IDENTIFICATION OF ALZHEIMER-SPECIFIC ANTIGENS IN CSF

Information

• Research Project
• 3504356

• ApplicationId

  3504356

• Core Project Number

  R43NS027391

• Full Project Number

  1R43NS027391-01

• Serial Number

  27391

• FOA Number

• Sub Project Id

• Project Start Date

  3/15/1989 - 35 years ago

• Project End Date

  9/15/1989 - 35 years ago

• Program Officer Name

• Budget Start Date

  3/15/1989 - 35 years ago

• Budget End Date

  9/15/1989 - 35 years ago

• Fiscal Year

  1989

• Support Year

  1

• Suffix

• Award Notice Date

  3/7/1989 - 35 years ago

Organizations

• ATHENA NEUROSCIENCES, INC

The objective of the proposal is to define antigens in the CSF that are specific to Alzheimer's disease. This effort has two important potential results. The first is a CSF-based diagnostic immunoassay for use as both a diagnostic marker and as a useful adjunct to monitor eventual therapy. The methodology to identify the diagnostic markers involves the screening of-a large number of monoclonal antibodies with a highly sensitive and predictive fluorometric test. The assay is configured in such a way that only monoclonal antibodies of diagnostic potential are identified. In addition, the immuno-genes that are to be used are those related directly to the disease. Thus, the proposed research plan brings together macromolecules known to be involved in Alzheimer's disease with a sensitive high volume screen capable of detecting antibodies of diagnostic potential. The ultimate goal of the research plan will be to immunoaffinity purify and structurally characterize antigens that are specifically elevated in Alzheimer's disease.

IC Name

• Activity

  R43

• Administering IC

  NS

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  853

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SSS

• Study Section Name

• Organization Name

  ATHENA NEUROSCIENCES, INC.

• Organization Department

• Organization DUNS

• Organization City

  SOUTH SAN FRANCISCO

• Organization State

  CA

• Organization Country

  UNITED STATES

• Organization Zip Code

  94080

• Organization District

  UNITED STATES