Claims
- 1. A method for the treatment or prevention of convulsions or migraine which comprises administering to a patient in need thereof an effective amount of a compound of the formula I: wherein:X1 represents hydrogen or fluoro; R11 represents hydrogen, C1-6 alkyl, halo(C1-6)alkyl, dihalo(C1-6)alkyl, hydroxy(C1-6)alkyl, halogen, trifluoromethyl, C1-6 alkoxy, formyl, C2-6 alkylcarbonyl, C2-6 alkoxycarbonyl or —CR4═NOR5, or a heteroaryl selected from the group consisting of: pyridinyl, quinolinyl, isoquinolinyl, pyridazinyl, pyrimidinyl, pyrazinyl, furyl, benzofuryl, dibenzofuryl, thienyl, benzthienyl, pyrrolyl, indolyl, pyrazolyl, indazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, benzimidazolyl, oxadiazolyl, thiadiazolyl, triazolyl and tetrazolyl; R4 represents hydrogen or C1-6 alkyl; R5 represents hydrogen, C1-6 alkyl, hydroxy(C1-6)alkyl or di(C1-6)alkylamino(C1-6)alkyl; and R6 represents fluoro, or a pharmaceutically acceptable salt thereof.
- 2. The method of claim 1 wherein the compound of formula I the fluorine atom R6 is attached to the phenyl ring at the 6-position (relative to the cyano group at position 2).
- 3. The method of claim 1 wherein the compound of formula I X1 represents fluorine.
- 4. The method of claim 1 wherein the compound of formula I R11 represents 2-hydroxyprop-2-yl.
- 5. The method of claim 1 wherein the compound is selected from the group consisting of:4,2′-difluoro-5′-[3-(1-fluoro-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile; 5,2′-difluoro-5′-(3-trifluoromethylimidazo[1,2-b][1,2,4]triazin-7-yl)-biphenyl-2-carbonitrile; 4,2′-difluoro-5′-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile; 4-fluoro-3′-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]-biphenyl-2-carbonitrile; 6,2′-difluoro-5′-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile; and pharmaceutically acceptable salts thereof.
- 6. A method for the treatment of convulsions which comprises administering to a patient in need thereof an effective amount of 6,2′-difluoro-5′-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile or a pharmaceutically acceptable salt thereof.
- 7. A method for the prevention of convulsions which comprises administering to a patient in need thereof an effective amount of 6,2′-difluoro-5′-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile or a pharmaceutically acceptable salt thereof.
- 8. A method for the treatment of migraine which comprises administering to a patient in need thereof an effective amount of 6,2′-difluoro-5′-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile or a pharmaceutically acceptable salt thereof.
- 9. A method for the prevention of migraine which comprises administering to a patient in need thereof an effective amount of 6,2′-difluoro-5′-[3-(1-hydroxy-1-methylethyl)imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile or a pharmaceutically acceptable salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
0117277 |
Jul 2001 |
GB |
|
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a division of application Ser. No. 10/195,274, filed Jul. 15, 2002, now U.S. Pat. No. 6,617,326, which claims priority under 35 U.S.C. §119 from GB Application No. 0117277.4, filed Jul. 16, 2001.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3422194 |
Loev |
Jan 1969 |
A |
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