Claims
- 1-27. (canceled).
- 28. A composition comprising a compound of formula X-Y-Z, wherein X comprises a chelator moiety, Y comprises a linker moiety, and Z comprises a polymerizing moiety.
- 29. The composition of claim 28, wherein the compound further comprises a paramagnetic or superparamagnetic metal atom or ion.
- 30. The composition of claim 29, wherein the paramagnetic or superparamagnetic metal atom or ion is a transition metal atom or ion.
- 31. The composition of claim 29, wherein the paramagnetic or superparamagnetic metal atom or ion is a lanthanide atom or ion.
- 32. The composition of claim 29, wherein the metal ion is selected from the group consisting of an iron ion, a dysprosium ion, a europium ion and a manganese ion.
- 33. The composition of claim 29, wherein the metal ion is a gadolinium ion.
- 34. The composition of claim 28, wherein the polymerizing moiety comprises any chemical group that can be chemically modified as a result of the catalytic activity of an enzyme to form a covalent chemical bond between either (1) Z and another compound of formula X-Y-Z or (2) Z and any polymer or macromolecule.
- 35. The composition of claim 28, wherein Z is a moiety that can be accommodated by the catalytic center of an enzyme.
- 36. The composition of claim 28, wherein X comprises a structure selected from the group consisting of:
1,4,7,10-tetraazacyclodo-decane-N,N′,N″,N′″-tetraacetic acid; 1,4,7,10-tetraaza-cyclododecane-N,N′,N″-triacetic acid; 1,4,7-tris(carboxymethyl)-10-(2′-hydroxypropyl)-1,4,7,10-tetraazocyclodecane; 1,4,7-triazacyclonane-N,N′,N″-triacetic acid; 1,4,8,11-tetraazacyclotetra-decane-N,N′,N″,N′″-tetraacetic acid; diethylenetriamine-pentaacetic acid (DTPA); ethylenedicysteine; bis(aminoethanethiol)carboxylic acid; triethylenetetraamine-hexaacetic acid; ethylenediamine-tetraacetic acid (EDTA); 1,2-diaminocyclohexane-N,N,N′,N′-tetraacetic acid; N-(hydroxy-ethyl)ethylenediaminetriacetic acid; nitrilotriacetic acid; and ethylene-bis(oxyethylene-nitrilo)tetraacetic acid.
- 37. The composition of claim 28, wherein Z comprises the following structure:
- 38. The composition of claim 37, wherein R1, R2, R3, R4 or R5 is at an ortho position relative to the OH substituent, and is selected from the group consisting of OH and OCH3.
- 39. The composition of claim 37, wherein R1, R2, R3, R4 or R5 is at a meta position relative to the OH substituent, and is selected from the group consisting of NHC(O)R6 and NR7R8.
- 40. The composition of claim 28, wherein Y comprises a structure selected from the group consisting of: an amino acid, an oligopeptide comprising 2-6 amino acid residues, a nucleotide, an oligonucleotide comprising 2-6 nucleotide residues, a C3-C12 alkyl group, a polyethyleneimine, a saccharide, an oligosaccharide, a medium chain fatty acid, a polyamidoamine, a polyacrylic acid, and a polyalcohol.
- 41. The composition of claim 28, wherein Y comprises an amino acid or oligopeptide containing 2-6 amino acid residues.
- 42. The composition of claim 41, wherein the oligopeptide comprises a glycine residue.
- 43. The composition of claim 29, wherein the compound comprises the formula:
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of U.S. Provisional Application No. 60/241,566, filed Oct. 19, 2000, and U.S. Provisional Application No. 60/310,335, filed Aug. 6, 2001, both of which are incorporated herein by reference in their entirety.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60241566 |
Oct 2000 |
US |
|
60310335 |
Aug 2001 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09999665 |
Oct 2001 |
US |
Child |
10837504 |
Apr 2004 |
US |