Claims
- 1. A compound of formula I:
- 2. A compound according to claim 1, wherein:
G is selected from the group: 47A is selected from one of the following carbocyclic and heterocyclic systems which are substituted with 0-2 R4;
phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thiophenyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl; B is Y or X-Y; X is selected from C1-4 alkylene, —C(O)—, —C (═NR)—, —CR2(NR2R2a)—, —C(O)CR2R2a—, —CR2R2aC(O), —C(O)NR2—, —NR2C(O)—, —C(O)NR2CR2R2a—, —NR2C(O)CR2R2a—, —CR2R2aC(O)NR2, —CR2R2aNR2C(O)—, —NR2C(O)NR2—, —NR2—, —NR2CR2R2a—, —CR2R2aNR2—, O, —CR2R2aO—, and —OCR2R2a—; Y is CH2NR2R2a or CH2CH2NR2R2a; alternatively, Y is selected from one of the following carbocyclic and heterocyclic systems that are substituted with 0-2 R4a;
cyclopropyl, cyclopentyl, cyclohexyl, phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thiophenyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, isoxazolinyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl; alternatively, Y is selected from the following bicyclic heteroaryl ring systems: 48K is selected from O, S, NH, and N.
- 3. A compound according to claim 2, wherein:
G is selected from the group: 49S is 0.
- 4. A compound according to claim 3, wherein:
G is selected from: 50
- 5. A compound according to claim 4, wherein:
A is selected from phenyl, pyridyl, and pyrimidyl, and is substituted with 0-2 R4; and, B is selected from phenyl, pyrrolidino, N-pyrrolidino-carbonyl, morpholino, N-morpholino-carbonyl, 1,2,3-triazolyl, imidazolyl, and benzimidazolyl, and is substituted with 0-1 R4a; R2, at each occurrence, is selected from H, CH3, CH2CH3, cyclopropylmethyl, cyclobutyl, and cyclopentyl; R2a, at each occurrence, is H or CH3; alternatively, R2 and R2a, together with the atom to which they are attached, combine to form pyrrolidine substituted with 0-2 R4b; R4, at each occurrence, is selected from OH, (CH2)rOR2, halo, C1-4 alkyl, (CH2)rNR2R2a, and (CF2)rCF3; R4a is selected from C1-4 alkyl, CF3, (CH2)rOR2, (CH2)rNR2R2a, S(O)pR5, SO2NR2R2a, and 1-CF3-tetrazol-2-yl; R4b, at each occurrence, is selected from H, CH3, and OH; R5, at each occurrence, is selected from CF3, C1-6 alkyl, phenyl, and benzyl; and, r, at each occurrence, is selected from 0, 1, and 2.
- 6. A compound according to claim 5, wherein:
A is selected from the group: phenyl, 2-pyridyl, 3-pyridyl, 2-pyrimidyl, 2—Cl-phenyl, 3—Cl-phenyl, 2-F-phenyl, 3-F-phenyl, 2-methylphenyl, 2-aminophenyl, and 2-methoxyphenyl; and, B is selected from the group: 2-(aminosulfonyl)phenyl, 2-(methylaminosulfonyl)phenyl, 1-pyrrolidinocarbonyl, 2-(methylsulfonyl)phenyl, 2-(N,N-dimethylaminomethyl)phenyl, 2-(N-pyrrolidinylmethyl)phenyl, 1-methyl-2-imidazolyl, 2-methyl-1-imidazolyl, 2-(dimethylaminomethyl)-1-imidazolyl, 2-(N-(cyclopropylmethyl)aminomethyl)phenyl, 2-(N-(cyclobutyl)aminomethyl)phenyl, 2-(N-(cyclopentyl)aminomethyl)phenyl, and 2-(N-(3-hydroxypyrrolidinyl)methyl)phenyl.
- 7. A compound according to claim 1, wherein the compound is selected from:
1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl)-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-t[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[l-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2,-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-1,11′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-51-yl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl)-2-fluoro-phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine; 3-[6,7-dihydro-6-[2′-[aminomethyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[dimethylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl][,1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[N-ethyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[pyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl[methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[N-propyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[t-butylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[aminomethyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[dimethylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[N-ethyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-iH-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[pyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3[6,7-dihydro-6[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo [4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[N-propyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[2′-[[t-butylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[6,7-dihydro-6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; and, 3-[6,7-dihydro-6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; or a pharmaceutically acceptable salt form thereof.
- 8. A compound of formula III:
- 9. A compound according to claim 8, wherein:
ring M is substituted with 0-2 R3 and is selected from the group: 54Z2 is selected from H, C1-4 alkyl, phenyl, benzyl, C(O)R3, and S(O)pR3c; G is selected from the group: 55A is selected from one of the following carbocyclic and heterocyclic systems which are substituted with 0-2 R4;
phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thiophenyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl; B is Y or X-Y; X is selected from C1-4 alkylene, —C(O)—, —C (═NR)—, —CR2 (NR2R2a)—, —C(O) CR2R2a—, —CR2R2aC(O), —C(O) NR2—, —NR2C(O)—, —C(O)NR2CR2R2a—, —NR2C(O)CR2R2a—, —CR2R2aC(O)NR2—, CR2R2aNR2C(O)—, —NR2C(O)NR2—, —NR2—, —NR2CR2R2a—, CR2R2aNR2—, —CR2R2aO—, and —OCR2R2a—; Y is CH2NR2R2a or CH2CH2NR2R2a; alternatively, Y is selected from one of the following carbocyclic and heterocyclic systems that are substituted with 0-2 R4a;
cyclopropyl, cyclopentyl, cyclohexyl, phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thiophenyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, isoxazolinyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl; alternatively, Y is selected from the following bicyclic heteroaryl ring systems: 56K is selected from O, S, NH, and N.
- 10. A compound according to claim 9, wherein:
ring M is substituted with 0-2 R3 and is selected from the group: 57G is selected from the group: 58s is 0.
- 11. A compound according to claim 10, wherein:
ring M is substituted with 0-1 R3 and is selected from the group: 59G is selected from: 60
- 12. A compound according to claim 11, wherein:
A is selected from phenyl, pyridyl, and pyrimidyl, and is substituted with 0-2 R4; and, B is selected from phenyl, pyrrolidino, N-pyrrolidino-carbonyl, morpholino, N-morpholino-carbonyl, 1,2,3-triazolyl, imidazolyl, and benzimidazolyl, and is substituted with 0-1 R4a; R2, at each occurrence, is selected from H, CH3, CH2CH3, cyclopropylmethyl, cyclobutyl, and cyclopentyl; R2a at each occurrence, is H or CH3; alternatively, R2 and R2a, together with the atom to which they are attached, combine to form pyrrolidine substituted with 0-2 R4b; R4, at each occurrence, is selected from OH, (CH2)rOR2, halo, C1-4 alkyl, (CH2)rNR2R2a, and (CF2)rCF3; R4a is selected from C1-4 alkyl, CF3, (CH2)rOR2, (CH2)rNR2R2a, S(O)pR5, SO2NR2R2a, and 1-CF3-tetrazol-2-yl; R4b, at each occurrence, is selected from H, CH3, and OH; R5, at each occurrence, is selected from CF3, C1-6 alkyl, phenyl, and benzyl; and, r, at each occurrence, is selected from 0, 1, and 2.
- 13. A compound according to claim 12, wherein:
A is selected from the group: phenyl, 2-pyridyl, 3-pyridyl, 2-pyrimidyl, 2—Cl-phenyl, 3—Cl-phenyl, 2-F-phenyl, 3-F-phenyl, 2-methylphenyl, 2-aminophenyl, and 2-methoxyphenyl; and, B is selected from the group: 2-(aminosulfonyl)phenyl, 2-(methylaminosulfonyl)phenyl, 1-pyrrolidinocarbonyl, 2-(methylsulfonyl)phenyl, 2-(N,N-dimethylaminomethyl)phenyl, 2-(N-pyrrolidinylmethyl)phenyl, 1-methyl-2-imidazolyl, 2-methyl-1-imidazolyl, 2-(dimethylaminomethyl)-1-imidazolyl, 2-(N-(cyclopropylmethyl)aminomethyl)phenyl, 2-(N-(cyclobutyl)aminomethyl)phenyl, 2-(N-(cyclopentyl)aminomethyl)phenyl, and 2-(N-(3-hydroxypyrrolidinyl)methyl)phenyl.
- 14. A compound according to claim 8, wherein the compound is selected from:
7-(3-aminomethyl-phenyl)-1(2′-methanesulfonyl-biphenyl-4-yl)-3-propyl-3,7-dihydro-purine-2,6 dione; 1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-iH-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-f[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine; 3-[4,5,6,7-tetrahydro-6-[2′-[aminomethyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[dimethylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[N-ethyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[pyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[N-propyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-cl]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[t-butylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl}phenyl}-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[aminomethyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[dimethylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[N-ethyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[pyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[N-propyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[t-butylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; and, 3-[4,5,6,7-tetrahydro-6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; or a pharmaceutically acceptable salt form thereof.
- 15. A compound according to claim 8, wherein the compound is selected from:
1-(4-Methoxyphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-Methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl}-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[l-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2 ′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′biphenyl-4yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-1,1-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo [4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{21-[(N-methyl-N-propylamino)methyl -1,1′-biphenyl-4-yl}-7-oxo-1,6-6 dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[l-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine; 3-[1,6-dihydro-6-[2′-[aminomethyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[dimethylamino]methyl][1,11-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[21-[[4-hydroxypiperidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[N-ethyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[pyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[N-propyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[t-butylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[aminomethyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[methylamino]methyl}-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[dimethylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[N-ethyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[pyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[N-propyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-dl pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[2′-[[t-butylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; 3-[1,6-dihydro-6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide; or a pharmaceutically acceptable salt form thereof.
- 16. A compound according to claim 8, wherein the compound is selected from:
1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl]-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[l-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{2′-[(4-hydroxy-1-piperidinyl}methyl]-1,1′-biphenyl-4-yl]-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 6-(2′-methylsulfonyl-3-fluoro-11′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine; 3-[4,5,6,7-tetrahydro-6-[2′-[aminomethyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[methylamino]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[dimethylamino]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo [4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6[2′-[[N-ethyl-N-methylamino]methyl][1, ′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[pyrrolidin-1-yl]methyl][1,11′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[N-propyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[t-butylamino]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[aminomethyl]-3-fluoro-[1,11-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[dimethylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[N-ethyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[pyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[l,′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[N-propyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[2′-[[t-butylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; 3-[4,5,6,7-tetrahydro-6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; or a pharmaceutically acceptable salt form thereof.
- 17. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
- 18. A method for treating a thromboembolic disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
CROSS-REFERENCED APPLICATIONS
[0001] This application is a continuation in part of U.S. application Ser. No. 09/470,326, filed Dec. 22, 1999, pending, which claims the benefit of U.S. Provisional Application No. 60/127,633, filed Apr. 2, 1999, now abandoned and U.S. Provisional Application No. 60/113,628, filed Dec. 23, 1998, no abandoned. The contents of each application are incorporated herein by reference.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60127633 |
Apr 1999 |
US |
|
60113628 |
Dec 1998 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09470326 |
Dec 1999 |
US |
Child |
09898279 |
Jul 2001 |
US |