Claims
- 1. A surface provided with antibiotic or antiseptic properties, comprising a solid substrate modified by covalently fixing one or more spacers having reactive extremities via a proximate reactive extremity, and one or more antibiotic, bactericidal, viricidal or fungicidal molecules covalently bonded to a distal reactive extremity of said spacer or spacers, said spacer having formulaA1—(CH2)n—A2, where:A1 is where Z=H, OH or Cl; or SiY3 where Y3 is Cl or an alkoxy group containing 1 to 3 carbon atoms;n is in the range 2 to 18; A2 is selected from the following residues: CH═CH2, OH, halogen or where Z=H, OH or Cl.
- 2. The surface according to claim 1, wherein n is in the range 5 to 18.
- 3. The surface according to claim 1, wherein the bound molecule is an antibiotic selected from the group consisting of penicillin, cephalosporin, monobactam, thienamycin, β-lactamase inhibitor, peptidoglycan synthesis inhibitor, bacitracin and novobiocin.
- 4. The surface according to claim 1, wherein the bound molecule is a quaternary ammonium compound having bactericidal properties.
- 5. The surface according to claim 1, comprising a density of active antibiotic sites per unit surface area in the range 1011 to 5×1014 molecules of antibiotics per cm2.
- 6. The surface according to claim 1, comprising at least one additional antibiotic grafted to said surface, on which it forms a monolayer with a thickness of less than 4 mm.
Priority Claims (1)
Number |
Date |
Country |
Kind |
96 09677 |
Jul 1996 |
FR |
|
Parent Case Info
This application is a continuation of international application PCT/FR97/01403 filed Jul. 25, 1997, which designated the United States.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5104649 |
Jansson et al. |
Apr 1992 |
|
5490938 |
Sawan et al. |
Feb 1996 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
0 328 421 |
Aug 1989 |
EP |
WO 8002840 |
Dec 1980 |
WO |
WO 8905616 |
Jun 1989 |
WO |
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/FR97/01403 |
Jul 1997 |
US |
Child |
09/240626 |
|
US |