Patent Application
20190076124
Oral health problems can take many forms, such as tooth decay, oral cancer, periodontal disease, and bad breath. While some health problems manifest on the surface of oral tissue, others are subsurface. Currently, there are no reliable clinical imaging systems which can provide indicators of oral health problems in a quantitative depth resolved manner.
Optical coherence tomography is one imaging technology which has shown promise for a wide range of oral diagnostic applications. However, the imaging depth of optical coherence tomography is limited to 1 to 2 mm and it is incapable of providing any spectroscopic information at spectral wavelengths which penetrate deeper into tissue. Intraoral fluorescence and cross-polarization imaging are another imaging modality which has shown promise by providing surface images of oral tissue in real time. This technology is, however, incapable of providing depth resolved or spectroscopic information of imaged tissue. Ultrasonography (US) is another imaging technology which has gained more use for diagnosing oral tissue. This technology has the advantage of being able to produce cross sectional images of tissue at varying depths, which is useful for detecting and diagnosing subsurface diseases and health problems. Ultrasonography can also produce ultrasound Doppler images, which show vascular flow for differentiating normal tissue from tissue showing signs of disease. However, traditional ultrasonography can only provide limited spatial resolution in deep tissues, and the contrast it provides between tissue structures can be limited. Photoacoustic imaging (PAI) is one of the more recent imaging technologies that has been used for oral tissue diagnostics. PAI has the advantage that it combines the high spectroscopic based contrast of optical imaging with high spatial resolution, and it is capable of providing subsurface imaging combined with information about tissue function.
None of these imaging technologies alone are sufficient for diagnosing tissue health, both one the surface and sub-surface, and particularly with the range of tissue structure and potential issues that may manifest sub-surface. An imaging technology is therefore desirable that includes several of the advantages found in multiple ones of the aforementioned imaging technologies. Such an imaging technology should also be cost-effective, compact, and easy to use, such that it can readily be used for point-of-care diagnostic applications. In addition, such an imaging technology should enable the rapid and accurate diagnosis and monitoring of patients, while also reducing the cost and time associated with healthcare services.
Exemplary embodiments according to the present disclosure are directed to imaging systems and methods which employ photoacoustic imaging (PAI) to image tissue. The imaging system includes a miniature hand-held imaging probe coupled to a data processing and display unit. The system may also incorporate an ultrasound transducer as part of the probe, thereby enabling both photoacoustic images and ultrasound images (B-mode and/or Doppler) to be processed at the same time. The images obtained from the different modalities may be displayed in a co-registered manner so that relationships may be seen between structures and features of the different images. In addition, both individual and co-registered images may be displayed as a video. The imaging method includes positioning the probe head adjacent tissue to be imaged, obtaining the desired images by actuating at least the light source used to obtain photoacoustic images, and then processing the data signal generated by the probe to produce one or more images of the tissue. By also actuating the ultrasound transducer using a common timing signal that is also used to actuate the light source, data for both photoacoustic images and ultrasound images may be generated using a single probe. The imaging method may also include using a display device to display the one or more images in real time.
In one aspect, the invention can be an imaging system including: a probe head including: a light source for emitting light in at least one spectral waveband suitable to generate a photoacoustic response in tissue; an ultrasound transducer having a transmit mode for transmitting ultrasound energy into the tissue and a receive mode for receiving the ultrasound energy reflected by the tissue and photoacoustic energy from the tissue; and a programmable system configured to actuate the light source and to actuate the ultrasound transducer between the transmit mode and the receive mode in response to a timing signal.
In another aspect, the invention can be an imaging method including: positioning a probe head adjacent a tissue, the probe head including: a light source positioned by the probe head to emit light toward the tissue, the light source including at least one spectral waveband suitable to generate a photoacoustic response in the tissue; and an ultrasound transducer positioned by the probe head to direct ultrasound energy into the tissue in a transmit mode and to receive the ultrasound energy reflected by the tissue and photoacoustic energy from the tissue in a receive mode; and actuating the light source and actuating the ultrasound transducer between the transmit mode and the receive mode in response to a timing signal.
In still another aspect, the invention can be an imaging system including: a probe head including: a light source for emitting light in at least one spectral waveband suitable to generate a photoacoustic response in tissue, the light source comprising at least two light emitting elements, each light emitting element comprising an emission plane; and an ultrasound receiver comprising a receiver plane, wherein each emission plane is positioned at an acute angle with respect to the receiver plane; and a programmable system configured to actuate the light source.
In yet another aspect, the invention can be an imaging method including: positioning a probe head adjacent a tissue, the probe head including: a light source positioned by the probe head to emit light toward the tissue, the light source comprising at least two light emitting elements, each light emitting element comprising an emission plane, the light including at least one spectral waveband suitable to generate a photoacoustic response in the tissue; and an ultrasound receiver positioned by the probe head to receive photoacoustic energy from the tissue, the ultrasound receiver comprising a receiver plane, wherein each emission plane is positioned at an acute angle with respect to the receiver plane; and actuating the light source.
Further areas of applicability of the present invention will become apparent from the detailed description provided hereinafter. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.
The foregoing summary, as well as the following detailed description of the exemplary embodiments, will be better understood when read in conjunction with the appended drawings. It should be understood, however, that the invention is not limited to the precise arrangements and instrumentalities shown in the following figures:
The following description of the preferred embodiment(s) is merely exemplary in nature and is in no way intended to limit the invention, its application, or uses.
The description of illustrative embodiments according to principles of the present invention is intended to be read in connection with the accompanying drawings, which are to be considered part of the entire written description. In the description of embodiments of the invention disclosed herein, any reference to direction or orientation is merely intended for convenience of description and is not intended in any way to limit the scope of the present invention. Relative terms such as “lower,” “upper,” “horizontal,” “vertical,” “above,” “below,” “up,” “down,” “left,” “right,” “top” and “bottom” as well as derivatives thereof (e.g., “horizontally,” “downwardly,” “upwardly,” etc.) should be construed to refer to the orientation as then described or as shown in the drawing under discussion. These relative terms are for convenience of description only and do not require that the apparatus be constructed or operated in a particular orientation unless explicitly indicated as such. Terms such as “attached,” “affixed,” “connected,” “coupled,” “interconnected,” and similar refer to a relationship wherein structures are secured or attached to one another either directly or indirectly through intervening structures, as well as both movable or rigid attachments or relationships, unless expressly described otherwise. Moreover, the features and benefits of the invention are illustrated by reference to the preferred embodiments. Accordingly, the invention expressly should not be limited to such preferred embodiments illustrating some possible non-limiting combinations of features that may exist alone or in other combinations of features; the scope of the invention being defined by the claims appended hereto.
Features of the present invention may be implemented in software, hardware, firmware, or combinations thereof. The programmable processes described herein are not limited to any particular embodiment, and may be implemented in an operating system, application program, foreground or background processes, driver, or any combination thereof. The computer programmable processes may be executed on a single processor or on or across multiple processors.
Processors described herein may be any central processing unit (CPU), microprocessor, micro-controller, computational, or programmable device or circuit configured for executing computer program instructions (e.g. code). Various processors may be embodied in computer and/or server hardware and/or computing device of any suitable type (e.g. desktop, laptop, notebook, tablet, cellular phone, smart phone, PDA, etc.) and may include all the usual ancillary components necessary to form a functional data processing device including without limitation a bus, software and data storage such as volatile and non-volatile memory, input/output devices, a display screen, graphical user interfaces (GUIs), removable data storage, and wired and/or wireless communication interface devices including Wi-Fi, Bluetooth, LAN, etc.
Computer-executable instructions or programs (e.g. software or code) and data described herein may be programmed into and tangibly embodied in a non-transitory computer-readable medium that is accessible to and retrievable by a respective processor as described herein which configures and directs the processor to perform the desired functions and processes by executing the instructions encoded in the medium. A device embodying a programmable processor configured to such non-transitory computer-executable instructions or programs is referred to hereinafter as a “programmable device”, or just a “device” for short, and multiple programmable devices in mutual communication is referred to as a “programmable system”. It should be noted that non-transitory “computer-readable medium” as described herein may include, without limitation, any suitable volatile or non-volatile memory including random access memory (RAM) and various types thereof, read-only memory (ROM) and various types thereof, USB flash memory, and magnetic or optical data storage devices (e.g. internal/external hard disks, floppy discs, magnetic tape CD-ROM, DVD-ROM, optical disk, ZIP™ drive, Blu-ray disk, and others), which may be written to and/or read by a processor operably connected to the medium.
In certain embodiments, the present invention may be embodied in the form of computer-implemented processes and apparatuses such as processor-based data processing and communication systems or computer systems for practicing those processes. The present invention may also be embodied in the form of software or computer program code embodied in a non-transitory computer-readable storage medium, which when loaded into and executed by the data processing and communications systems or computer systems, the computer program code segments configure the processor to create specific logic circuits configured for implementing the processes.
Turning in detail to the drawings,
The probe body 111 includes a button 115 which electronically actuates operation of the probe 103. The button 115 is electronically coupled to the controller and data signal processor 105, and when the button 115 is pressed, the controller and data signal processor 105 begins the data acquisition process. When the button 115 is released, the controller and data signal processor 105 terminates the data acquisition process. In certain embodiments, the button 115 may be a dual action button, such that a first press begins the data acquisition process, and a second press terminates the data acquisition process. In still other embodiments, the button 115 may be replaced by a switch or any other type of device which accepts user input to control operation of the probe 103.
The probe head 113 includes a probe face 117 which is positioned adjacent tissue that is to be imaged. Although the tissue is discussed herein in terms of being oral tissue, any type of tissue may be imaged, such as, without limitation, nasal tissue, epidermal tissue, subepidermal tissue, and colorectal tissue. The type of tissue is not to be limiting of the invention unless otherwise stated in the claims. As shown in greater detail in
Each light emitting element 131 may include one or more laser diodes (LDs) or light emitting diodes (LEDs), such that each light emitting element 131 may emit light in at least one spectral waveband suitable to generate a photoacoustic response in tissue. For simplification, the following description will use LDs as the light emitting elements 131, with the understanding that and LED may also be used. As shown, each light emitting element 131 includes a plurality of LDs 133 so that each can emit light in several different spectral wavebands. Each light emitting element 131 includes four LDs 133, with each producing light in a different spectral waveband. As discussed in more detail below, the different spectral wavebands enable the imaging system 101 to measure the absorption of certain compounds within the tissue, thereby allowing for quantification of the presence of those compounds in a depth resolved manner.
In certain embodiments, each light emitting element 131 includes at least one LD, and emits light in at least one of a waveband in the visual spectrum and a waveband in the infrared spectrum. In certain other embodiments, each light emitting element 131 includes at least two LDs, and emits light in one waveband in the visual spectrum and in one waveband in the infrared spectrum. In still other embodiments, each light emitting element 131 includes four LDs, and emits light in one waveband in the visual spectrum and three distinct wavebands in the infrared spectrum. In yet other embodiments, the number of wavebands emitted by the light emitting elements 131 may vary from one to many, not to be limiting of the invention unless otherwise expressly indicated in the claims.
The computing device 107 includes a display screen 123 for displaying images of the tissue. The images may be ultrasound B-mode and/or Doppler images, and/or the images may be photoacoustic images. The images may be displayed on the display screen 123 individually, or two or more of the image modalities may be displayed co-registered.
A cross-sectional view of the probe head 113 is shown in
The light emitting elements 131 form two rows 127, 129 located on opposite sides of the ultrasound transducer 119, with each light emitting element 131 positioned on an emission plane 141. Each light emitting element 131 directs light away from the emission plane 141 and into the tissue 137. The emission planes 141 for all the light emitting elements 131 in each of the individual rows 127, 129 are coplanar. In certain embodiments, the emission plane 141 for each light emitting element 131 may be defined by a polycarbonate board to which the LDs 133 are mounted. In other embodiments, the emission planes 141 may be defined by other structure within the probe head 113. In still other embodiments, each emission plane 141 may be an imaginary plane defined within the probe head 113 by the respective positions of the LDs 133 of each light emitting element 131. Each emission plane 141 is positioned at an acute angle with respect to the transducer plane, such that the light cones 143, 145 produced by each light emitting element 131 are directed into the tissue 137 to form an imaging zone 149. As used herein, an acute angle is a non-zero angle. The depth D of the imaging zone 149 determines the depth of the photoacoustic image produced by the imaging system 101. Depending on the angle formed between the emission plane 141 and the transducer plane, the depth D of the imaging zone may vary between about 2 mm to 20 mm. In certain embodiments, each light emitting element 131 may include light beam shaping optics to shape the light cones 143, 145 and achieve a more uniform delivery of multiple wavebands of light from multiple LDs onto and in the tissue.
The graph 161 of
An alternative embodiment of a probe head 201 is shown in
A schematic diagram of the imaging system 101 is illustrated in
The data acquisition module 251 is coupled to the probe face 117 to control of the ultrasound transducer and the light source and operates in a similar manner as compared to existing ultrasound imaging systems and existing photoacoustic imaging systems. However, the integration of the two systems does result in some important differences from known systems, and those differences are described herein. The data acquisition module 251 includes a transmit beam former 255 which generates the signal to be transmitted by the ultrasound transducer. The signal from the transmit beam former 255 passes through a digital to analogue converter 257 to a trigger control 259. The control and image processing module 253 includes a trigger generator 261 which generates a timing signal for actuating the light source on and off and for actuating the ultrasound transducer between a transmit mode and a receive mode. Through the use of a single timing signal, actuation of the light source and the ultrasound transducer can be used in tandem to gather both ultrasound data and photoacoustic data. The timing signal thus triggers the data acquisition module 251 to switch between an ultrasound mode and a photoacoustic mode. In the ultrasound mode, the data acquisition module 251 acquires data that is used to produce one or both of B-mode or Doppler ultrasound images, and in the photoacoustic mode, the data acquisition module 251 acquires data that is used to produce photoacoustic images. As indicated above, in the ultrasound mode, the data acquisition module 251 may generate ultrasound data in much the same way as a traditional ultrasound imaging system, and in the photoacoustic mode, the data acquisition module 251 may generate photoacoustic data in much the same way as a traditional photoacoustic imaging system.
In certain embodiments, the timing signal is configured to actuate the light source to emit thirty light pulses per second. By having thirty light pulses per second, the imaging system 101 is able to directly translate the images produced into a video having thirty frames per second (30 fps). In certain embodiments, the timing signal may be configured to actuate the light source to emit more or fewer than 30 pulses per second. The timing signal and the number of pulses emitted by the light source, however, are not to be limiting of the invention unless otherwise stated in the claims.
The timing signal from the trigger generator 261 is provided to the trigger control 259 and the LD driver 263. In response to the timing signal, the LD driver 263 controls the on and off state of the light source. Similarly, in response to the timing signal, the trigger control 259 controls the transmit and receive modes of the transducer. During the transmit mode, the trigger control 259 passes the converted signal generated by the transmit beam former 255 to the high voltage pulse generator 265, which in turn drives the transducer to generate the ultrasound energy directed into the tissue.
The timing signal from the trigger generator 261 is also provided to the transmit/receive switches 267, which includes one switch per ultrasound transducer element. The transmit/receive switches 267 control when a data signal received by the transducer is passed on for further processing by the signal conditioner 269. The transmit/receive switches 267 thus act as gate for data signals generated by the transducer, thereby effectively placing the transducer into a receive mode when the transmit/receive switches 267 enable the transducer signal to pass.
The signal conditioner 269 conditions the data signals received from the transducer for further processing. One of the issues that arise from the transducer sensing both reflected ultrasound energy and photoacoustic energy is that these two different types of energy can result in two different types of data signals being generated by the transducer. The data signal resulting from ultrasound energy will generally have a much higher voltage than the data signal resulting from photoacoustic energy. One purpose of the signal conditioner 269, therefore, is to normalize voltage levels of the data signals from the transducer so that the image processing module 253 can more easily process the two different types of data signals without having to have different circuits for each. The signal conditioner 269 also serves to protect down-circuit elements, which are designed to process the lower voltage photoacoustic data signals, from the higher voltage ultrasound data signals.
Data signals are passed from the signal conditioner 269 to an analogue to digital converter 271 and then to the receive beam former 273. The receive beam former 273 uses the data signal as feedback to help shape the signal generated by the transmit beam former 255. The data signal then passes into the image processing module 253, where it is processed first by the RF demodulator 279 and then by the photoacoustic image processor 283 or by the B-mode processor 281, as appropriate depending on whether the source of the data signal is ultrasound energy or photoacoustic energy. The source of the data signal may be determined based on the timing signal from the trigger generator 281.
The conditioned data signal from the signal conditioner 269 is also passed to the continuous wave (CW) beam former 275, which helps process the analog data signal for eventually producing Doppler images. From the CW beam former 275, the data signal is passed to another analogue to digital converter 277, and then into the image processing module 253, wherein it is processed by the Doppler processor 285 to produce Doppler images. As previously indicated, the different types of images (photoacoustic, B-mode, and Doppler) produced by the image processing module 253 are then communicated to the programmable device 107 for display on the display screen 287.
In certain embodiments, image processing may be performed solely within the image processing module 253, so that the programmable device 107 receives fully formed images and/or video for display. In certain other embodiments, aspects of image processing may be distributed between the image processing module 253 and the programmable device 107. In still other embodiments, the image processing module 253 may be incorporated into the programmable device 107 such that the entirety to of the image processing is performed by the programmable device 107.
In certain embodiments, the image processing system of
The different types of images may be displayed individually on the display screen, or one or more of the image types may be displayed overlapped with co-registration. Displaying the co-registered images often aids in providing additional contextual information which is unavailable from viewing the images individually or even side-by-side. Co-registration, therefore, may provide significant advantages in the clinical setting.
An alternative configuration for the probe head 311 is illustrated in
The light emitting elements 321 are shown on opposite sides of the ultrasound receiver 319, with each light emitting element 321 positioned on an emission plane 325. Each light emitting element 321 directs light away from the emission plane 325 and into the tissue 315. In certain embodiments, the emission plane 325 for each light emitting element 321 may be defined by a polycarbonate board to which the LDs 323 are mounted. In other embodiments, the emission planes 325 may be defined by other structure within the probe head 311. In still other embodiments, each emission plane 325 may be an imaginary plane defined within the probe head 311 by the respective positions of the LDs 323 of each light emitting element 321. Each emission plane 325 is positioned at an acute angle with respect to the transducer plane (which is parallel to the x-y plane and normal to the z-axis), such that the light cones 325, 327 produced by each light emitting element 321 are directed into the tissue 315 to form an imaging zone 329. The depth D of the imaging zone 329 determines the depth of the photoacoustic image produced by the imaging system. In certain embodiments, each light emitting element 321 may include light beam shaping optics to shape the light cones 325, 327 and achieve a more uniform delivery of multiple wavebands of light from multiple LDs onto and in the tissue.
An alternative configuration for a probe head 401 is shown in
As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. In addition, all references cited herein are hereby incorporated by referenced in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.
While the invention has been described with respect to specific examples including presently preferred modes of carrying out the invention, those skilled in the art will appreciate that there are numerous variations and permutations of the above described systems and techniques. It is to be understood that other embodiments may be utilized and structural and functional modifications may be made without departing from the scope of the present invention. Thus, the spirit and scope of the invention should be construed broadly as set forth in the appended claims.
