Claims
- 1. A method of lowering the blood glucose in a hyperglycemic mammal which comprises administering a blood glucose lowering amount of a racemic or optically active compound of the formula ##STR22## wherein R is hydrogen, (C.sub.1 -C.sub.4))-alkanoyl, benzoyl, (C.sub.2 -C.sub.4)-carbalkoxy, (C.sub.1 -C.sub.3)-alkylcarbamoyl, (C.sub.5 -C.sub.7)-cycloalkylcarbamoyl or di(C.sub.1 -C.sub.3)-alkylcarbamoyl; and
- R" is ##STR23## wherein Z is hydrogen or fluoro; Z.sup.1 is acetamido, amino, benzyloxy, chloro, phenoxy, nitro or trifluoromethyl;
- Z.sup.2 is acetamido, amino, benzyloxy, phenoxy, nitro or trifluoromethyl;
- Z.sup.3 is methyl, (C.sub.1 -C.sub.2)alkoxy, methylthio, chloro or fluoro; and
- Z.sup.4 and Z.sup.5 are each independently hydrogen, methyl, bromo, chloro, fluoro, cyano, nitro, or trifluoromethyl;
- or a pharmaceutically acceptable salt thereof when R is hydrogen.
- 2. A method of claim 1 wherein R is hydrogen.
- 3. A method of claim 1 wherein
- R" is ##STR24## and Z.sup.2 is acetamido or fluoro; or R" is ##STR25## and Z.sup.3 is (C.sub.1 -C.sub.2)alkoxy,
- Z.sup.4 is hydrogen and
- Z.sup.5 is hydrogen, chloro, bromo, fluoro, cyano or methyl.
- 4. A method of claim 3 wherein R is hydrogen.
- 5. A method of claim 4 wherein R" is ##STR26##
- 6. A method of claim 4 wherein R" is ##STR27##
- 7. A method of claim 4 wherein R" is ##STR28##
- 8. A method of claim 4 wherein R" is ##STR29##
CROSS REFERENCE TO RELATED APPLICATION
This application is a division of copending application Ser. No. 222,202, filed Jan. 2, 1981, which is a continuation-in-part of application Ser. No. 173,206, filed July 28, 1980, now abandoned. Said applications Ser. Nos. 222,202 and 173,206 are also the parent/grandparents of copending applications Ser. No. 252,961 now U.S. Pat. No. 4,332,952 and Ser. No. 252,962, now U.S. Pat. No. 4,342,771 both filed Apr. 23. 1981.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3699229 |
Plotnikoff |
Oct 1972 |
|
Non-Patent Literature Citations (2)
Entry |
Clark-Lewis, Chem. Rev. 58, pp. 63-99, (1958). |
Brink and Freeman, J. Neuro. Chem. 19 (7), pp. 1783-1788 (1972). |
Divisions (1)
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Number |
Date |
Country |
Parent |
222202 |
Jan 1981 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
173206 |
Jul 1980 |
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