Claims
- 1. A compound of the formula ##STR7## wherein R.sub.1 and R.sub.3 are hydrogen or lower-alkyl;
- R.sub.5 is lower-alkyl or fluorinated lower-alkyl; and the pyridine-N-oxide is attached at the 4- or 3-position; or a pharmaceutically acceptable acid-addition salt thereof.
- 2. 1,3-Dihydro-6-(4-pyridinyl)-5-trifluoromethyl-2H-imidazo[4,5-b]pyridin-2-one N-(py)-oxide according to claim 1.
- 3. A composition for effecting phosphodiesterase inhibition in a mammalian organism which comprises an effective amount of a compound according to claim 1 in admixture with a suitable carrier or diluent.
- 4. A method of treating congestive heart failure or hypertension in a mammalian organism which comprises administering to said organism a composition according to claim 3.
- 5. A method for effecting phosphodiesterase inhibition in a mammalian organism which comprises administering to said organism a composition according to claim 3.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of our application Ser. No. 07/486,637 filed on Feb. 28, 1990 now U.S. Pat. No. 4,963,561.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4276293 |
Lesher et al. |
Jun 1981 |
|
4294837 |
Lesher et al. |
Oct 1981 |
|
4374141 |
Lesher et al. |
Feb 1983 |
|
4963561 |
Lesher et al. |
Oct 1990 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
486637 |
Feb 1990 |
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