Claims
- 1. A compound of the formula ##STR92## wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, hydroxy lower alkyl, C.sub.1 to C.sub.7 acyloxy lower alkyl, phenyl, C.sub.1 to C.sub.7 alkoxy lower alkyl, halo lower alkyl, amino lower alkyl, mono- or di- C.sub.1 to C.sub.7 alkyl or phenyl or chlorophenyl or tolyl substituted amino lower alkyl pyridyl, tolyl alkyl and the groups ##STR93## wherein R is hydrogen or lower alkyl and COOR wherein R is lower alkyl; R.sub.2 is selected from the group consisting of hydrogen, lower alkyl, hydroxy lower alkyl, C.sub.1 to C.sub.7 acyloxy lower alkyl, C.sub.1 to C.sub.7 alkoxy lower alkyl, halo lower alkyl, chloro, bromo, iodo, cyano, cyano lower alkyl, mono- or di- C.sub.1 to C.sub.7 alkyl or phenyl or chlorophenyl or tolyl substituted amino lower alkyl, amino lower alkyl, amino, mono- or di- C.sub.1 to C.sub.7 alkyl or phenyl or chlorophenyl or tolyl substituted amino, the group --COOR where R is hydrogen or lower alkyl, the group ##STR94## where R is hydrogen or lower alkyl, or the group ##STR95## wherein R' is hydrogen, lower alkyl, hydroxy, phenyl, C.sub.1 to C.sub.7 alkoxy, amino, mono or di-alkylamino and phenyl or tolyl amino and R is hydrogen or lower alkyl, the group ##STR96## (where R, R' are hydrogen, lower alkyl, phenyl or tolyl, hydroxy lower alkyl, lower alkenyl, or together R and R' with the nitrogen atom may form a part of a 5- or 6-membered heterocyclic ring and the group (CH.sub.2).sub.n NRR' where R and R' are hydrogen, lower alkyl, hydroxy lower alkyl, lower alkenyl, phenyl, tolyl or together R and R' with the nitrogen atom form a part of a 5- or 6-membered heterocyclic ring); the group ##STR97## where R.sup.10, R.sup.11, R.sup.12 are hydrogen or lower alkyl, and the group (CH.sub.2).sub.n NR.sup.13 R.sup.14 where n is 1 to 4 and R.sup.13, R.sup.14 are hydrogen or lower alkyl with limitation that where R.sup.10, R.sup.11 or R.sup.12 is a basic side chain, then remaining substituents are hydrogen or lower alkyl; R.sub.4 is selected from the group consisting of hydrogen, halogen, nitro, cyano, trifluoromethyl, lower alkyl, hydroxy lower alkyl and lower alkanoyl; R.sub.3 is selected from the group consisting of hydrogen and lower alkyl; R.sub.6 is selected from the group consisting of phenyl, mono-halo or mono-nitro substituted phenyl, di-halo or halo/nitro substituted phenyl, pyridyl and mono-halo or mono-nitro substituted pyridyl; and ##STR98## is selected from the group consisting of ##STR99## and the pharmaceutically acceptable salts thereof.
Parent Case Info
This is a division of application Ser. No. 905,820 filed May 15, 1978, now U.S. Pat. No. 4,280,957, which is a continuation of Ser. No. 663,660, filed Mar. 4, 1978 (now abandoned) which is a CIP of Ser. No. 602,691, filed Aug. 7, 1975 (now abandoned) which is a CIP of Ser. No. 504,924, filed Sept. 11, 1974 (now abandoned).
US Referenced Citations (5)
Divisions (1)
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Number |
Date |
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Parent |
905820 |
May 1978 |
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Continuations (2)
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Number |
Date |
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Parent |
663660 |
Mar 1978 |
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Parent |
602691 |
Aug 1975 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
504924 |
Sep 1974 |
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