Patent Application
20230230339
The present application claims priority under 35 U.S.C. §119 to Japanese Patent Application No. 2022-006671 filed on Jan. 19, 2022. The above application is hereby expressly incorporated by reference, in its entirety, into the present application.
The present disclosure relates to an image processing apparatus, an image processing method, and a program.
A technique for recognizing a tissue of a breast in which calcification may occur by using a radiation image obtained by irradiating the breast with radiations is known. For example, JP2016-022143A discloses a technique of specifying pixel regions in which calcification may occur from a radiation image or the like, grouping a set of the specified pixel regions, and displaying the set of the specified pixel regions in color or brightness according to the number of the pixel regions belonging to the group. Thereby, it is possible to intuitively recognize a dense state of a fine calcification tissue.
In addition, tomosynthesis imaging in which a series of a plurality of projection images is acquired by irradiating a breast with radiations having a plurality of angles is known. By reconfiguring the plurality of projection images obtained by tomosynthesis imaging, a plurality of tomographic images in which an overlap of mammary glands is reduced are obtained. Further, a technique of generating one synthesized two-dimensional image in which an overlap of mammary glands is reduced by combining a plurality of tomographic images is known. In addition, JP2020-141867A discloses a technique of generating a two-dimensional image corresponding to the synthesized two-dimensional image by inputting a projection image obtained at a radiation irradiation angle of approximately 0 degree to a learned model instead of the plurality of tomographic images.
In image diagnosis for diagnosing calcification of a breast, a shape of a calcification image appearing in a tomographic image, a synthesized two-dimensional image, or the like is important information. However, in the tomographic image, the calcification image is blurred due to noise and visibility is lowered. In addition, in the synthesized two-dimensional image generated based on the plurality of tomographic images, a shape of the calcification image is not accurately represented.
In JP2016-022143A, a distribution state of the calcification image is considered as useful information for image diagnosis for diagnosing calcification. However, a shape of the calcification image is not considered. Further, also in JP2020-141867A, a shape of the calcification image is not considered as useful information for image diagnosis for diagnosing calcification. In image diagnosis for diagnosing calcification, in order to determine whether the calcification image represents malignancy or benignancy, it is desired to accurately determine a type of a shape of the calcification image.
An object of a technique of the present disclosure is to provide an image processing apparatus, an image processing method, and a program capable of accurately determining a type of a shape of a calcification image.
In order to achieve the above object, according to an aspect of the present disclosure, there is provided an image processing apparatus including: at least one processor, in which the processor is configured to execute calcification image detection processing of detecting a calcification image based on a plurality of tomographic images obtained from a series of a plurality of projection images obtained by tomosynthesis imaging of a breast, region-of-interest image group generation processing of generating a region-of-interest image group by cutting out, as a region-of-interest image, a region including the calcification image detected by the calcification image detection processing from each of the plurality of projection images, variance value calculation processing of calculating a variance value of feature amounts of each of the region-of-interest images included in the region-of-interest image group, and shape type determination processing of determining a type of a shape of the calcification image based on the variance value calculated by the variance value calculation processing.
Preferably, the processor is configured to individually generate the region-of-interest image group for each of a plurality of the calcification images in the region-of-interest image group generation processing in a case where the plurality of calcification images are detected in the calcification image detection processing.
Preferably, the processor is configured to detect only the calcification image of which a signal value is equal to or smaller than a certain value in the calcification image detection processing.
Preferably, the processor is configured to determine a shape of the calcification image based on a relationship between a predetermined variance value and a type of a shape in the shape type determination processing.
Preferably, the feature amount is a variance value of pixel values included in one of the region-of-interest images.
Preferably, the feature amount is a variance value of pixel values included in one of the region-of-interest images with respect to an average value of pixel values in a breast region of one of the projection images.
Preferably, the feature amount is the number of pixels having a pixel value equal to or larger than a threshold value among a plurality of pixels included in one of the region-of-interest images.
Preferably, the processor is configured to further execute display processing of displaying a shape type determination result by the shape type determination processing on a display device.
Preferably, the processor is configured to highlight and display the calcification image having a specific shape based on the shape type determination result in the display processing.
According to another aspect of the present disclosure, there is provided an image processing method including: a calcification image detection step of detecting a calcification image based on a plurality of tomographic images obtained from a series of a plurality of projection images obtained by tomosynthesis imaging of a breast; a region-of-interest image group generation step of generating a region-of-interest image group by cutting out, as a region-of-interest image, a region corresponding to the calcification image detected by the calcification image detection step from each of the plurality of projection images; a variance value calculation step of calculating a variance value of feature amounts of each of the region-of-interest images included in the region-of-interest image group; and a shape type determination step of determining a type of a shape of the calcification image based on the variance value calculated by the variance value calculation step.
According to still another aspect of the present disclosure, there is provided a program causing a computer to execute a process including: calcification image detection processing of detecting a calcification image based on a plurality of tomographic images obtained from a series of a plurality of projection images obtained by tomosynthesis imaging of a breast; region-of-interest image group generation processing of generating a region-of-interest image group by cutting out, as a region-of-interest image, a region corresponding to the calcification image detected by the calcification image detection processing from each of the plurality of projection images; variance value calculation processing of calculating a variance value of feature amounts of each of the region-of-interest images included in the region-of-interest image group; and shape type determination processing of determining a type of a shape of the calcification image based on the variance value calculated by the variance value calculation processing.
According to the technique of the present disclosure, it is possible to provide an image processing apparatus, an image processing method, and a program capable of accurately determining a type of a shape of a calcification image.
Exemplary embodiments according to the technique of the present disclosure will be described in detail based on the following figures, wherein:
Hereinafter, an embodiment of the present disclosure will be described with reference to the drawings.
The mammography apparatus 10 operates according to a control of the console 12, and is a radiography apparatus that acquires a radiation image of a breast M by irradiating the breast M of the subject as a target with radiations R (for example, X rays) from a radiation source 29.
The mammography apparatus 10 has a function of performing normal imaging in which imaging is performed in a state where the radiation source 29 is positioned at an irradiation position along a normal direction of a detection surface 20A of a radiation detector 20 and a function of performing tomosynthesis imaging in which imaging is performed in a state where the radiation source 29 is moved to each of a plurality of irradiation positions.
As illustrated in
The radiation detector 20 detects radiations R passing through the breast M as a target. Specifically, the radiation detector 20 detects the radiations R that pass through the breast M of the subject, enter into the imaging table 24, and reach a detection surface 20A of the radiation detector 20, and generates a radiation image based on the detected radiations R. The radiation detector 20 outputs image data representing the generated radiation image. In the following, a series of operations of irradiating the breast with radiations R from the radiation source 29 and generating a radiation image by the radiation detector 20 may be referred to as “imaging”. The radiation detector 20 may be an indirect-conversion-type radiation detector that converts the radiations R into light beams and converts the converted light beams into charges, or may be a direct-conversion-type radiation detector that directly converts the radiations R into charges.
A compression plate 30 that is used for compressing the breast M when performing imaging is attached to the compression unit 32. The compression plate 30 is moved in a direction toward or away from the imaging table 24 (hereinafter, referred to as a “vertical direction”) by a compression plate driving unit (not illustrated) provided in the compression unit 32. The compression plate 30 compresses the breast M between the compression plate 30 and the imaging table 24 by moving in the vertical direction.
The arm portion 28 can be rotated with respect to the base 26 by a shaft portion 27. The shaft portion 27 is fixed to the base 26, and the shaft portion 27 and the arm portion 28 are rotated as one body. Gears are provided in each of the shaft portion 27 and the compression unit 32 of the imaging table 24. By switching the gears between an engaged state and a non-engaged state, the compression unit 32 of the imaging table 24 and the shaft portion 27 can be switched between a state where the compression unit 32 and the shaft portion 27 are connected to each other and are rotated as one body and a state where the shaft portion 27 is separated from the imaging table 24 and idles. Elements for switching between transmission and non-transmission of power of the shaft portion 27 are not limited to the gears, and various mechanical elements can be used. The arm portion 28 and the imaging table 24 can be separately rotated with respect to the base 26 with the shaft portion 27 as a rotation axis.
In a case of performing tomosynthesis imaging in the mammography apparatus 10, the radiation source 29 is sequentially moved to each of a plurality of irradiation positions having different irradiation angles by rotation of the arm portion 28. The radiation source 29 includes a radiation tube (not illustrated) that generates the radiations R, and the radiation tube is moved to each of the plurality of irradiation positions in accordance with the movement of the radiation source 29.
At each irradiation position Pk, the radiation R is emitted from the radiation source 29 toward the breast M, and the radiation detector 20 generates a radiation image by detecting the radiation R passing through the breast M. In the radiography system 2, in a case where the radiation source 29 is moved to each of the irradiation positions Pk and tomosynthesis imaging for generating a radiation image at each irradiation position Pk is performed, in the example of
In the following, in the tomosynthesis imaging, the radiation image obtained by performing imaging at each irradiation position Pk is referred to as a “projection image” in a case of distinguishing and describing the radiation image from a tomographic image, and a plurality of projection images obtained by performing tomosynthesis imaging once are referred to as a “series of the plurality of projection images”. Further, in a case where the projection image is referred to without distinguishing the projection image from the tomographic image, the projection image is simply referred to as a “radiation image”.
In addition, as illustrated in
On the other hand, in a case of performing normal imaging in the mammography apparatus 10, the position of the radiation source 29 is fixed to the irradiation position P4 at which the irradiation angle a is 0 degree. The radiation R is emitted from the radiation source 29 according to an instruction of the console 12, and the radiation detector 20 generates a radiation image by detecting the radiation R passing through the breast M.
The mammography apparatus 10 and the console 12 are connected to each other by wired communication or wireless communication. The radiation image generated by the radiation detector 20 in the mammography apparatus 10 is output to the console 12 by wired communication or wireless communication via a communication interface (I/F) (not illustrated).
The console 12 includes a controller 40, a storage unit 42, a user I/F 44, and a communication I/F 46. As described above, the controller 40 has a function of performing control related to radiography by the mammography apparatus 10. The controller 40 is configured with, for example, a computer system including a central processing unit (CPU), a read only memory (ROM), and a random access memory (RAM).
The storage unit 42 stores information related to radiography, the radiation image acquired from the mammography apparatus 10, and the like. The storage unit 42 is a non-volatile storage such as a hard disk drive (HDD) or a solid state drive (SSD).
The user I/F 44 includes an input device including various buttons and switches, which are related to imaging of the radiation image and are operated by a user such as a technician, and a lamp, a display, or the like that displays information related to imaging, the radiation image obtained by imaging, and the like.
The communication I/F 46 performs communication of various types of data such as the information related to radiography, the radiation image, and the like between the console 12 and the mammography apparatus 10 by wired communication or wireless communication. Further, the communication I/F 46 performs communication of various types of data such as the radiation image between the PACS 14 and the image processing apparatus 16 via the network 17 by wired communication or wireless communication.
In addition, the PACS 14 includes a storage unit 50 (refer to
The image processing apparatus 16 has a function of supporting diagnosis by a doctor by performing determination related to diagnosis of a lesion in a case where a doctor or the like (hereinafter, simply referred to as a “doctor”) performs diagnosis related to a lesion of the breast M using the radiation image.
The controller 60 controls overall operations of the image processing apparatus 16. The controller 60 is configured with a computer system including a CPU 60A, a ROM 60B, and a RAM 60C. Various programs, data, and the like for performing control by the CPU 60A are stored in advance in the ROM 60B. The RAM 60C temporarily stores various types of data.
The storage unit 62 is a non-volatile storage such as an HDD or an SSD. The storage unit 62 stores a program 63 or the like for causing the controller 60 to execute various processing.
The display device 70 is a display that displays a radiation image, various types of information, and the like. The operation unit 72 is used to allow a doctor to input an instruction for diagnosing a lesion of a breast using a radiation image, various types of information, and the like. The operation unit 72 includes, for example, various switches, a touch panel, a touch pen, a mouse, and the like.
The communication I/F 74 performs communication of various types of information between the console 12 and the PACS 14 via the network 17 by wireless communication or wired communication.
The tomographic image generation unit 80 has a function of generating a plurality of tomographic images 90 (refer to
The calcification image detection unit 81 performs calcification image detection processing of detecting a tissue image in which an occurrence of calcification is expected in the breast M (hereinafter, calcification image) based on the plurality of tomographic images 90 generated by the tomographic image generation unit 80. As the calcification image detection unit 81, a detector using a known computer-aided diagnosis (CAD) algorithm can be used. In the CAD algorithm, a probability (likelihood) indicating that a pixel in the tomographic image 90 is a calcification image is derived, and a pixel of which the probability is equal to or higher than a predetermined threshold value is detected as the calcification image.
The calcification image detection unit 81 is not limited to the detector using the CAD algorithm, and may be configured by a machine-learned model obtained by performing machine learning.
The detection result of the calcification image by the calcification image detection unit 81 is output as, for example, a plurality of mask images 91 each of which represents a position of the calcification image. Each of the plurality of mask images 91 is a binary image in which a pixel included in the calcification image is represented by “1” and the other pixels are represented by “0”. The calcification image detection unit 81 outputs the plurality of mask images 91 corresponding to each of the plurality of tomographic images 90. By performing the detection processing using the plurality of tomographic images 90, the calcification image can be detected with high detection accuracy. In the example illustrated in
The region-of-interest image group generation unit 82 performs region-of-interest image group generation processing of generating a region-of-interest image group (hereinafter, referred to as a ROI (region of interest) image group) based on a series of the plurality of projection images 100 used for reconfiguration processing by the tomographic image generation unit 80, a detection result of the calcification image by the calcification image detection unit 81, and position information of the radiation tube at a time when imaging each of a series of the plurality of projection images 100.
The variance value derivation unit 83 performs variance value calculation processing of calculating a variance value of feature amounts of each of the ROI images included in the ROI image group.
Here, r(x, y) is a pixel value of a pixel at a coordinate (x, y) in the ROI image Rk. rais an average value of pixel values r(x, y) included in the ROI image Rk. In addition, n is the number of pixels included in the ROI image Rk.
In the present embodiment, the feature amount Fk is a variance value of the pixel values r(x, y) included in the ROI image Rk. Seven feature amounts F1 to F7 are calculated from the seven ROI images R1 to R7. It is considered that more pixels (for example, high-brightness pixels) corresponding to the calcification image are included in the ROI image Rk as the feature amount Fk is larger.
In addition, the variance value derivation unit 83 calculates a variance value D based on the following Equation (2).
Here, Fa is an average value of the feature amounts F1 to F7. The variance value D is a value representing a degree of variation of the feature amounts F1 to F7. As the variance value D is larger, a change in shape due to a difference in the irradiation position Pk is larger. For example, as the variance value D is smaller, the shape of the calcification image is closer to a circle shape. As the variance value D is larger, the shape of the calcification image is closer to a linear shape.
In the example illustrated in
The shape type determination unit 84 performs shape type determination processing of determining a type of a shape of the calcification image based on the variance value calculated by the variance value derivation unit 83. The shape type determination unit 84 holds information in which a relationship between a predetermined variance value and a type of a shape of the calcification image is defined, and determines a type of a shape of the calcification image based on the information. That is, the shape type determination unit 84 is a rule-based determination model based on a relationship between a predetermined variance value and a type of a shape of the calcification image.
In the example illustrated in
In the present embodiment, the type of the shape of the calcification image includes not only a difference in shape but also a difference in size. The type of the shape of the calcification image is not limited to the above-described example. Preferably, the type of the shape of the calcification image is classified into classes such that whether the calcification image represents benignancy or malignancy can be determined.
In addition, the shape type determination unit 84 may perform shape type determination processing using a machine-learned model obtained by performing machine learning of the relationship between the variance value and the type of the shape of the calcification image.
The display controller 85 performs display processing for displaying the shape type determination result 84A by the shape type determination processing on the display device 70. Specifically, the display controller 85 highlights and displays the calcification image having a specific shape based on the shape type determination result 84A.
In the example illustrated in
In addition, the highlight display is not limited to the form in which the calcification image is surrounded by the frame 110. The color of the calcification image may be different based on the shape type determination result 84A. For example, the highlight display may be performed by coloring only the calcification image having a shape representing a high degree of malignancy. In addition, texts, symbols, and the like representing the shape type determination result 84A may be displayed on the display device 70.
Next, a series of processing by the image processing apparatus 16 will be described with reference to
In step S11, the tomographic image generation unit 80 generates a plurality of tomographic images 90 based on a series of the plurality of projection images 100 acquired in step S10.
In step S12, the calcification image detection unit 81 detects a calcification image from the plurality of tomographic images 90 generated in step S11, and generates a plurality of mask images 91 as a detection result.
In step S13, the region-of-interest image group generation unit 82 generates a ROI image group by cutting out, as a ROI image, a region including a calcification image from each of a series of the plurality of projection images 100 by using the plurality of mask images 91 generated in step S12.
In step S14, the variance value derivation unit 83 calculates a variance value of feature amounts of each of the ROI images included in the ROI image group generated in step S13.
In step S15, the shape type determination unit 84 determines a type of a shape of the calcification image based on the variance value calculated in step S14, and outputs a shape type determination result 84A.
In step S16, the display controller 85 performs display processing of displaying the shape type determination result 84A obtained in step S15 on the display device 70. Specifically, the display controller 85 highlights and displays the calcification image having a shape representing a high degree of malignancy.
Generally, in the synthesized two-dimensional image generated from the plurality of tomographic images, a shape of the calcification image is not accurately represented in many cases. Further, in the tomographic image, the calcification image is blurred due to noise and visibility is lowered. On the other hand, according to the technique of the present disclosure, the ROI image group is generated by cutting out a region including the calcification image from each of a series of the plurality of projection images, and the type of the shape of the calcification image is determined based on the variance value of the feature amounts of each of the ROI images included in the ROI image group. Therefore, it is possible to accurately determine the type of the shape of the calcification image.
Further, in the embodiment, the calcification image detection unit 81 detects the calcification image from the plurality of tomographic images 90. The calcification image detection unit 81 may detect only a calcification image (so-called pale calcification image) of which a signal value is equal to or smaller than a certain value. This is because a shape of the pale calcification image is not accurately represented and it is difficult to determine a type of the shape on the tomographic image 90 as a clinical image that is displayed on the display device 70.
Hereinafter, a modification example of the embodiment will be described.
In addition, additional information 93 other than the shape type determination result 84A may be input to the benignancy/malignancy determination unit 86. The additional information 93 is, for example, information such as a distribution of the calcification image, the calcification image in the synthesized two-dimensional image, and the like. The benignancy/malignancy determination unit 86 can accurately perform benignancy/malignancy determination by using the additional information 93 in addition to the shape type determination result 84A.
In the present modification example, the display controller 85 performs display processing of displaying the benignancy/malignancy determination result 86A output from the benignancy/malignancy determination unit 86 on the display device 70. For example, the display controller 85 highlights and displays the calcification image determined as a malignancy based on the benignancy/malignancy determination result 86A. The display controller 85 may display a text, a symbol, or the like representing the benignancy/malignancy determination result 86A on the display device 70.
As the benignancy/malignancy determination unit 86, for example, a determination device using a known CAD algorithm can be used. The benignancy/malignancy determination unit 86 may be configured by a machine-learned model obtained by performing machine learning.
In the embodiment and the modification example, the feature amount Fk calculated by the variance value derivation unit 83 is, as described in Equation (1), a variance value of the pixel values included in the ROI image Rk with respect to the average value ra of the pixel values included in the ROI image Rk. Instead, the feature amount Fk calculated by the variance value derivation unit 83 may be a variance value of the pixel values included in the ROI image Rk with respect to an average value of pixel values in a region of the breast M (hereinafter, referred to as a breast region) of one projection image among a series of the plurality of projection images 100. That is, the average value ra in Equation (1) may be an average value of pixel values in a breast region of one projection image (for example, a projection image from which the ROI image Rk is cut out). In this case, the feature amount Fk is represented as a variation in pixel value with respect to a normal value in the breast region.
In addition, the feature amount Fk calculated by the variance value derivation unit 83 may be the number of pixels having a pixel value equal to or larger than a threshold value among a plurality of pixels included in the ROI image Rk. In this case, by setting the threshold value to a lower limit value of values that are allowable for the calcification image, the number of pixels having a pixel value equal to or larger than the threshold value can correspond to the number of pixels included in the calcification image.
The embodiment and the modification examples can be appropriately combined as long as there is no contradiction.
In addition, in the embodiment and the modification examples, as a hardware structure of a processing unit that executes various processing such as the tomographic image generation unit 80, the calcification image detection unit 81, the region-of-interest image group generation unit 82, the variance value derivation unit 83, the shape type determination unit 84, the display controller 85, and the benignancy/malignancy determination unit 86, for example, various processors to be described below can be used. The various processors include a graphics processing unit (GPU) in addition to a CPU. In addition, the various processors are not limited to a general-purpose processor such as a CPU that functions as various processing units by executing software (program), and include a dedicated electric circuit, which is a processor having a circuit configuration specifically designed to execute specific processing, such as a programmable logic device (PLD) or an application specific integrated circuit (ASIC) that is a processor of which the circuit configuration may be changed after manufacturing such as a field programmable gate array (FPGA).
One processing unit may be configured by one of these various processors, or may be configured by a combination of two or more processors of the same type or different types (for example, a combination of a plurality of FPGAs or a combination of a CPU and an FPGA). Further, the plurality of processing units may be configured by one processor.
As an example in which the plurality of processing units are configured by one processor, firstly, as represented by a computer such as a client and a server, a form in which one processor is configured by a combination of one or more CPUs and software and the processor functions as the plurality of processing units may be adopted. Secondly, as represented by a system on chip (SoC) or the like, a form in which a processor that realizes the function of the entire system including the plurality of processing units by one integrated circuit (IC) chip is used may be adopted. As described above, the various processing units are configured by using one or more various processors as a hardware structure.
Further, as the hardware structure of the various processors, more specifically, an electric circuit (circuitry) in which circuit elements such as semiconductor elements are combined may be used.
In addition, in the embodiment and the modification examples, a form in which the program 63 is stored in the storage unit 62 in advance has been described. On the other hand, the present invention is not limited thereto. The program 63 may be provided by being recorded in a non-transitory recording medium such as a compact disc read only memory (CD-ROM), a digital versatile disc read only memory (DVD-ROM), or a Universal Serial Bus (USB) memory. Further, the program 63 may be downloaded from an external apparatus via a network.
The described contents and the illustrated contents are detailed explanations of a part according to the technique of the present disclosure, and are merely examples of the technique of the present disclosure. For example, the descriptions related to the configuration, the function, the operation, and the effect are descriptions related to examples of a configuration, a function, an operation, and an effect of a part according to the technique of the present disclosure. Therefore, it goes without saying that, in the described contents and illustrated contents, unnecessary parts may be deleted, new components may be added, or replacements may be made without departing from the spirit of the technique of the present disclosure. Further, in order to avoid complications and facilitate understanding of the part according to the technique of the present disclosure, in the described contents and illustrated contents, descriptions of technical knowledge and the like that do not require particular explanations to enable implementation of the technique of the present disclosure are omitted.
All documents, patent applications, and technical standards mentioned in this specification are incorporated herein by reference to the same extent as in a case where each document, each patent application, and each technical standard are specifically and individually described by being incorporated by reference.
| Number | Date | Country | Kind |
|---|---|---|---|
| 2022-006671 | Jan 2022 | JP | national |
