Claims
- 1. A method of lowering plasma triglycerides in a patient in need thereof comprising administering to said patient a therapeutically effective hypotriglyceridemic amount of a compound of the formula ##STR44## wherein B.sub.1 and B.sub.2 are each independently hydrogen; hydroxy; --OR.sub.1 wherein R.sub.1 is a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group wherein Ar is aryl and Y is a C.sub.0 -C.sub.4 alkyl; or, where B.sub.1 and B.sub.2 are attached to adjacent carbon atoms, B.sub.1 and B.sub.2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy;
- A.sub.1, A.sub.2 and A.sub.3 are each independently hydrogen; hydroxy; nitro; amino; fluoro, chloro, --OR.sub.1 or an Ar--Y group; or, where A.sub.1 and A.sub.2 are attached to adjacent carbon atoms, A.sub.1 and A.sub.2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy;
- R.sub.2 is hydrogen, a C.sub.1 -C.sub.4 alkyl, an Ar--Y-- group or --CH.sub.2 O--C(O)C(CH.sub.3).sub.3 ;
- Z is --CH.sub.2 --, --O--, --S--, ##STR45## or a bond wherein R.sub.3 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group and R.sub.4 is --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Y-- group;
- m is an integer 0 to 5;
- X is selected from the group consisting of ##STR46## wherein R.sub.5 and R.sub.6 are each independently a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group and n is an integer 0-2; n' is an integer 1-2; and the pharmaceutically acceptable salts thereof.
- 2. A method of treating a patient suffering from hypertriglyceridemia comprising administering to said patient a therapeutically effective hypotriglyceridemic amount of a compound of the Formula ##STR47## wherein B.sub.1 and B.sub.2 are each independently hydrogen; hydroxy; --OR.sub.1 wherein R.sub.1 is a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group wherein Ar is aryl and Y is a C.sub.0 -C.sub.4 alkyl; or, where B.sub.1 and B.sub.2 are attached to adjacent carbon atoms, B.sub.1 and B.sub.2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy;
- A.sub.1, A.sub.2 and A.sub.3 are each independently hydrogen; hydroxy; nitro; amino; fluoro, chloro, --OR.sub.1 or an Ar--Y group; or, where A.sub.1 and A.sub.2 are attached to adjacent carbon atoms, A.sub.1 and A.sub.2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy;
- R.sub.2 is hydrogen, a C.sub.1 -C.sub.4 alkyl, an Ar--Y-- group or --CH.sub.2 O--C(O)C(CH.sub.3).sub.3 ;
- Z is --CH.sub.2 --, --O--, --S--, ##STR48## or a bond wherein R.sub.3 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group and R.sub.4 is --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Y-- group;
- m is an integer 0 to 5;
- X is selected from the group consisting of ##STR49## wherein R.sub.5 and R.sub.6 are each independently a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group and n is an integer 0-2; n' is an integer 1-2; and the pharmaceutically acceptable salts thereof.
- 3. A method according to claims 1 or 2 wherein the compound is [4S-[4.alpha.-7.alpha.(R*),12b.beta.]]-7-[(1-Oxo-2(S)-(4-morpholino)-acetylthio-3-phenylpropyl)amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxopyrido[2,1-a][2]benzazepine-4-carboxylic acid.
- 4. A method according to claims 1 or 2 wherein the compound is [4S-[4.alpha.-7.alpha.(R*),12b.beta.]]-7-[(1-Oxo-2(S)-(4-morpholino)-acetylthio-3-phenylpropyl)amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxopyrido[2,1-a][2]benzazepine-4-carboxylic acid, maleate salt.
- 5. A method according to claims 1 or 2 wherein the compound is [4S-[4.alpha.-7.alpha.(R*),12b.beta.]]-7-[(1-Oxo-2(S)-(4-morpholino)-acetylthio-3-phenylpropyl)amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxopyrido[2,1-a][2]benzazepine-4carboxylic acid, dihydrochloride salt.
- 6. A method according to claims 1 or 2 wherein the compound is [4S-[4.alpha.-7.alpha.(R*),12b.beta.]]-7-[(1-Oxo-2(S)-(4-morpholino)-acetylthio-3-phenylpropyl)amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxopyrido[2,1-a][2]benzazepine-4-carboxylic acid, citrate salt.
Parent Case Info
This is a division of application Ser. No. 08/217,350, filed Mar. 24, 1994, which is now abandoned.
Foreign Referenced Citations (1)
Number |
Date |
Country |
B130446140 |
Sep 1991 |
EPX |
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts (121:9999g) Flynn et al. (1994). |
Divisions (1)
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Number |
Date |
Country |
Parent |
217350 |
Mar 1994 |
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