HYDROXYUREA RESISTANCE AND GENE REGULATION

Information

• Research Project
• 2683677

• ApplicationId

  2683677

• Core Project Number

  R29CA072767

• Full Project Number

  5R29CA072767-02

• Serial Number

  72767

• FOA Number

• Sub Project Id

• Project Start Date

  4/1/1997 - 27 years ago

• Project End Date

  3/31/2002 - 22 years ago

• Program Officer Name

  JOHNSON, GEORGE S.

• Budget Start Date

  4/1/1998 - 26 years ago

• Budget End Date

  3/31/1999 - 25 years ago

• Fiscal Year

  1998

• Support Year

  2

• Suffix

• Award Notice Date

  3/12/1998 - 26 years ago

Organizations

• City of Hope-A National Medical Center

DESCRIPTION: The major objective of Dr. Yun Yen's proposal is to understand the gene structure and function of ribonucleotide reductase (RR) and its role in hydroxyurea (HU)-associated resistance. HU is a simple chemotherapeutic chemical that inhibits the M2 subunit of RR. An HU-resistant phenotype has been associated with M2 overexpression. Specific Aim 1 is to clone the genomic DNA segments containing the M1 and M2 genes from wild type and HU-resistant KB cells. Specific Aim 2 is to study the promoter and 5' flanking regions. Specific Aim 3 has the aim of examining the role of 9 critical amino acids that may play a mechanistic role in HU resistance. Specific Aim 4 will focus on the development of novel RR inhibitors, and HU/nucleoside combinations to circumvent HU resistance. These studies should lead to a substantially improved understanding of RR genetic structure and mechanism of HU resistance, and also to the development of new HU analogs capable of overcoming HU resistance.

IC Name

• Activity

  R29

• Administering IC

  CA

• Application Type

  5

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  395

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  CPA

• Study Section Name

  Chemical Pathology Study Section

• Organization Name

  CITY OF HOPE NATIONAL MEDICAL CENTER

• Organization Department

• Organization DUNS

• Organization City

  DUARTE

• Organization State

  CA

• Organization Country

  UNITED STATES

• Organization Zip Code

  91010

• Organization District

  UNITED STATES