Claims
- 1. A polymer having a structure selected from the group consisting of:
- 2. The polymer of claim 1, wherein x is 3 or 4.
- 3. The polymer of claim 2, having the structure R(—NH—R1)x, wherein R(—NH—)x a polyamine moiety.
- 4. The polymer of claim 2, having the structure R(—O—R1)x, wherein R(—O—)x is a polyol moiety.
- 5. The polymer of claim 4, wherein said polyol moiety is an aromatic polyol moiety.
- 6. The polymer of claim 5, wherein said polyol moiety is a 1,1,1-tris(hydroxyphenyl)ethane moiety.
- 7. The polymer of claim 1, wherein every hydroxyl group of said divalent dicarboxylic acid moiety is acylated with a 6 to 24 carbon atom carboxylic acid group.
- 8. The polymer of claim 7, wherein y is 0.
- 9. The polymer of claim 7, wherein said divalent dicarboxylic acid mucic acid moiety is a mucic acid moiety.
- 10. The polymer of claim 4, wherein said polyol moiety is an aliphatic or cycloaliphatic polyol moiety.
- 11. The polymer of claim 4, wherein said polyol moiety is a cyclic crown ether or cyclodextrin moiety.
- 12. The polymer of claim 1, wherein said poly(alkylene oxide) is a methoxy-terminated poly(ethylene glycol) and Q is —NH—.
- 13. The polymer of claim 1, wherein Q is —O—, or forms an anhydride linkage.
- 14. A hydrophobic molecule encapsulated in a polymer, said polymer having a structure selected from the group consisting of:
- 15. The encapsulate of claim 14, wherein said hydrophobic molecule has biological or pharmaceutical activity.
- 16. The encapsulate of claim 14, wherein said hydrophobic molecule is a fragrance, dye, protein or vitamin.
- 17. The encapsulate of claim 14, having the structure R(—O—R1)x, wherein R(—O—)x, is a polyol moiety.
- 18. The encapsulate of claim 17, wherein said polyol moiety is a 1,1,1-tris(hydroxyphenyl)ethane moiety.
- 19. The encapsulate of claim 17, wherein all of said hydroxyl groups of said dicarboxylic acid moiety are acylated with carboxylic acids having from 6 to 24 carbon atoms.
- 20. The encapsulate of claim 19, wherein y is 0.
- 21. The encapsulate of claim 19, wherein said divalent dicarboxylic acid moiety is a mucic acid moiety.
- 22. The encapsulate of claim 14, wherein said poly(alkylene oxide) is a methoxy-terminated poly(ethylene glycol) and Q is —NH—.
- 23. A formulation comprising the encapsulate of claim 14 and an acceptable vehicle.
- 24. The formulation of claim 23 wherein the accetable vehicle comprises an aqueous solution, suspension, dispersion, emollient, lotion, cream, salve, balm or ointment.
- 25. The formulation of claim 23, wherein the concentration of said encapsulate in said formulation is between about 10−10 M and 106 M.
- 26. The formulation of claim 25, wherein said encapsulate concentration is between about 10−8 M and about 106 M.
- 27. The formulation of claim 23, wherein the hydrophobic molecule of the encapsulate has biological or pharmaceutical activity.
- 28. The formulation of claim 23, wherein the hydrophobic molecule of the encapsulate is a dye, fragrance, protein, or vitamin.
- 29. A method of delivering a hydrophobic molecule to a host comprising administering to the host an encapsulate of claim 14.
- 30. The method of claim 29 wherein the host is an animal and the encapsulate is administered orally, subcutaneously, intramuscularly, intraperitoneally or intravenously.
- 31. The method of claim 29, wherein the encapsulate is administered topically to the host.
- 32. The method of claim 29 wherein the hydrophobic molecule of the encapsulate is biologically or pharmaceutically active.
- 33. The method of claim 29 wherein the hydrophobic molecule of the encapsulate is a dye, fragrance, protein or vitamin and the encapsulate is administered topically.
- 34. A transdermal device for the controlled release of a biologically or pharmaceutically active agent to the skin or mucosa of an animal, said device comprising a laminate of:
(a) a reservoir layer having a first surface and a second surface, and having the encapsulate of claim 15 incorporated therein; (b) a backing layer having an inner surface and an outer surface, wherein said second surface of said reservoir layer and said inner surface of said backing layer are laminated together so that said encapsulate cannot permeate from said second surface of said reservoir layer through said outer surface of said backing layer; and (c) a pressure sensitive adhesive layer coated on said first surface of said reservoir layer or said inner surface of said backing layer for affixing said laminate to said skin or mucosa of said host, so that said encapsulate is capable of being continuously released from said first surface of said reservoir layer thereto.
- 35. The device of claim 34, wherein said backing layer comprises one or more layers of an occlusive material.
- 36. A method of stabilizing a liposome or lipid-based formulation comprising adding to the liposome or lipid-based formulation a polymer of claim 1.
INTRODUCTION
[0001] This application is a continuation-in-part of U.S. application Ser. No. 09/298,729, filed Apr. 23, 1999.
Divisions (1)
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Number |
Date |
Country |
Parent |
09422295 |
Oct 1999 |
US |
Child |
09974218 |
Oct 2001 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
09974218 |
Oct 2001 |
US |
Child |
10323699 |
Dec 2002 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09298729 |
Apr 1999 |
US |
Child |
09422295 |
Oct 1999 |
US |