyclobutyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4415-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide4425-cyclobutyl-N-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4435-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide4445-cyclopentyl-N-ethyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide445N-allyl-5-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4465 -cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide447N-benzyl-5-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4485-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide4495-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide4505-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide4515-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide452N-(2-chlorobenzyl)-5-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4535-cyclopentyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4545-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4555-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide456N-(sec-butyl)-5-cyclopentyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4575-cyclopentyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4585-cyclopentyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4595-cyclopentyl-N-cyclopropyl-3-{2-hydroxy-4-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide4605-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide4615-cyclopropyl-N-ethyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide462N-allyl-5-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4635-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide464N-benzyl-5-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4655-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide4665-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide4675-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide4685-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide469N-(2-chlorobenzyl)-5-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4705-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide4715-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4725-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide473N-(sec-butyl)-5-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4745-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide4755-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide476N,5-dicyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4775-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide4785-cyclobutyl-N-ethyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide479N-allyl-5-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4805-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide481N-benzyl-5-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4825-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide4835-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide4845-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide4855-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide486N-(2-chlorobenzyl)-5-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4875-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide4885-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4895-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide490N-(sec-butyl)-5-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4915-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide4925-cyclobutyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide4935-cyclobutyl-N-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4945-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide4955-cyclopentyl-N-ethyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide496N-allyl-5-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4975-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide498N-benzyl-5 -cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide4995-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide5005-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide5015-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide5025-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide503N-(2-chlorobenzyl)-5-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide5045-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide5055-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide5065-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide507N-(sec-butyl)-5-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide5085-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide5095-cyclopentyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide5105-cyclopentyl-N-cyclopropyl-3-{4-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide5115-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide5125-cyclopropyl-N-ethyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide513N-allyl-5-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5145-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide515N-benzyl-5-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5165-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide5175-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide5185-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide5195-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide520N-(2-chlorobenzyl)-5-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5215-cyclopropyl-N-(4-fluorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5225-cyclopropyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5235-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide524N-(sec-butyl)-5-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5255-cyclopropyl-N-(2-fluorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5265-cyclopropyl-N-(3-fluorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide527N,5-dicyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5285-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide5295-cyclobutyl-N-ethyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide530N-allyl-5-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5315-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide532N-benzyl-5-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5335-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide5345-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide5355-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide5365-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide537N-(2-chlorobenzyl)-5-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5385-cyclobutyl-N-(4-fluorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5395-cyclobutyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5405-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide541N-(sec-butyl)-5-cyclobutyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5425-cyclobutyl-N-(2-fluorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5435-cyclobutyl-N-(3-fluorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5445-cyclobutyl-N-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5455-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide5465-cyclopentyl-N-ethyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide547N-allyl-5-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5485-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide549N-benzyl-5-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5505-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide5515-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide5525-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide5535-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide554N-(2-chlorobenzyl)-5-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5555-cyclopentyl-N-(4-fluorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5565-cyclopentyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5575-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide558N-(sec-butyl)-5-cyclopentyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5595-cyclopentyl-N-(2-fluorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5605-cyclopentyl-N-(3-fluorobenzyl)-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5615-cyclopentyl-N-cyclopropyl-3-[2-hydroxy-4-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide5623-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide5633-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide5643-[4-(acetylamino)-2-hydroxyphenyl]-N-allyl-5-cyclopropyl-1H-pyrazole-1-carboxamide5653-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide5663-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide5673-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide5683-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide5693-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide5703-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide5713-[4-(acetylamino)-2-hydroxyphenyl]-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide5723-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide5733-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide5743-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide5753-[4-(acetylamino)-2-hydroxyphenyl]-N-(sec-butyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide5763-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide5773-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide5783-[4-(acetylamino)-2-hydroxyphenyl]-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide5793-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide5803-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide5813-[4-(acetylamino)-2-hydroxyphenyl]-N-allyl-5-cyclobutyl-1H-pyrazole-1-carboxamide5823-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide5833-[4-(acetylamino)-2-hydroxyphenyl]-N-benzyl-5-cyclobutyl-1H-pyrazole-1-carboxamide5843-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide5853-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide5863-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide5873-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide5883-[4-(acetylamino)-2-hydroxyphenyl]-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide5893-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide5903-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide5913-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide5923-[4-(acetylamino)-2-hydroxyphenyl]-N-(sec-butyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide5933-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide5943-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide5953-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide5963-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide5973-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide5983-[4-(acetylamino)-2-hydroxyphenyl]-N-allyl-5-cyclopentyl-1H-pyrazole-1-carboxamide5993-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide6003-[4-(acetylamino)-2-hydroxyphenyl]-N-benzyl-5-cyclopentyl-1H-pyrazole-1-carboxamide6013-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide6023-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide6033-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide6043-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide6053-[4-(acetylamino)-2-hydroxyphenyl]-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide6063-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide6073-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide6083-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide6093-[4-(acetylamino)-2-hydroxyphenyl]-N-(sec-butyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide6103-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide6113-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide6123-[4-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide6135-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide6145-cyclopropyl-N-ethyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide615N-allyl-5-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6165-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide617N-benzyl-5-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6185-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide6195-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide6205-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide6215-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide622N-(2-chlorobenzyl)-5-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6235-cyclopropyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6245-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6255-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide626N-(sec-butyl)-5-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6275-cyclopropyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6285-cyclopropyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide629N,5-dicyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6305-cyclobutyl-N-ethyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6315-cyclobutyl-N-ethyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide632N-allyl-5-cyclobutyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6335-cyclobutyl-3-{2-hydroxy-4-[(3 -methylbutanoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide634N-benzyl-5-cyclobutyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6355-cyclobutyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide6365-cyclobutyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide6375-cyclobutyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide6385-cyclobutyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide639N-(2-chlorobenzyl)-5-cyclobutyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6405-cyclobutyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6415-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6425-cyclobutyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide643N-(sec-butyl)-5-cyclobutyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6445-cyclobutyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6455-cyclobutyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6465-cyclobutyl-N-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6475-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide6485-cyclopentyl-N-ethyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide649N-allyl-5-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6505-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide651N-benzyl-5-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6525-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide6535-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide6545-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide6555-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide656N-(2-chlorobenzyl)-5-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6575-cyclopentyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6585-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6595-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide660N-(sec-butyl)-5-cyclopentyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6615-cyclopentyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6625-cyclopentyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6635-cyclopentyl-N-cyclopropyl-3-{2-hydroxy-4-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide6645-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide6655-cyclopropyl-N-ethyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide666N-allyl-5-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6675-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide668N-benzyl-5-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6695-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide6705-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide6715-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide672N,5-dicyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide673N-(2-chlorobenzyl)-5-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6745-cyclopropyl-N-(4-fluorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6755-cyclopropyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6765-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide677N-(sec-butyl)-5-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6785-cyclopropyl-N-(2-fluorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6795-cyclopropyl-N-(3-fluorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide680N,5-dicyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6815-cyclobutyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide6825-cyclobutyl-N-ethyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide683N-allyl-5-cyclobutyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6845-cyclobutyl-3-[2-hydroxy-4-propionylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide685N-benzyl-5-cyclobutyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6865-cyclobutyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide6875-cyclobutyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide6885-cyclobutyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide6895-cyclobutyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide690N-(2-chlorobenzyl)-5-cyclobutyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6915-cyclobutyl-N-(4-fluorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6925-cyclobutyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6935-cyclobutyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide694N-(sec-butyl)-5-cyclobutyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6955-cyclobutyl-N-(2-fluorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6965-cyclobutyl-N-(3-fluorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6975-cyclobutyl-N-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide6985-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide6995-cyclopentyl-N-ethyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide700N-allyl-5-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide7015-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide702N-benzyl-5-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide7035-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide7045-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide7055-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide7065-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide707N-(2-chlorobenzyl)-5-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide7085-cyclopentyl-N-(4-fluorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide7095-cyclopentyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide7105-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide711N-(sec-butyl)-5-cyclopentyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide7125-cyclopentyl-N-(2-fluorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide7135-cyclopentyl-N-(3-fluorobenzyl)-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide7145-cyclopentyl-N-cyclopropyl-3-[2-hydroxy-4-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide7155-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide7165-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide717N-allyl-5-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7185-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide719N-benzyl-5-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7205-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide7215-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide7225-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide7235-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide724N-(2-chlorobenzyl)-5-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7255-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide7265-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide7275-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide728N-(sec-butyl)-5-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7295-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide7305-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide731N,5-dicyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7325-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide7335-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide734N-allyl-5-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7355-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide736N-benzyl-5-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7375-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide7385-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide7395-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide7405-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide741N-(2-chlorobenzyl)-5-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7425-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide7435-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide7445-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide745N-(sec-butyl)-5-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7465-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide7475-cyclobutyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide7485-cyclobutyl-N-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7495-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide7505-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide751N-allyl-5-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7525-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide753N-benzyl-5-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7545-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide7555-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide7565-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide7575-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide758N-(2-chlorobenzyl)-5-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7595-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide7605-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide7615-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide762N-(sec-butyl)-5-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7635-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide7645-cyclopentyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide7655-cyclopentyl-N-cyclopropyl-3-{4-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide7665-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-isopropyl-1H-pyrazole-1-carboxamide7675-cyclopropyl-N-ethyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide768N-allyl-5-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7695-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-propyl-1H-pyrazole-1-carboxamide770N-benzyl-5-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7715-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide7725-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide7735-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide7745-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide775N-(2-chlorobenzyl)-5-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7765-cyclopropyl-N-(4-fluorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7775-cyclopropyl-N-(3,4-dichlorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7785-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide779N-(sec-butyl)-5-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7805-cyclopropyl-N-(2-fluorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7815-cyclopropyl-N-(3-fluorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide782N,5-dicyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7835-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-isopropyl-1H-pyrazole-1-carboxamide7845-cyclobutyl-N-ethyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide785N-allyl-5-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7865-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-propyl-1H-pyrazole-1-carboxamide787N-benzyl-5-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7885-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide7895-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide7905-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide7915-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide792N-(2-chlorobenzyl)-5-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7935-cyclobutyl-N-(4-fluorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7945-cyclobutyl-N-(3,4-dichlorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7955-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide796N-(sec-butyl)-5-cyclobutyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7975-cyclobutyl-N-(2-fluorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7985-cyclobutyl-N-(3-fluorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide7995-cyclobutyl-N-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide8005-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-isopropyl-1H-pyrazole-1-carboxamide8015-cyclopentyl-N-ethyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide802N-allyl-5-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide8035-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-propyl-1H-pyrazole-1-carboxamide8045-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide8055-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide8065-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide8075-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide8085-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide809N-(2-chlorobenzyl)-5-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide8105-cyclopentyl-N-(4-fluorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide8115-cyclopentyl-N-(3,4-dichlorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide8125-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide813N-(sec-butyl)-5-cyclopentyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide8145-cyclopentyl-N-(2-fluorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide8155-cyclopentyl-N-(3-fluorobenzyl)-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide8165-cyclopentyl-N-cyclopropyl-3-[4-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide8175-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide8185-cyclopropyl-N-ethyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide819N-allyl-5-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8205-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide821N-benzyl-5-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8225-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide8235-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide8245-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide8255-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide826N-(2-chlorobenzyl)-5-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8275-cyclopropyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8285-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8295-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide830N-(sec-butyl)-5-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8315-cyclopropyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8325-cyclopropyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide833N,5-dicyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8345-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide8355-cyclobutyl-N-ethyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide836N-allyl-5-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8375-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide838N-benzyl-5-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8395-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide8405-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide8415-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide8425-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide843N-(2-chlorobenzyl)-5-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8445-cyclobutyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8455-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8465-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide847N-(sec-butyl)-5-cyclobutyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8485-cyclobutyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8495-cyclobutyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8505-cyclobutyl-N-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8515-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide8525-cyclopentyl-N-ethyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide853N-allyl-5-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8545-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide855N-benzyl-5-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8565-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide8575-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide8585-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide8595-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide860N-(2-chlorobenzyl)-5-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8615-cyclopentyl-N-(4-fluorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8625-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8635-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide864N-(sec-butyl)-5-cyclopentyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8655-cyclopentyl-N-(2-fluorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8665-cyclopentyl-N-(3-fluorobenzyl)-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide8675-cyclopentyl-N-cyclopropyl-3-{2-hydroxy-4-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide868N-(4-{5-cyclopropyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide869N-(4-{5-cyclopropyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide870N-(4-{1-[(allylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide871N-(4-{5-cyclopropyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide872N-(4-{1-[(benzylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide873N-[4-(5-cyclopropyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide874N-[4-(5-cyclopropyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide875N-[4-(5-cyclopropyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide876N-[4-(5-cyclopropyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide877N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopropyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide878N-[4-(5-cyclopropyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide879N-[4-(5-cyclopropyl-1-{[(3 ,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide880N-[4-(5-cyclopropyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide881N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide882N-[4-(5-cyclopropyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide883N-[4-(5-cyclopropyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide884N-(4-{5-cyclopropyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide885N-(4-{5-cyclobutyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide886N-(4-{5-cyclobutyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide887N-(4-{1-[(allylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide888N-(4-{5-cyclobutyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide889N-(4-{1-[(benzylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide890N-[4-(5-cyclobutyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide891N-[4-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide892N-[4-(5-cyclobutyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide893N-[4-(5-cyclobutyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide894N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclobutyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide895N-[4-(5-cyclobutyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide896N-[4-(5-cyclobutyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide897N-[4-(5-cyclobutyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide898N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide899N-[4-(5-cyclobutyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide900N-[4-(5-cyclobutyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide901N-(4-{5-cyclobutyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide902N-(4-{5-cyclopentyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide903N-(4-{5-cyclopentyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide904N-(4-{1-[(allylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide905N-(4-{5-cyclopentyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide906N-(4-{1-[(benzylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide907N-[4-(5-cyclopentyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide908N-[4-(5-cyclopentyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide909N-[4-(5-cyclopentyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide910N-[4-(5-cyclopentyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide911N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopentyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide912N-[4-(5-cyclopentyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide913N-[4-(5-cyclopentyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide914N-[4-(5-cyclopentyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide915N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide916N-[4-(5-cyclopentyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide917N-[4-(5-cyclopentyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]quinoxaline-2-carboxamide918N-(4-{5-cyclopentyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)quinoxaline-2-carboxamide919N-(4-{5-cyclopropyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide920N-(4-{5-cyclopropyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide921N-(4-{1-[(allylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide922N-(4-{5-cyclopropyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide923N-(4-{1-[(benzylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide924N-[4-(5-cyclopropyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide925N-[4-(5-cyclopropyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide926N-[4-(5-cyclopropyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide927N-[4-(5-cyclopropyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide928N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopropyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide929N-[4-(5-cyclopropyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3 -hydroxyphenyl]nicotinamide930N-[4-(5-cyclopropyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide931N-[4-(5-cyclopropyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide932N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide933N-[4-(5 -cyclopropyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide934N-[4-(5-cyclopropyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide935N-(4-{5-cyclopropyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide936N-(4-{5-cyclobutyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide937N-(4-{5-cyclobutyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide938N-(4-{1-[(allylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide939N-(4-{5-cyclobutyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide940N-(4-{1-[(benzylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide941N-[4-(5-cyclobutyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide942N-[4-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide943N-[4-(5-cyclobutyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide944N-[4-(5-cyclobutyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide945N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclobutyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide946N-[4-(5-cyclobutyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide947N-[4-(5-cyclobutyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide948N-[4-(5-cyclobutyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide949N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide950N-[4-(5-cyclobutyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide951N-[4-(5-cyclobutyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide952N-(4-{5-cyclobutyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide953N-(4-{5-cyclopentyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide954N-(4-{5-cyclopentyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide955N-(4-{1-[(allylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide956N-(4-{5-cyclopentyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide957N-(4-{1-[(benzylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide958N-[4-(5-cyclopentyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide959N-[4-(5-cyclopentyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide960N-[4-(5-cyclopentyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide961N-[4-(5-cyclopentyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide962N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopentyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide963N-[4-(5-cyclopentyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide964N-[4-(5-cyclopentyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide965N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide966N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide967N-[4-(5-cyclopentyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide968N-[4-(5-cyclopentyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide969N-(4-{5-cyclopentyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide970N-(4-{5-cyclopropyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide971N-(4-{5-cyclopropyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide972N-(4-{1-[(allylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide973N-(4-{5-cyclopropyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide974N-(4-{1-[(benzylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide975N-[4-(5-cyclopropyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide976N-[4-(5-cyclopropyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide977N-[4-(5-cyclopropyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide978N-[4-(5-cyclopropyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide979N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopropyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide980N-[4-(5-cyclopropyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide981N-[4-(5-cyclopropyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide982N-[4-(5-cyclopropyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide983N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide984N-[4-(5-cyclopropyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide985N-[4-(5-cyclopropyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide986N-(4-{5-cyclopropyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide987N-(4-{5-cyclobutyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide988N-(4-{5-cyclobutyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide989N-(4-{1-[(allylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide990N-(4-{5-cyclobutyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide991N-(4-{1-[(benzylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide992N-[4-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide993N-[4-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide994N-[4-(5-cyclobutyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide995N-[4-(5-cyclobutyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide996N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclobutyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide997N-[4-(5-cyclobutyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide998N-[4-(5-cyclobutyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide999N-[4-(5-cyclobutyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1000N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide1001N-[4-(5-cyclobutyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1002N-[4-(5-cyclobutyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1003N-(4-{5-cyclobutyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide1004N-(4-{5-cyclopentyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide1005N-(4-{5-cyclopentyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide1006N-(4-{1-[(allylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide1007N-(4-{5-cyclopentyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide1008N-(4-{1-[(benzylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide1009N-[4-(5-cyclopentyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1010N-[4-(5-cyclopentyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1011N-[4-(5-cyclopentyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1012N-[4-(5-cyclopentyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1013N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopentyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1014N-[4-(5-cyclopentyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1015N-[4-(5-cyclopentyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1016N-[4-(5-cyclopentyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1017N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide1018N-[4-(5-cyclopentyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1019N-[4-(5-cyclopentyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isonicotinamide1020N-(4-{5-cyclopentyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isonicotinamide10213-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide10223-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide1023N-allyl-3-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide10243-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide10253-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclopropyl-1H-pyrazole-1-carboxamide10263-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide10273-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide10283-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide10293-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide10303-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide10313-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide10323-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide10333-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide10343-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide10353-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide10363-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide10373-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide10383-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide10393-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide1040N-allyl-3-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide10413-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide10423-{4[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclobutyl-1H-pyrazole-1-carboxamide10433-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide10443-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide10453-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide10463-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide10473-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide10483-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide10493-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide10503-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide10513-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide10523-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide10533-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide10543-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide10553-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide10563-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide1057N-allyl-3-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide10583-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide10593-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclopentyl-1H-pyrazole-1-carboxamide10603-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide10613-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide10623-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide10633-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide10643-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl-5-cyclopentyl-1H-pyrazole-1-carboxamide10653-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide10663-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide10673-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide10683-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide10693-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide10703-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide10713-{4-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide10725-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide10735-cyclopropyl-N-ethyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide1074N-allyl-5-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide10755-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1076N-benzyl-5-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide10775-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide10785-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide10795-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide10805-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1081N-(2-chlorobenzyl)-5-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide10825-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide10835-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide10845-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1085N-(sec-butyl)-5-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide10865-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide10875-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide1088N,5-dicyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide10895-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide10905-cyclobutyl-N-ethyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide1091N-allyl-5-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide10925-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1093N-benzyl-5-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide10945-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide10955-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide10965-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide10975-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1098N-(2-chlorobenzyl)-5-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide10995-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide11005-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide11015-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1102N-(sec-butyl)-5-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide11035-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide11045-cyclobutyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide11055-cyclobutyl-N-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide11065-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide11075-cyclopentyl-N-ethyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide1108N-allyl-5-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide11095-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1110N-benzyl-5-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide11115-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide11125-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide11135-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide11145-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1115N-(2-chlorobenzyl)-5-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide11165-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide11175-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide11185-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1119N-(sec-butyl)-5-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide11205-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide11215-cyclopentyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide11225-cyclopentyl-N-cyclopropyl-3-{4-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide11233-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide11243-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide1125N-allyl-3-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide11263-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide11273-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclopropyl-1H-pyrazole-1-carboxamide11283-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide11293-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide11303-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide11313-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide11323-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide11333-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide11343-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide11353-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide11363-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide11373-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide11383-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide11393-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide11403-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide11413-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide1142N-allyl-3-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide11433-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide11443-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclobutyl-1H-pyrazole-1-carboxamide11453-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide11463-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide11473-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide11483-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide11493-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide11503-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide11513-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide11523-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide11533-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide11543-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide11553-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide11563-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide11573-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide11583-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide1159N-allyl-3-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide11603-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide11613-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclopentyl-1H-pyrazole-1-carboxamide11623-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide11633-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide11643-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide11653-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide11663-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide11673-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide11683-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide11693-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide11703-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide11713-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide11723-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide11733-{4-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide11742-chloro-N-(4-{5-cyclopropyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide11752-chloro-N-(4-{5-cyclopropyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide1176N-(4-{1-[(allylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)-2-chloronicotinamide11772-chloro-N-(4-{5-cyclopropyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide1178N-(4-{1-[(benzylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)-2-chloronicotinamide11792-chloro-N-[4-(5-cyclopropyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11802-chloro-N-[4-(5-cyclopropyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11812-chloro-N-[4-(5-cyclopropyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11822-chloro-N-[4-(5-cyclopropyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11832-chloro-N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopropyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11842-chloro-N-[4-(5-cyclopropyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11852-chloro-N-[4-(5-cyclopropyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11862-chloro-N-[4-(5-cyclopropyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide1187N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)-2-chloronicotinamide11882-chloro-N-[4-(5-cyclopropyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11892-chloro-N-[4-(5-cyclopropyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11902-chloro-N-(4-{5-cyclopropyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide11912-chloro-N-(4-{5-cyclobutyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide11922-chloro-N-(4-{5-cyclobutyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide1193N-(4-{1-[(allylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)-2-chloronicotinamide11942-chloro-N-(4-{5-cyclobutyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide1195N-(4-{1-[(benzylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)-2-chloronicotinamide11962-chloro-N-[4-(5-cyclobutyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11972-chloro-N-[4-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11982-chloro-N-[4-(5-cyclobutyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide11992-chloro-N-[4-(5-cyclobutyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12002-chloro-N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclobutyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12012-chloro-N-[4-(5-cyclobutyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12022-chloro-N-[4-(5-cyclobutyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12032-chloro-N-[4-(5-cyclobutyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide1204N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)-2-chloronicotinamide12052-chloro-N-[4-(5-cyclobutyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12062-chloro-N-[4-(5-cyclobutyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12072-chloro-N-(4-{5-cyclobutyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide12082-chloro-N-(4-{5-cyclopentyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide12092-chloro-N-(4-{5-cyclopentyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide1210N-(4-{1-[(allylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)-2-chloronicotinamide12112-chloro-N-(4-{5-cyclopentyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide1212N-(4-{1-[(benzylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)-2-chloronicotinamide12132-chloro-N-[4-(5-cyclopentyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12142-chloro-N-[4-(5-cyclopentyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12152-chloro-N-[4-(5-cyclopentyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12162-chloro-N-[4-(5-cyclopentyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12172-chloro-N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopentyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12182-chloro-N-[4-(5-cyclopentyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12192-chloro-N-[4-(5-cyclopentyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12202-chloro-N-[4-(5-cyclopentyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide1221N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)-2-chloronicotinamide12222-chloro-N-[4-(5-cyclopentyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12232-chloro-N-[4-(5-cyclopentyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]nicotinamide12242-chloro-N-(4-{5-cyclopentyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)nicotinamide12255-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide12265-cyclopropyl-N-ethyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide1227N-allyl-5-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12285-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide1229N-benzyl-5-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12305-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide12315-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide12325-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide12335-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1234N-(2-chlorobenzyl)-5-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12355-cyclopropyl-N-(4-fluorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12365-cyclopropyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12375-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1238N-(sec-butyl)-5-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12395-cyclopropyl-N-(2-fluorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12405-cyclopropyl-N-(3-fluorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide1241N,5-dicyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12425-cyclobutyl-N-ethyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12435-cyclobutyl-N-ethyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide1244N-allyl-5-cyclobutyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12455-cyclobutyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide1246N-benzyl-5-cyclobutyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12475-cyclobutyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide12485-cyclobutyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide12495-cyclobutyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide12505-cyclobutyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1251N-(2-chlorobenzyl)-5-cyclobutyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12525-cyclobutyl-N-(4-fluorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12535-cyclobutyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12545-cyclobutyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1255N-(sec-butyl)-5-cyclobutyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12565-cyclobutyl-N-(2-fluorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12575-cyclobutyl-N-(3-fluorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide1258N-allyl-5-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12595-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide12605-cyclopentyl-N-ethyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide1261N-allyl-5-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12625-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide1263N-benzyl-5-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12645-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide12655-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide12665-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide12675-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1268N-(2-chlorobenzyl)-5-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12695-cyclopentyl-N-(4-fluorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12705-cyclopentyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12715-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1272N-(sec-butyl)-5-cyclopentyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12735-cyclopentyl-N-(2-fluorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12745-cyclopentyl-N-(3-fluorobenzyl)-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide12755-cyclopentyl-N-cyclopropyl-3-(2-hydroxy-4-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide1276N-(4-{5-cyclopropyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1277N-(4-{5-cyclopropyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1278N-(4-{1-[(allylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1279N-(4-{5-cyclopropyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1280N-(4-{1-[(benzylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1281N-[4-(5-cyclopropyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1282N-[4-(5-cyclopropyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1283N-[4-(5-cyclopropyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1284N-[4-(5-cyclopropyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1285N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopropyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1286N-[4-(5-cyclopropyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1287N-[4-(5-cyclopropyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1288N-[4-(5-cyclopropyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1289N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1290N-[4-(5-cyclopropyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1291N-[4-(5-cyclopropyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1292N-(4-{5-cyclopropyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1293N-(4-{5-cyclobutyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1294N-(4-{5-cyclobutyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1295N-(4-{1-[(allylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1296N-(4-{5-cyclobutyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1297N-(4-{1-[(benzylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1298N-[4-(5-cyclobutyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1299N-[4-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1300N-[4-(5-cyclobutyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1301N-[4-(5-cyclobutyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1302N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclobutyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1303N-[4-(5-cyclobutyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1304N-[4-(5-cyclobutyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1305N-[4-(5-cyclobutyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1306N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1307N-[4-(5-cyclobutyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1308N-[4-(5-cyclobutyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1309N-(4-{5-cyclobutyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1310N-(4-{5-cyclopentyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1311N-(4-{5-cyclopentyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1312N-(4-{1-[(allylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1313N-(4-{5-cyclopentyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1314N-(4-{1-[(benzylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1315N-[4-(5-cyclopentyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1316N-[4-(5-cyclopentyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1317N-[4-(5-cyclopentyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1318N-[4-(5-cyclopentyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1319N-[4-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopentyl-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1320N-[4-(5-cyclopentyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1321N-[4-(5-cyclopentyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1322N-[4-(5-cyclopentyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1323N-(4-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide1324N-[4-(5-cyclopentyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1325N-[4-(5-cyclopentyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-3-hydroxyphenyl]isoxazole-5-carboxamide1326N-(4-{5-cyclopentyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-3-hydroxyphenyl)isoxazole-5-carboxamide13275-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide13285-cyclopropyl-N-ethyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide1329N-allyl-5-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13305-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide1331N-benzyl-5-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13325-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide13335-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide13345-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide13355-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1336N-(2-chlorobenzyl)-5-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13375-cyclopropyl-N-(4-fluorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13385-cyclopropyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13395-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1340N-(sec-butyl)-5-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13415-cyclopropyl-N-(2-fluorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13425-cyclopropyl-N-(3-fluorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide1343N,5-dicyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13445-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide13455-cyclobutyl-N-ethyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide1346N-allyl-5-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13475-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide1348N-benzyl-5-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13495-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide13505-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide13515-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide13525-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1353N-(2-chlorobenzyl)-5-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13545-cyclobutyl-N-(4-fluorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13555-cyclobutyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13565-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1357N-(sec-butyl)-5-cyclobutyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13585-cyclobutyl-N-(2-fluorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13595-cyclobutyl-N-(3-fluorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13605-cyclobutyl-N-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13615-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide13625-cyclopentyl-N-ethyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide1363N-allyl-5-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13645-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide1365N-benzyl-5-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13665-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide13675-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide13685-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide13695-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1370N-(2-chlorobenzyl)-5-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13715-cyclopentyl-N-(4-fluorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13725-cyclopentyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13735-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1374N-(sec-butyl)-5-cyclopentyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13755-cyclopentyl-N-(2-fluorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13765-cyclopentyl-N-(3-fluorobenzyl)-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13775-cyclopentyl-N-cyclopropyl-3-(2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide13783-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide13793-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide1380N-allyl-3-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide13813-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide1382N-benzyl-3-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide13833-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide13843-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide13853-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide13863-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide13873-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide13883-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide13893-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide13903-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1391N-(sec-butyl)-3-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide13923-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide13933-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide13943-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide13953-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide13963-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide1397N-allyl-3-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide13983-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide1399N-benzyl-3-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide14003-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide14013-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide14023-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide14033-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide14043-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide14053-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide14063-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide14073-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1408N-(sec-butyl)-3-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide14093-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide14103-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide14113-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide14123-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide14133-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide1414N-allyl-3-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide14153-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide1416N-benzyl-3-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide14173-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide14183-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide14193-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide14203-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide14213-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide14223-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide14233-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide14243-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1425N-(sec-butyl)-3-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide14263-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide14273-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide14283-{5-[(2-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide14295-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide14305-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide1431N-allyl-5-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14325-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1433N-benzyl-5-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14345-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide14355-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide14365-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide14375-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1438N-(2-chlorobenzyl)-5-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14395-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide14405-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide14415-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1442N-(sec-butyl)-5-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14435-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide14445-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide1445N,5-dicyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14465-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide14475-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide1448N-allyl-5-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14495-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1450N-benzyl-5-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14515-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide14525-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide14535-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide14545-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1455N-(2-chlorobenzyl)-5-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14565-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide14575-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide14585-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1459N-(sec-butyl)-5-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14605-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide14615-cyclobutyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide14625-cyclobutyl-N-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14635-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide14645-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide1465N-allyl-5-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14665-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1467N-benzyl-5-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14685-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide14695-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide14705-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide14715-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1472N-(2-chlorobenzyl)-5-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14735-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide14745-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide14755-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1476N-(sec-butyl)-5-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14775-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide14785-cyclopentyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide14795-cyclopentyl-N-cyclopropyl-3-{5-[(2,6-dichlorobenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide14805-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide14815-cyclopropyl-N-ethyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1482N-allyl-5-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide14835-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide1484N-benzyl-5-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide14855-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide14865-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide14875-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide14885-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1489N-(2-chlorobenzyl)-5-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide14905-cyclopropyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide14915-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide14925-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1493N-(sec-butyl)-5-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide14945-cyclopropyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide14955-cyclopropyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1496N,5-dicyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide14975-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide14985-cyclobutyl-N-ethyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1499N-allyl-5-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15005-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide1501N-benzyl-5-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15025-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide15035-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide15045-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide15055-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1506N-(2-chlorobenzyl)-5-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15075-cyclobutyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15085-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15095-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1510N-(sec-butyl)-5-cyclobutyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15115-cyclobutyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15125-cyclobutyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15135-cyclobutyl-N-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15145-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide15155-cyclopentyl-N-ethyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1516N-allyl-5-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15175-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide1518N-benzyl-5-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15195-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide15205-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide15215-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide15225-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1523N-(2-chlorobenzyl)-5-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15245-cyclopentyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15255-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15265-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1527N-(sec-butyl)-5-cyclopentyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15285-cyclopentyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15295-cyclopentyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15305-cyclopentyl-N-cyclopropyl-3-{2-hydroxy-5-[(2-methoxybenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15315-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide15325-cyclopropyl-N-ethyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1533N-allyl-5-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15345-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide1535N-benzyl-5-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15365-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide15375-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide15385-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide15395-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1540N-(2-chlorobenzyl)-5-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15415-cyclopropyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15425-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15435-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1544N-(sec-butyl)-5-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15455-cyclopropyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15465-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide1547N,5-dicyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15485-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide15495-cyclobutyl-N-ethyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1550N-allyl-5-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15515-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide1552N-benzyl-5-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15535-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide15545-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide15555-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide15565-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1557N-(2-chlorobenzyl)-5-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15585-cyclobutyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15595-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15605-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1561N-(sec-butyl)-5-cyclobutyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15625-cyclobutyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15635-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide15645-cyclobutyl-N-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15655-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide15665-cyclopentyl-N-ethyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1567N-allyl-5-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15685-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide1569N-benzyl-5-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15705-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide15715-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide15725-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide15735-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1574N-(2-chlorobenzyl)-5-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15755-cyclopentyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15765-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15775-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1578N-(sec-butyl)-5-cyclopentyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15795-cyclopentyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15805-cyclopentyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15815-cyclopentyl-N-cyclopropyl-3-{2-hydroxy-5-[(2-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide15825-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide15835-cyclopropyl-N-ethyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide1584N-allyl-5-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide15855-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide1586N-benzyl-5-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide15875-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide15885-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide15895-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide15905-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1591N-(2-chlorobenzyl)-5-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide15925-cyclopropyl-N-(4-fluorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide15935-cyclopropyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide15945-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1595N-(sec-butyl)-5-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide15965-cyclopropyl-N-(2-fluorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide15975-cyclopropyl-N-(3-fluorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide1598N,5-dicyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide15995-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide16005-cyclobutyl-N-ethyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide1601N-allyl-5-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16025-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide1603N-benzyl-5-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16045-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide16055-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide16065-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide16075-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1608N-(2-chlorobenzyl)-5-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16095-cyclobutyl-N-(4-fluorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16105-cyclobutyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16115-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1612N-(sec-butyl)-5-cyclobutyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16135-cyclobutyl-N-(2-fluorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16145-cyclobutyl-N-(3-fluorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16155-cyclobutyl-N-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16165-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide16175-cyclopentyl-N-ethyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide1618N-allyl-5-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16195-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide1620N-benzyl-5-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16215-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide16225-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide16235-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide16245-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1625N-(2-chlorobenzyl)-5-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16265-cyclopentyl-N-(4-fluorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16275-cyclopentyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16285-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1629N-(sec-butyl)-5-cyclopentyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16305-cyclopentyl-N-(2-fluorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16315-cyclopentyl-N-(3-fluorobenzyl)-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16325-cyclopentyl-N-cyclopropyl-3-(2-hydroxy-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide16333-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide16343-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide1635N-allyl-3-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide16363-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide1637N-benzyl-3-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide16383-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide16393-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide16403-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide16413-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide16423-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide16433-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide16443-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide16453-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1646N-(sec-butyl)-3-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide16473-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide16483-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide16493-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide16503-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide16513-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide1652N-allyl-3-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide16533-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide1654N-benzyl-3-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide16553-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide16563-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide16573-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide16583-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide16593-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide16603-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide16613-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide16623-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1663N-(sec-butyl)-3-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide16643-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide16653-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide16663-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide16673-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide16683-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide1669N-allyl-3-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide16703-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide1671N-benzyl-3-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide16723-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide16733-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide16743-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide16753-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide16763-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide16773-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide16783-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide16793-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1680N-(sec-butyl)-3-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide16813-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide16823-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide16833-{5-[(4-chlorobenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide16845-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide16855-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide1686N-allyl-5-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide16875-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1688N-benzyl-5-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide16895-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide16905-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide16915-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide16925-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1693N-(2-chlorobenzyl)-5-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide16945-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide16955-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide16965-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1697N-(sec-butyl)-5-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide16985-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide16995-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide1700N,5-dicyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17015-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide17025-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide1703N-allyl-5-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17045-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1705N-benzyl-5-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17065-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide17075-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide17085-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide17095-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1710N-(2-chlorobenzyl)-5-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17115-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide17125-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17135-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1714N-(sec-butyl)-5-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17155-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide17165-cyclobutyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide17175-cyclobutyl-N-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17185-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide17195-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide1720N-allyl-5-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17215-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1722N-benzyl-5-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17235-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide17245-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide17255-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide17265-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1727N-(2-chlorobenzyl)-5-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17285-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide17295-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17305-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1731N-(sec-butyl)-5-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17325-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide17335-cyclopentyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide17345-cyclopentyl-N-cyclopropyl-3-{5-[(4-ethoxybenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide17353-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide17363-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide1737N-allyl-3-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide17383-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide1739N-benzyl-3-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide17403-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide17413-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide17423-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide17433-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide17443-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide17453-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide17463-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide17473-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1748N-(sec-butyl)-3-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide17493-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide17503-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide17513-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide17523-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide17533-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide1754N-allyl-3-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide17553-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide1756N-benzyl-3-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide17573-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide17583-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide17593-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide17603-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide17613-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide17623-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide17633-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide17643-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1765N-(sec-butyl)-3-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide17663-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide17673-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide17683-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide17693-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide17703-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide1771N-allyl-3-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide17723-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide1773N-benzyl-3-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide17743-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide17753-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide17763-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide17773-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide17783-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide17793-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide17803-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide17813-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1782N-(sec-butyl)-3-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide17833-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide17843-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide17853-{5-[(4-tert-butylbenzoyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide17865-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide17875-cyclopropyl-N-ethyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1788N-allyl-5-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide17895-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide1790N-benzyl-5-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide17915-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide17925-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide17935-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide17945-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1795N-(2-chlorobenzyl)-5-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide17965-cyclopropyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide17975-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide17985-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1799N-(sec-butyl)-5-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18005-cyclopropyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18015-cyclopropyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1802N,5-dicyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18035-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide18045-cyclobutyl-N-ethyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1805N-allyl-5-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18065-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide1807N-benzyl-5-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18085-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide18095-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide18105-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide18115-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1812N-(2-chlorobenzyl)-5-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18135-cyclobutyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18145-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18155-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1816N-(sec-butyl)-5-cyclobutyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18175-cyclobutyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18185-cyclobutyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18195-cyclobutyl-N-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18205-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide18215-cyclopentyl-N-ethyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1822N-allyl-5-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18235-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide1824N-benzyl-5-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18255-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide18265-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide18275-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide18285-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1829N-(2-chlorobenzyl)-5-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18305-cyclopentyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18315-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18325-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1833N-(sec-butyl)-5-cyclopentyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18345-cyclopentyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18355-cyclopentyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18365-cyclopentyl-N-cyclopropyl-3-{2-hydroxy-5-[(4-methylbenzoyl)amino]phenyl}-1H-pyrazole-1-carboxamide18375-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide18385-cyclopropyl-N-ethyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide1839N-allyl-5-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18405-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1841N-benzyl-5-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18425-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide18435-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide18445-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide18455-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1846N-(2-chlorobenzyl)-5-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18475-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide18485-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18495-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1850N-(sec-butyl)-5-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18515-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide18525-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide1853N,5-dicyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18545-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide18555-cyclobutyl-N-ethyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide1856N-allyl-5-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18575-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1858N-benzyl-5-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18595-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide18605-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide18615-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide18625-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1863N-(2-chlorobenzyl)-5-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18645-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide18655-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18665-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1867N-(sec-butyl)-5-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18685-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide18695-cyclobutyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide18705-cyclobutyl-N-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18715-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide18725-cyclopentyl-N-ethyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide1873N-allyl-5-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18745-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide1875N-benzyl-5-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18765-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide18775-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide18785-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide18795-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1880N-(2-chlorobenzyl)-5-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18815-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide18825-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18835-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1884N-(sec-butyl)-5-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18855-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide18865-cyclopentyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide18875-cyclopentyl-N-cyclopropyl-3-{5-[(4-ethylbenzoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide18885-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide18895-cyclopropyl-N-ethyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide1890N-allyl-5-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide18915-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide1892N-benzyl-5-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide18935-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide18945-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide18955-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide18965-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1897N-(2-chlorobenzyl)-5-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide18985-cyclopropyl-N-(4-fluorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide18995-cyclopropyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19005-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1901N-(sec-butyl)-5-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19025-cyclopropyl-N-(2-fluorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19035-cyclopropyl-N-(3-fluorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide1904N,5-dicyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19055-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide19065-cyclobutyl-N-ethyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide1907N-allyl-5-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19085-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide1909N-benzyl-5-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19105-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide19115-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide19125-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide19135-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1914N-(2-chlorobenzyl)-5-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19155-cyclobutyl-N-(4-fluorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19165-cyclobutyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19175-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1918N-(sec-butyl)-5-cyclobutyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19195-cyclobutyl-N-(2-fluorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19205-cyclobutyl-N-(3-fluorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19215-cyclobutyl-N-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19225-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide19235-cyclopentyl-N-ethyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide1924N-allyl-5-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19255-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide1926N-benzyl-5-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19275-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide19285-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide19295-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide19305-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1931N-(2-chlorobenzyl)-5-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19325-cyclopentyl-N-(4-fluorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19335-cyclopentyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19345-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide1935N-(sec-butyl)-5-cyclopentyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19365-cyclopentyl-N-(2-fluorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19375-cyclopentyl-N-(3-fluorobenzyl)-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19385-cyclopentyl-N-cyclopropyl-3-[2-hydroxy-5-(isobutyrylamino)phenyl]-1H-pyrazole-1-carboxamide19393-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide19403-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide19413-[5-(acetylamino)-2-hydroxyphenyl]-N-allyl-5-cyclopropyl-1H-pyrazole-1-carboxamide19423-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide19433-[5-(acetylamino)-2-hydroxyphenyl]-N-benzyl-5-cyclopropyl-1H-pyrazole-1-carboxamide19443-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide19453-[5-(acetylamino)-2-hydroxyphenyl]5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide19463-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide19473-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide19483-[5-(acetylamino)-2-hydroxyphenyl]-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide19493-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide19503-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide19513-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide19523-[5-(acetylamino)-2-hydroxyphenyl]-N-(sec-butyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide19533-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide19543-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide19553-[5-(acetylamino)-2-hydroxyphenyl]-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide19563-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide19573-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide19583-[5-(acetylamino)-2-hydroxyphenyl]-N-allyl-5-cyclobutyl-1H-pyrazole-1-carboxamide19593-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide19603-[5-(acetylamino)-2-hydroxyphenyl]-N-benzyl-5-cyclobutyl-1H-pyrazole-1-carboxamide19613-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide19623-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide19633-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide19643-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide19653-[5-(acetylamino)-2-hydroxyphenyl]-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide19663-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide19673-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide19683-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide19693-[5-(acetylamino)-2-hydroxyphenyl]-N-(sec-butyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide19703-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide19713-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide19723-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide19733-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide19743-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide19753-[5-(acetylamino)-2-hydroxyphenyl]-N-allyl-5-cyclopentyl-1H-pyrazole-1-carboxamide19763-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide19773-[5-(acetylamino)-2-hydroxyphenyl]-N-benzyl-5-cyclopentyl-1H-pyrazole-1-carboxamide19783-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide19793-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide19803-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide19813-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide19823-[5-(acetylamino)-2-hydroxyphenyl]-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide19833-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide19843-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide19853-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide19863-[5-(acetylamino)-2-hydroxyphenyl]-N-(sec-butyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide19873-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide19883-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide19893-[5-(acetylamino)-2-hydroxyphenyl]-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide19905-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide19915-cyclopropyl-N-ethyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide1992N-allyl-5-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide19935-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide1994N-benzyl-5-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide19955-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide19965-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide19975-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide19985-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide1999N-(2-chlorobenzyl)-5-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20005-cyclopropyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20015-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20025-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2003N-(sec-butyl)-5-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20045-cyclopropyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20055-cyclopropyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide2006N,5-dicyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20075-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide20085-cyclobutyl-N-ethyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide2009N-allyl-5-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20105-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide2011N-benzyl-5-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20125-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide20135-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide20145-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide20155-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2016N-(2-chlorobenzyl)-5-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20175-cyclobutyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20185-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20195-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2020N-(sec-butyl)-5-cyclobutyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20215-cyclobutyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20225-cyclobutyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20235-cyclobutyl-N-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20245-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide20255-cyclopentyl-N-ethyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide2026N-allyl-5-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20275-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide2028N-benzyl-5-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20295-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide20305-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide20315-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide20325-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2033N-(2-chlorobenzyl)-5-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20345-cyclopentyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20355-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20365-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2037N-(sec-butyl)-5-cyclopentyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20385-cyclopentyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20395-cyclopentyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20405-cyclopentyl-N-cyclopropyl-3-{2-hydroxy-5-[(3-methylbutanoyl)amino]phenyl}-1H-pyrazole-1-carboxamide20415-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide20425-cyclopropyl-N-ethyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide2043N-allyl-5-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20445-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide2045N-benzyl-5-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20465-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide20475-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide20485-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide20495-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(4-methylbenzyly)-1H-pyrazole-1-carboxamide2050N-(2-chlorobenzyl)-5-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20515-cyclopropyl-N-(4-fluorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20525-cyclopropyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20535-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2054N-(sec-butyl)-5-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20555-cyclopropyl-N-(2-fluorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20565-cyclopropyl-N-(3-fluorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide2057N,5-dicyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20585-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide20595-cyclobutyl-N-ethyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide2060N-allyl-5-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20615-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide2062N-benzyl-5-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20635-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide20645-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide20655-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide20665-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2067N-(2-chlorobenzyl)-5-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20685-cyclobutyl-N-(4-fluorobenzyl)-3-[2-hydroxy-5-{propionylamino)phenyl]-1H-pyrazole-1-carboxamide20695-cyclobutyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20705-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2071N-(sec-butyl)-5-cyclobutyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20725-cyclobutyl-N-(2-fluorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20735-cyclobutyl-N-(3-fluorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20745-cyclobutyl-N-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20755-cyclopentyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-isopropyl-1H-pyrazole-1-carboxamide20765-cyclopentyl-N-ethyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide2077N-allyl-5-cyclopentyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20785-cyclopentyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-propyl-1H-pyrazole-1-carboxamide2079N-benzyl-5-cyclopentyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20805-cyclopentyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide20815-cyclopentyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide20825-cyclopentyl-3-[2-hydroxy-5-propionylamino)phenyl]-N-(3-methylbenyl)-1H-pyrazole-1-carboxamide20835-cyclopentyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2084N-(2-chlorobenzyl)-5-cyclopentyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20855-cyclopentyl-N-(4-fluorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20865-cyclopentyl-N-(3,4-dichlorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20875-cyclopentyl-3-[2-hydroxy-5-(propionylamino)phenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2088N-(sec-butyl)-5-cyclopentyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20895-cyclopentyl-N-(2-fluorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20905-cyclopentyl-N-(3-fluorobenzyl)-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20915-cyclopentyl-N-cyclopropyl-3-[2-hydroxy-5-(propionylamino)phenyl]-1H-pyrazole-1-carboxamide20925-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide20935-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide2094N-allyl-5-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide20955-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide2096N-benzyl-5-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide20975-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide20985-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide20995-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide21005-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2101N-(2-chlorobenzyl)-5-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-Hydroxyphenyl}-1H-pyrazole-1-carboxamide21025-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide21035-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide21045-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2105N-(sec-butyl)-5-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21065-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide21075-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide2108N,5-dicyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21095-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide21105-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide2111N-allyl-5-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21125-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide2113N-benzyl-5-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21145-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide21155-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide21165-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide21175-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2118N-(2-chlorobenzyl)-5-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21195-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide21205-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide21215-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2122N-(sec-butyl)-5-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21235-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide21245-cyclobutyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide21255-cyclobutyl-N-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21265-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide21275-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-ethyl-1H-pyrazole-1-carboxamide2128N-allyl-5-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21295-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide2130N-benzyl-5-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21315-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide21325-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide21335-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide21345-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2135N-(2-chlorobenzyl)-5-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21365-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide21375-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide21385-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2139N-(sec-butyl)-5-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21405-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide21415-cyclopentyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide21425-cyclopentyl-N-cyclopropyl-3-{5-[(cyclopropylcarbonyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide21435-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-isopropyl-1H-pyrazole-1-carboxamide21445-cyclopropyl-N-ethyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide2145N-allyl-5-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21465-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-propyl-1H-pyrazole-1-carboxamide2147N-benzyl-5-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21485-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide21495-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide21505-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide21515-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2152N-(2-chlorobenzyl)-5-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21535-cyclopropyl-N-(4-fluorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21545-cyclopropyl-N-(3,4-dichlorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21555-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2156N-(sec-butyl)-5-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21575-cyclopropyl-N-(2-fluorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21585-cyclopropyl-N-(3-fluorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide2159N,5-dicyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21605-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-isopropyl-1H-pyrazole-1-carboxamide21615-cyclobutyl-N-ethyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide2162N-allyl-5-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21635-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-propyl-1H-pyrazole-1-carboxamide2164N-benzyl-5-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21655-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide21665-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide21675-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide21685-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2169N-(2-chlorobenzyl)-5-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21705-cyclobutyl-N-(4-fluorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21715-cyclobutyl-N-(3,4-dichlorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21725-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2173N-(sec-butyl)-5-cyclobutyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21745-cyclobutyl-N-(2-fluorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21755-cyclobutyl-N-(3-fluorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21765-cyclobutyl-N-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21775-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-isopropyl-1H-pyrazole-1-carboxamide21785-cyclopentyl-N-ethyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide2179N-allyl-5-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21805-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-propyl-1H-pyrazole-1-carboxamide2181N-benzyl-5-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21825-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide21835-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide21845-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide21855-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2186N-(2-chlorobenzyl)-5-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21875-cyclopentyl-N-(4-fluorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21885-cyclopentyl-N-(3,4-dichlorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21895-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2190N-(sec-butyl)-5-cyclopentyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21915-cyclopentyl-N-(2-fluorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21925-cyclopentyl-N-(3-fluorobenzyl)-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21935-cyclopentyl-N-cyclopropyl-3-[5-(2-furoylamino)-2-hydroxyphenyl]-1H-pyrazole-1-carboxamide21945-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide21955-cyclopropyl-N-ethyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide2196N-allyl-5-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide21975-cylopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide2198N-benyl-5-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide21995-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide22005-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide22015-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide22025-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2203N-(2-chlorobenzyl)-5-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22045-cyclopropyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22055-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22065-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2207N-(sec-butyl)-5-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22085-cyclopropyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22095-cyclopropyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide2210N,5-dicyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22115-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide22125-cyclobutyl-N-ethyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide2213N-allyl-5-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22145-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide2215N-benzyl-5-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22165-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide22175-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide22185-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide22195-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2220N-(2-chlorobenzyl)-5-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22215-cyclobutyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22225-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22235-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2224N-(sec-butyl)-5-cyclobutyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22255-cyclobutyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22265-cyclobutyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22275-cyclobutyl-N-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22285-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-isopropyl-1H-pyrazole-1-carboxamide22295-cyclopentyl-N-ethyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide2230N-allyl-5-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22315-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-propyl-1H-pyrazole-1-carboxamide2232N-benzyl-5-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22335-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide22345-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide22355-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide22365-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2237N-(2-chlorobenzyl)-5-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22385-cyclopentyl-N-(4-fluorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22395-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22405-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2241N-(sec-butyl)-5-cyclopentyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22425-cyclopentyl-N-(2-fluorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22435-cyclopentyl-N-(3-fluorobenzyl)-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide22445-cyclopentyl-N-cyclopropyl-3-{2-hydroxy-5-[(thien-2-ylcarbonyl)amino]phenyl}-1H-pyrazole-1-carboxamide2245N-(3-{5-cyclopropyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2246N-(3-{5-cyclopropyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2247N-(3-{1-[(allylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2248N-(3-{5-cyclopropyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2249N-(3-{1-[(benzylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2250N-[3-(5-cyclopropyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2251N-[3-(5-cyclopropyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2252N-[3-(5-cyclopropyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2253N-[3-(5-cyclopropyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2254N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopropyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2255N-[3-(5-cyclopropyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2256N-[3-(5-cyclopropyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2257N-[3-(5-cyclopropyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2258N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2259N-[3-(5-cyclopropyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2260N-[3-(5-cyclopropyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2261N-(3-{5-cyclopropyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2262N-(3-{5-cyclobutyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2263N-(3-{5-cyclobutyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2264N-(3-{1-[(allylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2265N-(3-{5-cyclobutyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2266N-(3-{1-[(benzylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2267N-[3-(5-cyclobutyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2268N-[3-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2269N-[3-(5-cyclobutyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2270N-[3-(5-cyclobutyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2271N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclobutyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2272N-[3-(5-cyclobutyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2273N-[3-(5-cyclobutyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2274N-[3-(5-cyclobutyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2275N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2276N-[3-(5-cyclobutyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2277N-[3-(5-cyclobutyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2278N-(3-{5-cyclobutyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2279N-(3-{5-cyclopentyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2280N-(3-{5-cyclopentyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2281N-(3-{1-[(allylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2282N-(3-{5-cyclopentyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2283N-(3-{1-[(benzylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl) quinoxaline-2-carboxamide2284N-[3-(5-cyclopentyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2285N-[3-(5-cyclopentyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2286N-[3-(5-cyclopentyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2287N-[3-(5-cyclopentyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2288N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopentyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2289N-[3-(5-cyclopentyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2290N-[3-(5-cyclopentyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2291N-[3-(5-cyclopentyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2292N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2293N-[3-(5-cyclopentyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2294N-[3-(5-cyclopentyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]quinoxaline-2-carboxamide2295N-(3-{5-cyclopentyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)quinoxaline-2-carboxamide2296N-(3-{5-cyclopropyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2297N-(3-{5-cyclopropyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2298N-(3-{1-[(allylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2299N-(3-{5-cyclopropyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2300N-(3-{1-[(benzylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2301N-[3-(5-cyclopropyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2302N-[3-(5-cyclopropyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2303N-[3-(5-cyclopropyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2304N-[3-(5-cyclopropyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2305N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopropyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2306N-[3-(5-cyclopropyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2307N-[3-(5-cyclopropyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2308N-[3-(5-cyclopropyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2309N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl) nicotinamide2310N-[3-(5-cyclopropyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2311N-[3-(5-cyclopropyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2312N-(3-{5-cyclopropyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2313N-(3-{5-cyclobutyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2314N-(3-{5-cyclobutyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2315N-(3-{1-[(allylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2316N-(3-{5-cyclobutyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2317N-(3-{1-[(benzylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2318N-[3-(5-cyclobutyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2319N-[3-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2320N-[3-(5-cyclobutyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2321N-[3-(5-cyclobutyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2322N-[3-( 1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclobutyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2323N-[3-(5-cyclobutyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2324N-[3-(5-cyclobutyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2325N-[3-(5-cyclobutyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2326N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2327N-[3-(5-cyclobutyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2328N-[3-(5-cyclobutyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2329N-(3-{5-cyclobutyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2330N-(3-{5-cyclopentyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2331N-(3-{5-cyclopentyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2332N-(3-{1-[(allylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2333N-(3-{5-cyclopentyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2334N-(3-{1-[(benzylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2335N-[3-(5-cyclopentyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2336N-[3-(5-cyclopentyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2337N-[3-(5-cyclopentyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2338N-[3-(5-cyclopentyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2339N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopentyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2340N-[3-(5-cyclopentyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2341N-[3-(5-cyclopentyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2342N-[3-(5-cyclopentyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2343N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2344N-[3-(5-cyclopentyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2345N-[3-(5-cyclopentyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2346N-(3-{5-cyclopentyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2347N-(3-{5-cyclopropyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2348N-(3-{5-cyclopropyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2349N-(3-{1-[(allylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2350N-(3-{5-cyclopropyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2351N-(3-{1-[(benzylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2352N-[3-(5-cyclopropyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2353N-[3-(5-cyclopropyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2354N-[3-(5-cyclopropyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2355N-[3-(5-cyclopropyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2356N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopropyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2357N-[3-(5-cyclopropyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2358N-[3-(5-cyclopropyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2359N-[3-(5-cyclopropyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2360N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2361N-[3-(5-cyclopropyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2362N-[3-(5-cyclopropyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2363N-(3-{5-cyclopropyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2364N-(3-{5-cyclobutyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2365N-(3-{5-cyclobutyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2366N-(3-{1-[(allylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2367N-(3-{5-cyclobutyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2368N-(3-{1-[(benzylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2369N-[3-(5-cyclobutyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2370N-[3-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2371N-[3-(5-cyclobutyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2372N-[3-(5-cyclobutyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2373N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclobutyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2374N-[3-(5-cyclobutyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2375N-[3-(5-cyclobutyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2376N-[3-(5-cyclobutyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2377N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl) isonicotinamide2378N-[3-(5-cyclobutyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2379N-[3-(5-cyclobutyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2380N-(3-{5-cyclobutyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2381N-(3-{5-cyclopentyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2382N-(3-{5-cyclopentyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2383N-(3-{1-[(allylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2384N-(3-{5-cyclopentyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2385N-(3-{1-[(benzylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2386N-[3-(5-cyclopentyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2387N-[3-(5-cyclopentyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2388N-[3-(5-cyclopentyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2389N-[3-(5-cyclopentyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2390N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopentyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2391N-[3-(5-cyclopentyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2392N-[3-(5-cyclopentyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2393N-[3-(5-cyclopentyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2394N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide2395N-[3-(5-cyclopentyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2396N-[3-(5-cyclopentyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isonicotinamide2397N-(3-{5-cyclopentyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isonicotinamide23983-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide23993-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide2400N-allyl-3-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide24013-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide24023-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclopropyl-1H-pyrazole-1-carboxamide24033-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide24043-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide24053-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide24063-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide24073-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide24083-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide24093-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide24103-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide24113-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide24123-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide24133-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide24143-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide24153-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide24163-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide2417N-allyl-3-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide24183-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide24193-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclobutyl-1H-pyrazole-1-carboxamide24203-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide24213-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide24223-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide24233-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide24243-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide24253-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide24263-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide24273-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide24283-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide24293-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide24303-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide24313-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide24323-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide24333-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide2434N-allyl-3-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide24353-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide24363-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclopentyl-1H-pyrazole-1-carboxamide24373-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide24383-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide24393-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide24403-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide24413-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide24423-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide24433-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide24443-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide24453-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide24463-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide24473-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide24483-{5-[(1,3-benzodioxol-5-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide24495-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide24505-cyclopropyl-N-ethyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide2451N-allyl-5-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24525-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide2453N-benzyl-5-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24545-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide24555-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide24565-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide24575-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2458N-(2-chlorobenzyl)-5-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24595-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide24605-cyclopropyl-N-(3,4-dichlorobenzyl)-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24615-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2462N-(sec-butyl)-5-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24635-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide24645-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide2465N,5-dicyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24665-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide24675-cyclobutyl-N-ethyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide2468N-allyl-5-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24695-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide2470N-benzyl-5-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24715-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide24725-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide24735-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide24745-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2475N-(2-chlorobenzyl)-5-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24765-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide24775-cyclobutyl-N-(3,4-dichlorobenzyl)-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24785-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2479N-(sec-butyl)-5-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24805-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide24815-cyclobutyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide24825-cyclobutyl-N-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24835-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-isopropyl-1H-pyrazole-1-carboxamide24845-cyclopentyl-N-ethyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide2485N-allyl-5-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24865-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-propyl-1H-pyrazole-1-carboxamide2487N-benzyl-5-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24885-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide24895-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide24905-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide24915-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide24925-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide24935-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide24945-cyclopentyl-N-(3,4-dichlorobenzyl)-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24955-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2496N-(sec-butyl)-5-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide24975-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide24985-cyclopentyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide24995-cyclopentyl-N-cyclopropyl-3-{5-[(2-ethylbutanoyl)amino]-2-hydroxyphenyl}-1H-pyrazole-1-carboxamide25003-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-isopropyl-1H-pyrazole-1-carboxamide25013-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-ethyl-1H-pyrazole-1-carboxamide2502N-allyl-3-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-1H-pyrazole-1-carboxamide25033-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-propyl-1H-pyrazole-1-carboxamide25043-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclopropyl-1H-pyrazole-1-carboxamide25053-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide25063-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide25073-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide25083-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide25093-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide25103-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide25113-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide25123-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide25133-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclopropyl-1H-pyrazole-1-carboxamide25143-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide25153-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopropyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide25163-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N,5-dicyclopropyl-1H-pyrazole-1-carboxamide25173-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-isopropyl-1H-pyrazole-1-carboxamide25183-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-ethyl-1H-pyrazole-1-carboxamide2519N-allyl-3-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-1H-pyrazole-1-carboxamide25203-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-propyl-1H-pyrazole-1-carboxamide25213-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclobutyl-1H-pyrazole-1-carboxamide25223-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide25233-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide25243-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide25253-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide25263-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide25273-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide25283-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide25293-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide25303-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclobutyl-1H-pyrazole-1-carboxamide25313-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide25323-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide25333-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclobutyl-N-cyclopropyl-1H-pyrazole-1-carboxamide25343-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-isopropyl-1H-pyrazole-1-carboxamide25353-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-ethyl-1H-pyrazole-1-carboxamide2536N-allyl-3-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-1H-pyrazole-1-carboxamide25373-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-propyl-1H-pyrazole-1-carboxamide25383-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-benzyl-5-cyclopentyl-1H-pyrazole-1-carboxamide25393-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide25403-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide25413-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide25423-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide25433-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(2-chlorobenzyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide25443-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-fluorobenzyl)-1H-pyrazole-1-carboxamide25453-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3,4-dichlorobenzyl)-1H-pyrazole-1-carboxamide25463-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide25473-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-N-(sec-butyl)-5-cyclopentyl-1H-pyrazole-1-carboxamide25483-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(2-fluorobenzyl)-1H-pyrazole-1-carboxamide25493-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-(3-fluorobenzyl)-1H-pyrazole-1-carboxamide25503-{5-[(1-benzothien-2-ylcarbonyl)amino]-2-hydroxyphenyl}-5-cyclopentyl-N-cyclopropyl-1H-pyrazole-1-carboxamide25512-chloro-N-(3-{5-cyclopropyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide25522-chloro-N-(3-{5-cyclopropyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2553N-(3-{1-[(allylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)-2-chloronicotinamide25542-chloro-N-(3-{5-cyclopropyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2555N-(3-{1-[(benzylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)-2-chloronicotinamide25562-chloro-N-[3-(5-cyclopropyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25572-chloro-N-[3-(5-cyclopropyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25582-chloro-N-[3-(5-cyclopropyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25592-chloro-N-[3-(5-cyclopropyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25602-chloro-N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopropyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25612-chloro-N-[3-(5-cyclopropyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25622-chloro-N-[3-(5-cyclopropyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazo1-3-yl)-4-hydroxyphenyl]nicotinamide25632-chloro-N-[3-(5-cyclopropyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2564N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)-2-chloronicotinamide25652-chloro-N-[3-(5-cyclopropyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25662-chloro-N-[3-(5-cyclopropyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-y1)-4-hydroxyphenyl]nicotinamide25672-chloro-N-(3-{5-cyclopropyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide25682-chloro-N-(3-{5-cyclobutyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide25692-chloro-N-(3-{5-cyclobutyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2570N-(3-{1-[(allylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)-2-chloronicotinamide25712-chloro-N-(3-{5-cyclobutyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2572N-(3-{1-[(benzylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)-2-chloronicotinamide25732-chloro-N-[3-(5-cyclobutyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25742-chloro-N-[3-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25752-chloro-N-[3-(5-cyclobutyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25762-chloro-N-[3-(5-cyclobutyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25772-chloro-N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclobutyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25782-chloro-N-[3-(5-cyclobutyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25792-chloro-N-[3-(5-cyclobutyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25802-chloro-N-[3-(5-cyclobutyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2581N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)-2-chloronicotinamide25822-chloro-N-[3-(5-cyclobutyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25832-chloro-N-[3-(5-cyclobutyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25842-chloro-N-(3-{5-cyclobutyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide25852-chloro-N-(3-{5-cyclopentyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide25862-chloro-N-(3-{5-cyclopentyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2587N-(3-{1-[(allylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)-2-chloronicotinamide25882-chloro-N-(3-{5-cyclopentyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide2589N-(3-{1-[(benzylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)-2-chloronicotinamide25902-chloro-N-[3-(5-cyclopentyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25912-chloro-N-[3-(5-cyclopentyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25922-chloro-N-[3-(5-cyclopentyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25932-chloro-N-[3-(5-cyclopentyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25942-chloro-N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopentyl-1H-pyrazol3-yl)-4-hydroxyphenyl]nicotinamide25952-chloro-N-[3-(5-cyclopentyl-1-{[(4-flurobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxphenyl]nicotinamide25962-chloro-N-[3-(5-cyclopentyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide25972-chloro-N-[3-(5-cyclopentyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide2598N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)-2-chloronicotinamide25992-chloro-N-[3-(5-cyclopentyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide26002-chloro-N-[3-(5-cyclopentyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]nicotinamide26012-chloro-N-(3-{5-cyclopentyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)nicotinamide26025-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide26035-cyclopropyl-N-ethyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2604N-allyl-5-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26055-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide2606N-benzyl-5-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26075-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide26085-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide26095-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide26105-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2611N-(2-chlorobenzyl)-5-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26125-cyclopropyl-N-(4-fluorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26135-cyclopropyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26145-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2615N-(sec-butyl)-5-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26165-cyclopropyl-N-(2-fluorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26175-cyclopropyl-N-(3-fluorobenzyl)-3-(2-hydroxy-5-{[4-trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2618N,5-dicyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26195-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide26205-cyclobutyl-N-ethyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2621N-allyl-5-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26225-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide2623N-benzyl-5-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26245-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide26255-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide26265-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide26275-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2628N-(2-chlorobenzyl)-5-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26295-cyclobutyl-N-(4-fluorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26305-cyclobutyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26315-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2632N-(sec-butyl)-5-cyclobutyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26335-cyclobutyl-N-(2-fluorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26345-cyclobutyl-N-(3-fluorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26355-cyclobutyl-N-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26365-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide26375-cyclopentyl-N-ethyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2638N-allyl-5-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26395-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide2640N-benzyl-5-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26415-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide26425-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide26435-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide26445-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2645N-(2-chlorobenzyl)-5-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26465-cyclopentyl-N-(4-fluorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26475-cyclopentyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26485-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2649N-(sec-butyl)-5-cyclopentyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26505-cyclopentyl-N-(2-fluorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26515-cyclopentyl-N-(3-fluorobenzyl)-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide26525-cyclopentyl-N-cyclopropyl-3-(2-hydroxy-5-{[4-(trifluoromethoxy)benzoyl]amino}phenyl)-1H-pyrazole-1-carboxamide2653N-(3-{5-cyclopropyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2654N-(3-{5-cyclopropyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2655N-(3-{1-[(allylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2656N-(3-{5-cyclopropyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2657N-(3-{1-[(benzylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2658N-[3-(5-cyclopropyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2659N-[3-(5-cyclopropyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2660N-[3-(5-cyclopropyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2661N-[3-(5-cyclopropyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2662N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopropyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2663N-[3-(5-cyclopropyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2664N-[3-(5-cyclopropyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2665N-[3-(5-cyclopropyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2666N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclopropyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2667N-[3-(5-cyclopropyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2668N-[3-(5-cyclopropyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2669N-(3-{5-cyclopropyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2670N-(3-{5-cyclobutyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2671N-(3-{5-cyclobutyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2672N-(3-{1-[(allylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2673N-(3-{5-cyclobutyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2674N-(3-{1-[(benzylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2675N-[3-(5-cyclobutyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2676N-[3-(5-cyclobutyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2677N-[3-(5-cyclobutyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2678N-[3-(5-cyclobutyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2679N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclobutyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2680N-[3-(5-cyclobutyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2681N-[3-(5-cyclobutyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2682N-[3-(5-cyclobutyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazo1e-5-carboxamide2683N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclobutyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2684N-[3-(5-cyclobutyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2685N-[3-(5-cyclobutyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2686N-(3-{5-cyclobutyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2687N-(3-{5-cyclopentyl-1-[(isopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2688N-(3-{5-cyclopentyl-1-[(ethylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2689N-(3-{1-[(allylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2690N-(3-{5-cyclopentyl-1-[(propylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2691N-(3-{1-[(benzylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2692N-[3-(5-cyclopentyl-1-{[(2-phenylethyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2693N-[3-(5-cyclopentyl-1-{[(2-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2694N-[3-(5-cyclopentyl-1-{[(3-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2695N-[3-(5-cyclopentyl-1-{[(4-methylbenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2696N-[3-(1-{[(2-chlorobenzyl)amino]carbonyl}-5-cyclopentyl-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2697N-[3-(5-cyclopentyl-1-{[(4-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2698N-[3-(5-cyclopentyl-1-{[(3,4-dichlorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2699N-[3-(5-cyclopentyl-1-{[(4-methoxybenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2700N-(3-{1-[(sec-butylamino)carbonyl]-5-cyclopentyl-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide2701N-[3-(5-cyclopentyl-1-{[(2-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2702N-[3-(5-cyclopentyl-1-{[(3-fluorobenzyl)amino]carbonyl}-1H-pyrazol-3-yl)-4-hydroxyphenyl]isoxazole-5-carboxamide2703N-(3-{5-cyclopentyl-1-[(cyclopropylamino)carbonyl]-1H-pyrazol-3-yl}-4-hydroxyphenyl)isoxazole-5-carboxamide27045-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide27055-cyclopropyl-N-ethyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide2706N-allyl-5-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27075-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide2708N-benzyl-5-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27095-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide27105-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide27115-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide27125-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2713N-(2-chlorobenzyl)-5-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27145-cyclopropyl-N-(4-fluorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27155-cyclopropyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27165-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2717N-(sec-butyl)-5-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27185-cyclopropyl-N-(2-fluorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27195-cyclopropyl-N-(3-fluorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide2720N,5-dicyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27215-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide27225-cyclobutyl-N-ethyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide2723N-allyl-5-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27245-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide2725N-benzyl-5-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27265-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide27275-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide27285-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide27295-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2730N-(2-chlorobenzyl)-5-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27315-cyclobutyl-N-(4-fluorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27325-cyclobutyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27335-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2734N-(sec-butyl)-5-cyclobutyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27355-cyclobutyl-N-(2-fluorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27365-cyclobutyl-N-(3-fluorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27375-cyclobutyl-N-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27385-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-isopropyl-1H-pyrazole-1-carboxamide27395-cyclopentyl-N-ethyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide2740N-allyl-5-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27415-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-propyl-1H-pyrazole-1-carboxamide2742N-benzyl-5-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27435-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-phenylethyl)-1H-pyrazole-1-carboxamide27445-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(2-methylbenzyl)-1H-pyrazole-1-carboxamide27455-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(3-methylbenzyl)-1H-pyrazole-1-carboxamide27465-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methylbenzyl)-1H-pyrazole-1-carboxamide2747N-(2-chlorobenzyl)-5-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27485-cyclopentyl-N-(4-fluorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27495-cyclopentyl-N-(3,4-dichlorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27505-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-N-(4-methoxybenzyl)-1H-pyrazole-1-carboxamide2751N-(sec-butyl)-5-cyclopentyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27525-cyclopentyl-N-(2-fluorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27535-cyclopentyl-N-(3-fluorobenzyl)-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide27545-cyclopentyl-N-cyclopropyl-3-(2-hydroxy-5-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}phenyl)-1H-pyrazole-1-carboxamide

Hydroxphenyl-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical comositions comprising them

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