Claims
- 1. A compound having the formula ##STR10## wherein R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached are 1-pyrrolidinyl, 1-piperidinyl, 1-homopiperidinyl, 4-morpholinyl, 4-alkyl-1piperazinyl, or 4-aryl-1-piperazinyl;
- R.sub.3 is hydrogen, alkyl, aryl, arylalkyl, alkanoyl or arylcarbonyl;
- R.sub.4 is hydrogen, alkyl, alkylthio, or trifluoromethyl;
- R.sub.5 is hydrogen, alkyl, or arylalkyl;
- n is 0, 1 or 2; and
- p is 1 or 2;
- or a non-toxic, physiologically acceptable salt thereof, or symmetrical dimer thereof; wherein the term "aryl" refers to phenyl, 1-naphthyl, 2-naphthyl, or phenyl monosubstituted with halogen, alkyl, alkoxy, alkylthio, hydroxy, alkanoyl, nitro, amino, dialkylamino, phenyl or trifluoromethyl groups; the term "alkanoyl" refers to groups having up to 9 carbon atoms; and the terms "alkyl" and "alkoxy" refer to groups having 1 to 8 carbon atoms.
- 2. A compound in accordance with claim 1 wherein R.sub.3 is hydrogen.
- 3. A compound in accordance with claim 1 wherein R.sub.4 is hydrogen.
- 4. A compound in accordance with claim 1 wherein R.sub.4 is alkyl.
- 5. A compound in accordance with claim 1 wherein R.sub.4 is alkylthio.
- 6. A compound in accordance with claim 1 wherein R.sub.4 is trifluoromethyl.
- 7. A compound in accordance with claim 1 wherein n is 1.
- 8. A compound in accordance with claim 1 wherein n is 2.
- 9. A compound in accordance with claim 1 wherein p is 1.
- 10. A compound in accordance with claim 1 wherein p is 2.
- 11. A compound in accordance with claim 1 wherein R.sub.5 is hydrogen.
- 12. A compound in accordance with claim 1 wherein n is 1, p is 1, R.sub.4 is methyl, and R.sub.5 is hydrogen.
Parent Case Info
This is a division of application Ser. No. 162,341, filed June 23, 1980, now U.S. Pat. No. 4,310,461, issued Jan. 12, 1982.
US Referenced Citations (11)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2028327 |
Mar 1980 |
GBX |
Divisions (1)
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Number |
Date |
Country |
Parent |
162341 |
Jun 1980 |
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