Claims
- 1. A quinoline compound of the formula ##STR8## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, cyano, lower alkynyl, phenyl, phenyl-lower alkyl, lower alkenyl, nitro, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl;
- M is 0 or 1;
- R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, phenyl, phenyl-lower alkyl, alkylaminoalkyl, aminoalkyl or carboxyalkyl; and
- X is cyano, formyloximino, tetrazolyl, carbalkoxyalkyl, carboxyalkyl, or COOR.sub.4 in which the R.sub.4 group is hydrogen, alkyl or an alkyl substituted by an alkoxy or amino group.
- 2. A compound according to claim 1 in which R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halogen, trifluoromethyl, cyano, nitro or lower alkoxy.
- 3. The compound of claim 1 wherein X is of the formula ##STR9## wherein a is 0 or 1 and R.sub.4 is hydrogen, alkyl or alkyl substituted with an alkoxy or amino group.
- 4. The compound of claim 3 wherein R.sub.1 is H and R.sub.2 is hydrogen, C.sub.1 -C.sub.5 alkyl, halo, nitro, cyano, trifluoromethyl, C.sub.1 -C.sub.5 alkyl amino.
- 5. The compound of claim 4 wherein R.sub.2 is at the 5 position.
Parent Case Info
This application is a division of our prior copending application Ser. No. 476,673, filed Mar. 18, 1983, which was a continuation-in-part of now pending U.S. application Ser. No. 362,712, filed Mar. 29, 1982.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4075552 |
Traficante et al. |
Feb 1978 |
|
4129822 |
Traficante |
Dec 1978 |
|
4446431 |
McKay |
May 1984 |
|
4525584 |
Gallick-Whitaker |
Jun 1985 |
|
Non-Patent Literature Citations (2)
Entry |
Z. Ovary et al., Proc. of Soc. of Exptl. Biology and Medicine, 81, 584-586 (1952). |
E. Kusner et al., J. Pharmacology and Experimental Therapeutics, 184, 41-46 (1973). |
Divisions (1)
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Number |
Date |
Country |
Parent |
476673 |
Mar 1983 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
362712 |
Mar 1982 |
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