Claims
- 1. A compound of the formula: ##STR5## wherein A taken together with the nitrogen and carbon atoms shown forms an imidazoline ring, said ring having a keto or thione group and optionally substituted by one or two lower alkyl, phenyl or benzyl groups; R is a grouping of the formula:
- Het--CH.sub.2 Z(CH.sub.2).sub.n --
- wherein Het is an imidazole ring, said ring being optionally substituted by lower alkyl, amino, hydroxy or halogen; Z is sulphur or a methylene group and n is 2 or 3 or a pharmaceutically acceptable acid addition salt thereof.
- 2. A compound of claim 1 of the following formula: ##STR6## wherein R has the same significance as in claim 1; X is oxygen or sulphur; and Y.sub.3 and Y.sub.4, which may be the same or different, are hydrogen, lower alkyl, phenyl or benzyl.
- 3. A compound of claim 1 wherein Het is an imidazole ring, optionally substituted by methyl.
- 4. A compound of claim 1 wherein n is 2.
- 5. A compound of claim 1, said compound being 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-2-imidazolin-4-one.
- 6. A compound of claim 1, said compound being 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-2-imidazolin-4-one dihydrochloride.
- 7. A compound of claim 1, said compound being 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-5-methyl-2-imidazolin-2-one.
- 8. A compound of claim 1, said compound being 5,5-dimethyl-2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-2-imidazolin-4-one.
- 9. A compound of claim 1, said compound being 5-benzyl-2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-2-imidazolin-4-one.
Priority Claims (2)
Number |
Date |
Country |
Kind |
21063/73 |
May 1973 |
GBX |
|
3551/73 |
Jul 1973 |
GBX |
|
Parent Case Info
This is a division of application Ser. No. 007,755 filed Jan. 30, 1979, now U.S. Pat. No. 4,260,744 which is a division of application Ser. No. 778,812 filed Mar. 17, 1977, now U.S. Pat. No. 4,153,793 which is a division of application Ser. No. 619,724 filed Oct. 6, 1975, now U.S. Pat. No. 4,035,374 which is a division of application Ser. No. 463,647 filed Apr. 24, 1974, now U.S. Pat. No. 3,932,644.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3666767 |
Wittekind et al. |
May 1972 |
|
4181730 |
Durant et al. |
Jan 1980 |
|
Divisions (4)
|
Number |
Date |
Country |
Parent |
7755 |
Jan 1979 |
|
Parent |
778812 |
|
|
Parent |
619724 |
Oct 1975 |
|
Parent |
463647 |
Apr 1974 |
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