Claims
- 1. A compound of the formula:
- 2. The compound according to claim 1, wherein R14 is hydrogen.
- 3. The compound according to claim 2, wherein R1 is alkyl.
- 4. The compound according to claim 3, wherein R1 is selected from the group consisting of methyl, ethyl, and isopropyl.
- 5. The compound according to claim 3, wherein R2 is hydrogen.
- 6. The compound according to claim 5, wherein each of R7 and R8 is independently hydrogen or methyl.
- 7. The compound according to claim 6, wherein each of R3, R4, R5, and R6 is independently hydrogen, halide, alkyl, or —OR9, where R9 is hydrogen, alkyl, a hydroxy protecting group, or cycloalkylalkyl; or R3 and R4 together with atoms to which they are attached to form heterocyclyl, heteroaryl, or cycloalkyl.
- 8. The compound according to claim 7, wherein at least one of R3, R4, R5, and R6 is alkyl, halide, or —OR9, where R9 is as defined in claim 1.
- 9. The compound according to claim 8, wherein at least one of R3, R4, R5, and R6 is bromo, chloro, fluoro, methoxy, ethoxy, methyl, and hydroxy.
- 10. The compound according to claim 9, wherein
(a) R3 is methoxy, and R4, R5 and R6 are hydrogen; (b) R3 is methyl, R6 is methoxy, and R4 and R5 are hydrogen; (c) R3 is methyl, R6 is chloro, and R4 and R5 are hydrogen; (d) R3 is chloro, R4 is methoxy, and R5 and R6 are hydrogen;. (e) R3 is methyl, R4 is chloro, and R5 and R6 are hydrogen; (f) R3 is methyl, R4 is methoxy, and R5 and R are hydrogen; (g) R4 is chloro, and R3, R5 and R6 are hydrogen; (h) R4 is methoxy, and R3, R5, and R6 are hydrogen. (i) R3 is methyl, R6 is bromo, and R4 and R5 are hydrogen; (j) R3 is bromo, R4 is methoxy, and R5 and R6 are hydrogen; (k) R3 is methyl, R4 is bromo, and R5 and R6 are hydrogen; (l) R4 is bromo, and R3, R5 and R6 are hydrogen; or (m) R3 is ethoxy and R4, R5 and R6 are hydrogen.
- 11. The compound according to claim 7, wherein R3 and R4 together with atoms to which they are attached to form furanyl, dihydrofuranyl, or pyrrolyl.
- 12. The compound according to claim 11, wherein R3 and R4 together with atoms to which they are attached to form furanyl or dihydrofuranyl.
- 13. The compound according to claim 12, wherein said compound is of the formula:
- 14. A method for producing an imidazolin-2-ylmethyl-substituted aromatic compound of the formula:
- 15. A method for producing an imidazolin-2-ylmethyl-substituted aromatic compound of the formula:
- 16. The method of claim 15, wherein the trialkylaluminum is trimethylaluminum or triethylaluminum.
- 17. A composition comprising:
(a) a therapeutically effective amount of a compound of claim 1; and (b) a pharmaceutically acceptable carrier.
- 18. A method for treating a disease state selected from the groups consisting of urge incontinence, stress incontinence, overflow incontinence, functional incontinence, sexual dysfunction, nasal congestion, and CNS disorders selected from the group depression, anxiety, dementia, senility, Alzheimer's, deficiencies in attentiveness and cognition, eating disorders, obesity, bulimia and anorexia, said method comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound of claim 1.
- 19. A method for treating a disease state comprising urinary incontinence by administering to a subject in need of such treatment an effective amount of a Compound of claim 1.
- 20. The method of claim 19, wherein the disorder is stress incontinence.
- 21. The method of claim 19, wherein the disorder is urge incontinence.
- 22. A method for treating nasal congestion by administering to a mammal in need of such treatment an effective amount of a Compound of claim 1.
- 23. The method of claim 22, wherein the disorder is nasal congestion.
- 24. The method of claim 23, wherein the disorder is sinusitis or otitis.
- 25. A method for treating sexual dysfunction by administering to a mammal in need of such treatment an effective amount of a Compound of claim 1.
CROSS REFERENCE TO RELATED INVENTIONS
[0001] This application claims the priority benefit under Title 35 U.S.C. 119(e) of U.S. Provisional Applications Serial No. 60/374,700, filed Apr. 23, 2002 and Serial No. 60/378,775, filed May 8, 2002, the disclosures of which are herein incorporated by reference in their entirety.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60374700 |
Apr 2002 |
US |
|
60378775 |
May 2002 |
US |