Claims
- 1. A compound of the formula ##STR40## the stereoisomers and pharmaceutically acceptable salts thereof wherein R.sub.1 is selected from the group consisting of H and C.sub.1-6 alkyl; R.sub.2 is selected from the group consisting of H and halogen;
- Y is selected from the group consisting of NH and O; and
- a is 0 or 1.
- 2. A pharmaceutical composition for the treatment of anxiety, psychoses, depression, substance abuse, cognitive disorders, gastrointestinal motility disturbances or conditions responsive to 5-HT.sub.3 antagonists comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier or diluent.
- 3. A method of treating anxiety, psychoses, depression or gastrointestinal motility disturbances comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound of claim 1.
- 4. A compound according to claim 1 selected from the group consisting of
- N-exo[(4-s,7.alpha.-s)tetrahydro-1H-pyrrolizin-4(5H)-yl]-6-chloroimidazo[1,2-a]pyridine-8-carboxamide dihydrochloride;
- N-exo[tetrahydro-1H-pyrrolizin-4(5H)-yl]-6chloroimidazo[1,2-a]pyridine-8-carboxamide dihydrochloride; and
- N-exo[tetrahydro-1H-pyrrolizin-4(5H)-yl]imidazo[1,2a-]pyridine-8-carboxamide dihydrochloride.
Parent Case Info
This is a Divisional application of application Ser. No. 07/973,126, filed on Nov. 6, 1992 U.S. Pat. No. 5,434,161, which is a continuation of International Application Ser. No. US92/01524 filed Mar. 4, 1992 which is a Continuation-in-Part of Ser. No. 07/666,113 filed Mar. 7, 1991 U.S. Pat. No. 5,260,303.
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Divisions (1)
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Number |
Date |
Country |
Parent |
973126 |
Nov 1992 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
666113 |
Mar 1991 |
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