Claims
- 1. A compound of the formula I
- wherein Z.sub.3 is
- (a) 1-imidazolyl, or
- (b) 1-imidazolyl substituted by (C.sub.1 -C.sub.3)alkyl;
- wherein X.sub.3 is
- (a) --(CH.sub.2).sub.n --,
- (b) --CHOH--, or
- (c) --C(O)--;
- with the proviso that when X.sub.3 is --(CH.sub.2).sub.n -- and n is not zero, Z.sub.3 is 1-imidazolyl substituted by (C.sub.1 -C.sub.3)alkyl and Z.sub.3 X.sub.3 -- is attached to the 4-position of the benzofuran,
- wherein R.sub.1 is hydrogen, a pharmacologically acceptable cation, (C.sub.1 -C.sub.12) alkyl, (C.sub.3 -C.sub.10) cycloalkyl, (C.sub.7 -C.sub.12) aralkyl, phenyl, phenyl mono-, di-, or trisubstituted by chloro, (C.sub.1 -C.sub.3) or alkyl, or phenyl para-substituted by
- (a) --NHCO--R.sub.25,
- (b) --O--CO--R.sub.26,
- (c) --CO--R.sub.24,
- (d) --O--CO--(p--Ph)--R.sub.27, or
- (e) --CH.dbd.N--NH--CO--NH.sub.2,
- wherein R.sub.24 is phenyl or acetamidophenyl, R.sub.25 is methyl, phenyl, acetamidophenyl, benzamidophenyl, or amino, R.sub.26 is methyl, phenyl, amino or methoxy; and R.sub.27 is hydrogen or acetamido, and wherein --(p--Ph) is 1,4-phenylene;
- wherein R.sub.7 is
- (a) hydrogen,
- (b) --CH.sub.2 OH,
- (c) --COOR.sub.1,
- (d) --CH.sub.2 N(R.sub.4).sub.2,
- (e) --CN
- (f) --CON(R.sub.4).sub.2, or
- (g) --C(O)--R.sub.4 ;
- wherein R.sub.4 is
- (a) hydrogen,
- (b) (C.sub.1 -C.sub.4)alkyl, or
- (c) phenyl;
- wherein R.sub.9 and R.sub.12 are the same or different and are
- (a) hydrogen,
- (b) (C.sub.1 -C.sub.4)alkyl
- (c) fluoro,
- (d) chloro,
- (e) bromo,
- (f) --OCH.sub.3, or,
- (g) when taken together and attached to contiguous carbon atoms, --O--CH.sub.2 --O--;
- wherein D represents a single or a double bond;
- wherein m and n are the same or different and are the integers 0 to 4, inclusive; including, a pharmacologically acceptable acid addition salt thereof; and
- when D represents a single bond, an enantiomer or a racemic mixture of enantiomers thereof.
- 2. A compound of claim 1, wherein D denotes a double bond, X.sub.3 is --(CH.sub.2).sub.n --, n is one or two, m is zero, R.sub.9 and R.sub.12 are hydrogen, and R.sub.7 is --COOR.sub.1.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation in part of application Ser. No. 385,619, filed June 8, 1982, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4112224 |
Bundy |
Sep 1978 |
|
4259338 |
Paioni et al. |
Mar 1981 |
|
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Country |
50957 |
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EPX |
2537837 |
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DEX |
2039903A |
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GBX |
Non-Patent Literature Citations (3)
Entry |
D. Harris, et al., Advances in Prostaglandin and Thromboxane Research, 6:437 (1980). |
T. Miyamoto, et al., Advances in Prostaglandin and Thromboxane Research, 6:443 (1980). |
H. Tai, et al., Advances in Prostaglandin and Thromboxane Research, 6:447 (1980). |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
385619 |
Jun 1982 |
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