Claims
- 1. The compound of the formula: ##STR41## wherein R is hydrogen; C.sub.1-7 alkyl; C.sub.2-6 alkenyl; C.sub.1-7 alkyl substituted with C.sub.3-6 cycloalkyl, C.sub.1-5 alkoxy, or hydroxy, or C.sub.4-7 cycloalkyl; R.sup.1 and R.sup.2 and R.sup.4 is hydrogen; 5- or 6- fluoro; 5- or 6- chloro; or 5- or 6- C.sub.1-5 alkoxy carbonylamino on adjacent carbon atoms taken together ##STR42## wherein R.sup.5 and R.sup.6 are hydrogen or lower alkyl.
- 2. The compound of claim 1 being 1-isopropyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)-imidazo[4,5-b]pyridin-2-one.
- 3. The compound of claim 1 being 1-butyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)-imidazo[4,5-b]pyridin-2-one.
- 4. The compound of claim 1 being 6-ethoxycarbonylamino-1-n-propyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl-imidazo[4,5-pyridin-2-one.
- 5. The compound of claim 1 being 5-fluoro-1-allyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one.
- 6. The compound of claim 1 being 6-fluoro-1-n-propyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5b]pyridin-2-one.
- 7. The compound of claim 1 being 5-ethoxycarbonylamino-1-allyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-]-one.
- 8. The compound of claim 1 being 5-fluoro-1,3-dihydro-3-(3,4-methylenedioxyphenyl) imidazo[4,5-b]pyridin-2-one.
- 9. The compound of claim 1 being 1-n-propyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one.
- 10. The compound of claim 1 being 1-methyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one.
- 11. The compound of claim 1 being 1-ethyl-1,2-dihydro-/3-(3,4-methylenedioxyphenyl)imidazo[4.5-pyridin-2-one.
- 12. The compound of claim 1 being 1-cyclopropylmethyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one.
- 13. The compound of claim 1 being 1-hydroxyethyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one.
- 14. The compound of claim 1 being 1-cyclopentyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one.
- 15. The compound of claim 1 being 1-methoxymethyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one.
- 16. The compound of claim 1 being 5-chloro-1-allyl-1,3-dihydro-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one.
- 17. The compound of claim 1 being 1-allyl-1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one.
- 18. The compound of claim 1 being 1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one.
- 19. A method of treating pain and/or inflammation and/or fever which comprise the administration to a patient in need of such treatment an effective amount of a compound of formula: ##STR43## wherein R is hydrogen; C.sub.1-7 alkyl; C.sub.2-6 alkenyl; substituted with C.sub.3-6 cylcoalkyl, C.sub.1-5 alkoxy, or hydroxy; or C.sub.4-7 cycloalkyl;
- R.sup.1 and R.sup.2 are hydrogen; fluoro; C.sub.1-5 alkyl; or --O--CH.sub.2 --O-- attached to adjacent carbon atoms; and R.sup.4 is hydrogen; 5- or 6- fluoro; 5- or 6- chloro; or 5- or 6- C.sub.1-5 alkoxy carbonylamino.
- 20. A pharmaceutical composition comprising a carrier and an effective amount of a compound of formula: ##STR44## wherein R is hydrogen; C.sub.1-7 alkyl; C.sub.2-7 alkenyl; substituted with C.sub.3-6 cycloalkyl, C.sub.1-5 alkoxy, or hydroxy; or C.sub.4-7 cycloalkyl;
- R.sup.1 and R.sup.2 are hydrogen; fluoro; C.sub.1-5 alkyl; or --O--CH.sub.2 --O-- attached to adjacent carbon atoms; and R.sup.4 is hydrogen; 5- or 6- fluoro; 5- or 6- chloro; or 5- or 6- C.sub.1-5 alkoxy carbonylamino.
Parent Case Info
This application is a continuation-in-part of prior co-pending application Ser. No. 670,798, filed Mar. 26, 1976 and now abandoned, which in turn was a continuation-in-part of application Ser. No. 601,672, filed May 28, 1975, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3719683 |
Robinson et al. |
Mar 1973 |
|
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
670798 |
Mar 1976 |
|
Parent |
601672 |
May 1975 |
|