Claims
- 1. A non-human transgenic animal that overexpresses GRK2 in vascular smooth muscle cells thereof, and cells derived from said animal.
- 2. The animal according to claim 1 wherein said animal is a rodent.
- 3. The animal according to claim 2 wherein said animal is a mouse.
- 4. A method of screening a test compound for antihypertensive activity comprising administering said compound to said animal according to claim 1 and assessing the effect of said compound on GRK2 activity in vascular smooth muscle cells of said animal, wherein a compound that reduces GRK2 activity is an anti-hypertensive.
- 5. A compound identifiable according to the method of claim 4.
- 6. A method of treating hypertension in a mammal comprising administering a compound identifiable by the method according to claim 4 in an amount sufficient to effect said treatment.
Parent Case Info
[0001] This application claims priority from Provisional Application No. 60/244,212, filed Oct. 31, 2000, the entire content of which is incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60244212 |
Oct 2000 |
US |